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Livermore
Livermore
ZHEN

Ikarian Capital, LLC

SEC CIK
0001778253
Latest filing
Aug 14, 2026

Holdings in Q1 2024

Holdings as of Mar 31, 2024, filed May 17, 2024. Long positions only; changes compare share counts with Q4 2023.

Institution overview
Positions
82
+4 vs. Q4 2023
Portfolio value
$367.7M
+$2.11M (+0.6%) vs. Q4 2023
Filed
May 17, 2024
AmendedSEC
Holdings of Ikarian Capital, LLC in Q1 2024
SecurityClassSharesValue% of portfolioShare changeActionHistory
CRNXCrinetics Pharmaceuticals, Inc.COM643,751$30.1M8.2%−36,619−5.4%ReducedHistory
TARSTarsus Pharmaceuticals, Inc.COM710,277$25.8M7.0%+191,758+37.0%AddedHistory
SLNOSoleno Therapeutics IncCOM565,411$24.2M6.6%−24,832−4.2%ReducedHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM NEW559,271$21.9M6.0%+363,372+185.5%AddedHistory
SRPTSarepta Therapeutics, Inc.COM152,278$19.7M5.4%+19,638+14.8%AddedHistory
JBIOJade Biosciences, Inc.COM367,965$10.9M3.0%+367,965NewHistory
SLRNACELYRIN, Inc.COM1,564,340$10.6M2.9%−426,665−21.4%ReducedHistory
ALPNAlpine Immune Sciences, Inc.COM261,365$10.4M2.8%−225,883−46.4%ReducedHistory
PRAXPraxis Precision Medicines, Inc.COM NEW168,388$10.3M2.8%−31,612−15.8%ReducedHistory
CYTKCytokinetics IncCOM NEW145,147$10.2M2.8%+115,147+383.8%AddedHistory
ANNXAnnexon, Inc.COM1,405,000$10.1M2.7%−1,245,000−47.0%ReducedHistory
IMVTImmunovant, Inc.COM276,925$8.95M2.4%+43,531+18.7%AddedHistory
BBIOBridgeBio Pharma, Inc.COM282,013$8.72M2.4%−191,113−40.4%ReducedHistory
CPRXCatalyst Pharmaceuticals, Inc.COM518,386$8.26M2.2%+12,524+2.5%AddedHistory
RCKTRocket Pharmaceuticals, Inc.COM297,096$8.00M2.2%+57,370+23.9%AddedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM51,541$7.70M2.1%+51,541NewHistory
NUVLNuvalent, Inc.COM101,601$7.63M2.1%−156,541−60.6%ReducedHistory
PYXSPyxis Oncology, Inc.COMMON STOCK1,662,408$7.08M1.9%+1,662,408NewHistory
LYRALyra Therapeutics, Inc.COM1,056,829$6.57M1.8%−197,555−15.7%ReducedHistory
ABEOAbeona Therapeutics Inc.COM NEW888,593$6.44M1.8%+288,593+48.1%AddedHistory
VRNAVerona Pharma plcSPONSORED ADS375,310$6.04M1.6%+7,842+2.1%AddedHistory
ARQTArcutis Biotherapeutics, Inc.COM589,642$5.84M1.6%+589,642NewHistory
Cybin Ord23256X100COM13,953,488$5.77M1.6%+13,953,488New–
CRVOCervoMed Inc.COM237,345$5.53M1.5%+237,345NewHistory
SRRKScholar Rock Holding CorpCOM291,701$5.18M1.4%+291,701NewHistory
MRNSMarinus Pharmaceuticals, Inc.COM NEW537,925$4.86M1.3%−208,144−27.9%ReducedHistory
MGNXMacrogenics IncCOM318,167$4.68M1.3%+318,167NewHistory
XENEXenon Pharmaceuticals Inc.COM107,187$4.61M1.3%+107,187NewHistory
NRIXNurix Therapeutics, Inc.COM300,000$4.41M1.2%+300,000NewHistory
WVEWave Life Sciences, Inc.SHS590,088$3.64M1.0%+590,088NewHistory
LRMRLarimar Therapeutics, Inc.COM438,528$3.33M0.9%−164,340−27.3%ReducedHistory
JSPRJasper Therapeutics, Inc.COM NEW105,175$3.09M0.8%+105,175NewHistory
AEONAEON Biopharma, Inc.CL A257,977$2.99M0.8%00.0%UnchangedHistory
DFTXDefinium Therapeutics, Inc.Stock297,481$2.80M0.8%−302,519−50.4%ReducedHistory
VTYXVentyx Biosciences, Inc.COM507,647$2.79M0.8%+501,733+8,483.8%AddedHistory
KODKodiak Sciences Inc.COM476,586$2.51M0.7%+63,705+15.4%AddedHistory
TRMLTourmaline Bio, Inc.COM108,483$2.48M0.7%+108,483NewHistory
QUREuniQure N.V.SHS469,133$2.44M0.7%+311,768+198.1%AddedHistory
IBIOiBio, Inc.COM NEW600,000$2.44M0.7%+600,000NewHistory
NUVBNuvation Bio Inc.COM CL A633,282$2.31M0.6%−589,570−48.2%ReducedHistory
SGMTSagimet Biosciences Inc.COM SER A412,565$2.24M0.6%+412,565NewHistory
IMUXImmunic, Inc.COM1,612,378$2.13M0.6%+1,612,378NewHistory
APLSApellis Pharmaceuticals, Inc.COM35,092$2.06M0.6%+731+2.1%AddedHistory
ATXSAstria Therapeutics, Inc.COM140,687$1.98M0.5%−234,120−62.5%ReducedHistory
LENZLENZ Therapeutics, Inc.COM85,000$1.90M0.5%+85,000NewHistory
Achilles Therapeutics PLC00449L102SPONSORED ADS1,443,181$1.80M0.5%+1,443,181New–
VYGRVoyager Therapeutics, Inc.COM180,857$1.68M0.5%−125,000−40.9%ReducedHistory
IRONDisc Medicine, Inc.COM25,372$1.58M0.4%−169,610−87.0%ReducedHistory
INSMINSMED IncCOM PAR $.0151,335$1.39M0.4%+51,335NewHistory
RAPTRAPT Therapeutics, Inc.COM154,625$1.39M0.4%+154,625NewHistory
ITOSiTeos Therapeutics, Inc.COM101,325$1.38M0.4%−245,146−70.8%ReducedHistory
ALLKAllakos Inc.COM932,675$1.18M0.3%+695,619+293.4%AddedHistory
PRQRProQR Therapeutics N.V.SHS EURO483,583$1.10M0.3%+10,958+2.3%AddedHistory
IFRXInflaRx N.V.COM704,987$1.09M0.3%+16,383+2.4%AddedHistory
ABOSAcumen Pharmaceuticals, Inc.COM266,435$1.08M0.3%−48,830−15.5%ReducedHistory
ROIVRoivant Sciences Ltd.SHS100,609$1.06M0.3%−51,212−33.7%ReducedHistory
AVTXAvalo Therapeutics, Inc.COM NEW46,648$1.01M0.3%+46,648NewHistory
TECXTectonic Therapeutic, Inc.COM754,061$965.2K0.3%+35,802+5.0%AddedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM331,451$941.3K0.3%−546,049−62.2%ReducedHistory
MISTMilestone Pharmaceuticals Inc.COM466,019$834.2K0.2%+3,191+0.7%AddedHistory
TARAProtara Therapeutics, Inc.COM STK202,701$812.8K0.2%+14,037+7.4%AddedHistory
KZRKezar Life Sciences, Inc.COM868,992$783.5K0.2%+15,601+1.8%AddedHistory
ELEVElevation Acquisition Group Inc.COM148,089$759.7K0.2%−1,023,850−87.4%ReducedHistory
NYXHNyxoah SACOMMONSTOCK50,699$683.9K0.2%+50,699NewHistory
VERUVeru Inc.COM946,382$662.6K0.2%+946,382NewHistory
KPTIKaryopharm Therapeutics Inc.COM409,355$618.1K0.2%+9,355+2.3%AddedHistory
TERNTerns Pharmaceuticals, Inc.COM88,497$580.5K0.2%−76,983−46.5%ReducedHistory
IMTXImmatics N.V.SHS49,415$519.4K0.1%+384+0.8%AddedHistory
ANEBAnebulo Pharmaceuticals, Inc.COM157,862$453.1K0.1%00.0%UnchangedHistory
TPSTTempest Therapeutics, Inc.COM105,600$412.9K0.1%00.0%UnchangedHistory
QTTBQ32 Bio Inc.COM22,335$380.6K0.1%+22,335NewHistory
HOOKHOOKIPA Pharma Inc.COM530,776$377.9K0.1%00.0%UnchangedHistory
RLMDRelmada Therapeutics, Inc.COM40,369$187.7K0.1%00.0%UnchangedHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS213,392$166.2K<0.1%00.0%UnchangedHistory
STOKStoke Therapeutics, Inc.COM6,816$92.0K<0.1%−5,300−43.7%ReducedHistory
BCLIBrainstorm Cell Therapeutics Inc.COM NEW90,242$51.0K<0.1%00.0%UnchangedHistory
SYBXSynlogic, Inc.COM NEW20,448$36.6K<0.1%00.0%UnchangedHistory
EYPTEyePoint, Inc.COM NEW1,047$21.6K<0.1%−367,083−99.7%ReducedHistory
FNCHFinch Therapeutics Group, Inc.COM NEW6,892$18.1K<0.1%00.0%UnchangedHistory
TYRATyra Biosciences, Inc.COM501$8.22K<0.1%−47,669−99.0%ReducedHistory
Aslan Pharmaceuticals Ltd04522R200SPON ADS NEW35,420$6.27K<0.1%00.0%Unchanged–
LBPHLongboard Pharmaceuticals, Inc.COM236$5.10K<0.1%−979,226−100.0%ReducedHistory

Options (39)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ikarian Capital, LLC in Q1 2024
SecurityClassPutsCalls
KRYSKrystal Biotech, Inc.COM$66.7M$17.8M
State Street SPDR S&P Biotech ETF78464A870ETF$66.4M–
ALNYAlnylam Pharmaceuticals, Inc.COM$20.4M$18.1M
CORTCorcept Therapeutics IncCOM$25.1M$7.04M
IRONDisc Medicine, Inc.COM$24.7M$3.09M
AZNAstraZeneca PLCSPONSORED ADR–$20.9M
EYPTEyePoint, Inc.COM NEW$13.6M$4.27M
BMEABiomea Fusion, Inc.COM$1.54M$16.1M
AMGNAmgen IncStock–$17.1M
FDMT4D Molecular Therapeutics, Inc.COM$8.21M$8.21M
VKTXViking Therapeutics, Inc.COM$16.4M–
SRPTSarepta Therapeutics, Inc.COM–$15.0M
CRNXCrinetics Pharmaceuticals, Inc.COM$14.1M$407.2K
MDGLMadrigal Pharmaceuticals, Inc.COM$13.7M–
BHVNBiohaven Ltd.COM–$12.2M
BBIOBridgeBio Pharma, Inc.COM–$12.0M
INSMINSMED IncCOM PAR $.01$1.92M$9.42M
LNTHLantheus Holdings, Inc.Stock–$10.6M
AREAlexandria Real Estate Equities, Inc.COM$9.45M–
MLTXMoonLake ImmunotherapeuticsCLASS A ORD$7.94M–
ATXSAstria Therapeutics, Inc.COM$2.16M$5.63M
MGNXMacrogenics IncCOM–$7.71M
CYTKCytokinetics IncCOM NEW$7.01M–
SRRKScholar Rock Holding CorpCOM–$6.43M
ANVSAnnovis Bio, Inc.COM$3.00M$2.98M
APLSApellis Pharmaceuticals, Inc.COM$5.88M–
GPCRStructure Therapeutics Inc.SPONSORED ADS$5.16M$85.7K
MRNSMarinus Pharmaceuticals, Inc.COM NEW$1.92M$2.74M
TRMLTourmaline Bio, Inc.COM–$4.10M
ALPNAlpine Immune Sciences, Inc.COM–$4.08M
TARSTarsus Pharmaceuticals, Inc.COM–$3.63M
AMLXAmylyx Pharmaceuticals, Inc.COM$529.4K$3.01M
SLNOSoleno Therapeutics IncCOM–$3.47M
CABACabaletta Bio, Inc.COM$3.41M–
VRDNViridian Therapeutics, Inc.COM$3.13M–
RAPTRAPT Therapeutics, Inc.COM$2.21M$783.1K
PRAXPraxis Precision Medicines, Inc.COM NEW–$1.33M
CBIOCrescent Biopharma, Inc.COM$518.4K$518.4K
ABEOAbeona Therapeutics Inc.COM NEW–$489.4K

Sold out since Q4 2023 (20)

Positions held at the end of Q4 2023 that are gone from this filing.

Positions of Ikarian Capital, LLC sold out since Q4 2023
SecurityClassShares in Q4 2023Value in Q4 2023% of portfolio in Q4 2023History
ARGXArgenx SESPONSORED ADR70,000$26.5M7.3%History
State Street SPDR S&P Homebuilders ETF78464A888ETF200,000$19.1M5.2%–
PTGXProtagonist Therapeutics, IncCOM319,000$7.31M2.0%History
ICVXIcosavax, Inc.COM440,000$6.93M1.9%History
CABACabaletta Bio, Inc.COM216,620$4.92M1.3%History
FUSNFusion Pharmaceuticals Inc.COM500,000$4.81M1.3%History
CRSPCRISPR Therapeutics AGNAMEN AKT70,546$4.42M1.2%History
DYNDyne Therapeutics, Inc.COM285,900$3.80M1.0%History
EWTXEdgewise Therapeutics, Inc.COM270,000$2.95M0.8%History
IMGNImmunoGen, Inc.COM90,162$2.67M0.7%History
MRNAModerna, Inc.Stock24,546$2.44M0.7%History
AUTLAutolus Therapeutics plcSPON ADS262,694$1.69M0.5%History
BDTXBlack Diamond Therapeutics, Inc.COM555,572$1.56M0.4%History
CHRSCoherus Oncology, Inc.COM340,787$1.13M0.3%History
ESPREsperion Therapeutics, Inc.COM337,636$1.01M0.3%History
LNTHLantheus Holdings, Inc.Stock15,000$930.0K0.3%History
OKUROnKure Therapeutics, Inc.COM421,300$674.1K0.2%History
GPCRStructure Therapeutics Inc.SPONSORED ADS14,524$592.0K0.2%History
TCONTracon Pharmaceuticals, Inc.COM NEW2,765,530$484.2K0.1%History
ACRSAclaris Therapeutics, Inc.COM19,482$20.5K<0.1%History