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Livermore
Livermore
ZHEN

Ikarian Capital, LLC

SEC CIK
0001778253
Latest filing
Aug 14, 2026

Holdings in Q2 2022

Holdings as of Jun 30, 2022, filed Aug 12, 2022. Long positions only; changes compare share counts with Q1 2022.

Institution overview
Positions
99
−56 vs. Q1 2022
Portfolio value
$241.2M
−$87.5M (−26.6%) vs. Q1 2022
Filed
Aug 12, 2022
SEC
Holdings of Ikarian Capital, LLC in Q2 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
CLDXCelldex Therapeutics, Inc.COM NEW537,958$14.5M6.0%00.0%UnchangedHistory
ESPREsperion Therapeutics, Inc.COM2,054,602$13.1M5.4%+2,054,602NewHistory
HZNPHorizon Therapeutics Public Ltd CoSHS160,116$12.8M5.3%+50,000+45.4%AddedHistory
KRTXKaruna Therapeutics, Inc.COM100,000$12.7M5.2%+50,000+100.0%AddedHistory
KZRKezar Life Sciences, Inc.COM1,408,116$11.6M4.8%+325,000+30.0%AddedHistory
VRTXVertex Pharmaceuticals IncStock40,000$11.3M4.7%+15,000+60.0%AddedHistory
ALTAltimmune, Inc.COM NEW897,359$10.5M4.4%+897,359NewHistory
UTHRUnited Therapeutics CorpCOM40,000$9.43M3.9%+40,000NewHistory
Bellus Health Inc New07987C204COM NEW1,018,327$9.41M3.9%+105,000+11.5%Added–
ALNYAlnylam Pharmaceuticals, Inc.COM61,237$8.93M3.7%+60,000+4,850.4%AddedHistory
GOSSGossamer Bio, Inc.COM1,000,387$8.37M3.5%+225,072+29.0%AddedHistory
MISTMilestone Pharmaceuticals Inc.COM1,379,422$8.19M3.4%−549,330−28.5%ReducedHistory
XENEXenon Pharmaceuticals Inc.COM239,441$7.28M3.0%00.0%UnchangedHistory
TCONTracon Pharmaceuticals, Inc.COM NEW2,788,853$5.58M2.3%−54,379−1.9%ReducedHistory
BMRNBiomarin Pharmaceutical IncCOM60,000$4.97M2.1%+10,000+20.0%AddedHistory
PCVXVaxcyte, Inc.COM225,991$4.92M2.0%−90,000−28.5%ReducedHistory
LKFTLakefront Biotherapeutics NVSPON ADR86,865$4.83M2.0%00.0%UnchangedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM246,554$4.75M2.0%−150,100−37.8%ReducedHistory
SCPHscPharmaceuticals Inc.COM884,008$4.26M1.8%−86,090−8.9%ReducedHistory
HRMYHarmony Biosciences Holdings, Inc.COM86,035$4.20M1.7%+86,035NewHistory
PFEPfizer IncStock80,000$4.19M1.7%00.0%UnchangedHistory
NBIXNeurocrine Biosciences IncStock38,600$3.76M1.6%+38,600NewHistory
Kraneshares Trust500767306CSI CHI INTERNET100,000$3.28M1.4%+100,000New–
STSASatsuma Pharmaceuticals, Inc.COM653,448$2.70M1.1%00.0%UnchangedHistory
INSMINSMED IncCOM PAR $.01125,000$2.46M1.0%+125,000NewHistory
VKTXViking Therapeutics, Inc.COM835,275$2.41M1.0%+302,846+56.9%AddedHistory
COGTCogent Biosciences, Inc.COM250,000$2.26M0.9%+250,000NewHistory
ACETAdicet Bio, Inc.COM143,214$2.09M0.9%−364,134−71.8%ReducedHistory
LYRALyra Therapeutics, Inc.COM347,338$1.96M0.8%−75,000−17.8%ReducedHistory
APLSApellis Pharmaceuticals, Inc.COM41,900$1.89M0.8%+41,900NewHistory
SRPTSarepta Therapeutics, Inc.COM25,000$1.87M0.8%+25,000NewHistory
MCRBSeres Therapeutics, Inc.COM540,624$1.85M0.8%−300,000−35.7%ReducedHistory
ATXSAstria Therapeutics, Inc.COM592,123$1.78M0.7%+499,900+542.1%AddedHistory
TERNTerns Pharmaceuticals, Inc.COM700,000$1.74M0.7%+700,000NewHistory
XFORX4 Pharmaceuticals, IncCOM1,679,748$1.62M0.7%+307,726+22.4%AddedHistory
ALDXAldeyra Therapeutics, Inc.COM375,000$1.50M0.6%00.0%UnchangedHistory
ICPTIntercept Pharmaceuticals, Inc.COM105,000$1.45M0.6%+69,851+198.7%AddedHistory
DBVTDBV Technologies S.A.SPONSORED ADR316,939$1.40M0.6%00.0%UnchangedHistory
IMTXImmatics N.V.SHS157,190$1.37M0.6%−624,198−79.9%ReducedHistory
NTBLNotable Labs, Ltd.COM830,007$1.34M0.6%−740−0.1%ReducedHistory
WHWKWhitehawk Therapeutics, Inc.COM412,343$1.27M0.5%+203,975+97.9%AddedHistory
MRUSMerus N.V.COM53,703$1.22M0.5%00.0%UnchangedHistory
CABACabaletta Bio, Inc.COM944,431$1.00M0.4%−75,639−7.4%ReducedHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS268,104$992.0K0.4%00.0%UnchangedHistory
ARDXArdelyx, Inc.COM1,680,552$991.0K0.4%+1,680,552NewHistory
ANEBAnebulo Pharmaceuticals, Inc.COM181,199$942.0K0.4%00.0%UnchangedHistory
FNCHFinch Therapeutics Group, Inc.COM330,523$938.0K0.4%00.0%UnchangedHistory
CMRXChimerix IncCOM441,203$917.0K0.4%−400,000−47.6%ReducedHistory
AUTLAutolus Therapeutics plcSPON ADS322,217$912.0K0.4%−50,000−13.4%ReducedHistory
ELDNEledon Pharmaceuticals, Inc.COM362,537$884.0K0.4%00.0%UnchangedHistory
RIGLRigel Pharmaceuticals IncCOM NEW702,773$794.0K0.3%−1,434,355−67.1%ReducedHistory
CLVSClovis Oncology, Inc.COM422,339$761.0K0.3%−350,000−45.3%ReducedHistory
AYLAOld Ayala, IncCOM697,316$759.0K0.3%−11,067−1.6%ReducedHistory
TARAProtara Therapeutics, Inc.COM STK257,853$756.0K0.3%−38,573−13.0%ReducedHistory
RNTXRein Therapeutics, Inc.COM2,892,316$752.0K0.3%−9,770−0.3%ReducedHistory
IRONDisc Medicine, Inc.COM443,096$749.0K0.3%00.0%UnchangedHistory
BCLIBrainstorm Cell Therapeutics Inc.COM NEW253,432$698.0K0.3%−50,729−16.7%ReducedHistory
PRDSPardes Biosciences, Inc.COM223,934$687.0K0.3%−100,000−30.9%ReducedHistory
RETAReata Pharmaceuticals IncCL A20,805$632.0K0.3%−66,100−76.1%ReducedHistory
Bellicum Pharmaceuticals, Inc079481404COM NEW523,348$617.0K0.3%00.0%Unchanged–
TAOXTAO Synergies Inc.COM NEW121,191$614.0K0.3%−32,035−20.9%ReducedHistory
RCORRenovacor, Inc.COM293,283$595.0K0.2%−50,000−14.6%ReducedHistory
CNTBConnect Biopharma Holdings LtdADS677,859$591.0K0.2%00.0%UnchangedHistory
INBXInhibrx Biosciences, Inc.COM49,372$561.0K0.2%−108,470−68.7%ReducedHistory
SYBXSynlogic, Inc.COM474,360$545.0K0.2%−45,415−8.7%ReducedHistory
EOLSEvolus, Inc.COM45,516$529.0K0.2%+45,516NewHistory
OKUROnKure Therapeutics, Inc.COM185,597$491.0K0.2%00.0%UnchangedHistory
ISEEIVERIC bio, Inc.COM49,099$473.0K0.2%00.0%UnchangedHistory
CASICASI Pharmaceuticals, Inc (DE)COM NEW132,014$378.0K0.2%00.0%UnchangedConverted for a 1-for-10 splitHistory
NXTCNextCure, Inc.COM71,435$336.0K0.1%−69,623−49.4%ReducedHistory
WVEWave Life Sciences, Inc.SHS98,039$318.0K0.1%−950,000−90.6%ReducedHistory
ZLABZai Lab LtdADR81,843$278.0K0.1%00.0%UnchangedHistory
VSTMVerastem, Inc.COM228,023$265.0K0.1%−450,000−66.4%ReducedHistory
Immunoprecise Antibodies Ltd45257F200COM NEW61,433$237.0K0.1%−16,217−20.9%Reduced–
HEPAHepion Pharmaceuticals, Inc.COM410,189$235.0K0.1%−171,948−29.5%ReducedHistory
BIIBBiogen Inc.COM1,122$228.0K0.1%00.0%UnchangedHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM862,527$217.0K0.1%−135,100−13.5%ReducedHistory
RGLSRegulus Therapeutics Inc.COM105,341$217.0K0.1%−23,572−18.3%ReducedConverted for a 1-for-10 splitHistory
IMUXImmunic, Inc.COM61,500$214.0K0.1%+61,500NewHistory
VRNAVerona Pharma plcSPONSORED ADS300,000$200.0K0.1%+300,000NewHistory
MREOMereo BioPharma Group plcSPON ADS615,856$199.0K0.1%−300,000−32.8%ReducedHistory
KAKineta, Inc.COM104,392$190.0K0.1%−131,892−55.8%ReducedHistory
Aslan Pharmaceuticals Ltd04522R101ADS970,747$185.0K0.1%00.0%Unchanged–
CLNNClene Inc.COMMON STOCK70,000$177.0K0.1%−444,283−86.4%ReducedHistory
QCLSQ/C Technologies, Inc.COM81,089$176.0K0.1%−50,300−38.3%ReducedHistory
MBIOMustang Bio, Inc.COM246,824$145.0K0.1%−300,000−54.9%ReducedHistory
TPSTTempest Therapeutics, Inc.COM61,827$132.0K0.1%00.0%UnchangedHistory
Stealth Biotherapeutics Corp85789A105SPONSORED ADS501,836$127.0K0.1%00.0%Unchanged–
Bio Green Med Solution, Inc.23254L603COM104,741$113.0K<0.1%00.0%Unchanged–
LRMRLarimar Therapeutics, Inc.COM51,606$100.0K<0.1%00.0%UnchangedHistory
IVAInventiva S.A.ADS15,579$93.0K<0.1%00.0%UnchangedHistory
DRUGBright Minds Biosciences Inc.COM105,958$86.0K<0.1%00.0%UnchangedHistory
DFTXDefinium Therapeutics, Inc.COM105,958$68.0K<0.1%00.0%UnchangedHistory
OVIDOvid Therapeutics Inc.COM26,831$59.0K<0.1%−711,541−96.4%ReducedHistory
ENVBEnveric Biosciences, Inc.COM NEW223,834$48.0K<0.1%−200,000−47.2%ReducedHistory
CYTOFAltamira Therapeutics Ltd.SHS75,000$36.0K<0.1%−245,010−76.6%ReducedHistory
BXRXBaudax Bio, Inc.COM NEW2,966$3.00K<0.1%00.0%UnchangedHistory
KDNYChinook Therapeutics, Inc.COM332,295$00.0%+332,295NewHistory
OTICOtonomy, Inc.COM180$00.0%−218,358−99.9%ReducedHistory

Options (34)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ikarian Capital, LLC in Q2 2022
SecurityClassPutsCalls
ALNYAlnylam Pharmaceuticals, Inc.COM$5.82M$42.5M
AXSMAxsome Therapeutics, Inc.COM$19.2M$13.4M
CLDXCelldex Therapeutics, Inc.COM NEW$16.6M$13.7M
State Street SPDR S&P Biotech ETF78464A870ETF$26.0M–
AMGNAmgen IncStock–$24.3M
BIIBBiogen Inc.COM–$22.9M
KRTXKaruna Therapeutics, Inc.COM$12.7M–
RLMDRelmada Therapeutics, Inc.COM$5.36M$5.70M
KZRKezar Life Sciences, Inc.COM–$8.89M
BMRNBiomarin Pharmaceutical IncCOM–$8.84M
SAGESage Therapeutics, Inc.COM–$8.07M
HZNPHorizon Therapeutics Public Ltd CoSHS–$7.98M
SRPTSarepta Therapeutics, Inc.COM–$7.50M
AMLXAmylyx Pharmaceuticals, Inc.COM–$6.76M
LNTHLantheus Holdings, Inc.Stock–$6.60M
APLSApellis Pharmaceuticals, Inc.COM–$5.57M
RETAReata Pharmaceuticals IncCL A–$4.92M
ICPTIntercept Pharmaceuticals, Inc.COM–$4.83M
ALTAltimmune, Inc.COM NEW–$3.55M
VRDNViridian Therapeutics, Inc.COM–$3.47M
BPMCBlueprint Medicines CorpCOM–$3.23M
LONALeonaBio, Inc.COM$609.0K$2.39M
GOSSGossamer Bio, Inc.COM–$2.80M
ISEEIVERIC bio, Inc.COM–$2.35M
ITOSiTeos Therapeutics, Inc.COM–$2.06M
RCUSArcus Biosciences, Inc.COM$1.27M$588.0K
BBIOBridgeBio Pharma, Inc.COM–$1.82M
MISTMilestone Pharmaceuticals Inc.COM–$1.26M
Bellus Health Inc New07987C204COM NEW–$924.0K
TCDATricida, Inc.COM$899.0K–
FULCFulcrum Therapeutics, Inc.COM–$893.0K
CFRXCONTRAFECT CorpCOM NEW$615.0K–
PRAXPraxis Precision Medicines, Inc.COM–$263.0K
IMUXImmunic, Inc.COM$213.0K–

Sold out since Q1 2022 (72)

Positions held at the end of Q1 2022 that are gone from this filing.

Positions of Ikarian Capital, LLC sold out since Q1 2022
SecurityClassShares in Q1 2022Value in Q1 2022% of portfolio in Q1 2022History
BCYCBicycle Therapeutics PLCSPONSORED ADS478,784$21.0M6.4%History
ZNTLZentalis Pharmaceuticals, Inc.COM202,203$9.33M2.8%History
SAGESage Therapeutics, Inc.COM249,907$8.27M2.5%History
BHVNBiohaven Ltd.COM60,000$7.11M2.2%History
SRRASierra Oncology, Inc.COM NEW217,915$6.98M2.1%History
AMGNAmgen IncStock20,000$4.84M1.5%History
NTLAIntellia Therapeutics, Inc.COM47,408$3.44M1.0%History
SVRASavara IncCOM1,622,552$2.13M0.6%History
KYMRKymera Therapeutics, Inc.COM50,000$2.12M0.6%History
LQDALiquidia CorpCOM NEW243,904$1.75M0.5%History
GBTGlobal Blood Therapeutics, Inc.COM49,997$1.73M0.5%History
MGNXMacrogenics IncCOM164,119$1.45M0.4%History
NUVBNuvation Bio Inc.COM CL A213,310$1.12M0.3%History
AUPHAurinia Pharmaceuticals Inc.COM87,071$1.08M0.3%History
PHATPhathom Pharmaceuticals, Inc.COM78,550$1.07M0.3%History
ASNDAscendis Pharma A/SSPONSORED ADR8,763$1.03M0.3%History
MXCTMaxcyte, Inc.COM137,958$964.0K0.3%History
CRVSCorvus Pharmaceuticals, Inc.COM510,126$837.0K0.3%History
BCLS Acquisition CorpG0904B105COM CL A77,274$762.0K0.2%–
PBLAPanbela Therapeutics, Inc.COM355,959$750.0K0.2%History
QSIQuantum-Si IncCOM CL A157,363$736.0K0.2%History
IFRXInflaRx N.V.COM349,468$639.0K0.2%History
PLRXPliant Therapeutics, Inc.COM90,805$636.0K0.2%History
VTGNVistagen Therapeutics, Inc.COM NEW511,186$633.0K0.2%History
SLDBSolid Biosciences Inc.COM521,155$625.0K0.2%History
TENXTenax Therapeutics, Inc.COM NEW735,097$596.0K0.2%History
RLMDRelmada Therapeutics, Inc.COM21,801$588.0K0.2%History
KALVKalVista Pharmaceuticals, Inc.COM39,730$586.0K0.2%History
KRSAKorsana Biosciences, Inc.COM527,462$585.0K0.2%History
HARPHarpoon Therapeutics, Inc.COM117,009$582.0K0.2%History
AVTXAvalo Therapeutics, Inc.COM764,271$554.0K0.2%History
DMACDiaMedica Therapeutics Inc.COM NEW221,252$553.0K0.2%History
VTVTvTv Therapeutics Inc.CL A742,980$536.0K0.2%History
KODKodiak Sciences Inc.COM68,100$526.0K0.2%History
ASMBAssembly Biosciences, Inc.COM227,076$468.0K0.1%History
BDTXBlack Diamond Therapeutics, Inc.COM159,390$441.0K0.1%History
AGTCApplied Genetic Technologies CorpCOM412,293$440.0K0.1%History
IRDOpus Genetics, Inc.COM124,021$401.0K0.1%History
NRSNNeuroSense Therapeutics Ltd.ORDINARY SHARES100,000$397.0K0.1%History
GRIGRI Bio, Inc.COM201,758$380.0K0.1%History
FATEFate Therapeutics IncCOM9,640$374.0K0.1%History
CDAKCodiak BioSciences, Inc.COM52,177$328.0K0.1%History
GYREGyre Therapeutics, Inc.COM NEW476,625$314.0K0.1%History
ONCTOncternal Therapeutics, Inc.COM210,182$292.0K0.1%History
EYPTEyePoint, Inc.COM NEW22,552$274.0K0.1%History
AGENAgenus IncCOM NEW108,933$267.0K0.1%History
GNCAGenocea Biosciences, Inc.COM NEW206,336$259.0K0.1%History
PASGPassage BIO, Inc.COM71,856$223.0K0.1%History
SEELSeelos Therapeutics, Inc.COM257,883$215.0K0.1%History
ACRSAclaris Therapeutics, Inc.COM12,124$208.0K0.1%History
ATYRaTYR PHARMA INCCOM NEW37,017$197.0K0.1%History
OCULOcular Therapeutix, IncCOM29,644$147.0K<0.1%History
APTOAptose Biosciences Inc.COM NEW106,952$147.0K<0.1%History
PBYIPuma Biotechnology, Inc.COM49,843$144.0K<0.1%History
GMDAGamida Cell Ltd.SHS32,689$135.0K<0.1%History
BTAIQBioXcel Therapeutics, Inc.COM5,428$113.0K<0.1%History
ORTXOrchard Therapeutics plcADS155,606$110.0K<0.1%History
CMPXCompass Therapeutics, Inc.COM74,171$100.0K<0.1%History
NVAXNovavax IncCOM NEW1,362$100.0K<0.1%History
Amryt Pharma PLC03217L106SPONSORED ADS37,248$70.0K<0.1%–
ATNXAthenex, Inc.COM80,039$68.0K<0.1%History
ACADAcadia Pharmaceuticals IncCOM1,882$46.0K<0.1%History
IGMSIGM Biosciences, Inc.COM1,587$43.0K<0.1%History
TNGXTango Therapeutics, Inc.COM5,456$42.0K<0.1%History
TRAWTraws Pharma, Inc.COM NEW18,975$35.0K<0.1%History
SLNOSoleno Therapeutics IncCOM NEW128,454$29.0K<0.1%History
PDSBPDS Biotechnology CorpCOM3,672$22.0K<0.1%History
KNTEKinnate Biopharma Inc.COM1,990$22.0K<0.1%History
TGTXTG Therapeutics, Inc.COM2,292$21.0K<0.1%History
KPTIKaryopharm Therapeutics Inc.COM830$6.00K<0.1%History
BLUEbluebird bio, Inc.COM306$1.00K<0.1%History
TSVT2seventy bio, Inc.COMMON STOCK99$1.00K<0.1%History