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Livermore
Livermore
ZHEN

Ikarian Capital, LLC

SEC CIK
0001778253
Latest filing
Aug 14, 2026

Holdings in Q1 2022

Holdings as of Mar 31, 2022, filed May 13, 2022. Long positions only; changes compare share counts with Q4 2021.

Institution overview
Positions
155
+6 vs. Q4 2021
Portfolio value
$328.7M
−$20.7M (−5.9%) vs. Q4 2021
Filed
May 13, 2022
SEC
Holdings of Ikarian Capital, LLC in Q1 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
BCYCBicycle Therapeutics PLCSPONSORED ADS478,784$21.0M6.4%−134,342−21.9%ReducedHistory
CLDXCelldex Therapeutics, Inc.COM NEW537,958$18.3M5.6%+118,742+28.3%AddedHistory
KZRKezar Life Sciences, Inc.COM1,083,116$18.0M5.5%+62,199+6.1%AddedHistory
MISTMilestone Pharmaceuticals Inc.COM1,928,752$12.4M3.8%+178,709+10.2%AddedHistory
HZNPHorizon Therapeutics Public Ltd CoSHS110,116$11.6M3.5%+34,455+45.5%AddedHistory
ACETAdicet Bio, Inc.COM507,348$10.1M3.1%+29,930+6.3%AddedHistory
ZNTLZentalis Pharmaceuticals, Inc.COM202,203$9.33M2.8%+11,063+5.8%AddedHistory
SAGESage Therapeutics, Inc.COM249,907$8.27M2.5%+249,907NewHistory
PCVXVaxcyte, Inc.COM315,991$7.63M2.3%+20,880+7.1%AddedHistory
TCONTracon Pharmaceuticals, Inc.COM NEW2,843,232$7.48M2.3%+152,122+5.7%AddedHistory
XENEXenon Pharmaceuticals Inc.COM239,441$7.32M2.2%+60,303+33.7%AddedHistory
BHVNBiohaven Ltd.COM60,000$7.11M2.2%+60,000NewHistory
SRRASierra Oncology, Inc.COM NEW217,915$6.98M2.1%−351,114−61.7%ReducedHistory
GOSSGossamer Bio, Inc.COM775,315$6.73M2.0%−391,618−33.6%ReducedHistory
VRTXVertex Pharmaceuticals IncStock25,000$6.52M2.0%+25,000NewHistory
RIGLRigel Pharmaceuticals IncCOM NEW2,137,128$6.39M1.9%+1,697,772+386.4%AddedHistory
KRTXKaruna Therapeutics, Inc.COM50,000$6.34M1.9%+50,000NewHistory
Bellus Health Inc New07987C204COM NEW913,327$6.28M1.9%+863,327+1,726.7%Added–
IMTXImmatics N.V.SHS781,388$6.24M1.9%+43,842+5.9%AddedHistory
MCRBSeres Therapeutics, Inc.COM840,624$5.99M1.8%+44,721+5.6%AddedHistory
SCPHscPharmaceuticals Inc.COM970,098$5.51M1.7%+68,736+7.6%AddedHistory
LKFTLakefront Biotherapeutics NVSPON ADR86,865$5.41M1.6%00.0%UnchangedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM396,654$5.10M1.6%+396,654NewHistory
AMGNAmgen IncStock20,000$4.84M1.5%+20,000NewHistory
PFEPfizer IncStock80,000$4.14M1.3%+80,000NewHistory
BMRNBiomarin Pharmaceutical IncCOM50,000$3.86M1.2%+50,000NewHistory
CMRXChimerix IncCOM841,203$3.85M1.2%+45,793+5.8%AddedHistory
WHWKWhitehawk Therapeutics, Inc.COM208,368$3.54M1.1%+11,960+6.1%AddedHistory
INBXInhibrx Biosciences, Inc.COM157,842$3.52M1.1%+7,992+5.3%AddedHistory
NTLAIntellia Therapeutics, Inc.COM47,408$3.44M1.0%+47,408NewHistory
RETAReata Pharmaceuticals IncCL A86,905$2.85M0.9%+86,905NewHistory
AYLAOld Ayala, IncCOM708,383$2.82M0.9%+39,112+5.8%AddedHistory
STSASatsuma Pharmaceuticals, Inc.COM653,448$2.48M0.8%+24,064+3.8%AddedHistory
XFORX4 Pharmaceuticals, IncCOM1,372,022$2.40M0.7%−892,469−39.4%ReducedHistory
PRDSPardes Biosciences, Inc.COM323,934$2.34M0.7%−76,066−19.0%ReducedHistory
OVIDOvid Therapeutics Inc.COM738,372$2.32M0.7%+33,290+4.7%AddedHistory
SVRASavara IncCOM1,622,552$2.13M0.6%+82,861+5.4%AddedHistory
KYMRKymera Therapeutics, Inc.COM50,000$2.12M0.6%+50,000NewHistory
WVEWave Life Sciences, Inc.SHS1,048,039$2.10M0.6%+54,558+5.5%AddedHistory
CABACabaletta Bio, Inc.COM1,020,070$2.07M0.6%+49,672+5.1%AddedHistory
CNTBConnect Biopharma Holdings LtdADS677,859$2.05M0.6%+415,622+158.5%AddedHistory
CLNNClene Inc.COMMON STOCK514,283$2.03M0.6%+24,962+5.1%AddedHistory
LQDALiquidia CorpCOM NEW243,904$1.75M0.5%−81,541−25.1%ReducedHistory
GBTGlobal Blood Therapeutics, Inc.COM49,997$1.73M0.5%−114,085−69.5%ReducedHistory
LYRALyra Therapeutics, Inc.COM422,338$1.70M0.5%+27,802+7.0%AddedHistory
ALDXAldeyra Therapeutics, Inc.COM375,000$1.67M0.5%+375,000NewHistory
FNCHFinch Therapeutics Group, Inc.COM330,523$1.66M0.5%+14,791+4.7%AddedHistory
VKTXViking Therapeutics, Inc.COM532,429$1.60M0.5%+31,787+6.3%AddedHistory
CLVSClovis Oncology, Inc.COM772,339$1.56M0.5%−340,330−30.6%ReducedHistory
AUTLAutolus Therapeutics plcSPON ADS372,217$1.55M0.5%−172,602−31.7%ReducedHistory
TARAProtara Therapeutics, Inc.COM STK296,426$1.51M0.5%+17,170+6.1%AddedHistory
RNTXRein Therapeutics, Inc.COM2,902,086$1.49M0.5%+138,503+5.0%AddedHistory
RCORRenovacor, Inc.COM343,283$1.46M0.4%+381+0.1%AddedHistory
MGNXMacrogenics IncCOM164,119$1.45M0.4%+8,072+5.2%AddedHistory
ELDNEledon Pharmaceuticals, Inc.COM362,537$1.43M0.4%+17,959+5.2%AddedHistory
MRUSMerus N.V.COM53,703$1.42M0.4%+2,796+5.5%AddedHistory
NTBLNotable Labs, Ltd.COM830,747$1.40M0.4%+39,909+5.0%AddedHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS268,104$1.29M0.4%+2,840+1.1%AddedHistory
SYBXSynlogic, Inc.COM519,775$1.25M0.4%+35,957+7.4%AddedHistory
ANEBAnebulo Pharmaceuticals, Inc.COM181,199$1.23M0.4%+8,890+5.2%AddedHistory
TAOXTAO Synergies Inc.COM NEW153,226$1.19M0.4%+7,597+5.2%AddedHistory
Bellicum Pharmaceuticals, Inc079481404COM NEW523,348$1.13M0.3%+26,592+5.4%Added–
NUVBNuvation Bio Inc.COM CL A213,310$1.12M0.3%+13,310+6.7%AddedHistory
AUPHAurinia Pharmaceuticals Inc.COM87,071$1.08M0.3%+4,736+5.8%AddedHistory
PHATPhathom Pharmaceuticals, Inc.COM78,550$1.07M0.3%+3,990+5.4%AddedHistory
CASICASI Pharmaceuticals, Inc (DE)COM1,320,155$1.07M0.3%+97,088+7.9%AddedHistory
DBVTDBV Technologies S.A.SPONSORED ADR316,939$1.05M0.3%+6,829+2.2%AddedHistory
ASNDAscendis Pharma A/SSPONSORED ADR8,763$1.03M0.3%+363+4.3%AddedHistory
BCLIBrainstorm Cell Therapeutics Inc.COM NEW304,161$1.02M0.3%+14,611+5.0%AddedHistory
MXCTMaxcyte, Inc.COM137,958$964.0K0.3%+7,958+6.1%AddedHistory
VSTMVerastem, Inc.COM678,023$956.0K0.3%+40,652+6.4%AddedHistory
CRVSCorvus Pharmaceuticals, Inc.COM510,126$837.0K0.3%+27,516+5.7%AddedHistory
ISEEIVERIC bio, Inc.COM49,099$825.0K0.3%+2,580+5.5%AddedHistory
BCLS Acquisition CorpG0904B105COM CL A77,274$762.0K0.2%+3,485+4.7%Added–
HEPAHepion Pharmaceuticals, Inc.COM582,137$751.0K0.2%+28,864+5.2%AddedHistory
PBLAPanbela Therapeutics, Inc.COM355,959$750.0K0.2%+17,577+5.2%AddedHistory
QSIQuantum-Si IncCOM CL A157,363$736.0K0.2%+12,957+9.0%AddedHistory
NXTCNextCure, Inc.COM141,058$686.0K0.2%+7,003+5.2%AddedHistory
IFRXInflaRx N.V.COM349,468$639.0K0.2%+18,420+5.6%AddedHistory
PLRXPliant Therapeutics, Inc.COM90,805$636.0K0.2%+4,093+4.7%AddedHistory
VTGNVistagen Therapeutics, Inc.COM NEW511,186$633.0K0.2%+35,493+7.5%AddedHistory
SLDBSolid Biosciences Inc.COM521,155$625.0K0.2%00.0%UnchangedHistory
ATXSAstria Therapeutics, Inc.COM92,223$619.0K0.2%+4,643+5.3%AddedHistory
IRONDisc Medicine, Inc.COM443,096$615.0K0.2%+22,046+5.2%AddedHistory
QCLSQ/C Technologies, Inc.COM131,389$612.0K0.2%+7,389+6.0%AddedHistory
TENXTenax Therapeutics, Inc.COM NEW735,097$596.0K0.2%+40,902+5.9%AddedHistory
RLMDRelmada Therapeutics, Inc.COM21,801$588.0K0.2%+1,058+5.1%AddedHistory
KALVKalVista Pharmaceuticals, Inc.COM39,730$586.0K0.2%+3,154+8.6%AddedHistory
KRSAKorsana Biosciences, Inc.COM527,462$585.0K0.2%+24,835+4.9%AddedHistory
HARPHarpoon Therapeutics, Inc.COM117,009$582.0K0.2%+5,717+5.1%AddedHistory
ICPTIntercept Pharmaceuticals, Inc.COM35,149$572.0K0.2%+584+1.7%AddedHistory
AVTXAvalo Therapeutics, Inc.COM764,271$554.0K0.2%+45,566+6.3%AddedHistory
DMACDiaMedica Therapeutics Inc.COM NEW221,252$553.0K0.2%+12,170+5.8%AddedHistory
MBIOMustang Bio, Inc.COM546,824$551.0K0.2%+40,791+8.1%AddedHistory
OKUROnKure Therapeutics, Inc.COM185,597$546.0K0.2%+10,597+6.1%AddedHistory
VTVTvTv Therapeutics Inc.CL A742,980$536.0K0.2%+42,980+6.1%AddedHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM997,627$530.0K0.2%+49,101+5.2%AddedHistory
KODKodiak Sciences Inc.COM68,100$526.0K0.2%+68,100NewHistory
OTICOtonomy, Inc.COM218,538$525.0K0.2%+10,232+4.9%AddedHistory
ASMBAssembly Biosciences, Inc.COM227,076$468.0K0.1%+12,215+5.7%AddedHistory

Options (31)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ikarian Capital, LLC in Q1 2022
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF–$84.1M
ALNYAlnylam Pharmaceuticals, Inc.COM$19.2M$22.1M
NBIXNeurocrine Biosciences IncStock–$40.3M
CLDXCelldex Therapeutics, Inc.COM NEW$20.3M$11.7M
BMRNBiomarin Pharmaceutical IncCOM–$24.2M
AMGNAmgen IncStock–$24.2M
BIIBBiogen Inc.COM–$23.6M
RETAReata Pharmaceuticals IncCL A$21.3M$502.0K
GILDGilead Sciences, Inc.Stock$10.8M$10.8M
UTHRUnited Therapeutics CorpCOM–$17.9M
HZNPHorizon Therapeutics Public Ltd CoSHS–$16.6M
BCYCBicycle Therapeutics PLCSPONSORED ADS$4.68M$11.6M
LONALeonaBio, Inc.COM$2.70M$10.6M
APLSApellis Pharmaceuticals, Inc.COM–$8.90M
SAGESage Therapeutics, Inc.COM–$8.28M
RCUSArcus Biosciences, Inc.COM–$4.73M
KZRKezar Life Sciences, Inc.COM–$4.67M
PMVPPMV Pharmaceuticals, Inc.COM$2.08M$2.08M
BPMCBlueprint Medicines CorpCOM–$4.09M
PTGXProtagonist Therapeutics, IncCOM–$3.81M
AMLXAmylyx Pharmaceuticals, Inc.COM–$3.21M
ZLABZai Lab LtdADR–$2.34M
GOSSGossamer Bio, Inc.COM$129.0K$1.84M
INBXInhibrx Biosciences, Inc.COM–$1.91M
AKBAAkebia Therapeutics, Inc.COM$860.0K$575.0K
ACETAdicet Bio, Inc.COM–$1.24M
CABACabaletta Bio, Inc.COM–$912.0K
KODKodiak Sciences Inc.COM$565.0K$199.0K
TCDATricida, Inc.COM$764.0K–
NKTRNektar TherapeuticsCOM–$722.0K
IMUXImmunic, Inc.COM$696.0K–

Sold out since Q4 2021 (10)

Positions held at the end of Q4 2021 that are gone from this filing.

Positions of Ikarian Capital, LLC sold out since Q4 2021
SecurityClassShares in Q4 2021Value in Q4 2021% of portfolio in Q4 2021History
iShares Tr464287556ISHARES BIOTECH24,022$3.67M1.0%–
IOVAIovance Biotherapeutics, Inc.COM172,521$3.29M0.9%History
MDGLMadrigal Pharmaceuticals, Inc.COM23,700$2.01M0.6%History
FOLDAmicus Therapeutics, Inc.COM164,174$1.90M0.5%History
ODTOdonate Therapeutics, Inc.COM1,340,631$1.81M0.5%History
RFLRafael Holdings, Inc.COM CL B72,515$370.0K0.1%History
ARNAArena Pharmaceuticals IncCOM NEW2,161$200.0K0.1%History
BBIOBridgeBio Pharma, Inc.COM1,500$25.0K<0.1%History
BXRXBaudax Bio, Inc.COM95,059$21.0K<0.1%History
Frazier Lifesciences Acqu CoG3710A121UNIT 12/09/2025941$9.00K<0.1%–