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Livermore
ZHEN

Ikarian Capital, LLC

SEC CIK
0001778253
Latest filing
Aug 14, 2026

Holdings in Q4 2021

Holdings as of Dec 31, 2021, filed Feb 14, 2022. Long positions only; changes compare share counts with Q3 2021.

Institution overview
Positions
149
+5 vs. Q3 2021
Portfolio value
$349.4M
−$87.3M (−20.0%) vs. Q3 2021
Filed
Feb 14, 2022
SEC
Holdings of Ikarian Capital, LLC in Q4 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
BCYCBicycle Therapeutics PLCSPONSORED ADS613,126$37.3M10.7%+86,626+16.5%AddedHistory
KZRKezar Life Sciences, Inc.COM1,020,917$17.1M4.9%+1,020,917NewHistory
CLDXCelldex Therapeutics, Inc.COM NEW419,216$16.2M4.6%+148,785+55.0%AddedHistory
ZNTLZentalis Pharmaceuticals, Inc.COM191,140$16.1M4.6%+98,796+107.0%AddedHistory
GOSSGossamer Bio, Inc.COM1,166,933$13.2M3.8%−185,000−13.7%ReducedHistory
SRRASierra Oncology, Inc.COM NEW569,029$12.4M3.5%−4,351−0.8%ReducedHistory
MISTMilestone Pharmaceuticals Inc.COM1,750,043$11.5M3.3%00.0%UnchangedHistory
IMTXImmatics N.V.SHS737,546$9.91M2.8%−145,500−16.5%ReducedHistory
ACETAdicet Bio, Inc.COM477,418$8.35M2.4%+85,000+21.7%AddedHistory
HZNPHorizon Therapeutics Public Ltd CoSHS75,661$8.15M2.3%+50,000+194.8%AddedHistory
TCONTracon Pharmaceuticals, Inc.COM NEW2,691,110$7.45M2.1%00.0%UnchangedHistory
BIIBBiogen Inc.COM29,533$7.09M2.0%−2,710−8.4%ReducedHistory
PCVXVaxcyte, Inc.COM295,111$7.02M2.0%00.0%UnchangedHistory
MCRBSeres Therapeutics, Inc.COM795,903$6.63M1.9%+189,349+31.2%AddedHistory
PRDSPardes Biosciences, Inc.COM400,000$6.55M1.9%+400,000NewHistory
INBXInhibrx Biosciences, Inc.COM149,850$6.54M1.9%−140,000−48.3%ReducedHistory
AYLAOld Ayala, IncCOM669,271$5.70M1.6%+130,332+24.2%AddedHistory
XENEXenon Pharmaceuticals Inc.COM179,138$5.60M1.6%−198,300−52.5%ReducedHistory
XFORX4 Pharmaceuticals, IncCOM2,264,491$5.19M1.5%−275,426−10.8%ReducedHistory
CMRXChimerix IncCOM795,410$5.11M1.5%−5,898−0.7%ReducedHistory
LKFTLakefront Biotherapeutics NVSPON ADR86,865$4.86M1.4%00.0%UnchangedHistory
GBTGlobal Blood Therapeutics, Inc.COM164,082$4.80M1.4%+164,082NewHistory
WHWKWhitehawk Therapeutics, Inc.COM196,408$4.74M1.4%+185,000+1,621.7%AddedHistory
SCPHscPharmaceuticals Inc.COM901,362$4.53M1.3%00.0%UnchangedHistory
CABACabaletta Bio, Inc.COM970,398$3.68M1.1%−217,500−18.3%ReducedHistory
iShares Tr464287556ISHARES BIOTECH24,022$3.67M1.0%+24,022New–
IOVAIovance Biotherapeutics, Inc.COM172,521$3.29M0.9%00.0%UnchangedHistory
FNCHFinch Therapeutics Group, Inc.COM315,732$3.15M0.9%00.0%UnchangedHistory
WVEWave Life Sciences, Inc.SHS993,481$3.12M0.9%00.0%UnchangedHistory
CLVSClovis Oncology, Inc.COM1,112,669$3.02M0.9%00.0%UnchangedHistory
STSASatsuma Pharmaceuticals, Inc.COM629,384$2.83M0.8%00.0%UnchangedHistory
AUTLAutolus Therapeutics plcSPON ADS544,819$2.83M0.8%00.0%UnchangedHistory
RCORRenovacor, Inc.COM342,902$2.64M0.8%−100,000−22.6%ReducedHistory
MGNXMacrogenics IncCOM156,047$2.51M0.7%−32,431−17.2%ReducedHistory
VKTXViking Therapeutics, Inc.COM500,642$2.30M0.7%00.0%UnchangedHistory
OVIDOvid Therapeutics Inc.COM705,082$2.26M0.6%−400,000−36.2%ReducedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM23,700$2.01M0.6%00.0%UnchangedHistory
CLNNClene Inc.COMMON STOCK489,321$2.01M0.6%00.0%UnchangedHistory
TGTXTG Therapeutics, Inc.COM100,739$1.91M0.5%+100,739NewHistory
SVRASavara IncCOM1,539,691$1.91M0.5%00.0%UnchangedHistory
FOLDAmicus Therapeutics, Inc.COM164,174$1.90M0.5%−250,000−60.4%ReducedHistory
TARAProtara Therapeutics, Inc.COM STK279,256$1.89M0.5%−200,739−41.8%ReducedHistory
AUPHAurinia Pharmaceuticals Inc.COM82,335$1.88M0.5%+82,335NewHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS265,264$1.83M0.5%−20,000−7.0%ReducedHistory
ODTOdonate Therapeutics, Inc.COM1,340,631$1.81M0.5%−500,000−27.2%ReducedHistory
LYRALyra Therapeutics, Inc.COM394,536$1.72M0.5%−8,914−2.2%ReducedHistory
NUVBNuvation Bio Inc.COM CL A200,000$1.70M0.5%+200,000NewHistory
MRUSMerus N.V.COM50,907$1.62M0.5%00.0%UnchangedHistory
LQDALiquidia CorpCOM NEW325,445$1.58M0.5%−559,448−63.2%ReducedHistory
IFRXInflaRx N.V.COM331,048$1.58M0.5%−300,000−47.5%ReducedHistory
NTBLNotable Labs, Ltd.COM790,838$1.56M0.4%00.0%UnchangedHistory
RNTXRein Therapeutics, Inc.COM2,763,583$1.56M0.4%00.0%UnchangedHistory
ELDNEledon Pharmaceuticals, Inc.COM344,578$1.52M0.4%00.0%UnchangedHistory
OKUROnKure Therapeutics, Inc.COM175,000$1.50M0.4%00.0%UnchangedHistory
PHATPhathom Pharmaceuticals, Inc.COM74,560$1.47M0.4%−25,000−25.1%ReducedHistory
CNTBConnect Biopharma Holdings LtdADS262,237$1.35M0.4%+262,237NewHistory
MXCTMaxcyte, Inc.COM130,000$1.32M0.4%−20,000−13.3%ReducedHistory
VSTMVerastem, Inc.COM637,371$1.31M0.4%−590,000−48.1%ReducedHistory
TAOXTAO Synergies Inc.COM NEW145,629$1.24M0.4%−100,000−40.7%ReducedHistory
IRONDisc Medicine, Inc.COM421,050$1.23M0.4%00.0%UnchangedHistory
AVTXAvalo Therapeutics, Inc.COM718,705$1.22M0.3%00.0%UnchangedHistory
GRIGRI Bio, Inc.COM198,085$1.18M0.3%00.0%UnchangedHistory
SYBXSynlogic, Inc.COM483,818$1.17M0.3%−305,000−38.7%ReducedHistory
PLRXPliant Therapeutics, Inc.COM86,712$1.17M0.3%00.0%UnchangedHistory
RIGLRigel Pharmaceuticals IncCOM NEW439,356$1.16M0.3%+439,356NewHistory
CRVSCorvus Pharmaceuticals, Inc.COM482,610$1.16M0.3%−274,935−36.3%ReducedHistory
BCLIBrainstorm Cell Therapeutics Inc.COM NEW289,550$1.16M0.3%00.0%UnchangedHistory
QSIQuantum-Si IncCOM CL A144,406$1.14M0.3%00.0%UnchangedHistory
ASNDAscendis Pharma A/SSPONSORED ADR8,400$1.13M0.3%+8,400NewHistory
DBVTDBV Technologies S.A.SPONSORED ADR310,110$1.08M0.3%00.0%UnchangedHistory
ANEBAnebulo Pharmaceuticals, Inc.COM172,309$1.07M0.3%00.0%UnchangedHistory
CASICASI Pharmaceuticals, Inc (DE)COM1,223,067$978.0K0.3%00.0%UnchangedHistory
VTGNVistagen Therapeutics, Inc.COM NEW475,693$927.0K0.3%−125,000−20.8%ReducedHistory
SLDBSolid Biosciences Inc.COM521,155$911.0K0.3%00.0%UnchangedHistory
KRSAKorsana Biosciences, Inc.COM502,627$866.0K0.2%00.0%UnchangedHistory
HARPHarpoon Therapeutics, Inc.COM111,292$840.0K0.2%00.0%UnchangedHistory
MBIOMustang Bio, Inc.COM506,033$840.0K0.2%00.0%UnchangedHistory
NXTCNextCure, Inc.COM134,055$804.0K0.2%−375,100−73.7%ReducedHistory
BDTXBlack Diamond Therapeutics, Inc.COM150,484$801.0K0.2%00.0%UnchangedHistory
DMACDiaMedica Therapeutics Inc.COM NEW209,082$779.0K0.2%−101,959−32.8%ReducedHistory
ISEEIVERIC bio, Inc.COM46,519$778.0K0.2%−170,000−78.5%ReducedHistory
QCLSQ/C Technologies, Inc.COM124,000$751.0K0.2%+124,000NewHistory
AGTCApplied Genetic Technologies CorpCOM390,394$742.0K0.2%00.0%UnchangedHistory
Bellicum Pharmaceuticals, Inc079481404COM NEW496,756$739.0K0.2%00.0%Unchanged–
BCLS Acquisition CorpG0904B105COM CL A73,789$728.0K0.2%00.0%Unchanged–
TENXTenax Therapeutics, Inc.COM NEW694,195$722.0K0.2%+227,934+48.9%AddedHistory
VTVTvTv Therapeutics Inc.CL A700,000$697.0K0.2%+700,000NewHistory
KAKineta, Inc.COM228,761$678.0K0.2%00.0%UnchangedHistory
HEPAHepion Pharmaceuticals, Inc.COM553,273$630.0K0.2%00.0%UnchangedHistory
PBLAPanbela Therapeutics, Inc.COM338,382$592.0K0.2%00.0%UnchangedHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM948,526$584.0K0.2%00.0%UnchangedHistory
ICPTIntercept Pharmaceuticals, Inc.COM34,565$562.0K0.2%00.0%UnchangedHistory
CDAKCodiak BioSciences, Inc.COM49,680$554.0K0.2%−70,215−58.6%ReducedHistory
CYTOFAltamira Therapeutics Ltd.SHS304,791$553.0K0.2%−94,357−23.6%ReducedHistory
FATEFate Therapeutics IncCOM9,038$528.0K0.2%+9,038NewHistory
LRMRLarimar Therapeutics, Inc.COM47,193$510.0K0.1%00.0%UnchangedHistory
ASMBAssembly Biosciences, Inc.COM214,861$501.0K0.1%00.0%UnchangedHistory
KALVKalVista Pharmaceuticals, Inc.COM36,576$484.0K0.1%−60,000−62.1%ReducedHistory
ATXSAstria Therapeutics, Inc.COM87,580$473.0K0.1%00.0%UnchangedHistory
RLMDRelmada Therapeutics, Inc.COM20,743$467.0K0.1%00.0%UnchangedHistory

Options (31)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ikarian Capital, LLC in Q4 2021
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF$60.7M$10.3M
CLDXCelldex Therapeutics, Inc.COM NEW$17.4M$22.9M
SRPTSarepta Therapeutics, Inc.COM–$36.0M
ALNYAlnylam Pharmaceuticals, Inc.COM–$30.2M
HZNPHorizon Therapeutics Public Ltd CoSHS–$26.6M
BBIOBridgeBio Pharma, Inc.COM$15.2M$1.67M
KODKodiak Sciences Inc.COM–$14.2M
LONALeonaBio, Inc.COM–$11.2M
ZGNXZogenix, Inc.COM NEW–$9.59M
APLSApellis Pharmaceuticals, Inc.COM–$9.46M
BMRNBiomarin Pharmaceutical IncCOM–$8.84M
RETAReata Pharmaceuticals IncCL A$2.64M$5.27M
RCUSArcus Biosciences, Inc.COM$5.04M–
PTGXProtagonist Therapeutics, IncCOM–$4.34M
IOVAIovance Biotherapeutics, Inc.COM$3.74M–
INBXInhibrx Biosciences, Inc.COM–$3.53M
ACETAdicet Bio, Inc.COM–$3.50M
NKTRNektar TherapeuticsCOM–$3.38M
KZRKezar Life Sciences, Inc.COM–$2.83M
ALLKAllakos Inc.COM$366.0K$2.13M
GOSSGossamer Bio, Inc.COM–$2.26M
ARNAArena Pharmaceuticals IncCOM NEW–$2.07M
TGTXTG Therapeutics, Inc.COM$1.87M–
CABACabaletta Bio, Inc.COM–$1.60M
AVIRAtea Pharmaceuticals, Inc.COM–$1.04M
ZLABZai Lab LtdADR–$603.0K
RFLRafael Holdings, Inc.COM CL B$510.0K–
DCPHDeciphera Pharmaceuticals, Inc.COM$8.00K$291.0K
SAGESage Therapeutics, Inc.COM–$192.0K
MRTXMirati Therapeutics, Inc.COM$191.0K–
ICPTIntercept Pharmaceuticals, Inc.COM$18.0K–

Sold out since Q3 2021 (22)

Positions held at the end of Q3 2021 that are gone from this filing.

Positions of Ikarian Capital, LLC sold out since Q3 2021
SecurityClassShares in Q3 2021Value in Q3 2021% of portfolio in Q3 2021History
APLSApellis Pharmaceuticals, Inc.COM347,545$11.5M2.6%History
ITCIIntra-Cellular Therapies, Inc.COM211,670$7.89M1.8%History
CMPSCOMPASS Pathways plcSPONSORED ADS229,202$6.85M1.6%History
BCABBioAtla, Inc.COM196,400$5.78M1.3%History
ALLKAllakos Inc.COM31,526$3.34M0.8%History
VINCVincerx Pharma, Inc.COM NEW199,057$3.22M0.7%History
CRSPCRISPR Therapeutics AGNAMEN AKT27,968$3.13M0.7%History
TCDATricida, Inc.COM670,771$3.11M0.7%History
ARK ETF Tr00214Q302GENOMIC REV ETF40,961$3.06M0.7%–
STROSutro Biopharma, Inc.COM134,575$2.54M0.6%History
INCYIncyte CorpCOM32,666$2.25M0.5%History
OBIOOrchestra BioMed Holdings, Inc.ORD SHS197,173$1.95M0.4%History
QNCXQuince Therapeutics, Inc.COM20,160$1.85M0.4%History
CERECerevel Therapeutics Holdings, Inc.COM53,370$1.57M0.4%History
STTKShattuck Labs, Inc.COM36,240$739.0K0.2%History
IMVTImmunovant, Inc.COM83,046$722.0K0.2%History
KNSAKiniksa Pharmaceuticals International, plcCOM CL A59,422$677.0K0.2%History
SRPTSarepta Therapeutics, Inc.COM6,496$602.0K0.1%History
KLDOKaleido Biosciences, Inc.COM100,000$546.0K0.1%History
INMBInmune Bio, Inc.COM26,632$517.0K0.1%History
DCTHDelcath Systems, Inc.COM NEW44,857$468.0K0.1%History
COGTCogent Biosciences, Inc.COM30,727$258.0K0.1%History