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Livermore
ZHEN

Ikarian Capital, LLC

SEC CIK
0001778253
Latest filing
Aug 14, 2026

Holdings in Q3 2022

Holdings as of Sep 30, 2022, filed Nov 14, 2022. Long positions only; changes compare share counts with Q2 2022.

Institution overview
Positions
65
−34 vs. Q2 2022
Portfolio value
$200.3M
−$40.9M (−16.9%) vs. Q2 2022
Filed
Nov 14, 2022
SEC
Holdings of Ikarian Capital, LLC in Q3 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
ISEEIVERIC bio, Inc.COM978,783$17.6M8.8%+929,684+1,893.5%AddedHistory
ESPREsperion Therapeutics, Inc.COM2,131,147$14.3M7.1%+76,545+3.7%AddedHistory
RXDXPrometheus Biosciences, Inc.COM231,181$13.6M6.8%+231,181NewHistory
DCPHDeciphera Pharmaceuticals, Inc.COM492,275$9.11M4.5%+492,275NewHistory
Bellus Health Inc New07987C204COM NEW850,134$8.98M4.5%−168,193−16.5%Reduced–
CLDXCelldex Therapeutics, Inc.COM NEW317,476$8.92M4.5%−220,482−41.0%ReducedHistory
MISTMilestone Pharmaceuticals Inc.COM855,616$7.86M3.9%−523,806−38.0%ReducedHistory
GOSSGossamer Bio, Inc.COM610,407$7.31M3.7%−389,980−39.0%ReducedHistory
ATXSAstria Therapeutics, Inc.COM699,440$6.32M3.2%+107,317+18.1%AddedHistory
KZRKezar Life Sciences, Inc.COM728,586$6.27M3.1%−679,530−48.3%ReducedHistory
SAGESage Therapeutics, Inc.COM157,805$6.18M3.1%+157,805NewHistory
ALTAltimmune, Inc.COM NEW472,054$6.03M3.0%−425,305−47.4%ReducedHistory
XENEXenon Pharmaceuticals Inc.COM160,486$5.79M2.9%−78,955−33.0%ReducedHistory
TERNTerns Pharmaceuticals, Inc.COM904,119$5.33M2.7%+204,119+29.2%AddedHistory
ACADAcadia Pharmaceuticals IncCOM325,000$5.32M2.7%+325,000NewHistory
CERECerevel Therapeutics Holdings, Inc.COM178,100$5.03M2.5%+178,100NewHistory
TCONTracon Pharmaceuticals, Inc.COM NEW2,765,530$4.62M2.3%−23,323−0.8%ReducedHistory
HZNPHorizon Therapeutics Public Ltd CoSHS74,219$4.59M2.3%−85,897−53.6%ReducedHistory
IMVTImmunovant, Inc.COM811,700$4.53M2.3%+811,700NewHistory
ARDXArdelyx, Inc.COM3,178,825$3.78M1.9%+1,498,273+89.2%AddedHistory
ABOSAcumen Pharmaceuticals, Inc.COM350,000$3.51M1.8%+350,000NewHistory
PNTPOINT Biopharma Global Inc.COM450,406$3.48M1.7%+450,406NewHistory
JBIOJade Biosciences, Inc.COM200,000$3.32M1.7%+200,000NewHistory
ARK ETF Tr00214Q302GENOMIC REV ETF96,462$3.17M1.6%+96,462New–
SCPHscPharmaceuticals Inc.COM479,383$3.13M1.6%−404,625−45.8%ReducedHistory
BLUEbluebird bio, Inc.COM462,628$2.93M1.5%+462,628NewHistory
BIIBBiogen Inc.COM10,962$2.93M1.5%+9,840+877.0%AddedHistory
RVNCRevance Therapeutics, Inc.COM100,000$2.70M1.3%+100,000NewHistory
COGTCogent Biosciences, Inc.COM162,766$2.43M1.2%−87,234−34.9%ReducedHistory
SRPTSarepta Therapeutics, Inc.COM16,809$1.86M0.9%−8,191−32.8%ReducedHistory
LYRALyra Therapeutics, Inc.COM343,685$1.72M0.9%−3,653−1.1%ReducedHistory
CINCCinCor Pharma, Inc.COM45,100$1.48M0.7%+45,100NewHistory
VKTXViking Therapeutics, Inc.COM463,156$1.26M0.6%−372,119−44.6%ReducedHistory
ICPTIntercept Pharmaceuticals, Inc.COM85,200$1.19M0.6%−19,800−18.9%ReducedHistory
ETNB89bio, Inc.COM200,000$1.16M0.6%+200,000NewHistory
OCULOcular Therapeutix, IncCOM265,000$1.10M0.5%+265,000NewHistory
XFORX4 Pharmaceuticals, IncCOM568,612$973.0K0.5%−1,111,136−66.1%ReducedHistory
MCRBSeres Therapeutics, Inc.COM131,310$843.0K0.4%−409,314−75.7%ReducedHistory
BCLIBrainstorm Cell Therapeutics Inc.COM NEW189,935$839.0K0.4%−63,497−25.1%ReducedHistory
STSASatsuma Pharmaceuticals, Inc.COM136,059$815.0K0.4%−517,389−79.2%ReducedHistory
RCORRenovacor, Inc.COM288,119$725.0K0.4%−5,164−1.8%ReducedHistory
ELDNEledon Pharmaceuticals, Inc.COM221,830$612.0K0.3%−140,707−38.8%ReducedHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS245,896$612.0K0.3%−22,208−8.3%ReducedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM2,800$560.0K0.3%−58,437−95.4%ReducedHistory
TARAProtara Therapeutics, Inc.COM STK188,664$558.0K0.3%−69,189−26.8%ReducedHistory
AUTLAutolus Therapeutics plcSPON ADS260,087$556.0K0.3%−62,130−19.3%ReducedHistory
Bellicum Pharmaceuticals, Inc079481404COM NEW448,101$537.0K0.3%−75,247−14.4%Reduced–
OKUROnKure Therapeutics, Inc.COM155,819$521.0K0.3%−29,778−16.0%ReducedHistory
IMTXImmatics N.V.SHS49,031$490.0K0.2%−108,159−68.8%ReducedHistory
ANEBAnebulo Pharmaceuticals, Inc.COM156,203$437.0K0.2%−24,996−13.8%ReducedHistory
CLVSClovis Oncology, Inc.COM361,518$430.0K0.2%−60,821−14.4%ReducedHistory
FNCHFinch Therapeutics Group, Inc.COM237,553$397.0K0.2%−92,970−28.1%ReducedHistory
SYBXSynlogic, Inc.COM306,757$292.0K0.1%−167,603−35.3%ReducedHistory
CNTBConnect Biopharma Holdings LtdADS219,501$283.0K0.1%−458,358−67.6%ReducedHistory
VRNAVerona Pharma plcSPONSORED ADS315,131$193.0K0.1%+15,131+5.0%AddedHistory
ARK Innovation ETF00214Q104ETF4,519$171.0K0.1%+4,519New–
Aslan Pharmaceuticals Ltd04522R101ADS820,455$146.0K0.1%−150,292−15.5%Reduced–
Stealth Biotherapeutics Corp85789A105SPONSORED ADS435,516$134.0K0.1%−66,320−13.2%Reduced–
CABACabaletta Bio, Inc.COM168,623$109.0K0.1%−775,808−82.1%ReducedHistory
RETAReata Pharmaceuticals IncCL A4,064$102.0K0.1%−16,741−80.5%ReducedHistory
SPPISpectrum Pharmaceuticals IncCOM176,980$76.0K<0.1%+176,980NewHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM397,168$66.0K<0.1%−465,359−54.0%ReducedHistory
IVAInventiva S.A.ADS13,236$48.0K<0.1%−2,343−15.0%ReducedHistory
Erytech Pharma29604W108SPONSORED ADR3,019$2.00K<0.1%+3,019New–
KDNYChinook Therapeutics, Inc.COM283,464$00.0%−48,831−14.7%ReducedHistory

Options (31)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ikarian Capital, LLC in Q3 2022
SecurityClassPutsCalls
RLMDRelmada Therapeutics, Inc.COM$28.7M$28.7M
BIIBBiogen Inc.COM$14.2M$18.8M
DICEDICE Therapeutics, Inc.COM$10.2M$15.2M
SPYSPDR S&P 500 ETF TrustETF$21.4M–
SGENSeagen Inc.COM–$20.5M
AXSMAxsome Therapeutics, Inc.COM$18.2M–
TCDATricida, Inc.COM$7.63M$6.05M
State Street SPDR S&P Biotech ETF78464A870ETF$11.9M–
ALTAltimmune, Inc.COM NEW–$10.8M
RXDXPrometheus Biosciences, Inc.COM–$10.5M
SRPTSarepta Therapeutics, Inc.COM–$9.42M
ISEEIVERIC bio, Inc.COM–$7.86M
AMLXAmylyx Pharmaceuticals, Inc.COM–$7.04M
KRYSKrystal Biotech, Inc.COM$6.63M–
GOSSGossamer Bio, Inc.COM$209.0K$6.31M
HZNPHorizon Therapeutics Public Ltd CoSHS–$5.27M
MISTMilestone Pharmaceuticals Inc.COM$3.11M$1.66M
STOKStoke Therapeutics, Inc.COM$4.73M–
ARVNArvinas, Inc.COM–$4.45M
PRTAProthena Corp Public Ltd CoSHS–$4.05M
RETAReata Pharmaceuticals IncCL A$463.0K$3.47M
STSASatsuma Pharmaceuticals, Inc.COM–$2.40M
DCPHDeciphera Pharmaceuticals, Inc.COM–$2.27M
INSMINSMED IncCOM PAR $.01–$2.15M
CLNNClene Inc.COMMON STOCK$496.0K$903.0K
AKROAkero Therapeutics, Inc.COM–$1.39M
ESPREsperion Therapeutics, Inc.COM–$1.34M
GERNGeron CorpCOM–$1.17M
Bellus Health Inc New07987C204COM NEW–$900.0K
DSGNDesign Therapeutics, Inc.COM$811.0K–
PRAXPraxis Precision Medicines, Inc.COM–$168.0K

Sold out since Q2 2022 (52)

Positions held at the end of Q2 2022 that are gone from this filing.

Positions of Ikarian Capital, LLC sold out since Q2 2022
SecurityClassShares in Q2 2022Value in Q2 2022% of portfolio in Q2 2022History
KRTXKaruna Therapeutics, Inc.COM100,000$12.7M5.2%History
VRTXVertex Pharmaceuticals IncStock40,000$11.3M4.7%History
UTHRUnited Therapeutics CorpCOM40,000$9.43M3.9%History
BMRNBiomarin Pharmaceutical IncCOM60,000$4.97M2.1%History
PCVXVaxcyte, Inc.COM225,991$4.92M2.0%History
LKFTLakefront Biotherapeutics NVSPON ADR86,865$4.83M2.0%History
AMLXAmylyx Pharmaceuticals, Inc.COM246,554$4.75M2.0%History
HRMYHarmony Biosciences Holdings, Inc.COM86,035$4.20M1.7%History
PFEPfizer IncStock80,000$4.19M1.7%History
NBIXNeurocrine Biosciences IncStock38,600$3.76M1.6%History
Kraneshares Trust500767306CSI CHI INTERNET100,000$3.28M1.4%–
INSMINSMED IncCOM PAR $.01125,000$2.46M1.0%History
ACETAdicet Bio, Inc.COM143,214$2.09M0.9%History
APLSApellis Pharmaceuticals, Inc.COM41,900$1.89M0.8%History
ALDXAldeyra Therapeutics, Inc.COM375,000$1.50M0.6%History
DBVTDBV Technologies S.A.SPONSORED ADR316,939$1.40M0.6%History
NTBLNotable Labs, Ltd.COM830,007$1.34M0.6%History
WHWKWhitehawk Therapeutics, Inc.COM412,343$1.27M0.5%History
MRUSMerus N.V.COM53,703$1.22M0.5%History
CMRXChimerix IncCOM441,203$917.0K0.4%History
RIGLRigel Pharmaceuticals IncCOM NEW702,773$794.0K0.3%History
AYLAOld Ayala, IncCOM697,316$759.0K0.3%History
RNTXRein Therapeutics, Inc.COM2,892,316$752.0K0.3%History
IRONDisc Medicine, Inc.COM443,096$749.0K0.3%History
PRDSPardes Biosciences, Inc.COM223,934$687.0K0.3%History
TAOXTAO Synergies Inc.COM NEW121,191$614.0K0.3%History
INBXInhibrx Biosciences, Inc.COM49,372$561.0K0.2%History
EOLSEvolus, Inc.COM45,516$529.0K0.2%History
CASICASI Pharmaceuticals, Inc (DE)COM NEW132,014$378.0K0.2%History
NXTCNextCure, Inc.COM71,435$336.0K0.1%History
WVEWave Life Sciences, Inc.SHS98,039$318.0K0.1%History
ZLABZai Lab LtdADR81,843$278.0K0.1%History
VSTMVerastem, Inc.COM228,023$265.0K0.1%History
Immunoprecise Antibodies Ltd45257F200COM NEW61,433$237.0K0.1%–
HEPAHepion Pharmaceuticals, Inc.COM410,189$235.0K0.1%History
RGLSRegulus Therapeutics Inc.COM105,341$217.0K0.1%History
IMUXImmunic, Inc.COM61,500$214.0K0.1%History
MREOMereo BioPharma Group plcSPON ADS615,856$199.0K0.1%History
KAKineta, Inc.COM104,392$190.0K0.1%History
CLNNClene Inc.COMMON STOCK70,000$177.0K0.1%History
QCLSQ/C Technologies, Inc.COM81,089$176.0K0.1%History
MBIOMustang Bio, Inc.COM246,824$145.0K0.1%History
TPSTTempest Therapeutics, Inc.COM61,827$132.0K0.1%History
Bio Green Med Solution, Inc.23254L603COM104,741$113.0K<0.1%–
LRMRLarimar Therapeutics, Inc.COM51,606$100.0K<0.1%History
DRUGBright Minds Biosciences Inc.COM105,958$86.0K<0.1%History
DFTXDefinium Therapeutics, Inc.COM105,958$68.0K<0.1%History
OVIDOvid Therapeutics Inc.COM26,831$59.0K<0.1%History
ENVBEnveric Biosciences, Inc.COM NEW223,834$48.0K<0.1%History
CYTOFAltamira Therapeutics Ltd.SHS75,000$36.0K<0.1%History
BXRXBaudax Bio, Inc.COM NEW2,966$3.00K<0.1%History
OTICOtonomy, Inc.COM180$00.0%History