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Ghost Tree Capital, LLC

SEC CIK
0001595851
Latest filing
Nov 14, 2024

Holdings in Q3 2021

Holdings as of Sep 30, 2021, filed Nov 15, 2021. Long positions only; changes compare share counts with Q2 2021.

Institution overview
Positions
55
+6 vs. Q2 2021
Portfolio value
$303.3M
−$16.5M (−5.2%) vs. Q2 2021
Filed
Nov 15, 2021
SEC
Holdings of Ghost Tree Capital, LLC in Q3 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
ASNDAscendis Pharma A/SSPONSORED ADR120,000$19.1M6.3%−15,000−11.1%ReducedHistory
IOVAIovance Biotherapeutics, Inc.COM700,000$17.3M5.7%+250,000+55.6%AddedHistory
CLDXCelldex Therapeutics, Inc.COM NEW255,000$13.8M4.5%−30,000−10.5%ReducedHistory
COGTCogent Biosciences, Inc.COM1,500,000$12.6M4.2%−100,000−6.3%ReducedHistory
ARVNArvinas, Inc.COM150,000$12.3M4.1%−55,000−26.8%ReducedHistory
XENEXenon Pharmaceuticals Inc.COM790,000$12.1M4.0%−60,000−7.1%ReducedHistory
ISEEIVERIC bio, Inc.COM725,000$11.8M3.9%00.0%UnchangedHistory
SNDXSyndax Pharmaceuticals IncCOM575,000$11.0M3.6%−300,000−34.3%ReducedHistory
MRTXMirati Therapeutics, Inc.COM60,000$10.6M3.5%+10,000+20.0%AddedHistory
RCKTRocket Pharmaceuticals, Inc.COM350,000$10.5M3.4%+225,000+180.0%AddedHistory
ALLKAllakos Inc.COM85,000$9.00M3.0%+85,000NewHistory
GHRSGH Research PLCORDINARY SHARES400,000$8.82M2.9%+400,000NewHistory
KURAKura Oncology, Inc.COM425,000$7.96M2.6%−275,000−39.3%ReducedHistory
RAPTRAPT Therapeutics, Inc.COM250,000$7.76M2.6%−320,000−56.1%ReducedHistory
CYPHCypherpunk Technologies Inc.COM1,650,000$6.62M2.2%+1,650,000NewHistory
APLSApellis Pharmaceuticals, Inc.COM200,000$6.59M2.2%+200,000NewHistory
ALDXAldeyra Therapeutics, Inc.COM700,000$6.15M2.0%+100,000+16.7%AddedHistory
VRDNViridian Therapeutics, Inc.COM350,000$5.76M1.9%00.0%UnchangedHistory
VTGNVistagen Therapeutics, Inc.COM NEW2,000,000$5.48M1.8%00.0%UnchangedHistory
AVIRAtea Pharmaceuticals, Inc.COM150,000$5.26M1.7%+150,000NewHistory
RLMDRelmada Therapeutics, Inc.COM200,000$5.24M1.7%+200,000NewHistory
ACRSAclaris Therapeutics, Inc.COM275,000$4.95M1.6%+25,000+10.0%AddedHistory
MLTXMoonLake ImmunotherapeuticsCOM CL A500,000$4.94M1.6%00.0%UnchangedHistory
CTICCti Biopharma CorpCOM1,600,000$4.72M1.6%00.0%UnchangedHistory
PRAXPraxis Precision Medicines, Inc.COM250,000$4.62M1.5%+250,000NewHistory
SRRASierra Oncology, Inc.COM NEW200,000$4.38M1.4%00.0%UnchangedHistory
ZNTLZentalis Pharmaceuticals, Inc.COM65,000$4.33M1.4%+65,000NewHistory
STSASatsuma Pharmaceuticals, Inc.COM904,225$4.21M1.4%00.0%UnchangedHistory
BCYCBicycle Therapeutics PLCSPONSORED ADS100,000$4.16M1.4%−100,000−50.0%ReducedHistory
GYREGyre Therapeutics, Inc.COM NEW1,000,000$4.11M1.4%00.0%UnchangedHistory
VRNAVerona Pharma plcSPONSORED ADS750,000$4.11M1.4%−250,000−25.0%ReducedHistory
TCRRTCR2 Therapeutics Inc.COM477,323$4.06M1.3%+477,323NewHistory
PCVXVaxcyte, Inc.COM160,000$4.06M1.3%+15,000+10.3%AddedHistory
ALLOAllogene Therapeutics, Inc.COM150,000$3.85M1.3%−125,000−45.5%ReducedHistory
TARSTarsus Pharmaceuticals, Inc.COM170,000$3.66M1.2%00.0%UnchangedHistory
NMTR9 Meters Biopharma, Inc.COM2,750,000$3.58M1.2%+2,750,000NewHistory
CRNXCrinetics Pharmaceuticals, Inc.COM150,000$3.16M1.0%−93,309−38.3%ReducedHistory
CMPSCOMPASS Pathways plcSPONSORED ADS100,000$2.99M1.0%+100,000NewHistory
FATEFate Therapeutics IncCOM50,000$2.96M1.0%−135,000−73.0%ReducedHistory
HRMYHarmony Biosciences Holdings, Inc.COM75,000$2.88M0.9%−50,000−40.0%ReducedHistory
FOLDAmicus Therapeutics, Inc.COM265,000$2.53M0.8%00.0%UnchangedHistory
Bellus Health Inc New07987C204COM NEW400,000$2.46M0.8%+400,000New–
IMUXImmunic, Inc.COM265,000$2.35M0.8%00.0%UnchangedHistory
LRMRLarimar Therapeutics, Inc.COM200,000$2.31M0.8%+100,000+100.0%AddedHistory
MRNAModerna, Inc.Stock5,300$2.04M0.7%+1,300+32.5%AddedHistory
ALECAlector, Inc.COM80,000$1.83M0.6%+80,000NewHistory
MRUSMerus N.V.COM75,000$1.65M0.5%00.0%UnchangedHistory
FULCFulcrum Therapeutics, Inc.COM50,000$1.41M0.5%+50,000NewHistory
CMRXChimerix IncCOM200,000$1.24M0.4%00.0%UnchangedHistory
CABACabaletta Bio, Inc.COM100,000$1.22M0.4%+100,000NewHistory
OTICOtonomy, Inc.COM450,000$864.0K0.3%00.0%UnchangedHistory
CASICASI Pharmaceuticals, Inc (DE)COM650,000$774.0K0.3%00.0%UnchangedHistory
BNTXBioNTech SESPONSORED ADS2,000$546.0K0.2%+2,000NewHistory
TBIOTelesis Bio Inc.COM35,000$390.0K0.1%00.0%UnchangedHistory
PRVBProvention Bio, Inc.COM50,000$320.0K0.1%−50,000−50.0%ReducedHistory

Options (5)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ghost Tree Capital, LLC in Q3 2021
SecurityClassPutsCalls
iShares Russell 2000 ETF464287655ETF–$21.9M
BYSIBeyondSpring Inc.SHS–$6.30M
APLSApellis Pharmaceuticals, Inc.COM–$4.94M
XENEXenon Pharmaceuticals Inc.COM$3.82M–
IMVTImmunovant, Inc.COM–$1.74M

Sold out since Q2 2021 (10)

Positions held at the end of Q2 2021 that are gone from this filing.

Positions of Ghost Tree Capital, LLC sold out since Q2 2021
SecurityClassShares in Q2 2021Value in Q2 2021% of portfolio in Q2 2021History
Trillium Therapeutics Inc.89620X506COM NEW1,250,000$12.1M3.8%–
BIIBBiogen Inc.COM32,500$11.3M3.5%History
TGTXTG Therapeutics, Inc.COM180,000$6.98M2.2%History
MRSNMersana Therapeutics, Inc.COM450,000$6.11M1.9%History
EPIXESSA Pharma Inc.COM NEW207,500$5.93M1.9%History
LKFTLakefront Biotherapeutics NVSPON ADR75,000$5.17M1.6%History
KDMNKadmon Holdings, Inc.COM800,000$3.10M1.0%History
CRISCuris IncCOM NEW247,124$1.99M0.6%History
CERECerevel Therapeutics Holdings, Inc.COM75,000$1.92M0.6%History
ELEVElevation Acquisition Group Inc.COM100,000$1.36M0.4%History