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Ghost Tree Capital, LLC

SEC CIK
0001595851
Latest filing
Nov 14, 2024

Holdings in Q4 2021

Holdings as of Dec 31, 2021, filed Feb 16, 2022. Long positions only; changes compare share counts with Q3 2021.

Institution overview
Positions
43
−12 vs. Q3 2021
Portfolio value
$261.1M
−$42.2M (−13.9%) vs. Q3 2021
Filed
Feb 16, 2022
SEC
Holdings of Ghost Tree Capital, LLC in Q4 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
ASNDAscendis Pharma A/SSPONSORED ADR190,000$25.6M9.8%+70,000+58.3%AddedHistory
APLSApellis Pharmaceuticals, Inc.COM325,000$15.4M5.9%+125,000+62.5%AddedHistory
COGTCogent Biosciences, Inc.COM1,700,000$14.6M5.6%+200,000+13.3%AddedHistory
CLDXCelldex Therapeutics, Inc.COM NEW350,000$13.5M5.2%+95,000+37.3%AddedHistory
RAPTRAPT Therapeutics, Inc.COM350,000$12.9M4.9%+100,000+40.0%AddedHistory
MRUSMerus N.V.COM350,000$11.1M4.3%+275,000+366.7%AddedHistory
ISEEIVERIC bio, Inc.COM625,000$10.4M4.0%−100,000−13.8%ReducedHistory
VRDNViridian Therapeutics, Inc.COM500,000$9.88M3.8%+150,000+42.9%AddedHistory
RCKTRocket Pharmaceuticals, Inc.COM425,000$9.28M3.6%+75,000+21.4%AddedHistory
ARVNArvinas, Inc.COM110,000$9.04M3.5%−40,000−26.7%ReducedHistory
SRPTSarepta Therapeutics, Inc.COM100,000$9.01M3.4%+100,000NewHistory
ZNTLZentalis Pharmaceuticals, Inc.COM80,000$6.72M2.6%+15,000+23.1%AddedHistory
SNDXSyndax Pharmaceuticals IncCOM300,000$6.57M2.5%−275,000−47.8%ReducedHistory
PCVXVaxcyte, Inc.COM250,000$5.95M2.3%+90,000+56.3%AddedHistory
FOLDAmicus Therapeutics, Inc.COM500,000$5.78M2.2%+235,000+88.7%AddedHistory
SRRASierra Oncology, Inc.COM NEW250,000$5.43M2.1%+50,000+25.0%AddedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM30,000$5.09M1.9%+30,000NewHistory
VRNAVerona Pharma plcSPONSORED ADS750,000$5.04M1.9%00.0%UnchangedHistory
WHWKWhitehawk Therapeutics, Inc.COM200,000$4.83M1.8%+200,000NewHistory
ACRSAclaris Therapeutics, Inc.COM325,000$4.73M1.8%+50,000+18.2%AddedHistory
CMPSCOMPASS Pathways plcSPONSORED ADS210,000$4.64M1.8%+110,000+110.0%AddedHistory
RLMDRelmada Therapeutics, Inc.COM200,000$4.51M1.7%00.0%UnchangedHistory
MRTXMirati Therapeutics, Inc.COM30,000$4.40M1.7%−30,000−50.0%ReducedHistory
CYPHCypherpunk Technologies Inc.COM1,350,000$4.37M1.7%−300,000−18.2%ReducedHistory
KZRKezar Life Sciences, Inc.COM250,000$4.18M1.6%+250,000NewHistory
STSASatsuma Pharmaceuticals, Inc.COM904,225$4.07M1.6%00.0%UnchangedHistory
VTGNVistagen Therapeutics, Inc.COM NEW2,000,000$3.90M1.5%00.0%UnchangedHistory
TARSTarsus Pharmaceuticals, Inc.COM170,000$3.83M1.5%00.0%UnchangedHistory
Bellus Health Inc New07987C204COM NEW450,000$3.62M1.4%+50,000+12.5%Added–
CRNXCrinetics Pharmaceuticals, Inc.COM118,344$3.36M1.3%−31,656−21.1%ReducedHistory
PYXSPyxis Oncology, Inc.COMMON STOCK295,000$3.24M1.2%+295,000NewHistory
NMTR9 Meters Biopharma, Inc.COM3,250,000$3.18M1.2%+500,000+18.2%AddedHistory
KURAKura Oncology, Inc.COM225,000$3.15M1.2%−200,000−47.1%ReducedHistory
XENEXenon Pharmaceuticals Inc.COM100,000$3.12M1.2%−690,000−87.3%ReducedHistory
CTICCti Biopharma CorpCOM1,200,000$2.98M1.1%−400,000−25.0%ReducedHistory
DSGNDesign Therapeutics, Inc.COM135,000$2.89M1.1%+135,000NewHistory
LRMRLarimar Therapeutics, Inc.COM225,000$2.43M0.9%+25,000+12.5%AddedHistory
GHRSGH Research PLCORDINARY SHARES100,000$2.33M0.9%−300,000−75.0%ReducedHistory
GBTGlobal Blood Therapeutics, Inc.COM60,000$1.76M0.7%+60,000NewHistory
IMUXImmunic, Inc.COM165,000$1.58M0.6%−100,000−37.7%ReducedHistory
RETAReata Pharmaceuticals IncCL A55,000$1.45M0.6%+55,000NewHistory
PRDSPardes Biosciences, Inc.COM50,000$819.0K0.3%+50,000NewHistory
CABACabaletta Bio, Inc.COM135,000$512.0K0.2%+35,000+35.0%AddedHistory

Options (3)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ghost Tree Capital, LLC in Q4 2021
SecurityClassPutsCalls
IOVAIovance Biotherapeutics, Inc.COM–$9.54M
Bellus Health Inc New07987C204COM NEW$7.17M–
ALDXAldeyra Therapeutics, Inc.COM–$1.20M

Sold out since Q3 2021 (21)

Positions held at the end of Q3 2021 that are gone from this filing.

Positions of Ghost Tree Capital, LLC sold out since Q3 2021
SecurityClassShares in Q3 2021Value in Q3 2021% of portfolio in Q3 2021History
IOVAIovance Biotherapeutics, Inc.COM700,000$17.3M5.7%History
ALLKAllakos Inc.COM85,000$9.00M3.0%History
ALDXAldeyra Therapeutics, Inc.COM700,000$6.15M2.0%History
AVIRAtea Pharmaceuticals, Inc.COM150,000$5.26M1.7%History
MLTXMoonLake ImmunotherapeuticsCOM CL A500,000$4.94M1.6%History
PRAXPraxis Precision Medicines, Inc.COM250,000$4.62M1.5%History
BCYCBicycle Therapeutics PLCSPONSORED ADS100,000$4.16M1.4%History
GYREGyre Therapeutics, Inc.COM NEW1,000,000$4.11M1.4%History
TCRRTCR2 Therapeutics Inc.COM477,323$4.06M1.3%History
ALLOAllogene Therapeutics, Inc.COM150,000$3.85M1.3%History
FATEFate Therapeutics IncCOM50,000$2.96M1.0%History
HRMYHarmony Biosciences Holdings, Inc.COM75,000$2.88M0.9%History
MRNAModerna, Inc.Stock5,300$2.04M0.7%History
ALECAlector, Inc.COM80,000$1.83M0.6%History
FULCFulcrum Therapeutics, Inc.COM50,000$1.41M0.5%History
CMRXChimerix IncCOM200,000$1.24M0.4%History
OTICOtonomy, Inc.COM450,000$864.0K0.3%History
CASICASI Pharmaceuticals, Inc (DE)COM650,000$774.0K0.3%History
BNTXBioNTech SESPONSORED ADS2,000$546.0K0.2%History
TBIOTelesis Bio Inc.COM35,000$390.0K0.1%History
PRVBProvention Bio, Inc.COM50,000$320.0K0.1%History