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Livermore
ZHEN

EcoR1 Capital, LLC

SEC CIK
0001587114
Latest filing
Aug 14, 2026

Holdings in Q3 2024

Holdings as of Sep 30, 2024, filed Nov 14, 2024. Long positions only; changes compare share counts with Q2 2024.

Institution overview
Positions
63
+8 vs. Q2 2024
Portfolio value
$2.92B
−$348.0M (−10.7%) vs. Q2 2024
Filed
Nov 14, 2024
SEC
Holdings of EcoR1 Capital, LLC in Q3 2024
SecurityClassSharesValue% of portfolioShare changeActionHistory
APLSApellis Pharmaceuticals, Inc.COM11,890,843$342.9M11.8%+283,418+2.4%AddedHistory
ANABAnaptysbio, IncCOM7,794,996$261.1M9.0%+273,972+3.6%AddedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM4,288,120$219.1M7.5%+132,745+3.2%AddedHistory
PRTAProthena Corp Public Ltd CoSHS11,584,280$193.8M6.6%00.0%UnchangedHistory
JAZZJazz Pharmaceuticals plcSHS USD1,706,469$190.1M6.5%+692,517+68.3%AddedHistory
ZYMEZymeworks Inc.COM13,437,473$168.6M5.8%00.0%UnchangedHistory
ARVNArvinas, Inc.COM6,726,491$165.7M5.7%00.0%UnchangedHistory
KURAKura Oncology, Inc.COM5,806,871$113.5M3.9%00.0%UnchangedHistory
XNCRXencor IncCOM5,330,416$107.2M3.7%00.0%UnchangedHistory
TNGXTango Therapeutics, Inc.COM13,330,736$102.6M3.5%00.0%UnchangedHistory
JANXJanux Therapeutics, Inc.COM1,469,818$66.8M2.3%00.0%UnchangedHistory
CRSPCRISPR Therapeutics AGNAMEN AKT1,389,276$65.3M2.2%00.0%UnchangedHistory
IMNMImmunome Inc.COM3,879,415$56.7M1.9%00.0%UnchangedHistory
NGNENeurogene Inc.COM1,271,342$53.3M1.8%00.0%UnchangedHistory
CNTACentessa Pharmaceuticals plcSPONSORED ADS3,223,851$51.5M1.8%−2,490,553−43.6%ReducedHistory
VRDNViridian Therapeutics, Inc.COM1,958,847$44.6M1.5%+1,958,847NewHistory
NUVBNuvation Bio Inc.COM CL A19,209,643$44.0M1.5%00.0%UnchangedHistory
THRDThird Harmonic Bio, Inc.COM3,182,444$43.1M1.5%00.0%UnchangedHistory
PCVXVaxcyte, Inc.COM352,464$40.3M1.4%+52,464+17.5%AddedHistory
MRSNMersana Therapeutics, Inc.COM19,364,688$36.6M1.3%00.0%UnchangedHistory
ORICOric Pharmaceuticals, Inc.COM3,418,068$35.0M1.2%00.0%UnchangedHistory
Avidity Biosciences, Inc.05370A108COM757,576$34.8M1.2%00.0%Unchanged–
EWTXEdgewise Therapeutics, Inc.COM1,250,385$33.4M1.1%00.0%UnchangedHistory
MBXMBX Biosciences, Inc.COM1,175,809$30.5M1.0%+1,175,809NewHistory
NMRANeumora Therapeutics, Inc.COM2,071,450$27.4M0.9%00.0%UnchangedHistory
CRGXCARGO Therapeutics, Inc.COM1,470,000$27.1M0.9%00.0%UnchangedHistory
ADAPYAdaptimmune Therapeutics PLCSPONDS ADR27,404,070$26.0M0.9%00.0%UnchangedHistory
TECXTectonic Therapeutic, Inc.COM849,143$25.7M0.9%00.0%UnchangedHistory
TCRXTScan Therapeutics, Inc.COM5,000,000$24.9M0.9%00.0%UnchangedHistory
VYGRVoyager Therapeutics, Inc.COM3,917,546$22.9M0.8%00.0%UnchangedHistory
CLDXCelldex Therapeutics, Inc.COM NEW650,000$22.1M0.8%00.0%UnchangedHistory
BCYCBicycle Therapeutics PLCSPONSORED ADS910,000$20.6M0.7%00.0%UnchangedHistory
IONSIonis Pharmaceuticals IncCOM500,000$20.0M0.7%+500,000NewHistory
DYNDyne Therapeutics, Inc.COM555,644$20.0M0.7%+128,605+30.1%AddedHistory
AVIRAtea Pharmaceuticals, Inc.COM5,441,896$18.2M0.6%00.0%UnchangedHistory
RLAYRelay Therapeutics, Inc.COM2,500,000$17.7M0.6%+2,500,000NewHistory
PHVSPharvaris N.V.COM900,000$16.7M0.6%00.0%UnchangedHistory
ITOSiTeos Therapeutics, Inc.COM1,608,616$16.4M0.6%−1,641,219−50.5%ReducedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM75,000$15.9M0.5%00.0%UnchangedHistory
DAWNDay One Biopharmaceuticals, Inc.Stock862,068$12.0M0.4%+862,068NewHistory
KROSKeros Therapeutics, Inc.COM187,500$10.9M0.4%00.0%UnchangedHistory
REPLReplimune Group, Inc.COM850,341$9.32M0.3%00.0%UnchangedHistory
KLRSKalaris Therapeutics, Inc.COM11,294,585$9.13M0.3%00.0%UnchangedHistory
LENZLENZ Therapeutics, Inc.COM346,772$8.23M0.3%−873,002−71.6%ReducedHistory
VERVVerve Therapeutics, Inc.COM1,250,000$6.05M0.2%00.0%UnchangedHistory
GBIOGeneration Bio Co.COM2,046,867$5.06M0.2%00.0%UnchangedHistory
LKFTLakefront Biotherapeutics NVSPON ADR155,006$4.46M0.2%−5,601,262−97.3%ReducedHistory
BBIOBridgeBio Pharma, Inc.COM170,172$4.33M0.1%+170,172NewHistory
ATRAAtara Biotherapeutics, Inc.COM NEW468,938$3.81M0.1%+62,259+15.3%AddedHistory
WHWKWhitehawk Therapeutics, Inc.COM1,845,253$3.80M0.1%+1,845,253NewHistory
ETONEton Pharmaceuticals, Inc.COM566,075$3.40M0.1%+566,075NewHistory
PRQRProQR Therapeutics N.V.SHS EURO1,835,991$3.34M0.1%−206,780−10.1%ReducedHistory
PRMEPrime Medicine, Inc.COM700,000$2.71M0.1%00.0%UnchangedHistory
HOOKHOOKIPA Pharma Inc.COM571,727$2.46M0.1%00.0%UnchangedConverted for a 1-for-10 splitHistory
ALGSAligos Therapeutics, Inc.COM NEW255,573$2.21M0.1%00.0%UnchangedConverted for a 1-for-25 splitHistory
KYTXKyverna Therapeutics, Inc.COM450,000$2.20M0.1%00.0%UnchangedHistory
ARTVArtiva Biotherapeutics, Inc.COM41,453$640.4K<0.1%+41,453NewHistory
DSGNDesign Therapeutics, Inc.COM53,834$289.6K<0.1%+53,834NewHistory
MGNXMacrogenics IncCOM56,018$184.3K<0.1%+56,018NewHistory
ALLKAllakos Inc.COM192,346$125.6K<0.1%+192,346NewHistory
Surrozen, Inc.86889P117*W EXP 08/01/20366,665$799<0.1%00.0%Unchanged–
Nuvation Bio Inc.67080N119*W EXP 07/07/202963,333––00.0%Unchanged–
CareMax, Inc.14171W111*W EXP 06/08/202100,000––00.0%Unchanged–

Options (1)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of EcoR1 Capital, LLC in Q3 2024
SecurityClassPutsCalls
ETONEton Pharmaceuticals, Inc.COM–$1.37M

Sold out since Q2 2024 (4)

Positions held at the end of Q2 2024 that are gone from this filing.

Positions of EcoR1 Capital, LLC sold out since Q2 2024
SecurityClassShares in Q2 2024Value in Q2 2024% of portfolio in Q2 2024History
SRPTSarepta Therapeutics, Inc.COM1,407,322$222.4M6.8%History
MORFMorphic Holding, Inc.COM4,982,945$169.8M5.2%History
ACADAcadia Pharmaceuticals IncCOM1,346,475$21.9M0.7%History
RCKTRocket Pharmaceuticals, Inc.COM508,393$10.9M0.3%History