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Livermore
Livermore
ZHEN

EcoR1 Capital, LLC

SEC CIK
0001587114
Latest filing
Aug 14, 2026

Holdings in Q4 2024

Holdings as of Dec 31, 2024, filed Feb 14, 2025. Long positions only; changes compare share counts with Q3 2024.

Institution overview
Positions
55
−8 vs. Q3 2024
Portfolio value
$2.50B
−$421.0M (−14.4%) vs. Q3 2024
Filed
Feb 14, 2025
SEC
Holdings of EcoR1 Capital, LLC in Q4 2024
SecurityClassSharesValue% of portfolioShare changeActionHistory
APLSApellis Pharmaceuticals, Inc.COM11,890,843$379.4M15.2%00.0%UnchangedHistory
ZYMEZymeworks Inc.COM15,028,079$220.0M8.8%+1,590,606+11.8%AddedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM4,288,120$219.3M8.8%00.0%UnchangedHistory
JAZZJazz Pharmaceuticals plcSHS USD1,706,469$210.2M8.4%00.0%UnchangedHistory
PRTAProthena Corp Public Ltd CoSHS11,584,280$160.4M6.4%00.0%UnchangedHistory
XNCRXencor IncCOM6,144,767$141.2M5.7%+814,351+15.3%AddedHistory
ARVNArvinas, Inc.COM6,726,491$128.9M5.2%00.0%UnchangedHistory
ANABAnaptysbio, IncCOM7,873,448$104.2M4.2%+78,452+1.0%AddedHistory
SRPTSarepta Therapeutics, Inc.COM770,000$93.6M3.8%+770,000NewHistory
JANXJanux Therapeutics, Inc.COM1,469,818$78.7M3.2%00.0%UnchangedHistory
QUREuniQure N.V.SHS3,400,000$60.0M2.4%+3,400,000NewHistory
SWTXSpringWorks Therapeutics, Inc.COM1,560,000$56.4M2.3%+1,560,000NewHistory
CRSPCRISPR Therapeutics AGNAMEN AKT1,389,276$54.7M2.2%00.0%UnchangedHistory
IMNMImmunome Inc.COM3,879,415$41.2M1.7%00.0%UnchangedHistory
TECXTectonic Therapeutic, Inc.COM849,143$39.2M1.6%00.0%UnchangedHistory
TNGXTango Therapeutics, Inc.COM10,630,736$32.8M1.3%−2,700,000−20.3%ReducedHistory
THRDThird Harmonic Bio, Inc.COM3,182,444$32.7M1.3%00.0%UnchangedHistory
KURAKura Oncology, Inc.COM3,557,269$31.0M1.2%−2,249,602−38.7%ReducedHistory
NGNENeurogene Inc.COM1,271,342$29.1M1.2%00.0%UnchangedHistory
ORICOric Pharmaceuticals, Inc.COM3,418,068$27.6M1.1%00.0%UnchangedHistory
ETONEton Pharmaceuticals, Inc.COM1,829,603$24.4M1.0%+1,263,528+223.2%AddedHistory
MBXMBX Biosciences, Inc.COM1,259,273$23.2M0.9%+83,464+7.1%AddedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM75,000$23.1M0.9%00.0%UnchangedHistory
VYGRVoyager Therapeutics, Inc.COM3,917,546$22.2M0.9%00.0%UnchangedHistory
NMRANeumora Therapeutics, Inc.COM2,071,450$22.0M0.9%00.0%UnchangedHistory
CRGXCARGO Therapeutics, Inc.COM1,470,000$21.2M0.8%00.0%UnchangedHistory
MLTXMoonLake ImmunotherapeuticsCLASS A ORD332,522$18.0M0.7%+332,522NewHistory
DNAGinkgo Bioworks Holdings, Inc.CL A NEW1,743,344$17.1M0.7%+1,743,344NewHistory
Avidity Biosciences, Inc.05370A108COM557,576$16.2M0.6%−200,000−26.4%Reduced–
MRSNMersana Therapeutics, Inc.COM11,328,000$16.2M0.6%−8,036,688−41.5%ReducedHistory
TCRXTScan Therapeutics, Inc.COM5,000,000$15.2M0.6%00.0%UnchangedHistory
ADAPYAdaptimmune Therapeutics PLCSPONDS ADR27,404,070$14.8M0.6%00.0%UnchangedHistory
KYMRKymera Therapeutics, Inc.COM350,000$14.1M0.6%+350,000NewHistory
DYNDyne Therapeutics, Inc.COM555,644$13.1M0.5%00.0%UnchangedHistory
BCYCBicycle Therapeutics PLCSPONSORED ADS910,000$12.7M0.5%00.0%UnchangedHistory
AVIRAtea Pharmaceuticals, Inc.COM3,341,653$11.2M0.4%−2,100,243−38.6%ReducedHistory
DAWNDay One Biopharmaceuticals, Inc.Stock862,068$10.9M0.4%00.0%UnchangedHistory
REPLReplimune Group, Inc.COM850,341$10.3M0.4%00.0%UnchangedHistory
ALGSAligos Therapeutics, Inc.COM NEW255,573$10.2M0.4%00.0%UnchangedHistory
ATRAAtara Biotherapeutics, Inc.COM NEW532,134$7.08M0.3%+63,196+13.5%AddedHistory
VERVVerve Therapeutics, Inc.COM1,250,000$7.05M0.3%00.0%UnchangedHistory
FATEFate Therapeutics IncCOM3,049,405$5.03M0.2%+3,049,405NewHistory
LKFTLakefront Biotherapeutics NVSPON ADR155,006$4.26M0.2%00.0%UnchangedHistory
KROSKeros Therapeutics, Inc.COM187,500$2.97M0.1%00.0%UnchangedHistory
RLAYRelay Therapeutics, Inc.COM641,426$2.64M0.1%−1,858,574−74.3%ReducedHistory
DSGNDesign Therapeutics, Inc.COM426,683$2.63M0.1%+372,849+692.6%AddedHistory
GBIOGeneration Bio Co.COM2,046,867$2.17M0.1%00.0%UnchangedHistory
PRMEPrime Medicine, Inc.COM700,000$2.04M0.1%00.0%UnchangedHistory
WHWKWhitehawk Therapeutics, Inc.COM345,253$1.09M<0.1%−1,500,000−81.3%ReducedHistory
UPBUpstream Bio, Inc.COM60,000$986.4K<0.1%+60,000NewHistory
HOOKHOOKIPA Pharma Inc.COM388,861$781.6K<0.1%−182,866−32.0%ReducedHistory
ARTVArtiva Biotherapeutics, Inc.COM41,453$417.8K<0.1%00.0%UnchangedHistory
KLRSKalaris Therapeutics, Inc.COM408,688––−10,885,897−96.4%ReducedHistory
Nuvation Bio Inc.67080N119*W EXP 07/07/202963,333––00.0%Unchanged–
Surrozen, Inc.86889P117*W EXP 08/01/20366,665––00.0%Unchanged–

Options (4)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of EcoR1 Capital, LLC in Q4 2024
SecurityClassPutsCalls
PFEPfizer IncStock–$132.7M
QUREuniQure N.V.SHS–$6.80M
ETONEton Pharmaceuticals, Inc.COM–$2.02M
GLUEMonte Rosa Therapeutics, Inc.COM–$150.6K

Sold out since Q3 2024 (16)

Positions held at the end of Q3 2024 that are gone from this filing.

Positions of EcoR1 Capital, LLC sold out since Q3 2024
SecurityClassShares in Q3 2024Value in Q3 2024% of portfolio in Q3 2024History
CNTACentessa Pharmaceuticals plcSPONSORED ADS3,223,851$51.5M1.8%History
VRDNViridian Therapeutics, Inc.COM1,958,847$44.6M1.5%History
NUVBNuvation Bio Inc.COM CL A19,209,643$44.0M1.5%History
PCVXVaxcyte, Inc.COM352,464$40.3M1.4%History
EWTXEdgewise Therapeutics, Inc.COM1,250,385$33.4M1.1%History
CLDXCelldex Therapeutics, Inc.COM NEW650,000$22.1M0.8%History
IONSIonis Pharmaceuticals IncCOM500,000$20.0M0.7%History
PHVSPharvaris N.V.COM900,000$16.7M0.6%History
ITOSiTeos Therapeutics, Inc.COM1,608,616$16.4M0.6%History
LENZLENZ Therapeutics, Inc.COM346,772$8.23M0.3%History
BBIOBridgeBio Pharma, Inc.COM170,172$4.33M0.1%History
PRQRProQR Therapeutics N.V.SHS EURO1,835,991$3.34M0.1%History
KYTXKyverna Therapeutics, Inc.COM450,000$2.20M0.1%History
MGNXMacrogenics IncCOM56,018$184.3K<0.1%History
ALLKAllakos Inc.COM192,346$125.6K<0.1%History
CareMax, Inc.14171W111*W EXP 06/08/202100,000–––