Skip to main content
Livermore
Livermore
ZHEN

EcoR1 Capital, LLC

SEC CIK
0001587114
Latest filing
Aug 14, 2026

Holdings in Q3 2022

Holdings as of Sep 30, 2022, filed Nov 14, 2022. Long positions only; changes compare share counts with Q2 2022.

Institution overview
Positions
75
−3 vs. Q2 2022
Portfolio value
$3.38B
+$510.3M (+17.8%) vs. Q2 2022
Filed
Nov 14, 2022
SEC
Holdings of EcoR1 Capital, LLC in Q3 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
PRTAProthena Corp Public Ltd CoSHS11,584,280$702.4M20.8%00.0%UnchangedHistory
APLSApellis Pharmaceuticals, Inc.COM5,183,431$354.0M10.5%00.0%UnchangedHistory
SRPTSarepta Therapeutics, Inc.COM2,999,453$331.6M9.8%+131,308+4.6%AddedHistory
ANABAnaptysbio, IncCOM7,521,024$191.9M5.7%00.0%UnchangedHistory
ARVNArvinas, Inc.COM3,123,300$139.0M4.1%00.0%UnchangedHistory
XNCRXencor IncCOM5,282,516$137.2M4.1%+1000.0%AddedHistory
LKFTLakefront Biotherapeutics NVSPON ADR3,197,500$136.3M4.0%00.0%UnchangedHistory
MORFMorphic Holding, Inc.COM3,951,566$111.8M3.3%00.0%UnchangedHistory
SWTXSpringWorks Therapeutics, Inc.COM3,460,208$98.7M2.9%+3,460,208NewHistory
ACADAcadia Pharmaceuticals IncCOM5,991,479$98.0M2.9%00.0%UnchangedHistory
RLAYRelay Therapeutics, Inc.COM4,163,824$93.1M2.8%+440,283+11.8%AddedHistory
KURAKura Oncology, Inc.COM6,638,371$90.7M2.7%00.0%UnchangedHistory
MRTXMirati Therapeutics, Inc.COM1,015,572$70.9M2.1%+1,015,572NewHistory
ZLABZai Lab LtdADR2,030,252$69.4M2.1%−401,633−16.5%ReducedHistory
GOSSGossamer Bio, Inc.COM4,160,887$49.8M1.5%+4,160,887NewHistory
ALLOAllogene Therapeutics, Inc.COM4,488,200$48.5M1.4%00.0%UnchangedHistory
Avidity Biosciences, Inc.05370A108COM2,899,285$47.3M1.4%+139,780+5.1%Added–
DSGNDesign Therapeutics, Inc.COM2,519,268$42.1M1.2%−114,910−4.4%ReducedHistory
SGENSeagen Inc.COM285,793$39.1M1.2%−722,835−71.7%ReducedHistory
ALECAlector, Inc.COM4,056,548$38.4M1.1%00.0%UnchangedHistory
RVMDRevolution Medicines, Inc.COM1,801,847$35.5M1.1%−2,476,222−57.9%ReducedHistory
AVIRAtea Pharmaceuticals, Inc.COM6,184,861$35.2M1.0%−155,778−2.5%ReducedHistory
EWTXEdgewise Therapeutics, Inc.COM3,493,194$34.4M1.0%+1,133,386+48.0%AddedHistory
TSVT2seventy bio, Inc.COMMON STOCK2,341,313$34.1M1.0%−1,154,630−33.0%ReducedHistory
NUVBNuvation Bio Inc.COM CL A13,896,543$31.1M0.9%00.0%UnchangedHistory
VYGRVoyager Therapeutics, Inc.COM4,753,907$28.1M0.8%00.0%UnchangedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM1,330,263$26.1M0.8%00.0%UnchangedHistory
JANXJanux Therapeutics, Inc.COM1,421,319$19.2M0.6%00.0%UnchangedHistory
KYMRKymera Therapeutics, Inc.COM796,093$17.3M0.5%+796,093NewHistory
TNGXTango Therapeutics, Inc.COM4,201,414$15.2M0.4%+1,899,349+82.5%AddedHistory
CGEMCullinan Therapeutics, Inc.COM1,143,218$14.7M0.4%−26,671−2.3%ReducedHistory
VTYXVentyx Biosciences, Inc.COM400,000$14.0M0.4%−900,000−69.2%ReducedHistory
KDNYChinook Therapeutics, Inc.COM690,000$13.6M0.4%00.0%UnchangedHistory
AKUSAkouos, Inc.COM1,975,984$13.4M0.4%00.0%UnchangedHistory
CNTACentessa Pharmaceuticals plcSPONSORED ADS3,236,352$13.0M0.4%+2,944,032+1,007.1%AddedHistory
OVIDOvid Therapeutics Inc.COM6,117,400$11.3M0.3%00.0%UnchangedHistory
ORICOric Pharmaceuticals, Inc.COM3,418,068$10.9M0.3%00.0%UnchangedHistory
PSTXPoseida Therapeutics, Inc.COM2,650,000$9.36M0.3%+2,650,000NewHistory
ARQTArcutis Biotherapeutics, Inc.COM415,322$7.94M0.2%−480,181−53.6%ReducedHistory
NGMNGM Biopharmaceuticals IncCOM541,108$7.08M0.2%00.0%UnchangedHistory
HOOKHOOKIPA Pharma Inc.COM5,000,000$6.70M0.2%00.0%UnchangedHistory
DTILPrecision Biosciences IncCOM5,035,971$6.55M0.2%00.0%UnchangedHistory
ARGXArgenx SESPONSORED ADR17,527$6.19M0.2%−107,473−86.0%ReducedHistory
Gracell Biotechnologies Inc38406L103SPONSORED ADS1,921,310$6.19M0.2%00.0%Unchanged–
RNACCartesian Therapeutics, Inc.COM3,500,000$5.74M0.2%00.0%UnchangedHistory
GERNGeron CorpCOM2,301,980$5.39M0.2%−11,867,008−83.8%ReducedHistory
AVEOAveo Pharmaceuticals, Inc.COM NEW650,489$5.35M0.2%+3,000+0.5%AddedHistory
ERASErasca, Inc.COM678,441$5.29M0.2%00.0%UnchangedHistory
LENZLENZ Therapeutics, Inc.COM1,582,135$5.01M0.1%+419,956+36.1%AddedHistory
JYACJiya Acquisition Corp.COM CL A500,000$4.99M0.1%00.0%UnchangedHistory
FLACFrazier Lifesciences Acquisition CorpCL A SHS487,615$4.86M0.1%−100,000−17.0%ReducedHistory
ALGSAligos Therapeutics, Inc.COM3,948,360$4.34M0.1%00.0%UnchangedHistory
SURFSurface Oncology, Inc.COM3,924,713$4.08M0.1%−728,287−15.7%ReducedHistory
OBIOOrchestra BioMed Holdings, Inc.ORD SHS400,000$3.96M0.1%00.0%UnchangedHistory
PRAXPraxis Precision Medicines, Inc.COM1,496,324$3.40M0.1%+1,286,224+612.2%AddedHistory
MGNXMacrogenics IncCOM930,955$3.22M0.1%+930,955NewHistory
ASNDAscendis Pharma A/SSPONSORED ADR27,208$2.81M0.1%+27,208NewHistory
KNTEKinnate Biopharma Inc.COM175,000$2.09M0.1%00.0%UnchangedHistory
BCLS Acquisition CorpG0904B105COM CL A200,000$2.00M0.1%00.0%Unchanged–
Eucrates Biomedical Acqu CorG3141W106SHS200,000$2.00M0.1%00.0%Unchanged–
5 01 Acquisition Corp33836P105COM CL A200,000$2.00M0.1%00.0%Unchanged–
TPSTTempest Therapeutics, Inc.COM1,031,268$1.79M0.1%00.0%UnchangedHistory
ARYDARYA Sciences Acquisition Corp IVCL A150,000$1.49M<0.1%00.0%UnchangedHistory
KRONKronos Bio, Inc.COM326,780$1.09M<0.1%00.0%UnchangedHistory
Turmeric Acquisition CorpG9127T108CL A100,000$1.00M<0.1%00.0%Unchanged–
RETAReata Pharmaceuticals IncCL A38,467$967.0K<0.1%−1,937,144−98.1%ReducedHistory
NUVLNuvalent, Inc.COM40,970$796.0K<0.1%+40,970NewHistory
ITOSiTeos Therapeutics, Inc.COM40,480$771.0K<0.1%−239,519−85.5%ReducedHistory
CareMax, Inc.14171W111*W EXP 06/08/202100,000$709.0K<0.1%00.0%Unchanged–
Omega Alpha SpacG6749V107CL A50,000$497.0K<0.1%00.0%Unchanged–
Nuvation Bio Inc.67080N119*W EXP 07/07/202963,333––00.0%Unchanged–
Eucrates Biomedical Acqu CorG3141W122*W EXP 10/23/20266,666––00.0%Unchanged–
Frazier Lifesciences Acqu CoG3710A113*W EXP 11/30/20266,665––00.0%Unchanged–
Turmeric Acquisition CorpG9127T124*W EXP 10/08/20233,333––00.0%Unchanged–
Surrozen, Inc.86889P117*W EXP 08/01/20366,665––00.0%Unchanged–

Options (1)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of EcoR1 Capital, LLC in Q3 2022
SecurityClassPutsCalls
DSGNDesign Therapeutics, Inc.COM–$1.06M

Sold out since Q2 2022 (11)

Positions held at the end of Q2 2022 that are gone from this filing.

Positions of EcoR1 Capital, LLC sold out since Q2 2022
SecurityClassShares in Q2 2022Value in Q2 2022% of portfolio in Q2 2022History
CERECerevel Therapeutics Holdings, Inc.COM1,646,260$43.5M1.5%History
INCYIncyte CorpCOM182,783$13.9M0.5%History
SPRYARS Pharmaceuticals, Inc.COM575,359$2.44M0.1%History
VERVVerve Therapeutics, Inc.COM98,593$1.51M0.1%History
DYNDyne Therapeutics, Inc.COM215,000$1.48M0.1%History
OLMAOlema Pharmaceuticals, Inc.COM353,701$1.44M0.1%History
MRSNMersana Therapeutics, Inc.COM310,960$1.44M0.1%History
ADVMAdverum Biotechnologies, Inc.COM1,046,700$1.26M<0.1%History
PRDSPardes Biosciences, Inc.COM200,000$614.0K<0.1%History
EVLOEvelo Biosciences, Inc.COM200,417$423.0K<0.1%History
BOLTBolt Biotherapeutics, Inc.COM150,000$306.0K<0.1%History