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Livermore
Livermore
ZHEN

EcoR1 Capital, LLC

SEC CIK
0001587114
Latest filing
Aug 14, 2026

Holdings in Q2 2022

Holdings as of Jun 30, 2022, filed Aug 15, 2022. Long positions only; changes compare share counts with Q1 2022.

Institution overview
Positions
78
−8 vs. Q1 2022
Portfolio value
$2.87B
−$316.4M (−9.9%) vs. Q1 2022
Filed
Aug 15, 2022
SEC
Holdings of EcoR1 Capital, LLC in Q2 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
PRTAProthena Corp Public Ltd CoSHS11,584,280$314.5M10.9%00.0%UnchangedHistory
APLSApellis Pharmaceuticals, Inc.COM5,183,431$234.4M8.2%00.0%UnchangedHistory
SRPTSarepta Therapeutics, Inc.COM2,868,145$215.0M7.5%+798,511+38.6%AddedHistory
SGENSeagen Inc.COM1,008,628$178.5M6.2%+1,008,628NewHistory
LKFTLakefront Biotherapeutics NVSPON ADR3,197,500$178.4M6.2%+1,876+0.1%AddedHistory
ANABAnaptysbio, IncCOM7,521,024$152.7M5.3%00.0%UnchangedHistory
XNCRXencor IncCOM5,282,416$144.6M5.0%+313,660+6.3%AddedHistory
ARVNArvinas, Inc.COM3,123,300$131.5M4.6%+1,619,371+107.7%AddedHistory
KURAKura Oncology, Inc.COM6,638,371$121.7M4.2%00.0%UnchangedHistory
MORFMorphic Holding, Inc.COM3,951,566$85.7M3.0%00.0%UnchangedHistory
ACADAcadia Pharmaceuticals IncCOM5,991,479$84.4M2.9%00.0%UnchangedHistory
ZLABZai Lab LtdADR2,431,885$84.3M2.9%+208,673+9.4%AddedHistory
RVMDRevolution Medicines, Inc.COM4,278,069$83.4M2.9%+3,003,972+235.8%AddedHistory
RLAYRelay Therapeutics, Inc.COM3,723,541$62.4M2.2%+1,432,100+62.5%AddedHistory
RETAReata Pharmaceuticals IncCL A1,975,611$60.0M2.1%00.0%UnchangedHistory
ALLOAllogene Therapeutics, Inc.COM4,488,200$51.2M1.8%+4,488,200NewHistory
ARGXArgenx SESPONSORED ADR125,000$47.4M1.6%00.0%UnchangedHistory
TSVT2seventy bio, Inc.COMMON STOCK3,495,943$46.1M1.6%00.0%UnchangedHistory
NUVBNuvation Bio Inc.COM CL A13,896,543$45.0M1.6%00.0%UnchangedHistory
AVIRAtea Pharmaceuticals, Inc.COM6,340,639$45.0M1.6%00.0%UnchangedHistory
CERECerevel Therapeutics Holdings, Inc.COM1,646,260$43.5M1.5%00.0%UnchangedHistory
ALECAlector, Inc.COM4,056,548$41.2M1.4%−1,681,900−29.3%ReducedHistory
Avidity Biosciences, Inc.05370A108COM2,759,505$40.1M1.4%00.0%Unchanged–
DSGNDesign Therapeutics, Inc.COM2,634,178$36.9M1.3%+262,733+11.1%AddedHistory
VYGRVoyager Therapeutics, Inc.COM4,753,907$28.1M1.0%+1,196,400+33.6%AddedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM1,330,263$24.8M0.9%+540,054+68.3%AddedHistory
GERNGeron CorpCOM14,168,988$22.0M0.8%−116,726−0.8%ReducedHistory
ARQTArcutis Biotherapeutics, Inc.COM895,503$19.1M0.7%00.0%UnchangedHistory
EWTXEdgewise Therapeutics, Inc.COM2,359,808$18.8M0.7%00.0%UnchangedHistory
JANXJanux Therapeutics, Inc.COM1,421,319$17.4M0.6%00.0%UnchangedHistory
VTYXVentyx Biosciences, Inc.COM1,300,000$15.9M0.6%00.0%UnchangedHistory
ORICOric Pharmaceuticals, Inc.COM3,418,068$15.3M0.5%00.0%UnchangedHistory
CGEMCullinan Therapeutics, Inc.COM1,169,889$15.0M0.5%+1,169,889NewHistory
INCYIncyte CorpCOM182,783$13.9M0.5%+182,783NewHistory
OVIDOvid Therapeutics Inc.COM6,117,400$13.2M0.5%00.0%UnchangedHistory
KDNYChinook Therapeutics, Inc.COM690,000$12.1M0.4%00.0%UnchangedHistory
Gracell Biotechnologies Inc38406L103SPONSORED ADS1,921,310$10.6M0.4%+361,600+23.2%Added–
TNGXTango Therapeutics, Inc.COM2,302,065$10.4M0.4%+1,540,094+202.1%AddedHistory
AKUSAkouos, Inc.COM1,975,984$9.27M0.3%00.0%UnchangedHistory
HOOKHOOKIPA Pharma Inc.COM5,000,000$8.15M0.3%00.0%UnchangedHistory
DTILPrecision Biosciences IncCOM5,035,971$8.06M0.3%+5,035,971NewHistory
SURFSurface Oncology, Inc.COM4,653,000$7.63M0.3%00.0%UnchangedHistory
NGMNGM Biopharmaceuticals IncCOM541,108$6.94M0.2%00.0%UnchangedHistory
FLACFrazier Lifesciences Acquisition CorpCL A SHS587,615$5.80M0.2%00.0%UnchangedHistory
ITOSiTeos Therapeutics, Inc.COM279,999$5.77M0.2%+207,178+284.5%AddedHistory
JYACJiya Acquisition Corp.COM CL A500,000$4.94M0.2%00.0%UnchangedHistory
ALGSAligos Therapeutics, Inc.COM3,948,360$4.78M0.2%00.0%UnchangedHistory
RNACCartesian Therapeutics, Inc.COM3,500,000$4.58M0.2%+3,500,000NewHistory
AVEOAveo Pharmaceuticals, Inc.COM NEW647,489$4.25M0.1%+647,489NewHistory
OBIOOrchestra BioMed Holdings, Inc.ORD SHS400,000$3.98M0.1%00.0%UnchangedHistory
ERASErasca, Inc.COM678,441$3.78M0.1%00.0%UnchangedHistory
LENZLENZ Therapeutics, Inc.COM1,162,179$3.20M0.1%+137,900+13.5%AddedHistory
SPRYARS Pharmaceuticals, Inc.COM575,359$2.44M0.1%+245,822+74.6%AddedHistory
TPSTTempest Therapeutics, Inc.COM1,031,268$2.22M0.1%+1,031,268NewHistory
KNTEKinnate Biopharma Inc.COM175,000$2.21M0.1%00.0%UnchangedHistory
5 01 Acquisition Corp33836P105COM CL A200,000$1.98M0.1%00.0%Unchanged–
BCLS Acquisition CorpG0904B105COM CL A200,000$1.98M0.1%00.0%Unchanged–
Eucrates Biomedical Acqu CorG3141W106SHS200,000$1.98M0.1%00.0%Unchanged–
VERVVerve Therapeutics, Inc.COM98,593$1.51M0.1%00.0%UnchangedHistory
DYNDyne Therapeutics, Inc.COM215,000$1.48M0.1%00.0%UnchangedHistory
ARYDARYA Sciences Acquisition Corp IVCL A150,000$1.47M0.1%00.0%UnchangedHistory
OLMAOlema Pharmaceuticals, Inc.COM353,701$1.44M0.1%+353,701NewHistory
MRSNMersana Therapeutics, Inc.COM310,960$1.44M0.1%−15,618−4.8%ReducedHistory
CNTACentessa Pharmaceuticals plcSPONSORED ADS292,320$1.42M<0.1%−162,225−35.7%ReducedHistory
ADVMAdverum Biotechnologies, Inc.COM1,046,700$1.26M<0.1%00.0%UnchangedHistory
KRONKronos Bio, Inc.COM326,780$1.19M<0.1%00.0%UnchangedHistory
Turmeric Acquisition CorpG9127T108CL A100,000$993.0K<0.1%00.0%Unchanged–
PRDSPardes Biosciences, Inc.COM200,000$614.0K<0.1%00.0%UnchangedHistory
PRAXPraxis Precision Medicines, Inc.COM210,100$515.0K<0.1%+210,100NewHistory
Omega Alpha SpacG6749V107CL A50,000$493.0K<0.1%00.0%Unchanged–
EVLOEvelo Biosciences, Inc.COM200,417$423.0K<0.1%+200,417NewHistory
BOLTBolt Biotherapeutics, Inc.COM150,000$306.0K<0.1%00.0%UnchangedHistory
Nuvation Bio Inc.67080N119*W EXP 07/07/202963,333––00.0%Unchanged–
Eucrates Biomedical Acqu CorG3141W122*W EXP 10/23/20266,666––+66,666New–
Frazier Lifesciences Acqu CoG3710A113*W EXP 11/30/20266,665––00.0%Unchanged–
Turmeric Acquisition CorpG9127T124*W EXP 10/08/20233,333––00.0%Unchanged–
CareMax, Inc.14171W111*W EXP 06/08/202100,000––00.0%Unchanged–
Surrozen, Inc.86889P117*W EXP 08/01/20366,665––00.0%Unchanged–

Options (2)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of EcoR1 Capital, LLC in Q2 2022
SecurityClassPutsCalls
EXELExelixis, Inc.COM–$15.8M
CLDXCelldex Therapeutics, Inc.COM NEW$3.11M–

Sold out since Q1 2022 (20)

Positions held at the end of Q1 2022 that are gone from this filing.

Positions of EcoR1 Capital, LLC sold out since Q1 2022
SecurityClassShares in Q1 2022Value in Q1 2022% of portfolio in Q1 2022History
RCUSArcus Biosciences, Inc.COM3,265,101$103.0M3.2%History
MRTXMirati Therapeutics, Inc.COM500,622$41.2M1.3%History
PCVXVaxcyte, Inc.COM1,304,741$31.5M1.0%History
BCYCBicycle Therapeutics PLCSPONSORED ADS547,453$24.0M0.8%History
EXELExelixis, Inc.COM951,333$21.6M0.7%History
SWTXSpringWorks Therapeutics, Inc.COM325,881$18.4M0.6%History
PMVPPMV Pharmaceuticals, Inc.COM649,786$13.5M0.4%History
PTGXProtagonist Therapeutics, IncCOM381,711$9.04M0.3%History
IGMSIGM Biosciences, Inc.COM298,597$7.98M0.3%History
ZNTLZentalis Pharmaceuticals, Inc.COM115,236$5.32M0.2%History
CCCCC4 Therapeutics, Inc.COM STK200,000$4.85M0.2%History
NRIXNurix Therapeutics, Inc.COM254,473$3.56M0.1%History
SLDBSolid Biosciences Inc.COM2,565,102$3.08M0.1%History
MLTXMoonLake ImmunotherapeuticsCOM CL A200,000$2.22M0.1%History
ACIUAC Immune SASHS485,005$1.94M0.1%History
BCELAtreca, Inc.CL A COM358,780$1.14M<0.1%History
AMTIApplied Molecular Transport Inc.COM131,693$990.0K<0.1%History
RPTXRepare Therapeutics Inc.COM50,000$712.0K<0.1%History
CRBUCaribou Biosciences, Inc.COM75,000$689.0K<0.1%History
Radius Health, Inc.750469207COM NEW35,000$309.0K<0.1%–