EcoR1 Capital, LLC
- SEC CIK
- 0001587114
- Latest filing
- Aug 14, 2026
Holdings in Q4 2022
Holdings as of Dec 31, 2022, filed Feb 14, 2023. Long positions only; changes compare share counts with Q3 2022.
- Positions
- 66
- −9 vs. Q3 2022
- Portfolio value
- $3.28B
- −$101.2M (−3.0%) vs. Q3 2022
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| PRTAProthena Corp Public Ltd Co | SHS | 11,584,280 | $698.0M | 21.3% | 00.0% | Unchanged | History |
| SRPTSarepta Therapeutics, Inc. | COM | 2,999,453 | $388.7M | 11.8% | 00.0% | Unchanged | History |
| APLSApellis Pharmaceuticals, Inc. | COM | 5,183,431 | $268.0M | 8.2% | 00.0% | Unchanged | History |
| ANABAnaptysbio, Inc | COM | 7,521,024 | $233.1M | 7.1% | 00.0% | Unchanged | History |
| LKFTLakefront Biotherapeutics NV | SPON ADR | 3,730,730 | $165.6M | 5.0% | +533,230+16.7% | Added | History |
| XNCRXencor Inc | COM | 5,282,516 | $137.6M | 4.2% | 00.0% | Unchanged | History |
| ARVNArvinas, Inc. | COM | 3,123,300 | $106.8M | 3.3% | 00.0% | Unchanged | History |
| RVMDRevolution Medicines, Inc. | COM | 4,458,731 | $106.2M | 3.2% | +2,656,884+147.5% | Added | History |
| MORFMorphic Holding, Inc. | COM | 3,951,566 | $105.7M | 3.2% | 00.0% | Unchanged | History |
| ACADAcadia Pharmaceuticals Inc | COM | 5,991,479 | $95.4M | 2.9% | 00.0% | Unchanged | History |
| SWTXSpringWorks Therapeutics, Inc. | COM | 3,460,208 | $90.0M | 2.7% | 00.0% | Unchanged | History |
| KURAKura Oncology, Inc. | COM | 6,638,371 | $82.4M | 2.5% | 00.0% | Unchanged | History |
| ZLABZai Lab Ltd | ADR | 2,157,686 | $66.2M | 2.0% | +127,434+6.3% | Added | History |
| RLAYRelay Therapeutics, Inc. | COM | 4,163,824 | $62.2M | 1.9% | 00.0% | Unchanged | History |
| ZYMEZymeworks Inc. | COM | 7,568,573 | $59.5M | 1.8% | +7,568,573 | New | History |
| ALECAlector, Inc. | COM | 4,056,548 | $37.4M | 1.1% | 00.0% | Unchanged | History |
| NGMNGM Biopharmaceuticals Inc | COM | 6,435,518 | $32.3M | 1.0% | +5,894,410+1,089.3% | Added | History |
| ACETAdicet Bio, Inc. | COM | 3,560,700 | $31.8M | 1.0% | +3,560,700 | New | History |
| EWTXEdgewise Therapeutics, Inc. | COM | 3,493,194 | $31.2M | 1.0% | 00.0% | Unchanged | History |
| TNGXTango Therapeutics, Inc. | COM | 4,201,414 | $30.5M | 0.9% | 00.0% | Unchanged | History |
| AVIRAtea Pharmaceuticals, Inc. | COM | 6,184,861 | $29.7M | 0.9% | 00.0% | Unchanged | History |
| VYGRVoyager Therapeutics, Inc. | COM | 4,753,907 | $29.0M | 0.9% | 00.0% | Unchanged | History |
| ALLOAllogene Therapeutics, Inc. | COM | 4,488,200 | $28.2M | 0.9% | 00.0% | Unchanged | History |
| DYNDyne Therapeutics, Inc. | COM | 2,322,384 | $26.9M | 0.8% | +2,322,384 | New | History |
| NUVBNuvation Bio Inc. | COM CL A | 13,896,543 | $26.7M | 0.8% | 00.0% | Unchanged | History |
| CRNXCrinetics Pharmaceuticals, Inc. | COM | 1,330,263 | $24.3M | 0.7% | 00.0% | Unchanged | History |
| ORICOric Pharmaceuticals, Inc. | COM | 3,418,068 | $20.1M | 0.6% | 00.0% | Unchanged | History |
| KYMRKymera Therapeutics, Inc. | COM | 796,093 | $19.9M | 0.6% | 00.0% | Unchanged | History |
| LENZLENZ Therapeutics, Inc. | COM | 5,712,096 | $19.0M | 0.6% | +4,129,961+261.0% | Added | History |
| JANXJanux Therapeutics, Inc. | COM | 1,421,319 | $18.7M | 0.6% | 00.0% | Unchanged | History |
| KDNYChinook Therapeutics, Inc. | COM | 690,000 | $18.1M | 0.6% | 00.0% | Unchanged | History |
| CNTACentessa Pharmaceuticals plc | SPONSORED ADS | 5,232,279 | $16.2M | 0.5% | +1,995,927+61.7% | Added | History |
| PSTXPoseida Therapeutics, Inc. | COM | 2,650,000 | $14.0M | 0.4% | 00.0% | Unchanged | History |
| VTYXVentyx Biosciences, Inc. | COM | 400,000 | $13.1M | 0.4% | 00.0% | Unchanged | History |
| OVIDOvid Therapeutics Inc. | COM | 6,117,400 | $11.4M | 0.3% | 00.0% | Unchanged | History |
| PRMEPrime Medicine, Inc. | COM | 600,000 | $11.1M | 0.3% | +600,000 | New | History |
| CGEMCullinan Therapeutics, Inc. | COM | 1,035,038 | $10.9M | 0.3% | −108,180−9.5% | Reduced | History |
| TSVT2seventy bio, Inc. | COMMON STOCK | 1,143,494 | $10.7M | 0.3% | −1,197,819−51.2% | Reduced | History |
| GERNGeron Corp | COM | 4,028,507 | $9.75M | 0.3% | +1,726,527+75.0% | Added | History |
| AVEOAveo Pharmaceuticals, Inc. | COM NEW | 650,489 | $9.72M | 0.3% | 00.0% | Unchanged | History |
| BCABBioAtla, Inc. | COM | 1,124,439 | $9.28M | 0.3% | +1,124,439 | New | History |
| DSGNDesign Therapeutics, Inc. | COM | 884,903 | $9.08M | 0.3% | −1,634,365−64.9% | Reduced | History |
| Gracell Biotechnologies Inc38406L103 | SPONSORED ADS | 3,343,202 | $7.69M | 0.2% | +1,421,892+74.0% | Added | – |
| MGNXMacrogenics Inc | COM | 1,117,455 | $7.50M | 0.2% | +186,500+20.0% | Added | History |
| IMTXImmatics N.V. | SHS | 743,000 | $6.47M | 0.2% | +743,000 | New | History |
| ARQTArcutis Biotherapeutics, Inc. | COM | 415,322 | $6.15M | 0.2% | 00.0% | Unchanged | History |
| DTILPrecision Biosciences Inc | COM | 5,035,971 | $5.99M | 0.2% | 00.0% | Unchanged | History |
| OBIOOrchestra BioMed Holdings, Inc. | ORD SHS | 400,000 | $3.99M | 0.1% | 00.0% | Unchanged | History |
| RNACCartesian Therapeutics, Inc. | COM | 3,500,000 | $3.96M | 0.1% | 00.0% | Unchanged | History |
| PRAXPraxis Precision Medicines, Inc. | COM | 1,585,324 | $3.77M | 0.1% | +89,000+5.9% | Added | History |
| ALGSAligos Therapeutics, Inc. | COM | 3,948,360 | $3.76M | 0.1% | 00.0% | Unchanged | History |
| ABEOAbeona Therapeutics Inc. | COM NEW | 1,086,956 | $3.35M | 0.1% | +1,086,956 | New | History |
| SURFSurface Oncology, Inc. | COM | 3,924,713 | $3.22M | 0.1% | 00.0% | Unchanged | History |
| ERASErasca, Inc. | COM | 678,441 | $2.92M | 0.1% | 00.0% | Unchanged | History |
| HOOKHOOKIPA Pharma Inc. | COM | 2,473,489 | $2.00M | 0.1% | −2,526,511−50.5% | Reduced | History |
| Eucrates Biomedical Acqu CorG3141W106 | SHS | 200,000 | $2.00M | 0.1% | 00.0% | Unchanged | – |
| ARYDARYA Sciences Acquisition Corp IV | CL A | 150,000 | $1.51M | <0.1% | 00.0% | Unchanged | History |
| TPSTTempest Therapeutics, Inc. | COM | 1,031,268 | $1.19M | <0.1% | 00.0% | Unchanged | History |
| ITOSiTeos Therapeutics, Inc. | COM | 40,480 | $790.6K | <0.1% | 00.0% | Unchanged | History |
| KRONKronos Bio, Inc. | COM | 326,780 | $529.4K | <0.1% | 00.0% | Unchanged | History |
| BDTXBlack Diamond Therapeutics, Inc. | COM | 282,131 | $507.8K | <0.1% | +282,131 | New | History |
| Nuvation Bio Inc.67080N119 | *W EXP 07/07/202 | 963,333 | – | – | 00.0% | Unchanged | – |
| Eucrates Biomedical Acqu CorG3141W122 | *W EXP 10/23/202 | 66,666 | – | – | 00.0% | Unchanged | – |
| CareMax, Inc.14171W111 | *W EXP 06/08/202 | 100,000 | – | – | 00.0% | Unchanged | – |
| Surrozen, Inc.86889P117 | *W EXP 08/01/203 | 66,665 | – | – | 00.0% | Unchanged | – |
| NAMSWNewAmsterdam Pharma Co N.V. | *W EXP 11/22/202 | 66,665 | – | – | +66,665 | New | History |
Sold out since Q3 2022 (18)
Positions held at the end of Q3 2022 that are gone from this filing.
| Security | Class | Shares in Q3 2022 | Value in Q3 2022 | % of portfolio in Q3 2022 | History |
|---|---|---|---|---|---|
| MRTXMirati Therapeutics, Inc. | COM | 1,015,572 | $70.9M | 2.1% | History |
| GOSSGossamer Bio, Inc. | COM | 4,160,887 | $49.8M | 1.5% | History |
| Avidity Biosciences, Inc.05370A108 | COM | 2,899,285 | $47.3M | 1.4% | – |
| SGENSeagen Inc. | COM | 285,793 | $39.1M | 1.2% | History |
| AKUSAkouos, Inc. | COM | 1,975,984 | $13.4M | 0.4% | History |
| ARGXArgenx SE | SPONSORED ADR | 17,527 | $6.19M | 0.2% | History |
| JYACJiya Acquisition Corp. | COM CL A | 500,000 | $4.99M | 0.1% | History |
| FLACFrazier Lifesciences Acquisition Corp | CL A SHS | 487,615 | $4.86M | 0.1% | History |
| ASNDAscendis Pharma A/S | SPONSORED ADR | 27,208 | $2.81M | 0.1% | History |
| KNTEKinnate Biopharma Inc. | COM | 175,000 | $2.09M | 0.1% | History |
| BCLS Acquisition CorpG0904B105 | COM CL A | 200,000 | $2.00M | 0.1% | – |
| 5 01 Acquisition Corp33836P105 | COM CL A | 200,000 | $2.00M | 0.1% | – |
| Turmeric Acquisition CorpG9127T108 | CL A | 100,000 | $1.00M | <0.1% | – |
| RETAReata Pharmaceuticals Inc | CL A | 38,467 | $967.0K | <0.1% | History |
| NUVLNuvalent, Inc. | COM | 40,970 | $796.0K | <0.1% | History |
| Omega Alpha SpacG6749V107 | CL A | 50,000 | $497.0K | <0.1% | – |
| Frazier Lifesciences Acqu CoG3710A113 | *W EXP 11/30/202 | 66,665 | – | – | – |
| Turmeric Acquisition CorpG9127T124 | *W EXP 10/08/202 | 33,333 | – | – | – |