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Livermore
Livermore
ZHEN

Sphera Funds Management Ltd.

SEC CIK
0001496201
Latest filing
Aug 14, 2026

Holdings in Q1 2025

Holdings as of Mar 31, 2025, filed May 15, 2025. Long positions only; changes compare share counts with Q4 2024.

Institution overview
Positions
112
+9 vs. Q4 2024
Portfolio value
$405.5M
−$136.0M (−25.1%) vs. Q4 2024
Filed
May 15, 2025
SEC
Holdings of Sphera Funds Management Ltd. in Q1 2025
SecurityClassSharesValue% of portfolioShare changeActionHistory
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS1,572,181$24.2M6.0%+3,000+0.2%AddedHistory
SNDXSyndax Pharmaceuticals IncCOM1,663,974$20.4M5.0%+282,733+20.5%AddedHistory
SNYSanofiSPONSORED ADR304,515$16.9M4.2%−80,000−20.8%ReducedHistory
NVMINova Ltd.COM90,697$16.7M4.1%+22,551+33.1%AddedHistory
AZNAstraZeneca PLCSPONSORED ADR175,060$12.9M3.2%−50,000−22.2%ReducedHistory
BBIOBridgeBio Pharma, Inc.COM366,608$12.7M3.1%−538,671−59.5%ReducedHistory
SRPTSarepta Therapeutics, Inc.COM157,931$10.1M2.5%+59,010+59.7%AddedHistory
RAREUltragenyx Pharmaceutical Inc.COM267,385$9.68M2.4%+38,609+16.9%AddedHistory
LLYEli Lilly & CoStock11,690$9.65M2.4%−1,500−11.4%ReducedHistory
CLDXCelldex Therapeutics, Inc.COM NEW507,829$9.22M2.3%+33,726+7.1%AddedHistory
JNJJohnson & JohnsonStock52,831$8.76M2.2%−17,000−24.3%ReducedHistory
NVONovo Nordisk A SADR118,080$8.20M2.0%+20,000+20.4%AddedHistory
ELDNEledon Pharmaceuticals, Inc.COM2,307,119$7.82M1.9%−244,500−9.6%ReducedHistory
MLYSMineralys Therapeutics, Inc.COM465,526$7.39M1.8%+274,854+144.2%AddedHistory
AMZNAmazon Com IncStock36,607$6.96M1.7%−26,000−41.5%ReducedHistory
ABBVAbbVie Inc.Stock30,256$6.34M1.6%−4,000−11.7%ReducedHistory
PHVSPharvaris N.V.COM383,856$6.03M1.5%−4,327−1.1%ReducedHistory
ORAOrmat Technologies, Inc.COM84,000$5.94M1.5%+5,000+6.3%AddedHistory
CYTKCytokinetics IncCOM NEW144,961$5.83M1.4%−8,060−5.3%ReducedHistory
METAMeta Platforms, Inc.Stock9,962$5.74M1.4%−11,039−52.6%ReducedHistory
NVSNovartis AGADR50,000$5.57M1.4%00.0%UnchangedHistory
MRKMerck & Co., Inc.Stock59,600$5.35M1.3%00.0%UnchangedHistory
PRAXPraxis Precision Medicines, Inc.COM NEW140,660$5.33M1.3%+49,077+53.6%AddedHistory
Ormat Technologies, Inc.686688AC6DEBT 2.500% 7/15,037,000$5.23M1.3%00.0%Unchanged–
NICENICE Ltd.SPONSORED ADR33,303$5.13M1.3%−9,197−21.6%ReducedHistory
GSKGSK plcADR130,000$5.04M1.2%00.0%UnchangedHistory
SEDGSolaredge Technologies, Inc.COM309,216$5.00M1.2%−65,784−17.5%ReducedHistory
ETNB89bio, Inc.COM618,343$4.50M1.1%+61,811+11.1%AddedHistory
MRUSMerus N.V.COM106,532$4.48M1.1%−24,000−18.4%ReducedHistory
IMTXImmatics N.V.SHS921,111$4.15M1.0%00.0%UnchangedHistory
APLSApellis Pharmaceuticals, Inc.COM181,346$3.97M1.0%−24,905−12.1%ReducedHistory
MAZEMaze Therapeutics, Inc.COM355,554$3.91M1.0%+355,554NewHistory
TVTXTravere Therapeutics, Inc.COM200,000$3.58M0.9%−20,700−9.4%ReducedHistory
SVRASavara IncCOM1,284,151$3.56M0.9%+72,618+6.0%AddedHistory
ARWRArrowhead Pharmaceuticals, Inc.COM277,550$3.54M0.9%+80,000+40.5%AddedHistory
DYNDyne Therapeutics, Inc.COM329,262$3.44M0.8%+93,000+39.4%AddedHistory
ANNXAnnexon, Inc.COM1,764,387$3.41M0.8%+521,348+41.9%AddedHistory
JANXJanux Therapeutics, Inc.COM125,840$3.40M0.8%+57,507+84.2%AddedHistory
HELPHelus Pharma Inc.COM NEW527,222$3.34M0.8%−10,889−2.0%ReducedHistory
IMVTImmunovant, Inc.COM194,638$3.33M0.8%+194,638NewHistory
NVDANVIDIA CorpStock29,605$3.21M0.8%+29,605NewHistory
RZLTRezolute, Inc.COM NEW1,081,447$3.14M0.8%−84,448−7.2%ReducedHistory
Avidity Biosciences, Inc.05370A108COM106,000$3.13M0.8%+106,000New–
AMGNAmgen IncStock10,000$3.12M0.8%+10,000NewHistory
BIIBBiogen Inc.COM22,738$3.11M0.8%00.0%UnchangedHistory
ACOGAlpha Cognition Inc.COM NEW596,992$3.02M0.7%−23,008−3.7%ReducedHistory
VIGLVigil Neuroscience, Inc.COM1,604,429$2.86M0.7%+102,000+6.8%AddedHistory
NTLAIntellia Therapeutics, Inc.COM381,080$2.71M0.7%−85,000−18.2%ReducedHistory
DAWNDay One Biopharmaceuticals, Inc.Stock334,987$2.66M0.7%00.0%UnchangedHistory
AMATApplied Materials IncStock18,000$2.61M0.6%+18,000NewHistory
SRRKScholar Rock Holding CorpCOM78,193$2.51M0.6%−12,000−13.3%ReducedHistory
CRMSalesforce, Inc.Stock9,100$2.44M0.6%+9,100NewHistory
BHVNBiohaven Ltd.COM99,784$2.40M0.6%−56,710−36.2%ReducedHistory
ENGNenGene Therapeutics Inc.COM528,365$2.37M0.6%−31,635−5.6%ReducedHistory
SKYESkye Bioscience, Inc.COM NEW1,476,353$2.35M0.6%−88,275−5.6%ReducedHistory
WDAYWorkday, Inc.CL A10,000$2.34M0.6%00.0%UnchangedHistory
SWTXSpringWorks Therapeutics, Inc.COM52,009$2.30M0.6%−47,991−48.0%ReducedHistory
PFEPfizer IncStock90,000$2.28M0.6%00.0%UnchangedHistory
KURAKura Oncology, Inc.COM343,522$2.27M0.6%−266,565−43.7%ReducedHistory
ELVNEnliven Therapeutics, Inc.COM111,743$2.20M0.5%+111,743NewHistory
TSEMTower Semiconductor LtdSHS NEW61,549$2.19M0.5%−104,600−63.0%ReducedHistory
UBERUber Technologies, IncStock30,000$2.19M0.5%00.0%UnchangedHistory
GOOGAlphabet Inc.Stock13,500$2.11M0.5%−30,000−69.0%ReducedHistory
VKTXViking Therapeutics, Inc.COM83,270$2.01M0.5%−20,000−19.4%ReducedHistory
COGTCogent Biosciences, Inc.COM335,024$2.01M0.5%+335,024NewHistory
VTGNVistagen Therapeutics, Inc.COM790,550$1.98M0.5%−18,000−2.2%ReducedHistory
AVGOBroadcom Inc.Stock11,695$1.96M0.5%−5,185−30.7%ReducedHistory
IONSIonis Pharmaceuticals IncCOM63,821$1.93M0.5%00.0%UnchangedHistory
NKENIKE, Inc.Stock30,050$1.91M0.5%+30,050NewHistory
CHKPCheck Point Software Technologies LtdORD8,334$1.90M0.5%−27,301−76.6%ReducedHistory
RCKTRocket Pharmaceuticals, Inc.COM271,792$1.81M0.4%00.0%UnchangedHistory
MSFTMicrosoft CorpStock4,592$1.72M0.4%−17,735−79.4%ReducedHistory
NTRNutrien Ltd.COM30,894$1.53M0.4%−25,000−44.7%ReducedHistory
GPCRStructure Therapeutics Inc.SPONSORED ADS84,000$1.45M0.4%+84,000NewHistory
WIXWix.com Ltd.SHS8,800$1.44M0.4%−30,453−77.6%ReducedHistory
FROGJFrog LtdStock42,871$1.37M0.3%−147,510−77.5%ReducedHistory
CAMTCamtek LtdORD23,086$1.35M0.3%−13,201−36.4%ReducedHistory
PMNProMIS Neurosciences Inc.COM1,929,297$1.34M0.3%00.0%UnchangedHistory
SHL Telemedicine Ltd78423T200ADS632,456$1.31M0.3%00.0%Unchanged–
ORICOric Pharmaceuticals, Inc.COM234,834$1.31M0.3%−38,379−14.0%ReducedHistory
CEVACeva IncCOM48,920$1.25M0.3%+48,920NewHistory
BMYBristol Myers Squibb CoStock20,000$1.22M0.3%00.0%UnchangedHistory
VTYXVentyx Biosciences, Inc.COM1,012,749$1.16M0.3%00.0%UnchangedHistory
NNDMNano Dimension Ltd.SPONSORD ADS NEW717,518$1.14M0.3%+717,518NewHistory
INZYInozyme Pharma, Inc.COM1,191,140$1.08M0.3%00.0%UnchangedHistory
OTLKOutlook Therapeutics, Inc.Stock857,142$1.05M0.3%+857,142NewHistory
ATXSAstria Therapeutics, Inc.COM189,800$1.01M0.2%+50,000+35.8%AddedHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS900,428$981.5K0.2%−314,147−25.9%ReducedHistory
CATXPerspective Therapeutics, Inc.COM NEW460,247$980.3K0.2%00.0%UnchangedHistory
MRVLMarvell Technology, Inc.COM15,070$927.9K0.2%−63,541−80.8%ReducedHistory
ARVNArvinas, Inc.COM125,000$877.5K0.2%+125,000NewHistory
XENEXenon Pharmaceuticals Inc.COM26,097$875.6K0.2%−26,000−49.9%ReducedHistory
PERIPerion Network Ltd.SHS NEW102,612$835.3K0.2%00.0%UnchangedHistory
RGLSRegulus Therapeutics Inc.COM452,845$792.5K0.2%+452,845NewHistory
LRMRLarimar Therapeutics, Inc.COM366,304$787.6K0.2%−89,300−19.6%ReducedHistory
CRVSCorvus Pharmaceuticals, Inc.COM205,859$654.6K0.2%−294,632−58.9%ReducedHistory
HOWLWerewolf Therapeutics, Inc.COM626,810$609.4K0.2%00.0%UnchangedHistory
VIRVir Biotechnology, Inc.COM90,855$588.7K0.1%−490,974−84.4%ReducedHistory
APREAprea Therapeutics, Inc.COM NEW270,000$550.8K0.1%00.0%UnchangedHistory
ZURAZura Bio LtdCLASS A ORD SHS421,229$543.4K0.1%−269,489−39.0%ReducedHistory

Options (3)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Sphera Funds Management Ltd. in Q1 2025
SecurityClassPutsCalls
iShares Tr46428743220 YR TR BD ETF–$23.2M
PRAXPraxis Precision Medicines, Inc.COM NEW–$3.79M
RAREUltragenyx Pharmaceutical Inc.COM–$1.81M

Sold out since Q4 2024 (9)

Positions held at the end of Q4 2024 that are gone from this filing.

Positions of Sphera Funds Management Ltd. sold out since Q4 2024
SecurityClassShares in Q4 2024Value in Q4 2024% of portfolio in Q4 2024History
ACADAcadia Pharmaceuticals IncCOM288,539$5.29M1.0%History
PLRXPliant Therapeutics, Inc.COM297,362$3.92M0.7%History
ENPHEnphase Energy, Inc.Stock50,198$3.45M0.6%History
CRGXCARGO Therapeutics, Inc.COM179,674$2.59M0.5%History
CGEMCullinan Therapeutics, Inc.COM205,000$2.50M0.5%History
MRSNMersana Therapeutics, Inc.COM690,272$987.1K0.2%History
ALMSAlumis Inc.COM125,000$982.5K0.2%History
KYTXKyverna Therapeutics, Inc.COM118,758$444.2K0.1%History
CGENCompugen LtdORD177,094$271.0K0.1%History