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Livermore
Livermore
ZHEN

Sphera Funds Management Ltd.

SEC CIK
0001496201
Latest filing
Aug 14, 2026

Holdings in Q1 2024

Holdings as of Mar 31, 2024, filed May 15, 2024. Long positions only; changes compare share counts with Q4 2023.

Institution overview
Positions
93
+4 vs. Q4 2023
Portfolio value
$617.5M
+$78.9M (+14.7%) vs. Q4 2023
Filed
May 15, 2024
SEC
Holdings of Sphera Funds Management Ltd. in Q1 2024
SecurityClassSharesValue% of portfolioShare changeActionHistory
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS1,889,700$26.7M4.3%−579,400−23.5%ReducedHistory
SNYSanofiSPONSORED ADR499,515$24.3M3.9%00.0%UnchangedHistory
NICENICE Ltd.SPONSORED ADR85,881$22.4M3.6%+18,163+26.8%AddedHistory
CYTKCytokinetics IncCOM NEW281,671$19.7M3.2%+57,851+25.8%AddedHistory
SNDXSyndax Pharmaceuticals IncCOM812,964$19.3M3.1%+40,000+5.2%AddedHistory
BBIOBridgeBio Pharma, Inc.COM585,956$18.1M2.9%+303,810+107.7%AddedHistory
BIIBBiogen Inc.COM70,646$15.2M2.5%+24,300+52.4%AddedHistory
JSPRJasper Therapeutics, Inc.COM NEW505,242$14.8M2.4%+505,242NewHistory
CATXPerspective Therapeutics, Inc.COM12,443,621$14.8M2.4%+12,417,950+48,373.5%AddedHistory
MRKMerck & Co., Inc.Stock103,600$13.7M2.2%−20,000−16.2%ReducedHistory
KURAKura Oncology, Inc.COM610,826$13.0M2.1%−92,461−13.1%ReducedHistory
AZNAstraZeneca PLCSPONSORED ADR190,060$12.9M2.1%+10,000+5.6%AddedHistory
SSentinelOne, Inc.CL A550,818$12.8M2.1%+337,400+158.1%AddedHistory
JNJJohnson & JohnsonStock79,831$12.6M2.0%00.0%UnchangedHistory
METAMeta Platforms, Inc.Stock25,439$12.4M2.0%−8,864−25.8%ReducedHistory
CLDXCelldex Therapeutics, Inc.COM NEW276,996$11.6M1.9%−38,648−12.2%ReducedHistory
MSFTMicrosoft CorpStock27,548$11.6M1.9%+3,700+15.5%AddedHistory
RAREUltragenyx Pharmaceutical Inc.COM238,544$11.1M1.8%+37,500+18.7%AddedHistory
LLYEli Lilly & CoStock14,190$11.0M1.8%00.0%UnchangedHistory
PRAXPraxis Precision Medicines, Inc.COM NEW177,139$10.8M1.8%+177,139NewHistory
NVONovo Nordisk A SADR83,080$10.7M1.7%−10,000−10.7%ReducedHistory
Cybin Ord23256X100COM25,581,395$10.6M1.7%+25,581,395New–
INZYInozyme Pharma, Inc.COM1,372,907$10.5M1.7%−190,000−12.2%ReducedHistory
FROGJFrog LtdStock224,381$9.92M1.6%+114,476+104.2%AddedHistory
AMZNAmazon Com IncStock54,432$9.82M1.6%−1,244−2.2%ReducedHistory
FUSNFusion Pharmaceuticals Inc.COM449,041$9.57M1.6%−636,598−58.6%ReducedHistory
PHVSPharvaris N.V.COM392,877$9.08M1.5%+147,877+60.4%AddedHistory
MLYSMineralys Therapeutics, Inc.COM658,803$8.51M1.4%−84,788−11.4%ReducedHistory
DAWNDay One Biopharmaceuticals, Inc.Stock492,627$8.14M1.3%−20,373−4.0%ReducedHistory
GLBEGlobal-E Online Ltd.SHS208,784$7.59M1.2%−61,010−22.6%ReducedHistory
WIXWix.com Ltd.SHS52,877$7.27M1.2%−4,600−8.0%ReducedHistory
SRPTSarepta Therapeutics, Inc.COM55,614$7.20M1.2%+43,114+344.9%AddedHistory
IMTXImmatics N.V.SHS666,111$7.00M1.1%+45,000+7.2%AddedHistory
ABBVAbbVie Inc.Stock38,000$6.92M1.1%−8,000−17.4%ReducedHistory
OTLKOutlook Therapeutics, Inc.Stock571,429$6.82M1.1%+571,429NewHistory
MRUSMerus N.V.COM149,333$6.72M1.1%−81,000−35.2%ReducedHistory
AMATApplied Materials IncStock32,000$6.60M1.1%+32,000NewHistory
CAMTCamtek LtdORD74,909$6.28M1.0%+74,909NewHistory
NVMINova Ltd.COM35,106$6.23M1.0%−96,894−73.4%ReducedHistory
TSEMTower Semiconductor LtdSHS NEW179,600$6.01M1.0%−348,700−66.0%ReducedHistory
ETNB89bio, Inc.COM515,882$6.00M1.0%+107,208+26.2%AddedHistory
VIGLVigil Neuroscience, Inc.COM1,730,414$5.90M1.0%+1,195,294+223.4%AddedHistory
ENPHEnphase Energy, Inc.Stock47,183$5.71M0.9%+12,383+35.6%AddedHistory
VTYXVentyx Biosciences, Inc.COM992,749$5.46M0.9%+812,749+451.5%AddedHistory
TBLATaboola.com Ltd.ORD SHS1,191,070$5.29M0.9%−533,878−31.0%ReducedHistory
FDMT4D Molecular Therapeutics, Inc.COM162,161$5.17M0.8%+162,161NewHistory
INCYIncyte CorpCOM89,556$5.10M0.8%00.0%UnchangedHistory
RCKTRocket Pharmaceuticals, Inc.COM183,722$4.95M0.8%−7,061−3.7%ReducedHistory
NVSNovartis AGADR50,000$4.84M0.8%−10,000−16.7%ReducedHistory
CPRXCatalyst Pharmaceuticals, Inc.COM288,000$4.59M0.7%+288,000NewHistory
GSKGSK plcADR100,000$4.29M0.7%00.0%UnchangedHistory
VTGNVistagen Therapeutics, Inc.COM808,550$4.27M0.7%00.0%UnchangedHistory
APLTApplied Therapeutics, Inc.COM619,029$4.21M0.7%+619,029NewHistory
HOWLWerewolf Therapeutics, Inc.COM626,810$4.06M0.7%00.0%UnchangedHistory
AKROAkero Therapeutics, Inc.COM160,445$4.05M0.7%+160,445NewHistory
SHL Telemedicine Ltd78423T200ADS632,456$3.86M0.6%00.0%Unchanged–
PLRXPliant Therapeutics, Inc.COM258,554$3.85M0.6%+65,000+33.6%AddedHistory
PMNProMIS Neurosciences Inc.COM1,834,047$3.50M0.6%+50.0%AddedHistory
SWTXSpringWorks Therapeutics, Inc.COM70,269$3.46M0.6%−100,001−58.7%ReducedHistory
ALECAlector, Inc.COM560,000$3.37M0.5%+560,000NewHistory
IRONDisc Medicine, Inc.COM48,886$3.04M0.5%+48,886NewHistory
AAPLApple Inc.Stock17,500$3.00M0.5%+17,500NewHistory
ENLTEnlight Renewable Energy Ltd.SHS169,280$2.86M0.5%00.0%UnchangedHistory
SEDGSolaredge Technologies, Inc.COM40,175$2.85M0.5%−7,825−16.3%ReducedHistory
RZLTRezolute, Inc.COM NEW996,710$2.54M0.4%00.0%UnchangedHistory
QCOMQualcomm IncStock15,000$2.54M0.4%+15,000NewHistory
PFEPfizer IncStock90,000$2.50M0.4%00.0%UnchangedHistory
ACADAcadia Pharmaceuticals IncCOM125,000$2.31M0.4%+125,000NewHistory
ELEVElevation Acquisition Group Inc.COM430,000$2.21M0.4%−470,000−52.2%ReducedHistory
ESTCElastic N.V.ORD SHS20,000$2.00M0.3%+20,000NewHistory
AMDAdvanced Micro Devices IncStock11,000$1.99M0.3%−39,387−78.2%ReducedHistory
CGENCompugen LtdORD769,239$1.98M0.3%00.0%UnchangedHistory
NTRNutrien Ltd.COM35,730$1.94M0.3%+35,730NewHistory
KZRKezar Life Sciences, Inc.COM2,051,676$1.85M0.3%00.0%UnchangedHistory
APREAprea Therapeutics, Inc.COM NEW270,000$1.81M0.3%+270,000NewHistory
ALPNAlpine Immune Sciences, Inc.COM44,841$1.78M0.3%−190,000−80.9%ReducedHistory
FIVNFive9, Inc.COM27,500$1.71M0.3%+12,500+83.3%AddedHistory
CRGXCARGO Therapeutics, Inc.COM75,000$1.67M0.3%00.0%UnchangedHistory
ATXSAstria Therapeutics, Inc.COM112,842$1.59M0.3%−1,038,303−90.2%ReducedHistory
PRMEPrime Medicine, Inc.COM205,242$1.44M0.2%+131,262+177.4%AddedHistory
UPWKUpwork, IncCOM117,000$1.43M0.2%−135,784−53.7%ReducedHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM NEW35,000$1.37M0.2%+35,000NewHistory
AVGOBroadcom Inc.Stock1,001$1.33M0.2%−799−44.4%ReducedHistory
GERNGeron CorpCOM384,356$1.27M0.2%+384,356NewHistory
LVTXLAVA Therapeutics NVSHS367,582$1.22M0.2%+367,582NewHistory
GOSSGossamer Bio, Inc.COM1,027,134$1.21M0.2%−310,956−23.2%ReducedHistory
VRNSVaronis Systems IncCOM20,000$943.4K0.2%+20,000NewHistory
AMLXAmylyx Pharmaceuticals, Inc.COM267,250$759.0K0.1%+83,600+45.5%AddedHistory
ICLICL Group Ltd.SHS130,475$702.0K0.1%−289,525−68.9%ReducedHistory
RNACCartesian Therapeutics, Inc.COM25,071$488.9K0.1%−727,066−96.7%ReducedHistory
ANROAlto Neuroscience, Inc.COM SHS30,500$468.2K0.1%+30,500NewHistory
Immatics N.V.N44445117*W EXP 07/01/202100,000$270.0K<0.1%00.0%Unchanged–
ARBEArbe Robotics Ltd.COM43,165$90.2K<0.1%00.0%UnchangedHistory

Options (11)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Sphera Funds Management Ltd. in Q1 2024
SecurityClassPutsCalls
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS–$44.2M
State Street SPDR S&P Biotech ETF78464A870ETF$36.1M–
ALNYAlnylam Pharmaceuticals, Inc.COM–$2.99M
RAREUltragenyx Pharmaceutical Inc.COM–$2.57M
SEDGSolaredge Technologies, Inc.COM–$1.90M
ACADAcadia Pharmaceuticals IncCOM–$1.85M
IRONDisc Medicine, Inc.COM–$1.56M
BBIOBridgeBio Pharma, Inc.COM–$1.55M
INSMINSMED IncCOM PAR $.01–$762.4K
AMLXAmylyx Pharmaceuticals, Inc.COM–$681.6K
ANNXAnnexon, Inc.COM$81.7K–

Sold out since Q4 2023 (19)

Positions held at the end of Q4 2023 that are gone from this filing.

Positions of Sphera Funds Management Ltd. sold out since Q4 2023
SecurityClassShares in Q4 2023Value in Q4 2023% of portfolio in Q4 2023History
INBXInhibrx Biosciences, Inc.COM226,551$8.61M1.6%History
PRAXPraxis Precision Medicines, Inc.COM328,986$7.33M1.4%History
ALNYAlnylam Pharmaceuticals, Inc.COM36,230$6.93M1.3%History
MDGLMadrigal Pharmaceuticals, Inc.COM27,767$6.42M1.2%History
JSPRJasper Therapeutics, Inc.COM713,063$5.63M1.0%History
Gracell Biotechnologies Inc38406L103SPONSORED ADS502,936$5.05M0.9%–
PANWPalo Alto Networks IncStock16,585$4.89M0.9%History
ARWRArrowhead Pharmaceuticals, Inc.COM144,899$4.43M0.8%History
PTCTPTC Therapeutics, Inc.COM136,525$3.76M0.7%History
RIGLRigel Pharmaceuticals IncCOM NEW1,228,126$1.78M0.3%History
GILDGilead Sciences, Inc.Stock20,000$1.62M0.3%History
COGTCogent Biosciences, Inc.COM259,201$1.52M0.3%History
ORICOric Pharmaceuticals, Inc.COM126,800$1.17M0.2%History
APGEApogee Therapeutics, Inc.COM30,000$838.2K0.2%History
MDWDMediWound Ltd.SHS NEW48,980$498.1K0.1%History
MORFMorphic Holding, Inc.COM14,952$431.8K0.1%History
GLUEMonte Rosa Therapeutics, Inc.COM48,511$274.1K0.1%History
REPLReplimune Group, Inc.COM16,096$135.7K<0.1%History
Freeline Therapeutics Hldgs35655L206SPONSORED ADS16,445$104.8K<0.1%–