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Livermore
Livermore
ZHEN

Sphera Funds Management Ltd.

SEC CIK
0001496201
Latest filing
Aug 14, 2026

Holdings in Q4 2023

Holdings as of Dec 31, 2023, filed Feb 15, 2024. Long positions only; changes compare share counts with Q3 2023.

Institution overview
Positions
89
+14 vs. Q3 2023
Portfolio value
$538.6M
+$121.9M (+29.3%) vs. Q3 2023
Filed
Feb 15, 2024
AmendedSEC
Holdings of Sphera Funds Management Ltd. in Q4 2023
SecurityClassSharesValue% of portfolioShare changeActionHistory
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS2,469,100$25.8M4.8%+1,869,100+311.5%AddedHistory
SNYSanofiSPONSORED ADR499,515$24.8M4.6%00.0%UnchangedHistory
CYTKCytokinetics IncCOM NEW223,820$18.7M3.5%−10,113−4.3%ReducedHistory
NVMINova Ltd.COM132,000$18.1M3.4%+132,000NewHistory
SNDXSyndax Pharmaceuticals IncCOM772,964$16.7M3.1%−970.0%ReducedHistory
TSEMTower Semiconductor LtdSHS NEW528,300$16.1M3.0%+58,726+12.5%AddedHistory
NICENICE Ltd.SPONSORED ADR67,718$13.5M2.5%+30,236+80.7%AddedHistory
MRKMerck & Co., Inc.Stock123,600$13.5M2.5%00.0%UnchangedHistory
CLDXCelldex Therapeutics, Inc.COM NEW315,644$12.5M2.3%+135,644+75.4%AddedHistory
JNJJohnson & JohnsonStock79,831$12.5M2.3%−15,000−15.8%ReducedHistory
METAMeta Platforms, Inc.Stock34,303$12.1M2.3%+19,083+125.4%AddedHistory
AZNAstraZeneca PLCSPONSORED ADR180,060$12.1M2.3%−105,000−36.8%ReducedHistory
BIIBBiogen Inc.COM46,346$12.0M2.2%+20,500+79.3%AddedHistory
BBIOBridgeBio Pharma, Inc.COM282,146$11.4M2.1%−63,391−18.3%ReducedHistory
GLBEGlobal-E Online Ltd.SHS269,794$10.7M2.0%+269,794NewHistory
FUSNFusion Pharmaceuticals Inc.COM1,085,639$10.4M1.9%−268,619−19.8%ReducedHistory
KURAKura Oncology, Inc.COM703,287$10.1M1.9%00.0%UnchangedHistory
NVONovo Nordisk A SADR93,080$9.63M1.8%00.0%UnchangedHistory
RAREUltragenyx Pharmaceutical Inc.COM201,044$9.61M1.8%−58,091−22.4%ReducedHistory
MSFTMicrosoft CorpStock23,848$8.97M1.7%−10,594−30.8%ReducedHistory
ATXSAstria Therapeutics, Inc.COM1,151,145$8.84M1.6%+570,546+98.3%AddedHistory
INBXInhibrx Biosciences, Inc.COM226,551$8.61M1.6%−29,820−11.6%ReducedHistory
AMZNAmazon Com IncStock55,676$8.46M1.6%−39,624−41.6%ReducedHistory
LLYEli Lilly & CoStock14,190$8.27M1.5%00.0%UnchangedHistory
DAWNDay One Biopharmaceuticals, Inc.Stock513,000$7.49M1.4%−17,000−3.2%ReducedHistory
TBLATaboola.com Ltd.ORD SHS1,724,948$7.47M1.4%+1,724,948NewHistory
AMDAdvanced Micro Devices IncStock50,387$7.43M1.4%+2,067+4.3%AddedHistory
PRAXPraxis Precision Medicines, Inc.COM328,986$7.33M1.4%+5,632+1.7%AddedConverted for a 1-for-15 splitHistory
ABBVAbbVie Inc.Stock46,000$7.13M1.3%00.0%UnchangedHistory
WIXWix.com Ltd.SHS57,477$7.07M1.3%+57,477NewHistory
ALNYAlnylam Pharmaceuticals, Inc.COM36,230$6.93M1.3%+129+0.4%AddedHistory
PHVSPharvaris N.V.COM245,000$6.87M1.3%+245,000NewHistory
INZYInozyme Pharma, Inc.COM1,562,907$6.66M1.2%+328,000+26.6%AddedHistory
IMTXImmatics N.V.SHS621,111$6.54M1.2%+3,938+0.6%AddedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM27,767$6.42M1.2%−23,100−45.4%ReducedHistory
MLYSMineralys Therapeutics, Inc.COM743,591$6.39M1.2%+288,191+63.3%AddedHistory
MRUSMerus N.V.COM230,333$6.33M1.2%−23,000−9.1%ReducedHistory
SWTXSpringWorks Therapeutics, Inc.COM170,270$6.21M1.2%−149,641−46.8%ReducedHistory
NVSNovartis AGADR60,000$6.06M1.1%00.0%UnchangedHistory
SSentinelOne, Inc.CL A213,418$5.86M1.1%+213,418NewHistory
RCKTRocket Pharmaceuticals, Inc.COM190,783$5.72M1.1%−18,257−8.7%ReducedHistory
JSPRJasper Therapeutics, Inc.COM713,063$5.63M1.0%−4,974,071−87.5%ReducedHistory
INCYIncyte CorpCOM89,556$5.62M1.0%+89,556NewHistory
Gracell Biotechnologies Inc38406L103SPONSORED ADS502,936$5.05M0.9%−1,028,561−67.2%Reduced–
SHL Telemedicine Ltd78423T200ADS632,456$5.04M0.9%+2000.0%Added–
PANWPalo Alto Networks IncStock16,585$4.89M0.9%−12,174−42.3%ReducedHistory
ENPHEnphase Energy, Inc.Stock34,800$4.60M0.9%+34,800NewHistory
ETNB89bio, Inc.COM408,674$4.56M0.8%+89,373+28.0%AddedHistory
SEDGSolaredge Technologies, Inc.COM48,000$4.49M0.8%+48,000NewHistory
ALPNAlpine Immune Sciences, Inc.COM234,841$4.48M0.8%+54,841+30.5%AddedHistory
ARWRArrowhead Pharmaceuticals, Inc.COM144,899$4.43M0.8%+144,899NewHistory
VTGNVistagen Therapeutics, Inc.COM808,550$4.16M0.8%+708,550+708.6%AddedHistory
FROGJFrog LtdStock109,905$3.80M0.7%+109,905NewHistory
PTCTPTC Therapeutics, Inc.COM136,525$3.76M0.7%−81,934−37.5%ReducedHistory
UPWKUpwork, IncCOM252,784$3.76M0.7%+252,784NewHistory
GSKGSK plcADR100,000$3.71M0.7%00.0%UnchangedHistory
PLRXPliant Therapeutics, Inc.COM193,554$3.51M0.7%+37,420+24.0%AddedHistory
ENLTEnlight Renewable Energy Ltd.SHS169,280$3.24M0.6%+169,280NewHistory
AMLXAmylyx Pharmaceuticals, Inc.COM183,650$2.70M0.5%−10,000−5.2%ReducedHistory
PFEPfizer IncStock90,000$2.59M0.5%00.0%UnchangedHistory
HOWLWerewolf Therapeutics, Inc.COM626,810$2.42M0.4%00.0%UnchangedHistory
PMNProMIS Neurosciences Inc.COM1,834,042$2.11M0.4%00.0%UnchangedHistory
ICLICL Group Ltd.SHS420,000$2.10M0.4%−50,000−10.6%ReducedHistory
AVGOBroadcom Inc.Stock1,800$2.01M0.4%+1,800NewHistory
KZRKezar Life Sciences, Inc.COM2,051,676$1.94M0.4%00.0%UnchangedHistory
VIGLVigil Neuroscience, Inc.COM535,120$1.81M0.3%+535,120NewHistory
RIGLRigel Pharmaceuticals IncCOM NEW1,228,126$1.78M0.3%00.0%UnchangedHistory
CRGXCARGO Therapeutics, Inc.COM75,000$1.74M0.3%+75,000NewHistory
GILDGilead Sciences, Inc.Stock20,000$1.62M0.3%−20,000−50.0%ReducedHistory
COGTCogent Biosciences, Inc.COM259,201$1.52M0.3%−160,799−38.3%ReducedHistory
CGENCompugen LtdORD769,239$1.52M0.3%−550,000−41.7%ReducedHistory
GOSSGossamer Bio, Inc.COM1,338,090$1.22M0.2%−594,478−30.8%ReducedHistory
SRPTSarepta Therapeutics, Inc.COM12,500$1.21M0.2%−37,500−75.0%ReducedHistory
FIVNFive9, Inc.COM15,000$1.18M0.2%+15,000NewHistory
ORICOric Pharmaceuticals, Inc.COM126,800$1.17M0.2%+126,800NewHistory
RZLTRezolute, Inc.COM NEW996,710$989.2K0.2%00.0%UnchangedHistory
APGEApogee Therapeutics, Inc.COM30,000$838.2K0.2%00.0%UnchangedHistory
PRMEPrime Medicine, Inc.COM73,980$655.5K0.1%+73,980NewHistory
RNACCartesian Therapeutics, Inc.COM752,137$518.5K0.1%00.0%UnchangedHistory
MDWDMediWound Ltd.SHS NEW48,980$498.1K0.1%−59,553−54.9%ReducedHistory
ELEVElevation Acquisition Group Inc.COM900,000$483.3K0.1%00.0%UnchangedHistory
VTYXVentyx Biosciences, Inc.COM180,000$444.6K0.1%+180,000NewHistory
MORFMorphic Holding, Inc.COM14,952$431.8K0.1%−75,048−83.4%ReducedHistory
Immatics N.V.N44445117*W EXP 07/01/202100,000$292.0K0.1%00.0%Unchanged–
GLUEMonte Rosa Therapeutics, Inc.COM48,511$274.1K0.1%+48,511NewHistory
REPLReplimune Group, Inc.COM16,096$135.7K<0.1%−168,920−91.3%ReducedHistory
Freeline Therapeutics Hldgs35655L206SPONSORED ADS16,445$104.8K<0.1%+16,445New–
ARBEArbe Robotics Ltd.COM43,165$94.1K<0.1%+43,165NewHistory
CATXPerspective Therapeutics, Inc.COM25,671$10.3K<0.1%+25,671NewHistory

Options (10)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Sphera Funds Management Ltd. in Q4 2023
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF$44.6M–
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS–$13.4M
CLDXCelldex Therapeutics, Inc.COM NEW–$4.59M
ENPHEnphase Energy, Inc.Stock–$4.24M
ALNYAlnylam Pharmaceuticals, Inc.COM–$3.83M
CYTKCytokinetics IncCOM NEW–$2.99M
SRPTSarepta Therapeutics, Inc.COM–$2.55M
SEDGSolaredge Technologies, Inc.COM–$2.51M
PRTAProthena Corp Public Ltd CoSHS–$2.48M
AMLXAmylyx Pharmaceuticals, Inc.COM–$1.47M

Sold out since Q3 2023 (10)

Positions held at the end of Q3 2023 that are gone from this filing.

Positions of Sphera Funds Management Ltd. sold out since Q3 2023
SecurityClassShares in Q3 2023Value in Q3 2023% of portfolio in Q3 2023History
Enphase Energy, Inc.29355AAK3NOTE 3/020,900,000$17.3M4.2%–
PNTPOINT Biopharma Global Inc.COM952,642$6.35M1.5%History
IRONDisc Medicine, Inc.COM111,398$5.23M1.3%History
State Street SPDR S&P Biotech ETF78464A870ETF50,000$3.65M0.9%–
MIRMMirum Pharmaceuticals, Inc.COM114,284$3.61M0.9%History
CRWDCrowdStrike Holdings, Inc.Stock15,000$2.51M0.6%History
VERAVera Therapeutics, Inc.CL A105,000$1.44M0.3%History
XENEXenon Pharmaceuticals Inc.COM38,959$1.33M0.3%History
QUREuniQure N.V.SHS148,734$998.0K0.2%History
Calliditas Therapeutics AB13124Q106SPONSERED ADS11,863$216.6K0.1%–