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Livermore
Livermore
ZHEN

Sphera Funds Management Ltd.

SEC CIK
0001496201
Latest filing
Aug 14, 2026

Holdings in Q3 2023

Holdings as of Sep 30, 2023, filed Nov 14, 2023. Long positions only; changes compare share counts with Q2 2023.

Institution overview
Positions
75
−1 vs. Q2 2023
Portfolio value
$416.7M
−$49.9M (−10.7%) vs. Q2 2023
Filed
Nov 14, 2023
SEC
Holdings of Sphera Funds Management Ltd. in Q3 2023
SecurityClassSharesValue% of portfolioShare changeActionHistory
SNYSanofiSPONSORED ADR499,515$26.8M6.4%−30,000−5.7%ReducedHistory
AZNAstraZeneca PLCSPONSORED ADR285,060$19.3M4.6%00.0%UnchangedHistory
Enphase Energy, Inc.29355AAK3NOTE 3/020,900,000$17.3M4.2%+6,590,000+46.1%Added–
JNJJohnson & JohnsonStock94,831$14.8M3.5%−25,000−20.9%ReducedHistory
MRKMerck & Co., Inc.Stock123,600$12.7M3.1%+3,000+2.5%AddedHistory
AMZNAmazon Com IncStock95,300$12.1M2.9%−29,000−23.3%ReducedHistory
TSEMTower Semiconductor LtdSHS NEW469,574$11.5M2.8%+302,128+180.4%AddedHistory
SNDXSyndax Pharmaceuticals IncCOM773,061$11.2M2.7%+50,000+6.9%AddedHistory
MSFTMicrosoft CorpStock34,442$10.9M2.6%+130+0.4%AddedHistory
RAREUltragenyx Pharmaceutical Inc.COM259,135$9.24M2.2%+75,439+41.1%AddedHistory
BBIOBridgeBio Pharma, Inc.COM345,537$9.11M2.2%+23,902+7.4%AddedHistory
NVONovo Nordisk A SADR93,080$8.46M2.0%−20,000−17.7%ReducedConverted for a 2-for-1 splitHistory
PRAXPraxis Precision Medicines, Inc.COM4,850,317$8.29M2.0%−3,914,017−44.7%ReducedHistory
LLYEli Lilly & CoStock14,190$7.62M1.8%−1,500−9.6%ReducedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM50,867$7.43M1.8%+25,867+103.5%AddedHistory
SWTXSpringWorks Therapeutics, Inc.COM319,911$7.40M1.8%+7,286+2.3%AddedHistory
IMTXImmatics N.V.SHS617,173$7.15M1.7%00.0%UnchangedHistory
SHL Telemedicine Ltd78423T200ADS632,256$6.96M1.7%−82,317−11.5%Reduced–
CYTKCytokinetics IncCOM NEW233,933$6.89M1.7%+233,933NewHistory
ABBVAbbVie Inc.Stock46,000$6.86M1.6%−10,000−17.9%ReducedHistory
PANWPalo Alto Networks IncStock28,759$6.74M1.6%+1,759+6.5%AddedHistory
BIIBBiogen Inc.COM25,846$6.64M1.6%+2,000+8.4%AddedHistory
DAWNDay One Biopharmaceuticals, Inc.Stock530,000$6.50M1.6%00.0%UnchangedHistory
KURAKura Oncology, Inc.COM703,287$6.41M1.5%+100,000+16.6%AddedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM36,101$6.39M1.5%−3,899−9.7%ReducedHistory
NICENICE Ltd.SPONSORED ADR37,482$6.37M1.5%−50,000−57.2%ReducedHistory
PNTPOINT Biopharma Global Inc.COM952,642$6.35M1.5%00.0%UnchangedHistory
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS600,000$6.12M1.5%−450,000−42.9%ReducedHistory
NVSNovartis AGADR60,000$6.11M1.5%00.0%UnchangedHistory
SRPTSarepta Therapeutics, Inc.COM50,000$6.06M1.5%00.0%UnchangedHistory
MRUSMerus N.V.COM253,333$5.97M1.4%−25,000−9.0%ReducedHistory
IRONDisc Medicine, Inc.COM111,398$5.23M1.3%−59,180−34.7%ReducedHistory
INZYInozyme Pharma, Inc.COM1,234,907$5.19M1.2%+102,940+9.1%AddedHistory
AMDAdvanced Micro Devices IncStock48,320$4.97M1.2%+48,320NewHistory
CLDXCelldex Therapeutics, Inc.COM NEW180,000$4.95M1.2%+20,000+12.5%AddedHistory
ETNB89bio, Inc.COM319,301$4.93M1.2%+184,301+136.5%AddedHistory
PTCTPTC Therapeutics, Inc.COM218,459$4.90M1.2%+118,359+118.2%AddedHistory
INBXInhibrx Biosciences, Inc.COM256,371$4.70M1.1%+206,371+412.7%AddedHistory
METAMeta Platforms, Inc.Stock15,220$4.57M1.1%+15,220NewHistory
Gracell Biotechnologies Inc38406L103SPONSORED ADS1,531,497$4.41M1.1%+302,832+24.6%Added–
ATXSAstria Therapeutics, Inc.COM580,599$4.33M1.0%+109,581+23.3%AddedHistory
MLYSMineralys Therapeutics, Inc.COM455,400$4.33M1.0%+50,000+12.3%AddedHistory
RCKTRocket Pharmaceuticals, Inc.COM209,040$4.28M1.0%−26,960−11.4%ReducedHistory
COGTCogent Biosciences, Inc.COM420,000$4.09M1.0%00.0%UnchangedHistory
JSPRJasper Therapeutics, Inc.COM5,687,134$3.98M1.0%+1,413,126+33.1%AddedHistory
PMNProMIS Neurosciences Inc.COM1,834,042$3.69M0.9%+1,834,042NewHistory
State Street SPDR S&P Biotech ETF78464A870ETF50,000$3.65M0.9%00.0%Unchanged–
GSKGSK plcADR100,000$3.63M0.9%00.0%UnchangedHistory
MIRMMirum Pharmaceuticals, Inc.COM114,284$3.61M0.9%+114,284NewHistory
AMLXAmylyx Pharmaceuticals, Inc.COM193,650$3.55M0.9%+93,650+93.7%AddedHistory
FUSNFusion Pharmaceuticals Inc.COM1,354,258$3.52M0.8%+25,000+1.9%AddedHistory
REPLReplimune Group, Inc.COM185,016$3.17M0.8%+185,016NewHistory
GILDGilead Sciences, Inc.Stock40,000$3.00M0.7%00.0%UnchangedHistory
PFEPfizer IncStock90,000$2.99M0.7%−50,000−35.7%ReducedHistory
PLRXPliant Therapeutics, Inc.COM156,134$2.71M0.6%+156,134NewHistory
ICLICL Group Ltd.SHS470,000$2.61M0.6%+470,000NewHistory
CRWDCrowdStrike Holdings, Inc.Stock15,000$2.51M0.6%+15,000NewHistory
KZRKezar Life Sciences, Inc.COM2,051,676$2.44M0.6%+63,448+3.2%AddedHistory
MORFMorphic Holding, Inc.COM90,000$2.06M0.5%00.0%UnchangedHistory
ALPNAlpine Immune Sciences, Inc.COM180,000$2.06M0.5%−20,000−10.0%ReducedHistory
GOSSGossamer Bio, Inc.COM1,932,568$1.61M0.4%+1,932,568NewHistory
VERAVera Therapeutics, Inc.CL A105,000$1.44M0.3%00.0%UnchangedHistory
HOWLWerewolf Therapeutics, Inc.COM626,810$1.34M0.3%00.0%UnchangedHistory
XENEXenon Pharmaceuticals Inc.COM38,959$1.33M0.3%+38,959NewHistory
RIGLRigel Pharmaceuticals IncCOM NEW1,228,126$1.33M0.3%00.0%UnchangedHistory
RZLTRezolute, Inc.COM NEW996,710$1.32M0.3%−159,187−13.8%ReducedHistory
CGENCompugen LtdORD1,319,239$1.23M0.3%+89,431+7.3%AddedHistory
MDWDMediWound Ltd.SHS NEW108,533$1.15M0.3%−2,594−2.3%ReducedHistory
QUREuniQure N.V.SHS148,734$998.0K0.2%00.0%UnchangedHistory
RNACCartesian Therapeutics, Inc.COM752,137$797.3K0.2%−1,286,363−63.1%ReducedHistory
APGEApogee Therapeutics, Inc.COM30,000$639.0K0.2%+30,000NewHistory
ELEVElevation Acquisition Group Inc.COM900,000$596.3K0.1%00.0%UnchangedHistory
VTGNVistagen Therapeutics, Inc.COM100,000$524.0K0.1%+100,000NewHistory
Immatics N.V.N44445117*W EXP 07/01/202100,000$354.0K0.1%00.0%Unchanged–
Calliditas Therapeutics AB13124Q106SPONSERED ADS11,863$216.6K0.1%+11,863New–

Options (7)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Sphera Funds Management Ltd. in Q3 2023
SecurityClassPutsCalls
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS–$51.1M
Invesco QQQ Tr46090E953PUT$48.9M–
NICENICE Ltd.SPONSORED ADR–$17.9M
SEDGSolaredge Technologies, Inc.COM–$6.93M
XENEXenon Pharmaceuticals Inc.COM$2.81M–
CLDXCelldex Therapeutics, Inc.COM NEW–$2.75M
CYTKCytokinetics IncCOM NEW–$1.91M

Sold out since Q2 2023 (15)

Positions held at the end of Q2 2023 that are gone from this filing.

Positions of Sphera Funds Management Ltd. sold out since Q2 2023
SecurityClassShares in Q2 2023Value in Q2 2023% of portfolio in Q2 2023History
NVMINova Ltd.COM70,000$8.21M1.8%History
CAMTCamtek LtdORD189,494$6.75M1.4%History
SAGESage Therapeutics, Inc.COM128,000$6.02M1.3%History
ISEEIVERIC bio, Inc.COM134,414$5.29M1.1%History
QCOMQualcomm IncStock32,000$3.81M0.8%History
ENLTEnlight Renewable Energy Ltd.SHS211,586$3.76M0.8%History
TVTXTravere Therapeutics, Inc.COM213,462$3.28M0.7%History
ACLXArcellx, Inc.COMMON STOCK77,488$2.45M0.5%History
ALTAltimmune, Inc.COM NEW500,000$1.76M0.4%History
MRSNMersana Therapeutics, Inc.COM418,562$1.38M0.3%History
DYNDyne Therapeutics, Inc.COM119,918$1.35M0.3%History
PMVPPMV Pharmaceuticals, Inc.COM187,800$1.18M0.3%History
INFIInfinity Pharmaceuticals, Inc.COM1,476,000$310.7K0.1%History
Bio Green Med Solution, Inc.23254L603COM250,000$147.3K<0.1%–
ARBEArbe Robotics Ltd.COM43,165$124.7K<0.1%History