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Livermore
Livermore
ZHEN

Sphera Funds Management Ltd.

SEC CIK
0001496201
Latest filing
Aug 14, 2026

Holdings in Q2 2023

Holdings as of Jun 30, 2023, filed Aug 14, 2023. Long positions only; changes compare share counts with Q1 2023.

Institution overview
Positions
76
+1 vs. Q1 2023
Portfolio value
$466.6M
+$4.66M (+1.0%) vs. Q1 2023
Filed
Aug 14, 2023
SEC
Holdings of Sphera Funds Management Ltd. in Q2 2023
SecurityClassSharesValue% of portfolioShare changeActionHistory
SNYSanofiSPONSORED ADR529,515$28.5M6.1%00.0%UnchangedHistory
AZNAstraZeneca PLCSPONSORED ADR285,060$20.4M4.4%00.0%UnchangedHistory
JNJJohnson & JohnsonStock119,831$19.8M4.3%00.0%UnchangedHistory
NICENICE Ltd.SPONSORED ADR87,482$18.1M3.9%−28,000−24.2%ReducedHistory
AMZNAmazon Com IncStock124,300$16.2M3.5%+38,620+45.1%AddedHistory
SNDXSyndax Pharmaceuticals IncCOM723,061$15.1M3.2%+40,000+5.9%AddedHistory
MRKMerck & Co., Inc.Stock120,600$13.9M3.0%00.0%UnchangedHistory
Enphase Energy, Inc.29355AAK3NOTE 3/014,310,000$13.4M2.9%+3,585,000+33.4%Added–
MSFTMicrosoft CorpStock34,312$11.7M2.5%−20,311−37.2%ReducedHistory
PRAXPraxis Precision Medicines, Inc.COM8,764,334$10.1M2.2%+8,764,334NewHistory
NVONovo Nordisk A SADR56,540$9.15M2.0%−15,000−21.0%ReducedHistory
PNTPOINT Biopharma Global Inc.COM952,642$8.63M1.8%00.0%UnchangedHistory
RAREUltragenyx Pharmaceutical Inc.COM183,696$8.47M1.8%00.0%UnchangedHistory
NVMINova Ltd.COM70,000$8.21M1.8%+70,000NewHistory
SWTXSpringWorks Therapeutics, Inc.COM312,625$8.20M1.8%−5,000−1.6%ReducedHistory
SHL Telemedicine Ltd78423T200ADS714,573$7.96M1.7%+714,573New–
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS1,050,000$7.91M1.7%−989,500−48.5%ReducedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM40,000$7.60M1.6%+40,000NewHistory
IRONDisc Medicine, Inc.COM170,578$7.57M1.6%−49,435−22.5%ReducedHistory
ABBVAbbVie Inc.Stock56,000$7.54M1.6%−7,000−11.1%ReducedHistory
LLYEli Lilly & CoStock15,690$7.36M1.6%−16,000−50.5%ReducedHistory
MRUSMerus N.V.COM278,333$7.33M1.6%−58,660−17.4%ReducedHistory
IMTXImmatics N.V.SHS617,173$7.12M1.5%−163,679−21.0%ReducedHistory
MLYSMineralys Therapeutics, Inc.COM405,400$6.91M1.5%+66,400+19.6%AddedHistory
PANWPalo Alto Networks IncStock27,000$6.90M1.5%+7,000+35.0%AddedHistory
BIIBBiogen Inc.COM23,846$6.79M1.5%−9,670−28.9%ReducedHistory
CAMTCamtek LtdORD189,494$6.75M1.4%−50,000−20.9%ReducedHistory
KURAKura Oncology, Inc.COM603,287$6.38M1.4%00.0%UnchangedHistory
DAWNDay One Biopharmaceuticals, Inc.Stock530,000$6.33M1.4%+530,000NewHistory
INZYInozyme Pharma, Inc.COM1,131,967$6.31M1.4%−649,891−36.5%ReducedHistory
TSEMTower Semiconductor LtdSHS NEW167,446$6.28M1.3%+167,446NewHistory
FUSNFusion Pharmaceuticals Inc.COM1,329,258$6.21M1.3%+45,721+3.6%AddedHistory
NVSNovartis AGADR60,000$6.05M1.3%00.0%UnchangedHistory
SAGESage Therapeutics, Inc.COM128,000$6.02M1.3%−27,000−17.4%ReducedHistory
JSPRJasper Therapeutics, Inc.COM4,274,008$5.86M1.3%+230,000+5.7%AddedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM25,000$5.78M1.2%+6,000+31.6%AddedHistory
SRPTSarepta Therapeutics, Inc.COM50,000$5.73M1.2%+6,000+13.6%AddedHistory
BBIOBridgeBio Pharma, Inc.COM321,635$5.53M1.2%−240,348−42.8%ReducedHistory
CLDXCelldex Therapeutics, Inc.COM NEW160,000$5.43M1.2%+160,000NewHistory
ISEEIVERIC bio, Inc.COM134,414$5.29M1.1%−97,177−42.0%ReducedHistory
MORFMorphic Holding, Inc.COM90,000$5.16M1.1%+90,000NewHistory
PFEPfizer IncStock140,000$5.14M1.1%00.0%UnchangedHistory
COGTCogent Biosciences, Inc.COM420,000$4.97M1.1%+120,000+40.0%AddedHistory
KZRKezar Life Sciences, Inc.COM1,988,228$4.87M1.0%+100,000+5.3%AddedHistory
RCKTRocket Pharmaceuticals, Inc.COM236,000$4.69M1.0%00.0%UnchangedHistory
Gracell Biotechnologies Inc38406L103SPONSORED ADS1,228,665$4.68M1.0%−1,131,915−48.0%Reduced–
State Street SPDR S&P Biotech ETF78464A870ETF50,000$4.16M0.9%+50,000New–
PTCTPTC Therapeutics, Inc.COM100,100$4.07M0.9%−59,000−37.1%ReducedHistory
ATXSAstria Therapeutics, Inc.COM471,018$3.92M0.8%+50,000+11.9%AddedHistory
QCOMQualcomm IncStock32,000$3.81M0.8%+32,000NewHistory
ENLTEnlight Renewable Energy Ltd.SHS211,586$3.76M0.8%−239,278−53.1%ReducedHistory
GSKGSK plcADR100,000$3.56M0.8%+100,000NewHistory
TVTXTravere Therapeutics, Inc.COM213,462$3.28M0.7%+25,962+13.8%AddedHistory
GILDGilead Sciences, Inc.Stock40,000$3.08M0.7%+40,000NewHistory
ETNB89bio, Inc.COM135,000$2.56M0.5%+135,000NewHistory
ACLXArcellx, Inc.COMMON STOCK77,488$2.45M0.5%−90,000−53.7%ReducedHistory
RZLTRezolute, Inc.COM NEW1,155,897$2.29M0.5%00.0%UnchangedHistory
RNACCartesian Therapeutics, Inc.COM2,038,500$2.28M0.5%−286,500−12.3%ReducedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM100,000$2.16M0.5%+100,000NewHistory
ALPNAlpine Immune Sciences, Inc.COM200,000$2.06M0.4%00.0%UnchangedHistory
HOWLWerewolf Therapeutics, Inc.COM626,810$1.91M0.4%00.0%UnchangedHistory
ALTAltimmune, Inc.COM NEW500,000$1.76M0.4%+200,000+66.7%AddedHistory
QUREuniQure N.V.SHS148,734$1.70M0.4%+86,734+139.9%AddedHistory
VERAVera Therapeutics, Inc.CL A105,000$1.69M0.4%+105,000NewHistory
RIGLRigel Pharmaceuticals IncCOM NEW1,228,126$1.58M0.3%−650,719−34.6%ReducedHistory
CGENCompugen LtdORD1,229,808$1.40M0.3%+1,229,808NewHistory
MRSNMersana Therapeutics, Inc.COM418,562$1.38M0.3%+407,941+3,840.9%AddedHistory
ELEVElevation Acquisition Group Inc.COM900,000$1.37M0.3%+900,000NewHistory
DYNDyne Therapeutics, Inc.COM119,918$1.35M0.3%−99,398−45.3%ReducedHistory
INBXInhibrx Biosciences, Inc.COM50,000$1.30M0.3%+50,000NewHistory
MDWDMediWound Ltd.SHS NEW111,127$1.18M0.3%00.0%UnchangedHistory
PMVPPMV Pharmaceuticals, Inc.COM187,800$1.18M0.3%00.0%UnchangedHistory
Immatics N.V.N44445117*W EXP 07/01/202100,000$342.0K0.1%00.0%Unchanged–
INFIInfinity Pharmaceuticals, Inc.COM1,476,000$310.7K0.1%00.0%UnchangedHistory
Bio Green Med Solution, Inc.23254L603COM250,000$147.3K<0.1%00.0%Unchanged–
ARBEArbe Robotics Ltd.COM43,165$124.7K<0.1%00.0%UnchangedHistory

Options (11)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Sphera Funds Management Ltd. in Q2 2023
SecurityClassPutsCalls
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS–$61.3M
Invesco QQQ Trust Series I46090E103ETF$46.5M–
AMDAdvanced Micro Devices IncStock–$13.7M
TSEMTower Semiconductor LtdSHS NEW$12.5M–
SRPTSarepta Therapeutics, Inc.COM–$8.97M
GNRCGenerac Holdings Inc.Stock–$7.83M
MSFTMicrosoft CorpStock–$7.15M
ENPHEnphase Energy, Inc.Stock–$6.70M
ARGXArgenx SESPONSORED ADR$3.90M–
NICENICE Ltd.SPONSORED ADR–$3.10M
BBIOBridgeBio Pharma, Inc.COM–$2.24M

Sold out since Q1 2023 (17)

Positions held at the end of Q1 2023 that are gone from this filing.

Positions of Sphera Funds Management Ltd. sold out since Q1 2023
SecurityClassShares in Q1 2023Value in Q1 2023% of portfolio in Q1 2023History
NTRNutrien Ltd.COM145,466$10.7M2.3%History
Invesco QQQ Trust Series I46090E103ETF26,353$8.46M1.8%–
Bellus Health Inc New07987C204COM NEW799,860$5.76M1.2%–
PERIPerion Network Ltd.SHS NEW130,000$5.15M1.1%History
KNSAKiniksa Pharmaceuticals International, plcCOM CL A450,283$4.85M1.0%History
PCVXVaxcyte, Inc.COM90,000$3.37M0.7%History
MIRMMirum Pharmaceuticals, Inc.COM109,336$2.63M0.6%History
AMGNAmgen IncStock10,000$2.42M0.5%History
KDNYChinook Therapeutics, Inc.COM92,200$2.13M0.5%History
CRNXCrinetics Pharmaceuticals, Inc.COM82,747$1.33M0.3%History
KROSKeros Therapeutics, Inc.COM30,119$1.29M0.3%History
ANNXAnnexon, Inc.COM250,000$962.5K0.2%History
RETAReata Pharmaceuticals IncCL A7,689$699.1K0.2%History
Fiverr Intl Ltd33835LAA3NOTE 11/0250,000$208.2K<0.1%–
SYRESpyre Therapeutics, Inc.COM646,478$187.5K<0.1%History
OTMOOtonomo Technologies Ltd.ORDINARY SHARES391,863$186.4K<0.1%History
ONCROncorus, Inc.COM540,258$185.9K<0.1%History