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Livermore
Livermore
ZHEN

Sphera Funds Management Ltd.

SEC CIK
0001496201
Latest filing
Aug 14, 2026

Holdings in Q2 2022

Holdings as of Jun 30, 2022, filed Aug 15, 2022. Long positions only; changes compare share counts with Q1 2022.

Institution overview
Positions
50
−9 vs. Q1 2022
Portfolio value
$526.9M
−$69.7M (−11.7%) vs. Q1 2022
Filed
Aug 15, 2022
SEC
Holdings of Sphera Funds Management Ltd. in Q2 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
AZNAstraZeneca PLCSPONSORED ADR798,610$52.8M10.0%−38,207−4.6%ReducedHistory
JNJJohnson & JohnsonStock276,451$49.1M9.3%−18,572−6.3%ReducedHistory
LLYEli Lilly & CoStock132,250$42.9M8.1%+61,955+88.1%AddedHistory
SNYSanofiSPONSORED ADR846,215$42.3M8.0%−126,200−13.0%ReducedHistory
ABBVAbbVie Inc.Stock218,385$33.4M6.3%+27,391+14.3%AddedHistory
State Street SPDR S&P Biotech ETF78464A870ETF437,748$32.5M6.2%+437,748New–
NVONovo Nordisk A SADR261,440$29.1M5.5%+24,040+10.1%AddedHistory
MRKMerck & Co., Inc.Stock285,000$26.0M4.9%+6,800+2.4%AddedHistory
SNDXSyndax Pharmaceuticals IncCOM1,139,329$21.9M4.2%−138,084−10.8%ReducedHistory
ALTAltimmune, Inc.COM NEW1,392,884$16.3M3.1%+85,931+6.6%AddedHistory
SWTXSpringWorks Therapeutics, Inc.COM536,664$13.2M2.5%+76,639+16.7%AddedHistory
FIVNFive9, Inc.COM140,968$12.8M2.4%+111,269+374.7%AddedHistory
KDNYChinook Therapeutics, Inc.COM643,731$11.3M2.1%+150,054+30.4%AddedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM586,820$10.9M2.1%+64,873+12.4%AddedHistory
NICENICE Ltd.SPONSORED ADR55,482$10.7M2.0%+55,482NewHistory
MRUSMerus N.V.COM409,161$9.26M1.8%+200.0%AddedHistory
ISEEIVERIC bio, Inc.COM962,470$9.26M1.8%+188,340+24.3%AddedHistory
KURAKura Oncology, Inc.COM494,595$9.07M1.7%−123,649−20.0%ReducedHistory
RLMDRelmada Therapeutics, Inc.COM466,830$8.87M1.7%+175,578+60.3%AddedHistory
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS1,147,878$8.63M1.6%+315,000+37.8%AddedHistory
FOLDAmicus Therapeutics, Inc.COM753,037$8.09M1.5%+753,037NewHistory
METAMeta Platforms, Inc.Stock50,000$8.06M1.5%+50,000NewHistory
IMTXImmatics N.V.SHS730,712$6.37M1.2%+108,787+17.5%AddedHistory
INZYInozyme Pharma, Inc.COM1,165,600$5.56M1.1%+1,165,600NewHistory
CCCCC4 Therapeutics, Inc.COM STK705,736$5.32M1.0%+343,208+94.7%AddedHistory
Fiverr Intl Ltd33835LAA3NOTE 11/04,951,000$3.79M0.7%00.0%Unchanged–
RZLTRezolute, Inc.COM NEW1,155,897$3.73M0.7%+1,155,897NewHistory
VTGNVistagen Therapeutics, Inc.COM NEW3,291,135$2.90M0.5%−1,660,288−33.5%ReducedHistory
CNCEConcert Pharmaceuticals, Inc.COM679,400$2.86M0.5%+679,400NewHistory
RIGLRigel Pharmaceuticals IncCOM NEW2,525,000$2.85M0.5%+2,525,000NewHistory
PMVPPMV Pharmaceuticals, Inc.COM187,800$2.68M0.5%+187,800NewHistory
VVisa Inc.Stock12,600$2.48M0.5%−12,600−50.0%ReducedHistory
KZRKezar Life Sciences, Inc.COM299,654$2.48M0.5%+112,055+59.7%AddedHistory
ABNBAirbnb, Inc.Stock27,700$2.47M0.5%−2,300−7.7%ReducedHistory
HOWLWerewolf Therapeutics, Inc.COM597,003$2.44M0.5%+12,800+2.2%AddedHistory
Invesco QQQ Trust Series I46090E103ETF8,186$2.29M0.4%+8,186New–
KROSKeros Therapeutics, Inc.COM67,997$1.88M0.4%−71,584−51.3%ReducedHistory
NVDANVIDIA CorpStock11,288$1.71M0.3%+11,288NewHistory
ETNB89bio, Inc.COM450,000$1.45M0.3%+450,000NewHistory
Magic Software Enterprises L559166103ORD81,293$1.45M0.3%00.0%Unchanged–
AMDAdvanced Micro Devices IncStock15,773$1.21M0.2%−84,227−84.2%ReducedHistory
KNTEKinnate Biopharma Inc.COM91,673$1.16M0.2%+91,673NewHistory
ONCROncorus, Inc.COM540,258$681.0K0.1%00.0%UnchangedHistory
Nice Sys Inc65366HAB9NOTE 1.250% 1/1250,000$588.0K0.1%00.0%Unchanged–
Wix.com Ltd.92940WAD1NOTE 8/1700,000$566.0K0.1%+700,000New–
GNRCGenerac Holdings Inc.Stock2,310$486.0K0.1%−39,901−94.5%ReducedHistory
OTMOOtonomo Technologies Ltd.ORDINARY SHARES391,863$431.0K0.1%00.0%UnchangedHistory
ARBEArbe Robotics Ltd.COM43,165$237.0K<0.1%00.0%UnchangedHistory
Immatics N.V.N44445117*W EXP 07/01/202100,000$204.0K<0.1%00.0%Unchanged–
VINCVincerx Pharma, Inc.COM NEW70,467$93.0K<0.1%−649,694−90.2%ReducedHistory

Options (7)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Sphera Funds Management Ltd. in Q2 2022
SecurityClassPutsCalls
Invesco QQQ Trust Series I46090E103ETF–$278.3M
SPYSPDR S&P 500 ETF TrustETF–$75.3M
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS–$25.4M
State Street SPDR S&P Biotech ETF78464A870ETF–$14.9M
ALNYAlnylam Pharmaceuticals, Inc.COM–$10.9M
ISEEIVERIC bio, Inc.COM–$1.92M
VTGNVistagen Therapeutics, Inc.COM NEW–$1.32M

Sold out since Q1 2022 (23)

Positions held at the end of Q1 2022 that are gone from this filing.

Positions of Sphera Funds Management Ltd. sold out since Q1 2022
SecurityClassShares in Q1 2022Value in Q1 2022% of portfolio in Q1 2022History
PFEPfizer IncStock515,070$26.7M4.5%History
BMRNBiomarin Pharmaceutical IncCOM211,326$16.3M2.7%History
KYMRKymera Therapeutics, Inc.COM368,061$15.6M2.6%History
ZIMZIM Integrated Shipping Services Ltd.SHS148,000$10.8M1.8%History
PERIPerion Network Ltd.SHS NEW306,051$6.88M1.2%History
IMUXImmunic, Inc.COM583,206$6.59M1.1%History
RUNSunrun Inc.COM150,000$4.56M0.8%History
CSTECaesarstone Ltd.ORD SHS428,046$4.50M0.8%History
MAMastercard IncStock12,100$4.32M0.7%History
ALNYAlnylam Pharmaceuticals, Inc.COM24,768$4.04M0.7%History
NAUTNautilus Biotechnology, Inc.COM840,000$3.65M0.6%History
REPLReplimune Group, Inc.COM212,640$3.61M0.6%History
FATEFate Therapeutics IncCOM89,425$3.47M0.6%History
VRNAVerona Pharma plcSPONSORED ADS666,339$3.33M0.6%History
ASNDAscendis Pharma A/SSPONSORED ADR26,529$3.11M0.5%History
Ironsource LtdM5R75Y101CL A ORD SHS620,000$2.98M0.5%–
CATCaterpillar IncStock12,000$2.67M0.4%History
SSentinelOne, Inc.CL A65,000$2.52M0.4%History
KRYSKrystal Biotech, Inc.COM25,310$1.68M0.3%History
Bio Green Med Solution, Inc.23254L603COM508,322$1.55M0.3%–
LIANYLianBioSPONSORED ADS275,007$1.02M0.2%History
AYLAOld Ayala, IncCOM250,000$995.0K0.2%History
TEADTeads Holding Co.COM52,531$564.0K0.1%History