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Great Point Partners LLC

SEC CIK
0001281446
Latest filing
Aug 14, 2026

Holdings in Q4 2022

Holdings as of Dec 31, 2022, filed Feb 14, 2023. Long positions only; changes compare share counts with Q3 2022.

Institution overview
Positions
40
0 vs. Q3 2022
Portfolio value
$483.7M
+$68.4M (+16.5%) vs. Q3 2022
Filed
Feb 14, 2023
SEC
Holdings of Great Point Partners LLC in Q4 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
PCVXVaxcyte, Inc.COM800,000$38.4M7.9%+200,000+33.3%AddedHistory
XENEXenon Pharmaceuticals Inc.COM850,000$33.5M6.9%00.0%UnchangedHistory
RAPTRAPT Therapeutics, Inc.COM1,436,569$28.4M5.9%+1,121,569+356.1%AddedHistory
ALPNAlpine Immune Sciences, Inc.COM3,637,718$26.7M5.5%+189,197+5.5%AddedHistory
PLRXPliant Therapeutics, Inc.COM1,322,870$25.6M5.3%+281,133+27.0%AddedHistory
JAZZJazz Pharmaceuticals plcSHS USD160,000$25.5M5.3%−55,000−25.6%ReducedHistory
SGENSeagen Inc.COM160,500$20.6M4.3%+84,000+109.8%AddedHistory
PNTPOINT Biopharma Global Inc.COM2,541,779$18.5M3.8%−1,019,205−28.6%ReducedHistory
ISEEIVERIC bio, Inc.COM825,000$17.7M3.7%+825,000NewHistory
ACRSAclaris Therapeutics, Inc.COM1,019,282$16.1M3.3%00.0%UnchangedHistory
HRTXHeron Therapeutics, Inc.COM6,360,161$15.9M3.3%+715,000+12.7%AddedHistory
RAREUltragenyx Pharmaceutical Inc.COM342,300$15.9M3.3%+342,300NewHistory
OPTNOptiNose, Inc.COM7,894,736$14.6M3.0%+7,894,736NewHistory
VTYXVentyx Biosciences, Inc.COM400,695$13.1M2.7%+130,728+48.4%AddedHistory
CINCCinCor Pharma, Inc.COM1,019,153$12.5M2.6%+717,829+238.2%AddedHistory
VKTXViking Therapeutics, Inc.COM1,295,034$12.2M2.5%+1,295,034NewHistory
DAWNDay One Biopharmaceuticals, Inc.Stock544,451$11.7M2.4%+473,830+670.9%AddedHistory
PTCTPTC Therapeutics, Inc.COM302,135$11.5M2.4%+302,135NewHistory
JBIOJade Biosciences, Inc.COM378,522$11.1M2.3%+378,522NewHistory
TVTXTravere Therapeutics, Inc.COM475,000$9.99M2.1%−491,108−50.8%ReducedHistory
CBAYCymaBay Therapeutics, Inc.COM1,550,000$9.72M2.0%+750,561+93.9%AddedHistory
SRPTSarepta Therapeutics, Inc.COM73,000$9.46M2.0%+73,000NewHistory
KALVKalVista Pharmaceuticals, Inc.COM1,055,801$7.14M1.5%−495,918−32.0%ReducedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM190,000$7.02M1.5%+190,000NewHistory
MLTXMoonLake ImmunotherapeuticsCLASS A ORD642,566$6.75M1.4%+150,566+30.6%AddedHistory
ERASErasca, Inc.COM1,538,461$6.63M1.4%+1,538,461NewHistory
ICPTIntercept Pharmaceuticals, Inc.COM528,850$6.54M1.4%+423,850+403.7%AddedHistory
ABOSAcumen Pharmaceuticals, Inc.COM1,116,581$6.03M1.2%−83,419−7.0%ReducedHistory
MRTXMirati Therapeutics, Inc.COM133,000$6.03M1.2%+133,000NewHistory
VERVVerve Therapeutics, Inc.COM300,000$5.80M1.2%+300,000NewHistory
ALBOAlbireo Pharma, Inc.COM267,283$5.78M1.2%+267,283NewHistory
LRMRLarimar Therapeutics, Inc.COM1,273,635$5.26M1.1%+138,635+12.2%AddedHistory
URGNUroGen Pharma Ltd.COM560,000$4.97M1.0%−313,424−35.9%ReducedHistory
DTILPrecision Biosciences IncCOM3,801,305$4.52M0.9%+1,090,500+40.2%AddedHistory
Gracell Biotechnologies Inc38406L103SPONSORED ADS1,962,399$4.51M0.9%+1,513,350+337.0%Added–
GBIOGeneration Bio Co.COM1,022,537$4.02M0.8%+197,460+23.9%AddedHistory
EOLSEvolus, Inc.COM190,329$1.43M0.3%+190,329NewHistory
ALKSAlkermes plc.SHS46,185$1.21M0.2%−461,315−90.9%ReducedHistory
IMUXImmunic, Inc.COM632,184$885.1K0.2%+632,184NewHistory
ANABAnaptysbio, IncCOM15,000$464.9K0.1%+15,000NewHistory

Options (2)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Great Point Partners LLC in Q4 2022
SecurityClassPutsCalls
NVCRNovoCure LtdORD SHS$17.7M–
RCKTRocket Pharmaceuticals, Inc.COM–$8.83M

Sold out since Q3 2022 (15)

Positions held at the end of Q3 2022 that are gone from this filing.

Positions of Great Point Partners LLC sold out since Q3 2022
SecurityClassShares in Q3 2022Value in Q3 2022% of portfolio in Q3 2022History
RLMDRelmada Therapeutics, Inc.COM510,000$18.9M4.5%History
LKFTLakefront Biotherapeutics NVSPON ADR306,411$13.1M3.1%History
BBIOBridgeBio Pharma, Inc.COM1,050,000$10.4M2.5%History
TCDATricida, Inc.COM870,000$9.12M2.2%History
REPLReplimune Group, Inc.COM390,000$6.74M1.6%History
MDGLMadrigal Pharmaceuticals, Inc.COM95,500$6.21M1.5%History
MISTMilestone Pharmaceuticals Inc.COM674,656$6.20M1.5%History
ETNB89bio, Inc.COM955,000$5.53M1.3%History
NGMNGM Biopharmaceuticals IncCOM316,256$4.14M1.0%History
IMCRImmunocore Holdings plcADS78,527$3.69M0.9%History
Pieris Pharmaceuticals Inc720795103COM1,965,449$2.26M0.5%–
DNTHDianthus Therapeutics, Inc.COM1,019,091$1.44M0.3%History
NKTRNektar TherapeuticsCOM447,820$1.43M0.3%History
SYRESpyre Therapeutics, Inc.COM2,500,000$1.31M0.3%History
SLNSilence Therapeutics plcADS68,915$692.0K0.2%History