Baker Bros. Advisors LP
- SEC CIK
- 0001263508
- Latest filing
- Aug 14, 2026
Holdings in Q2 2022
Holdings as of Jun 30, 2022, filed Aug 15, 2022. Long positions only; changes compare share counts with Q1 2022.
- Positions
- 117
- −1 vs. Q1 2022
- Portfolio value
- $17.6B
- +$223.5M (+1.3%) vs. Q1 2022
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| SGENSeagen Inc. | COM | 46,912,266 | $8.30B | 47.1% | 00.0% | Unchanged | History |
| INCYIncyte Corp | COM | 36,154,117 | $2.75B | 15.6% | +4330.0% | Added | History |
| ONCBeOne Medicines Ltd. | ADR | 11,668,897 | $1.89B | 10.7% | 00.0% | Unchanged | History |
| BMRNBiomarin Pharmaceutical Inc | COM | 7,620,494 | $631.5M | 3.6% | 00.0% | Unchanged | History |
| ACADAcadia Pharmaceuticals Inc | COM | 41,923,486 | $590.7M | 3.4% | +12,7820.0% | Added | History |
| ASNDAscendis Pharma A/S | SPONSORED ADR | 4,852,655 | $451.1M | 2.6% | +311,051+6.8% | Added | History |
| ARGXArgenx SE | SPONSORED ADR | 1,119,557 | $424.2M | 2.4% | 00.0% | Unchanged | History |
| BCRXBiocryst Pharmaceuticals Inc | COM | 12,710,818 | $134.5M | 0.8% | 00.0% | Unchanged | History |
| KODKodiak Sciences Inc. | COM | 17,310,490 | $132.3M | 0.8% | +1,379,445+8.7% | Added | History |
| GBTGlobal Blood Therapeutics, Inc. | COM | 3,732,502 | $119.3M | 0.7% | +417,737+12.6% | Added | History |
| ABCLAbCellera Biologics Inc. | COM | 10,450,180 | $111.3M | 0.6% | 00.0% | Unchanged | History |
| MDGLMadrigal Pharmaceuticals, Inc. | COM | 1,499,213 | $107.3M | 0.6% | 00.0% | Unchanged | History |
| MRTXMirati Therapeutics, Inc. | COM | 1,409,784 | $94.6M | 0.5% | 00.0% | Unchanged | History |
| IMCRImmunocore Holdings plc | ADS | 2,520,730 | $94.0M | 0.5% | 00.0% | Unchanged | History |
| HZNPHorizon Therapeutics Public Ltd Co | SHS | 1,148,504 | $91.6M | 0.5% | +249,662+27.8% | Added | History |
| CERSCerus Corp | COM | 16,067,558 | $85.0M | 0.5% | +2,354,363+17.2% | Added | History |
| TVTXTravere Therapeutics, Inc. | COM | 3,300,009 | $80.0M | 0.5% | 00.0% | Unchanged | History |
| REPLReplimune Group, Inc. | COM | 3,591,081 | $62.8M | 0.4% | +1,979,378+122.8% | Added | History |
| TRDAEntrada Therapeutics, Inc. | COM | 4,865,819 | $59.3M | 0.3% | +161,400+3.4% | Added | History |
| IGMSIGM Biosciences, Inc. | COM | 3,156,102 | $56.9M | 0.3% | 00.0% | Unchanged | History |
| KYMRKymera Therapeutics, Inc. | COM | 2,879,825 | $56.7M | 0.3% | +495,083+20.8% | Added | History |
| KRYSKrystal Biotech, Inc. | COM | 807,735 | $53.0M | 0.3% | 00.0% | Unchanged | History |
| PRLDPrelude Therapeutics Inc | COM | 10,123,824 | $52.8M | 0.3% | 00.0% | Unchanged | History |
| NRIXNurix Therapeutics, Inc. | COM | 3,882,125 | $49.2M | 0.3% | +1,428,043+58.2% | Added | History |
| LEGNLegend Biotech Corp | SPONSORED ADS | 856,658 | $47.1M | 0.3% | −1,152,341−57.4% | Reduced | History |
| ALKSAlkermes plc. | SHS | 1,500,000 | $44.7M | 0.3% | 00.0% | Unchanged | History |
| ChemoCentryx, Inc.16383L106 | COM | 1,792,657 | $44.4M | 0.3% | +875,795+95.5% | Added | – |
| KDNYChinook Therapeutics, Inc. | COM | 2,534,102 | $44.3M | 0.3% | +200,000+8.6% | Added | History |
| INSMINSMED Inc | COM PAR $.01 | 2,156,001 | $42.5M | 0.2% | 00.0% | Unchanged | History |
| IMTXImmatics N.V. | SHS | 4,423,731 | $38.5M | 0.2% | 00.0% | Unchanged | History |
| DBVTDBV Technologies S.A. | SPONSORED ADR | 14,614,264 | $37.3M | 0.2% | 00.0% | Unchanged | History |
| Sarepta Therapeutics, Inc.803607AB6 | DBCV 1.500%11/1 | – | $36.6M | 0.2% | – | – | – |
| INSMED Inc457669AB5 | NOTE 0.750% 6/0 | – | $33.3M | 0.2% | – | – | – |
| JBIOJade Biosciences, Inc. | COM | 2,070,010 | $32.4M | 0.2% | 00.0% | Unchanged | History |
| AMRNAmarin Corp PLC | SPONS ADR NEW | 21,169,805 | $31.5M | 0.2% | 00.0% | Unchanged | History |
| VSTMVerastem, Inc. | COM | 26,988,898 | $31.3M | 0.2% | 00.0% | Unchanged | History |
| RAREUltragenyx Pharmaceutical Inc. | COM | 470,974 | $28.1M | 0.2% | +26,530+6.0% | Added | History |
| TSVT2seventy bio, Inc. | COMMON STOCK | 2,062,744 | $27.2M | 0.2% | 00.0% | Unchanged | History |
| KNSAKiniksa Pharmaceuticals International, plc | COM CL A | 2,799,577 | $27.1M | 0.2% | 00.0% | Unchanged | History |
| BMEABiomea Fusion, Inc. | COM | 2,104,559 | $25.2M | 0.1% | +553,114+35.7% | Added | History |
| ALTAltimmune, Inc. | COM NEW | 2,075,403 | $24.3M | 0.1% | +1,003,365+93.6% | Added | History |
| NVTAInvitae Corp | COM | 9,873,488 | $24.1M | 0.1% | 00.0% | Unchanged | History |
| PACBPacific Biosciences of California, Inc. | COM | 5,444,963 | $24.1M | 0.1% | 00.0% | Unchanged | History |
| XENEXenon Pharmaceuticals Inc. | COM | 751,639 | $22.9M | 0.1% | 00.0% | Unchanged | History |
| HRTXHeron Therapeutics, Inc. | COM | 8,131,678 | $22.7M | 0.1% | 00.0% | Unchanged | History |
| MRUSMerus N.V. | COM | 995,397 | $22.5M | 0.1% | −1,042,072−51.1% | Reduced | History |
| VERVVerve Therapeutics, Inc. | COM | 1,416,530 | $21.6M | 0.1% | 00.0% | Unchanged | History |
| DSGNDesign Therapeutics, Inc. | COM | 1,436,636 | $20.1M | 0.1% | 00.0% | Unchanged | History |
| Affimed N VN01045108 | COM | 6,596,830 | $18.3M | 0.1% | +1,443,661+28.0% | Added | – |
| TILInstil Bio, Inc. | COM | 3,893,700 | $18.0M | 0.1% | 00.0% | Unchanged | History |
| OTICOtonomy, Inc. | COM | 8,412,634 | $17.5M | 0.1% | +567,942+7.2% | Added | History |
| DNLIDenali Therapeutics Inc. | COM | 588,738 | $17.3M | 0.1% | +500,000+563.5% | Added | History |
| RYTMRhythm Pharmaceuticals, Inc. | COM | 4,125,062 | $17.1M | 0.1% | 00.0% | Unchanged | History |
| CYVNYOpthea Ltd | SPONSORED ADS | 2,696,191 | $17.0M | 0.1% | 00.0% | Unchanged | History |
| ADAPYAdaptimmune Therapeutics PLC | SPONDS ADR | 9,830,877 | $16.7M | 0.1% | 00.0% | Unchanged | History |
| CRNXCrinetics Pharmaceuticals, Inc. | COM | 827,480 | $15.4M | 0.1% | 00.0% | Unchanged | History |
| TCDATricida, Inc. | COM | 1,503,090 | $14.6M | 0.1% | −228,624−13.2% | Reduced | History |
| FMTXForma Therapeutics Holdings, Inc. | SHS | 2,024,876 | $14.0M | 0.1% | 00.0% | Unchanged | History |
| FLGTFulgent Genetics, Inc. | COM | 201,444 | $11.0M | 0.1% | 00.0% | Unchanged | History |
| BLUEbluebird bio, Inc. | COM | 2,499,715 | $10.3M | 0.1% | 00.0% | Unchanged | History |
| RLMDRelmada Therapeutics, Inc. | COM | 495,113 | $9.40M | 0.1% | 00.0% | Unchanged | History |
| DICEDICE Therapeutics, Inc. | COM | 588,235 | $9.13M | 0.1% | 00.0% | Unchanged | History |
| ZYMEZymeworks Inc. | COM | 1,708,472 | $9.05M | 0.1% | 00.0% | Unchanged | History |
| KRTXKaruna Therapeutics, Inc. | COM | 69,966 | $8.85M | 0.1% | 00.0% | Unchanged | History |
| TCRXTScan Therapeutics, Inc. | COM | 2,784,792 | $8.76M | <0.1% | +1,359,792+95.4% | Added | History |
| ANABAnaptysbio, Inc | COM | 427,179 | $8.67M | <0.1% | 00.0% | Unchanged | History |
| KYNBKyntra Bio, Inc. | COM | 815,718 | $8.61M | <0.1% | +233,968+40.2% | Added | History |
| Invitae Corp46185LAB9 | NOTE 2.000% 9/0 | – | $8.09M | <0.1% | – | – | – |
| CYTCyteir Therapeutics, Inc. | COM | 2,643,640 | $7.90M | <0.1% | +1,831,000+225.3% | Added | History |
| SRZNSurrozen, Inc. | COM | 2,500,000 | $7.50M | <0.1% | 00.0% | Unchanged | History |
| RETAReata Pharmaceuticals Inc | CL A | 223,976 | $6.81M | <0.1% | 00.0% | Unchanged | History |
| Achilles Therapeutics PLC00449L102 | SPONSORED ADS | 2,591,366 | $6.53M | <0.1% | 00.0% | Unchanged | – |
| CBAYCymaBay Therapeutics, Inc. | COM | 2,170,464 | $6.40M | <0.1% | 00.0% | Unchanged | History |
| BCELAtreca, Inc. | CL A COM | 3,532,760 | $6.32M | <0.1% | 00.0% | Unchanged | History |
| TLISTalis Biomedical Corp | COM | 7,624,835 | $6.19M | <0.1% | 00.0% | Unchanged | History |
| HRMYHarmony Biosciences Holdings, Inc. | COM | 123,600 | $6.03M | <0.1% | 00.0% | Unchanged | History |
| ATRAAtara Biotherapeutics, Inc. | COM | 744,186 | $5.80M | <0.1% | +744,186 | New | History |
| VORVor Biopharma Inc. | COM | 1,138,768 | $5.66M | <0.1% | +1,138,768 | New | History |
| CNTACentessa Pharmaceuticals plc | SPONSORED ADS | 1,127,273 | $5.49M | <0.1% | 00.0% | Unchanged | History |
| NKTXNkarta, Inc. | COM | 400,000 | $4.93M | <0.1% | +400,000 | New | History |
| VERAVera Therapeutics, Inc. | CL A | 333,333 | $4.54M | <0.1% | 00.0% | Unchanged | History |
| RVMDRevolution Medicines, Inc. | COM | 222,222 | $4.33M | <0.1% | 00.0% | Unchanged | History |
| EWTXEdgewise Therapeutics, Inc. | COM | 500,000 | $3.98M | <0.1% | 00.0% | Unchanged | History |
| NGNENeurogene Inc. | COM | 3,821,740 | $3.94M | <0.1% | 00.0% | Unchanged | History |
| HOOKHOOKIPA Pharma Inc. | COM | 2,400,481 | $3.91M | <0.1% | 00.0% | Unchanged | History |
| NTRANatera, Inc. | COM | 100,000 | $3.54M | <0.1% | +100,000 | New | History |
| TNGXTango Therapeutics, Inc. | COM | 750,000 | $3.40M | <0.1% | 00.0% | Unchanged | History |
| LONALeonaBio, Inc. | COM | 1,040,834 | $3.17M | <0.1% | +234,467+29.1% | Added | History |
| ITOSiTeos Therapeutics, Inc. | COM | 150,346 | $3.10M | <0.1% | 00.0% | Unchanged | History |
| EVFMEvofem Biosciences, Inc. | COM NEW | 2,583,616 | $2.92M | <0.1% | +2,583,616 | New | History |
| MGNXMacrogenics Inc | COM | 892,579 | $2.63M | <0.1% | +450,000+101.7% | Added | History |
| ALGSAligos Therapeutics, Inc. | COM | 2,076,400 | $2.51M | <0.1% | 00.0% | Unchanged | History |
| ALECAlector, Inc. | COM | 239,228 | $2.43M | <0.1% | 00.0% | Unchanged | History |
| BCABBioAtla, Inc. | COM | 825,000 | $2.35M | <0.1% | 00.0% | Unchanged | History |
| ALLKAllakos Inc. | COM | 703,050 | $2.20M | <0.1% | 00.0% | Unchanged | History |
| TCRRTCR2 Therapeutics Inc. | COM | 753,064 | $2.18M | <0.1% | 00.0% | Unchanged | History |
| SNDXSyndax Pharmaceuticals Inc | COM | 110,729 | $2.13M | <0.1% | 00.0% | Unchanged | History |
| SYRESpyre Therapeutics, Inc. | COM | 3,410,106 | $1.72M | <0.1% | 00.0% | Unchanged | History |
| EPZMEpizyme, Inc. | COM | 1,000,000 | $1.47M | <0.1% | 00.0% | Unchanged | History |
| AKROAkero Therapeutics, Inc. | COM | 118,378 | $1.12M | <0.1% | 00.0% | Unchanged | History |
Sold out since Q1 2022 (6)
Positions held at the end of Q1 2022 that are gone from this filing.
| Security | Class | Shares in Q1 2022 | Value in Q1 2022 | % of portfolio in Q1 2022 | History |
|---|---|---|---|---|---|
| NBIXNeurocrine Biosciences Inc | Stock | 676,975 | $63.5M | 0.4% | History |
| AXSMAxsome Therapeutics, Inc. | COM | 610,970 | $25.3M | 0.1% | History |
| SRPTSarepta Therapeutics, Inc. | COM | 123,456 | $9.64M | 0.1% | History |
| KURAKura Oncology, Inc. | COM | 274,458 | $4.41M | <0.1% | History |
| NVAXNovavax Inc | COM NEW | 48,168 | $3.55M | <0.1% | History |
| OYSTOyster Point Pharma, Inc. | COM | 61,424 | $715.0K | <0.1% | History |