Baker Bros. Advisors LP
- SEC CIK
- 0001263508
- Latest filing
- Aug 14, 2026
Holdings in Q1 2022
Holdings as of Mar 31, 2022, filed May 16, 2022. Long positions only; changes compare share counts with Q4 2021.
- Positions
- 118
- −3 vs. Q4 2021
- Portfolio value
- $17.4B
- −$3.15B (−15.3%) vs. Q4 2021
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| SGENSeagen Inc. | COM | 46,912,266 | $6.76B | 38.8% | +18,9020.0% | Added | History |
| INCYIncyte Corp | COM | 36,153,684 | $2.87B | 16.5% | +2,535,621+7.5% | Added | History |
| ONCBeOne Medicines Ltd. | ADR | 11,668,897 | $2.20B | 12.6% | 00.0% | Unchanged | History |
| ACADAcadia Pharmaceuticals Inc | COM | 41,910,704 | $1.02B | 5.8% | 00.0% | Unchanged | History |
| BMRNBiomarin Pharmaceutical Inc | COM | 7,620,494 | $587.5M | 3.4% | 00.0% | Unchanged | History |
| ASNDAscendis Pharma A/S | SPONSORED ADR | 4,541,604 | $533.0M | 3.1% | 00.0% | Unchanged | History |
| ARGXArgenx SE | SPONSORED ADR | 1,119,557 | $353.0M | 2.0% | 00.0% | Unchanged | History |
| BCRXBiocryst Pharmaceuticals Inc | COM | 12,710,818 | $206.7M | 1.2% | 00.0% | Unchanged | History |
| MDGLMadrigal Pharmaceuticals, Inc. | COM | 1,499,213 | $147.1M | 0.8% | 00.0% | Unchanged | History |
| KODKodiak Sciences Inc. | COM | 15,931,045 | $123.0M | 0.7% | +1,249,741+8.5% | Added | History |
| MRTXMirati Therapeutics, Inc. | COM | 1,409,784 | $115.9M | 0.7% | 00.0% | Unchanged | History |
| GBTGlobal Blood Therapeutics, Inc. | COM | 3,314,765 | $114.8M | 0.7% | 00.0% | Unchanged | History |
| ABCLAbCellera Biologics Inc. | COM | 10,450,180 | $101.9M | 0.6% | 00.0% | Unchanged | History |
| KYMRKymera Therapeutics, Inc. | COM | 2,384,742 | $100.9M | 0.6% | 00.0% | Unchanged | History |
| HZNPHorizon Therapeutics Public Ltd Co | SHS | 898,842 | $94.6M | 0.5% | +299,732+50.0% | Added | History |
| TVTXTravere Therapeutics, Inc. | COM | 3,300,009 | $85.0M | 0.5% | +630,955+23.6% | Added | History |
| IGMSIGM Biosciences, Inc. | COM | 3,156,102 | $84.4M | 0.5% | 00.0% | Unchanged | History |
| NVTAInvitae Corp | COM | 9,873,488 | $78.7M | 0.5% | 00.0% | Unchanged | History |
| IMCRImmunocore Holdings plc | ADS | 2,520,730 | $75.4M | 0.4% | 00.0% | Unchanged | History |
| CERSCerus Corp | COM | 13,713,195 | $75.3M | 0.4% | 00.0% | Unchanged | History |
| LEGNLegend Biotech Corp | SPONSORED ADS | 2,008,999 | $73.0M | 0.4% | −480,004−19.3% | Reduced | History |
| PRLDPrelude Therapeutics Inc | COM | 10,123,824 | $69.9M | 0.4% | 00.0% | Unchanged | History |
| AMRNAmarin Corp PLC | SPONS ADR NEW | 21,169,805 | $69.6M | 0.4% | 00.0% | Unchanged | History |
| NBIXNeurocrine Biosciences Inc | Stock | 676,975 | $63.5M | 0.4% | 00.0% | Unchanged | History |
| MRUSMerus N.V. | COM | 2,037,469 | $53.9M | 0.3% | 00.0% | Unchanged | History |
| KRYSKrystal Biotech, Inc. | COM | 807,735 | $53.7M | 0.3% | 00.0% | Unchanged | History |
| INSMINSMED Inc | COM PAR $.01 | 2,156,001 | $50.7M | 0.3% | 00.0% | Unchanged | History |
| PACBPacific Biosciences of California, Inc. | COM | 5,444,963 | $49.5M | 0.3% | 00.0% | Unchanged | History |
| RYTMRhythm Pharmaceuticals, Inc. | COM | 4,125,062 | $47.5M | 0.3% | +261,823+6.8% | Added | History |
| HRTXHeron Therapeutics, Inc. | COM | 8,131,678 | $46.5M | 0.3% | 00.0% | Unchanged | History |
| TRDAEntrada Therapeutics, Inc. | COM | 4,704,419 | $44.2M | 0.3% | 00.0% | Unchanged | History |
| TILInstil Bio, Inc. | COM | 3,893,700 | $41.9M | 0.2% | 00.0% | Unchanged | History |
| ALKSAlkermes plc. | SHS | 1,500,000 | $39.5M | 0.2% | 00.0% | Unchanged | History |
| INSMED Inc457669AB5 | NOTE 0.750% 6/0 | – | $38.6M | 0.2% | – | – | – |
| Sarepta Therapeutics, Inc.803607AB6 | DBCV 1.500%11/1 | – | $38.4M | 0.2% | – | – | – |
| KDNYChinook Therapeutics, Inc. | COM | 2,334,102 | $38.2M | 0.2% | 00.0% | Unchanged | History |
| VSTMVerastem, Inc. | COM | 26,988,898 | $38.1M | 0.2% | +5,497,268+25.6% | Added | History |
| JBIOJade Biosciences, Inc. | COM | 2,070,010 | $37.9M | 0.2% | +238,221+13.0% | Added | History |
| IMTXImmatics N.V. | SHS | 4,423,731 | $35.3M | 0.2% | 00.0% | Unchanged | History |
| TSVT2seventy bio, Inc. | COMMON STOCK | 2,062,744 | $35.2M | 0.2% | +1,229,508+147.6% | Added | History |
| NRIXNurix Therapeutics, Inc. | COM | 2,454,082 | $34.4M | 0.2% | 00.0% | Unchanged | History |
| VERVVerve Therapeutics, Inc. | COM | 1,416,530 | $32.3M | 0.2% | 00.0% | Unchanged | History |
| RAREUltragenyx Pharmaceutical Inc. | COM | 444,444 | $32.3M | 0.2% | 00.0% | Unchanged | History |
| KNSAKiniksa Pharmaceuticals International, plc | COM CL A | 2,799,577 | $27.8M | 0.2% | 00.0% | Unchanged | History |
| REPLReplimune Group, Inc. | COM | 1,611,703 | $27.4M | 0.2% | +1,018,308+171.6% | Added | History |
| AXSMAxsome Therapeutics, Inc. | COM | 610,970 | $25.3M | 0.1% | 00.0% | Unchanged | History |
| DBVTDBV Technologies S.A. | SPONSORED ADR | 14,614,264 | $23.2M | 0.1% | 00.0% | Unchanged | History |
| DSGNDesign Therapeutics, Inc. | COM | 1,436,636 | $23.2M | 0.1% | 00.0% | Unchanged | History |
| ChemoCentryx, Inc.16383L106 | COM | 916,862 | $23.0M | 0.1% | −714,404−43.8% | Reduced | – |
| XENEXenon Pharmaceuticals Inc. | COM | 751,639 | $23.0M | 0.1% | 00.0% | Unchanged | History |
| Affimed N VN01045108 | COM | 5,153,169 | $22.5M | 0.1% | +2,500,000+94.2% | Added | – |
| ADAPYAdaptimmune Therapeutics PLC | SPONDS ADR | 9,830,877 | $20.3M | 0.1% | 00.0% | Unchanged | History |
| FMTXForma Therapeutics Holdings, Inc. | SHS | 2,024,876 | $18.8M | 0.1% | 00.0% | Unchanged | History |
| OTICOtonomy, Inc. | COM | 7,844,692 | $18.8M | 0.1% | 00.0% | Unchanged | History |
| CYVNYOpthea Ltd | SPONSORED ADS | 2,696,191 | $18.5M | 0.1% | −500,000−15.6% | Reduced | History |
| CRNXCrinetics Pharmaceuticals, Inc. | COM | 827,480 | $18.2M | 0.1% | 00.0% | Unchanged | History |
| TCDATricida, Inc. | COM | 1,731,714 | $14.2M | 0.1% | +446,700+34.8% | Added | History |
| RLMDRelmada Therapeutics, Inc. | COM | 495,113 | $13.4M | 0.1% | 00.0% | Unchanged | History |
| FLGTFulgent Genetics, Inc. | COM | 201,444 | $12.6M | 0.1% | 00.0% | Unchanged | History |
| BLUEbluebird bio, Inc. | COM | 2,499,715 | $12.1M | 0.1% | 00.0% | Unchanged | History |
| DICEDICE Therapeutics, Inc. | COM | 588,235 | $11.3M | 0.1% | 00.0% | Unchanged | History |
| BCELAtreca, Inc. | CL A COM | 3,532,760 | $11.2M | 0.1% | 00.0% | Unchanged | History |
| ZYMEZymeworks Inc. | COM | 1,708,472 | $11.2M | 0.1% | 00.0% | Unchanged | History |
| LONALeonaBio, Inc. | COM | 806,367 | $10.9M | 0.1% | 00.0% | Unchanged | History |
| TLISTalis Biomedical Corp | COM | 7,624,835 | $10.8M | 0.1% | 00.0% | Unchanged | History |
| ANABAnaptysbio, Inc | COM | 427,179 | $10.6M | 0.1% | 00.0% | Unchanged | History |
| CNTACentessa Pharmaceuticals plc | SPONSORED ADS | 1,127,273 | $10.1M | 0.1% | 00.0% | Unchanged | History |
| SRPTSarepta Therapeutics, Inc. | COM | 123,456 | $9.64M | 0.1% | 00.0% | Unchanged | History |
| KRTXKaruna Therapeutics, Inc. | COM | 69,966 | $8.87M | 0.1% | 00.0% | Unchanged | History |
| Invitae Corp46185LAB9 | NOTE 2.000% 9/0 | – | $8.38M | <0.1% | – | – | – |
| SYRESpyre Therapeutics, Inc. | COM | 3,410,106 | $7.84M | <0.1% | 00.0% | Unchanged | History |
| VERAVera Therapeutics, Inc. | CL A | 333,333 | $7.83M | <0.1% | +333,333 | New | History |
| Achilles Therapeutics PLC00449L102 | SPONSORED ADS | 2,591,366 | $7.62M | <0.1% | 00.0% | Unchanged | – |
| SRZNSurrozen, Inc. | COM | 2,500,000 | $7.53M | <0.1% | 00.0% | Unchanged | History |
| RETAReata Pharmaceuticals Inc | CL A | 223,976 | $7.34M | <0.1% | 00.0% | Unchanged | History |
| NGNENeurogene Inc. | COM | 3,821,740 | $7.18M | <0.1% | 00.0% | Unchanged | History |
| KYNBKyntra Bio, Inc. | COM | 581,750 | $6.99M | <0.1% | +1,600+0.3% | Added | History |
| BMEABiomea Fusion, Inc. | COM | 1,551,445 | $6.92M | <0.1% | +1,026,828+195.7% | Added | History |
| CBAYCymaBay Therapeutics, Inc. | COM | 2,170,464 | $6.75M | <0.1% | 00.0% | Unchanged | History |
| ALTAltimmune, Inc. | COM NEW | 1,072,038 | $6.53M | <0.1% | 00.0% | Unchanged | History |
| HRMYHarmony Biosciences Holdings, Inc. | COM | 123,600 | $6.01M | <0.1% | 00.0% | Unchanged | History |
| TNGXTango Therapeutics, Inc. | COM | 750,000 | $5.68M | <0.1% | 00.0% | Unchanged | History |
| RVMDRevolution Medicines, Inc. | COM | 222,222 | $5.67M | <0.1% | 00.0% | Unchanged | History |
| HOOKHOOKIPA Pharma Inc. | COM | 2,400,481 | $5.47M | <0.1% | +1,700,000+242.7% | Added | History |
| EWTXEdgewise Therapeutics, Inc. | COM | 500,000 | $4.85M | <0.1% | 00.0% | Unchanged | History |
| ITOSiTeos Therapeutics, Inc. | COM | 150,346 | $4.84M | <0.1% | 00.0% | Unchanged | History |
| ALGSAligos Therapeutics, Inc. | COM | 2,076,400 | $4.46M | <0.1% | 00.0% | Unchanged | History |
| NGMNGM Biopharmaceuticals Inc | COM | 291,801 | $4.45M | <0.1% | 00.0% | Unchanged | History |
| KURAKura Oncology, Inc. | COM | 274,458 | $4.41M | <0.1% | −29,700−9.8% | Reduced | History |
| BCABBioAtla, Inc. | COM | 825,000 | $4.13M | <0.1% | 00.0% | Unchanged | History |
| ALLKAllakos Inc. | COM | 703,050 | $4.01M | <0.1% | 00.0% | Unchanged | History |
| TCRXTScan Therapeutics, Inc. | COM | 1,425,000 | $3.99M | <0.1% | 00.0% | Unchanged | History |
| MGNXMacrogenics Inc | COM | 442,579 | $3.90M | <0.1% | 00.0% | Unchanged | History |
| NVAXNovavax Inc | COM NEW | 48,168 | $3.55M | <0.1% | 00.0% | Unchanged | History |
| ALECAlector, Inc. | COM | 239,228 | $3.41M | <0.1% | 00.0% | Unchanged | History |
| ATYRaTYR PHARMA INC | COM NEW | 625,000 | $3.34M | <0.1% | 00.0% | Unchanged | History |
| CYTCyteir Therapeutics, Inc. | COM | 812,640 | $3.06M | <0.1% | 00.0% | Unchanged | History |
| DNLIDenali Therapeutics Inc. | COM | 88,738 | $2.85M | <0.1% | 00.0% | Unchanged | History |
| KZRKezar Life Sciences, Inc. | COM | 139,676 | $2.32M | <0.1% | 00.0% | Unchanged | History |
| TCRRTCR2 Therapeutics Inc. | COM | 753,064 | $2.08M | <0.1% | 00.0% | Unchanged | History |
Sold out since Q4 2021 (5)
Positions held at the end of Q4 2021 that are gone from this filing.
| Security | Class | Shares in Q4 2021 | Value in Q4 2021 | % of portfolio in Q4 2021 | History |
|---|---|---|---|---|---|
| Apellis Pharmaceuticals, Inc.03753UAB2 | NOTE 3.500% 9/1 | – | $48.0M | 0.2% | – |
| Tricida, Inc.89610FAB7 | NOTE 3.500% 5/1 | – | $14.8M | 0.1% | – |
| ALBOAlbireo Pharma, Inc. | COM | 104,521 | $2.43M | <0.1% | History |
| GMDAGamida Cell Ltd. | SHS | 610,626 | $1.55M | <0.1% | History |
| EVFMEvofem Biosciences, Inc. | COM | 2,697,110 | $1.01M | <0.1% | History |