Baker Bros. Advisors LP
- SEC CIK
- 0001263508
- Latest filing
- Aug 14, 2026
Holdings in Q3 2022
Holdings as of Sep 30, 2022, filed Nov 14, 2022. Long positions only; changes compare share counts with Q2 2022.
- Positions
- 115
- −2 vs. Q2 2022
- Portfolio value
- $15.3B
- −$2.36B (−13.4%) vs. Q2 2022
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| SGENSeagen Inc. | COM | 46,912,266 | $6.42B | 42.0% | 00.0% | Unchanged | History |
| INCYIncyte Corp | COM | 36,154,574 | $2.41B | 15.8% | +4570.0% | Added | History |
| ONCBeOne Medicines Ltd. | ADR | 11,668,897 | $1.57B | 10.3% | 00.0% | Unchanged | History |
| ACADAcadia Pharmaceuticals Inc | COM | 41,923,486 | $685.9M | 4.5% | 00.0% | Unchanged | History |
| BMRNBiomarin Pharmaceutical Inc | COM | 7,620,494 | $646.0M | 4.2% | 00.0% | Unchanged | History |
| ASNDAscendis Pharma A/S | SPONSORED ADR | 4,852,655 | $501.1M | 3.3% | 00.0% | Unchanged | History |
| GBTGlobal Blood Therapeutics, Inc. | COM | 3,732,502 | $254.2M | 1.7% | 00.0% | Unchanged | History |
| BCRXBiocryst Pharmaceuticals Inc | COM | 12,710,818 | $160.2M | 1.0% | 00.0% | Unchanged | History |
| RYTMRhythm Pharmaceuticals, Inc. | COM | 6,062,702 | $148.5M | 1.0% | +1,937,640+47.0% | Added | History |
| KODKodiak Sciences Inc. | COM | 17,310,490 | $134.0M | 0.9% | 00.0% | Unchanged | History |
| IMCRImmunocore Holdings plc | ADS | 2,520,731 | $118.3M | 0.8% | +10.0% | Added | History |
| ABCLAbCellera Biologics Inc. | COM | 10,450,180 | $103.4M | 0.7% | 00.0% | Unchanged | History |
| ARGXArgenx SE | SPONSORED ADR | 280,159 | $98.9M | 0.6% | −839,398−75.0% | Reduced | History |
| MRTXMirati Therapeutics, Inc. | COM | 1,409,784 | $98.5M | 0.6% | 00.0% | Unchanged | History |
| MDGLMadrigal Pharmaceuticals, Inc. | COM | 1,499,213 | $97.4M | 0.6% | 00.0% | Unchanged | History |
| ChemoCentryx, Inc.16383L106 | COM | 1,792,657 | $92.6M | 0.6% | 00.0% | Unchanged | – |
| TVTXTravere Therapeutics, Inc. | COM | 3,300,009 | $81.3M | 0.5% | 00.0% | Unchanged | History |
| AKROAkero Therapeutics, Inc. | COM | 2,368,378 | $80.6M | 0.5% | +2,250,000+1,900.7% | Added | History |
| TRDAEntrada Therapeutics, Inc. | COM | 4,865,819 | $76.7M | 0.5% | 00.0% | Unchanged | History |
| IGMSIGM Biosciences, Inc. | COM | 3,156,102 | $71.8M | 0.5% | 00.0% | Unchanged | History |
| REPLReplimune Group, Inc. | COM | 3,893,843 | $67.2M | 0.4% | +302,762+8.4% | Added | History |
| PRLDPrelude Therapeutics Inc | COM | 10,123,824 | $66.9M | 0.4% | 00.0% | Unchanged | History |
| KYMRKymera Therapeutics, Inc. | COM | 2,879,825 | $62.7M | 0.4% | 00.0% | Unchanged | History |
| HZNPHorizon Therapeutics Public Ltd Co | SHS | 969,727 | $60.0M | 0.4% | −178,777−15.6% | Reduced | History |
| CERSCerus Corp | COM | 16,067,558 | $57.8M | 0.4% | 00.0% | Unchanged | History |
| NRIXNurix Therapeutics, Inc. | COM | 3,882,125 | $50.6M | 0.3% | 00.0% | Unchanged | History |
| KDNYChinook Therapeutics, Inc. | COM | 2,534,102 | $49.8M | 0.3% | 00.0% | Unchanged | History |
| VERVVerve Therapeutics, Inc. | COM | 1,416,530 | $48.7M | 0.3% | 00.0% | Unchanged | History |
| IMTXImmatics N.V. | SHS | 4,423,731 | $44.2M | 0.3% | 00.0% | Unchanged | History |
| FMTXForma Therapeutics Holdings, Inc. | SHS | 1,886,760 | $37.6M | 0.2% | −138,116−6.8% | Reduced | History |
| INSMED Inc457669AB5 | NOTE 0.750% 6/0 | – | $36.3M | 0.2% | – | – | – |
| KNSAKiniksa Pharmaceuticals International, plc | COM CL A | 2,799,577 | $35.9M | 0.2% | 00.0% | Unchanged | History |
| HRTXHeron Therapeutics, Inc. | COM | 8,131,678 | $34.3M | 0.2% | 00.0% | Unchanged | History |
| JBIOJade Biosciences, Inc. | COM | 1,979,568 | $32.8M | 0.2% | −90,442−4.4% | Reduced | History |
| TSVT2seventy bio, Inc. | COMMON STOCK | 2,062,744 | $30.0M | 0.2% | 00.0% | Unchanged | History |
| KRYSKrystal Biotech, Inc. | COM | 422,185 | $29.4M | 0.2% | −385,550−47.7% | Reduced | History |
| XENEXenon Pharmaceuticals Inc. | COM | 751,639 | $27.1M | 0.2% | 00.0% | Unchanged | History |
| CINCCinCor Pharma, Inc. | COM | 807,212 | $26.5M | 0.2% | +807,212 | New | History |
| DBVTDBV Technologies S.A. | SPONSORED ADR | 14,614,264 | $25.9M | 0.2% | 00.0% | Unchanged | History |
| IDYAIDEAYA Biosciences, Inc. | COM | 1,668,355 | $24.9M | 0.2% | +1,668,355 | New | History |
| DSGNDesign Therapeutics, Inc. | COM | 1,436,636 | $24.0M | 0.2% | 00.0% | Unchanged | History |
| VSTMVerastem, Inc. | COM | 26,988,898 | $22.9M | 0.2% | 00.0% | Unchanged | History |
| ALTAltimmune, Inc. | COM NEW | 1,769,681 | $22.6M | 0.1% | −305,722−14.7% | Reduced | History |
| NVTAInvitae Corp | COM | 8,402,035 | $20.7M | 0.1% | −1,471,453−14.9% | Reduced | History |
| BMEABiomea Fusion, Inc. | COM | 2,104,559 | $20.6M | 0.1% | 00.0% | Unchanged | History |
| BCYCBicycle Therapeutics PLC | SPONSORED ADS | 843,814 | $19.6M | 0.1% | +843,814 | New | History |
| RAREUltragenyx Pharmaceutical Inc. | COM | 470,974 | $19.5M | 0.1% | 00.0% | Unchanged | History |
| TILInstil Bio, Inc. | COM | 3,893,700 | $18.8M | 0.1% | 00.0% | Unchanged | History |
| VERUVeru Inc. | COM | 1,609,579 | $18.5M | 0.1% | +1,609,579 | New | History |
| RLMDRelmada Therapeutics, Inc. | COM | 495,113 | $18.3M | 0.1% | 00.0% | Unchanged | History |
| ALKSAlkermes plc. | SHS | 815,016 | $18.2M | 0.1% | −684,984−45.7% | Reduced | History |
| DNLIDenali Therapeutics Inc. | COM | 588,738 | $18.1M | 0.1% | 00.0% | Unchanged | History |
| CYVNYOpthea Ltd | SPONSORED ADS | 2,691,391 | $16.7M | 0.1% | −4,800−0.2% | Reduced | History |
| BLUEbluebird bio, Inc. | COM | 2,499,715 | $15.8M | 0.1% | 00.0% | Unchanged | History |
| CRNXCrinetics Pharmaceuticals, Inc. | COM | 735,716 | $14.4M | 0.1% | −91,764−11.1% | Reduced | History |
| WHWKWhitehawk Therapeutics, Inc. | COM | 989,928 | $14.0M | 0.1% | +989,928 | New | History |
| TCDATricida, Inc. | COM | 1,320,290 | $13.8M | 0.1% | −182,800−12.2% | Reduced | History |
| Affimed N VN01045108 | COM | 6,596,830 | $13.6M | 0.1% | 00.0% | Unchanged | – |
| DICEDICE Therapeutics, Inc. | COM | 588,235 | $11.9M | 0.1% | 00.0% | Unchanged | History |
| ANABAnaptysbio, Inc | COM | 427,179 | $10.9M | 0.1% | 00.0% | Unchanged | History |
| KYNBKyntra Bio, Inc. | COM | 815,718 | $10.6M | 0.1% | 00.0% | Unchanged | History |
| ADAPYAdaptimmune Therapeutics PLC | SPONDS ADR | 9,830,877 | $10.6M | 0.1% | 00.0% | Unchanged | History |
| ZYMEZymeworks Inc. | COM | 1,708,472 | $10.5M | 0.1% | 00.0% | Unchanged | History |
| PNTPOINT Biopharma Global Inc. | COM | 1,169,103 | $9.04M | 0.1% | +1,169,103 | New | History |
| TCRXTScan Therapeutics, Inc. | COM | 2,784,792 | $8.49M | 0.1% | 00.0% | Unchanged | History |
| Invitae Corp46185LAB9 | NOTE 2.000% 9/0 | – | $8.15M | 0.1% | – | – | – |
| CBAYCymaBay Therapeutics, Inc. | COM | 2,170,464 | $7.60M | <0.1% | 00.0% | Unchanged | History |
| VERAVera Therapeutics, Inc. | CL A | 333,333 | $7.10M | <0.1% | 00.0% | Unchanged | History |
| PACBPacific Biosciences of California, Inc. | COM | 1,127,782 | $6.55M | <0.1% | −4,317,181−79.3% | Reduced | History |
| FLGTFulgent Genetics, Inc. | COM | 166,619 | $6.35M | <0.1% | −34,825−17.3% | Reduced | History |
| AMRNAmarin Corp PLC | SPONS ADR NEW | 5,377,113 | $5.86M | <0.1% | −15,792,692−74.6% | Reduced | History |
| Achilles Therapeutics PLC00449L102 | SPONSORED ADS | 2,591,366 | $5.86M | <0.1% | 00.0% | Unchanged | – |
| VORVor Biopharma Inc. | COM | 1,465,925 | $5.83M | <0.1% | +327,157+28.7% | Added | History |
| RETAReata Pharmaceuticals Inc | CL A | 223,976 | $5.63M | <0.1% | 00.0% | Unchanged | History |
| BCELAtreca, Inc. | CL A COM | 3,532,760 | $5.55M | <0.1% | 00.0% | Unchanged | History |
| NKTXNkarta, Inc. | COM | 400,000 | $5.26M | <0.1% | 00.0% | Unchanged | History |
| TLISTalis Biomedical Corp | COM | 7,624,835 | $5.20M | <0.1% | 00.0% | Unchanged | History |
| KRONKronos Bio, Inc. | COM | 1,539,616 | $5.16M | <0.1% | +1,539,616 | New | History |
| CYTCyteir Therapeutics, Inc. | COM | 2,643,640 | $5.08M | <0.1% | 00.0% | Unchanged | History |
| SRZNSurrozen, Inc. | COM | 2,500,000 | $5.05M | <0.1% | 00.0% | Unchanged | History |
| EWTXEdgewise Therapeutics, Inc. | COM | 500,000 | $4.92M | <0.1% | 00.0% | Unchanged | History |
| FATEFate Therapeutics Inc | COM | 215,695 | $4.83M | <0.1% | +215,695 | New | History |
| STOKStoke Therapeutics, Inc. | COM | 369,327 | $4.74M | <0.1% | +369,327 | New | History |
| NTRANatera, Inc. | COM | 100,000 | $4.38M | <0.1% | 00.0% | Unchanged | History |
| RVMDRevolution Medicines, Inc. | COM | 222,222 | $4.38M | <0.1% | 00.0% | Unchanged | History |
| ALLKAllakos Inc. | COM | 703,050 | $4.30M | <0.1% | 00.0% | Unchanged | History |
| EIGREiger BioPharmaceuticals, Inc. | COM | 539,851 | $4.07M | <0.1% | +539,851 | New | History |
| PMVPPMV Pharmaceuticals, Inc. | COM | 322,024 | $3.83M | <0.1% | +322,024 | New | History |
| IPSCCentury Therapeutics, Inc. | COM | 370,587 | $3.67M | <0.1% | +370,587 | New | History |
| HOOKHOOKIPA Pharma Inc. | COM | 2,400,481 | $3.22M | <0.1% | 00.0% | Unchanged | History |
| LONALeonaBio, Inc. | COM | 1,040,834 | $3.09M | <0.1% | 00.0% | Unchanged | History |
| MGNXMacrogenics Inc | COM | 892,579 | $3.09M | <0.1% | 00.0% | Unchanged | History |
| ITOSiTeos Therapeutics, Inc. | COM | 150,346 | $2.86M | <0.1% | 00.0% | Unchanged | History |
| ATRAAtara Biotherapeutics, Inc. | COM | 744,186 | $2.81M | <0.1% | 00.0% | Unchanged | History |
| TNGXTango Therapeutics, Inc. | COM | 750,000 | $2.71M | <0.1% | 00.0% | Unchanged | History |
| SNDXSyndax Pharmaceuticals Inc | COM | 110,729 | $2.66M | <0.1% | 00.0% | Unchanged | History |
| OTICOtonomy, Inc. | COM | 8,443,134 | $2.49M | <0.1% | +30,500+0.4% | Added | History |
| NGNENeurogene Inc. | COM | 3,821,740 | $2.45M | <0.1% | 00.0% | Unchanged | History |
| ALGSAligos Therapeutics, Inc. | COM | 2,076,400 | $2.28M | <0.1% | 00.0% | Unchanged | History |
| ALECAlector, Inc. | COM | 239,228 | $2.26M | <0.1% | 00.0% | Unchanged | History |
Sold out since Q2 2022 (14)
Positions held at the end of Q2 2022 that are gone from this filing.
| Security | Class | Shares in Q2 2022 | Value in Q2 2022 | % of portfolio in Q2 2022 | History |
|---|---|---|---|---|---|
| LEGNLegend Biotech Corp | SPONSORED ADS | 856,658 | $47.1M | 0.3% | History |
| Sarepta Therapeutics, Inc.803607AB6 | DBCV 1.500%11/1 | – | $36.6M | 0.2% | – |
| MRUSMerus N.V. | COM | 995,397 | $22.5M | 0.1% | History |
| KRTXKaruna Therapeutics, Inc. | COM | 69,966 | $8.85M | 0.1% | History |
| HRMYHarmony Biosciences Holdings, Inc. | COM | 123,600 | $6.03M | <0.1% | History |
| CNTACentessa Pharmaceuticals plc | SPONSORED ADS | 1,127,273 | $5.49M | <0.1% | History |
| EVFMEvofem Biosciences, Inc. | COM NEW | 2,583,616 | $2.92M | <0.1% | History |
| BCABBioAtla, Inc. | COM | 825,000 | $2.35M | <0.1% | History |
| EPZMEpizyme, Inc. | COM | 1,000,000 | $1.47M | <0.1% | History |
| NGMNGM Biopharmaceuticals Inc | COM | 55,294 | $709.0K | <0.1% | History |
| BNRBurning Rock Biotech Ltd | SPONSORED ADS | 209,131 | $609.0K | <0.1% | History |
| INZYInozyme Pharma, Inc. | COM | 106,999 | $510.0K | <0.1% | History |
| PASGPassage BIO, Inc. | COM | 117,161 | $276.0K | <0.1% | History |
| NEXINexImmune, Inc. | COM | 20,000 | $32.0K | <0.1% | History |