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Livermore
Livermore
ZHEN

Perceptive Advisors LLC

SEC CIK
0001224962
Latest filing
Aug 14, 2026

Holdings in Q4 2022

Holdings as of Dec 31, 2022, filed Feb 14, 2023. Long positions only; changes compare share counts with Q3 2022.

Institution overview
Positions
94
−21 vs. Q3 2022
Portfolio value
$3.47B
+$29.3M (+0.9%) vs. Q3 2022
Filed
Feb 14, 2023
SEC
Holdings of Perceptive Advisors LLC in Q4 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
FOLDAmicus Therapeutics, Inc.COM27,642,917$337.5M9.7%+270,000+1.0%AddedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM6,088,333$225.0M6.5%+616,300+11.3%AddedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM731,932$212.4M6.1%+400,909+121.1%AddedHistory
CERECerevel Therapeutics Holdings, Inc.COM6,511,727$205.4M5.9%00.0%UnchangedHistory
RXDXPrometheus Biosciences, Inc.COM1,212,694$133.4M3.8%−255,818−17.4%ReducedHistory
VRNAVerona Pharma plcSPONSORED ADS4,880,719$127.5M3.7%−166,545−3.3%ReducedHistory
HZNPHorizon Therapeutics Public Ltd CoSHS960,000$109.2M3.1%+960,000NewHistory
MRTXMirati Therapeutics, Inc.COM2,191,425$99.3M2.9%−593,371−21.3%ReducedHistory
LIANYLianBioSPONSORED ADS57,558,451$94.4M2.7%00.0%UnchangedHistory
SRPTSarepta Therapeutics, Inc.COM649,250$84.1M2.4%+396,250+156.6%AddedHistory
INBXInhibrx Biosciences, Inc.COM3,313,783$81.7M2.4%+425,923+14.7%AddedHistory
ACLXArcellx, Inc.COMMON STOCK2,598,305$80.5M2.3%+132,900+5.4%AddedHistory
ALDXAldeyra Therapeutics, Inc.COM11,350,085$79.0M2.3%00.0%UnchangedHistory
XENEXenon Pharmaceuticals Inc.COM1,921,273$75.8M2.2%−201,262−9.5%ReducedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM4,039,276$73.9M2.1%−1,281,756−24.1%ReducedHistory
Bellus Health Inc New07987C204COM NEW8,891,027$73.1M2.1%−1,356,046−13.2%Reduced–
SWTXSpringWorks Therapeutics, Inc.COM2,617,691$68.1M2.0%−852,872−24.6%ReducedHistory
NUVLNuvalent, Inc.COM2,255,007$67.2M1.9%+600,000+36.3%AddedHistory
IOVAIovance Biotherapeutics, Inc.COM9,971,780$63.7M1.8%−276,844−2.7%ReducedHistory
PCVXVaxcyte, Inc.COM1,170,000$56.1M1.6%+1,170,000NewHistory
BMRNBiomarin Pharmaceutical IncCOM506,481$52.4M1.5%+170,000+50.5%AddedHistory
ADMAAdma Biologics, Inc.COM11,900,255$46.2M1.3%+966,868+8.8%AddedHistory
MGTXMeiraGTx Holdings plcCOM6,963,277$45.4M1.3%00.0%UnchangedHistory
TMCITreace Medical Concepts, Inc.COM1,946,403$44.7M1.3%+344,424+21.5%AddedHistory
VERUVeru Inc.COM7,858,011$41.5M1.2%+3,965,011+101.8%AddedHistory
ALBOAlbireo Pharma, Inc.COM1,757,160$38.0M1.1%−602,979−25.5%ReducedHistory
COGTCogent Biosciences, Inc.COM3,207,441$37.1M1.1%00.0%UnchangedHistory
VRDNViridian Therapeutics, Inc.COM1,220,575$35.7M1.0%00.0%UnchangedHistory
RAPTRAPT Therapeutics, Inc.COM1,798,955$35.6M1.0%+85,821+5.0%AddedHistory
ZYMEZymeworks Inc.COM4,511,275$35.5M1.0%+111,176+2.5%AddedHistory
ACRVAcrivon Therapeutics, Inc.COMMON STOCK3,007,858$34.7M1.0%+3,007,858NewHistory
ESTAEstablishment Labs Holdings Inc.COM497,857$32.7M0.9%−80,396−13.9%ReducedHistory
ATXSAstria Therapeutics, Inc.COM2,189,462$32.6M0.9%+908,265+70.9%AddedHistory
CINCCinCor Pharma, Inc.COM2,576,325$31.7M0.9%−730,324−22.1%ReducedHistory
IMTXImmatics N.V.SHS3,491,500$30.4M0.9%+991,500+39.7%AddedHistory
RLAYRelay Therapeutics, Inc.COM1,943,097$29.0M0.8%00.0%UnchangedHistory
LYRALyra Therapeutics, Inc.COM9,146,730$28.7M0.8%00.0%UnchangedHistory
OMOutset Medical, Inc.COM1,089,427$28.1M0.8%−79,203−6.8%ReducedHistory
HRMYHarmony Biosciences Holdings, Inc.COM411,804$22.7M0.7%00.0%UnchangedHistory
RCKTRocket Pharmaceuticals, Inc.COM1,078,204$21.1M0.6%+578,204+115.6%AddedHistory
VBIVVBI Vaccines Inc/BCCOM NEW52,335,002$20.4M0.6%00.0%UnchangedHistory
Rain Oncology Inc.75082Q105COM2,483,619$19.9M0.6%00.0%Unchanged–
AKROAkero Therapeutics, Inc.COM350,525$19.2M0.6%−79,475−18.5%ReducedHistory
TARSTarsus Pharmaceuticals, Inc.COM1,296,416$19.0M0.5%00.0%UnchangedHistory
SLDBSolid Biosciences Inc.COM NEW3,495,933$18.8M0.5%+2,601,763+291.0%AddedConverted for a 1-for-15 splitHistory
NAUTNautilus Biotechnology, Inc.COM9,111,151$16.4M0.5%00.0%UnchangedHistory
ROIVRoivant Sciences Ltd.SHS1,981,570$15.8M0.5%+1,981,570NewHistory
LONALeonaBio, Inc.COM4,797,278$15.2M0.4%00.0%UnchangedHistory
PRTAProthena Corp Public Ltd CoSHS237,646$14.3M0.4%+7,646+3.3%AddedHistory
VRCAVerrica Pharmaceuticals Inc.COM5,038,983$13.9M0.4%00.0%UnchangedHistory
AXGNAxogen, Inc.COM1,388,126$13.9M0.4%+438,500+46.2%AddedHistory
RVNCRevance Therapeutics, Inc.COM729,097$13.5M0.4%−79,574−9.8%ReducedHistory
CTKBCytek Biosciences, Inc.COM1,289,534$13.2M0.4%00.0%UnchangedHistory
AORTArtivion, Inc.COM1,085,860$13.2M0.4%−118,369−9.8%ReducedHistory
BBIOBridgeBio Pharma, Inc.COM1,697,033$12.9M0.4%00.0%UnchangedHistory
ISEEIVERIC bio, Inc.COM587,400$12.6M0.4%−446,769−43.2%ReducedHistory
NBIXNeurocrine Biosciences IncStock100,050$11.9M0.3%00.0%UnchangedHistory
LRMRLarimar Therapeutics, Inc.COM2,860,000$11.8M0.3%00.0%UnchangedHistory
CMAXCareMax, Inc.COM CL A3,129,195$11.4M0.3%−265,744−7.8%ReducedHistory
ISRGIntuitive Surgical IncCOM NEW40,000$10.6M0.3%+40,000NewHistory
MORFMorphic Holding, Inc.COM363,197$9.72M0.3%00.0%UnchangedHistory
DICEDICE Therapeutics, Inc.COM293,362$9.15M0.3%−394,062−57.3%ReducedHistory
LABPLandos Biopharma, Inc.COM14,869,915$7.43M0.2%00.0%UnchangedHistory
SCPHscPharmaceuticals Inc.COM952,380$6.83M0.2%+952,380NewHistory
HLVXHilleVax, Inc.COM406,024$6.79M0.2%−358,883−46.9%ReducedHistory
OMICSingular Genomics Systems, Inc.COM3,282,275$6.60M0.2%−253,999−7.2%ReducedHistory
ISOIsoPlexis CorpCOM4,095,498$6.35M0.2%00.0%UnchangedHistory
PENPenumbra IncCOM25,400$5.65M0.2%+25,400NewHistory
ACRSAclaris Therapeutics, Inc.COM341,239$5.37M0.2%00.0%UnchangedHistory
NTRANatera, Inc.COM130,000$5.22M0.2%+10,000+8.3%AddedHistory
CBAYCymaBay Therapeutics, Inc.COM708,993$4.45M0.1%+708,993NewHistory
NVNOenVVeno Medical CorpCOMMON STOCK781,615$3.99M0.1%00.0%UnchangedHistory
NBTXNanobiotix S.A.SPONSORED ADS1,059,800$3.89M0.1%00.0%UnchangedHistory
SLGCSomaLogic, Inc.CLASS A COM1,500,000$3.77M0.1%00.0%UnchangedHistory
TYRATyra Biosciences, Inc.COM494,403$3.76M0.1%00.0%UnchangedHistory
PNTPOINT Biopharma Global Inc.COM500,000$3.65M0.1%00.0%UnchangedHistory
CYPHCypherpunk Technologies Inc.COM6,726,496$3.03M0.1%−745,652−10.0%ReducedHistory
CABACabaletta Bio, Inc.COM317,454$2.94M0.1%+317,454NewHistory
KRONKronos Bio, Inc.COM1,752,745$2.84M0.1%−403,406−18.7%ReducedHistory
PRCTPROCEPT BioRobotics CorpCOM64,537$2.68M0.1%−199,183−75.5%ReducedHistory
IMVTImmunovant, Inc.COM150,000$2.66M0.1%+150,000NewHistory
ATNXAthenex, Inc.COM15,532,467$2.29M0.1%00.0%UnchangedHistory
PRVAPrivia Health Group, Inc.COM90,000$2.04M0.1%+90,000NewHistory
TVTXTravere Therapeutics, Inc.COM90,748$1.91M0.1%00.0%UnchangedHistory
ABOSAcumen Pharmaceuticals, Inc.COM347,450$1.88M0.1%−52,550−13.1%ReducedHistory
DRIODarioHealth Corp.COM NEW327,869$1.40M<0.1%00.0%UnchangedHistory
CLOVClover Health Investments, Corp.COM CL A1,500,000$1.39M<0.1%00.0%UnchangedHistory
NVRONevro CorpCOM30,000$1.19M<0.1%−120,000−80.0%ReducedHistory
PEARPear Therapeutics, Inc.CLASS A COM900,548$1.06M<0.1%00.0%UnchangedHistory
TARAProtara Therapeutics, Inc.COM STK290,051$777.3K<0.1%00.0%UnchangedHistory
MOTSMotus GI Holdings, Inc.COM NEW90,027$75.6K<0.1%00.0%UnchangedHistory
EQRx, Inc.26886C115*W EXP 12/17/202250,000$67.0K<0.1%00.0%Unchanged–
CareMax, Inc.14171W111*W EXP 06/08/20260,000$31.3K<0.1%00.0%Unchanged–
Surrozen, Inc.86889P117*W EXP 08/01/203166,666$9.18K<0.1%00.0%Unchanged–

Options (2)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Perceptive Advisors LLC in Q4 2022
SecurityClassPutsCalls
MDGLMadrigal Pharmaceuticals, Inc.COM$87.1M–
FLNAFilana Therapeutics, Inc.COM$4.43M–

Sold out since Q3 2022 (32)

Positions held at the end of Q3 2022 that are gone from this filing.

Positions of Perceptive Advisors LLC sold out since Q3 2022
SecurityClassShares in Q3 2022Value in Q3 2022% of portfolio in Q3 2022History
GBTGlobal Blood Therapeutics, Inc.COM2,322,247$158.1M4.6%History
RLMDRelmada Therapeutics, Inc.COM2,383,478$88.2M2.6%History
Travere Therapeutics, Inc.89422GAA5NOTE 2.250% 3/0–$46.0M1.3%–
SGENSeagen Inc.COM316,544$43.3M1.3%History
EWEdwards Lifesciences CorpStock330,000$27.3M0.8%History
APLSApellis Pharmaceuticals, Inc.COM366,400$25.0M0.7%History
RCUSArcus Biosciences, Inc.COM666,477$17.4M0.5%History
CHRSCoherus Oncology, Inc.COM1,667,123$16.0M0.5%History
CNCEConcert Pharmaceuticals, Inc.COM2,150,641$14.4M0.4%History
ChemoCentryx, Inc.16383L106COM192,680$9.95M0.3%–
CCCCC4 Therapeutics, Inc.COM STK766,231$6.72M0.2%History
RVMDRevolution Medicines, Inc.COM310,500$6.12M0.2%History
NARIInari Medical, Inc.Stock70,000$5.08M0.1%History
WGSGeneDx Holdings Corp.COMMON STOCK5,000,000$4.39M0.1%History
CTICCti Biopharma CorpCOM735,165$4.28M0.1%History
HCATHealth Catalyst, Inc.COM389,962$3.78M0.1%History
Coherus Biosciences Inc19249HAB9NOTE 1.500% 4/1–$3.59M0.1%–
YMABY-mAbs Therapeutics, Inc.COM212,018$3.06M0.1%History
PYXSPyxis Oncology, Inc.COMMON STOCK1,528,812$3.01M0.1%History
ABSIAbsci CorpCOM894,346$2.80M0.1%History
PSTXPoseida Therapeutics, Inc.COM750,000$2.65M0.1%History
RETAReata Pharmaceuticals IncCL A100,000$2.51M0.1%History
QTNTQuotient LtdSHS16,200,818$2.43M0.1%History
SNCEScience 37 Holdings, Inc.COM1,500,000$2.42M0.1%History
FULCFulcrum Therapeutics, Inc.COM294,118$2.38M0.1%History
HYPRHyperfine, Inc.COM CL A927,388$751.0K<0.1%History
SONXSonendo, Inc.COM612,204$655.0K<0.1%History
PRVBProvention Bio, Inc.COM110,728$498.0K<0.1%History
ICVXIcosavax, Inc.COM93,591$296.0K<0.1%History
AGRXAgile Therapeutics IncCOM NEW532,361$158.0K<0.1%History
NEPTFNeptune Wellness Solutions Inc.COM NEW57,142$87.0K<0.1%History
SRZNSurrozen, Inc.COM6,017$12.0K<0.1%History