Skip to main content

OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q2 2024

Holdings as of Jun 30, 2024, filed Aug 14, 2024. Long positions only; changes compare share counts with Q1 2024.

Institution overview
Positions
108
−4 vs. Q1 2024
Portfolio value
$4.69B
−$416.7M (−8.2%) vs. Q1 2024
Filed
Aug 14, 2024
SEC
Holdings of OrbiMed Advisors LLC in Q2 2024
SecurityClassSharesValue% of portfolioShare changeActionHistory
LLYEli Lilly & CoStock337,600$305.7M6.5%−23,200−6.4%ReducedHistory
EWTXEdgewise Therapeutics, Inc.COM15,021,721$270.5M5.8%00.0%UnchangedHistory
BSXBoston Scientific CorpStock3,273,000$252.1M5.4%00.0%UnchangedHistory
ISRGIntuitive Surgical IncCOM NEW493,100$219.4M4.7%00.0%UnchangedHistory
BIIBBiogen Inc.COM900,900$208.8M4.5%00.0%UnchangedHistory
ELVNEnliven Therapeutics, Inc.COM7,959,538$186.0M4.0%−1,038,800−11.5%ReducedHistory
MRKMerck & Co., Inc.Stock1,316,000$162.9M3.5%00.0%UnchangedHistory
THCTenet Healthcare CorpCOM NEW1,173,300$156.1M3.3%00.0%UnchangedHistory
JANXJanux Therapeutics, Inc.COM2,979,828$124.8M2.7%−1,295,725−30.3%ReducedHistory
IONSIonis Pharmaceuticals IncCOM2,372,333$113.1M2.4%+359,300+17.8%AddedHistory
SRPTSarepta Therapeutics, Inc.COM646,000$102.1M2.2%−51,500−7.4%ReducedHistory
SYKStryker CorpStock269,000$91.5M2.0%00.0%UnchangedHistory
ELVElevance Health, Inc.Stock168,100$91.1M1.9%00.0%UnchangedHistory
ARGXArgenx SESPONSORED ADR209,100$89.9M1.9%+57,500+37.9%AddedHistory
IRONDisc Medicine, Inc.COM1,785,571$80.5M1.7%+83,334+4.9%AddedHistory
SPRYARS Pharmaceuticals, Inc.COM9,240,887$78.6M1.7%00.0%UnchangedHistory
THRDThird Harmonic Bio, Inc.COM5,779,071$75.1M1.6%00.0%UnchangedHistory
NTRANatera, Inc.COM687,500$74.4M1.6%−211,931−23.6%ReducedHistory
TMOThermo Fisher Scientific Inc.Stock132,000$73.0M1.6%00.0%UnchangedHistory
VRTXVertex Pharmaceuticals IncStock151,000$70.8M1.5%+28,300+23.1%AddedHistory
SWTXSpringWorks Therapeutics, Inc.COM1,707,331$64.3M1.4%00.0%UnchangedHistory
NBIXNeurocrine Biosciences IncStock448,200$61.7M1.3%+25,100+5.9%AddedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM250,300$60.8M1.3%+250,300NewHistory
PCVXVaxcyte, Inc.COM795,900$60.1M1.3%−270,231−25.3%ReducedHistory
KROSKeros Therapeutics, Inc.COM1,268,734$58.0M1.2%00.0%UnchangedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM1,280,800$57.4M1.2%−104,200−7.5%ReducedHistory
UNHUnitedHealth Group IncStock112,000$57.0M1.2%+42,000+60.0%AddedHistory
AVBPArriVent BioPharma, Inc.COM3,027,328$56.2M1.2%00.0%UnchangedHistory
ICLRIcon PLCCOM174,100$54.6M1.2%00.0%UnchangedHistory
TERNTerns Pharmaceuticals, Inc.COM7,619,135$51.9M1.1%00.0%UnchangedHistory
APLSApellis Pharmaceuticals, Inc.COM1,302,800$50.0M1.1%+5,000+0.4%AddedHistory
EVHEvolent Health, Inc.CL A2,605,615$49.8M1.1%00.0%UnchangedHistory
XTNTXtant Medical Holdings, Inc.COM NEW73,114,592$46.1M1.0%00.0%UnchangedHistory
CYTKCytokinetics IncCOM NEW812,906$44.0M0.9%+130,206+19.1%AddedHistory
AMGNAmgen IncStock134,900$42.1M0.9%+71,500+112.8%AddedHistory
SIBNSI-BONE, Inc.COM3,229,977$41.8M0.9%+55,456+1.7%AddedHistory
PRLDPrelude Therapeutics IncCOM10,909,256$41.6M0.9%00.0%UnchangedHistory
VRNAVerona Pharma plcSPONSORED ADS2,861,801$41.4M0.9%−536,266−15.8%ReducedHistory
QTTBQ32 Bio Inc.COM2,252,987$40.4M0.9%00.0%UnchangedHistory
ITGRInteger Holdings CorpCOM349,221$40.4M0.9%+349,221NewHistory
SNDXSyndax Pharmaceuticals IncCOM1,925,300$39.5M0.8%+176,300+10.1%AddedHistory
GERNGeron CorpCOM8,930,252$37.9M0.8%−3,963,359−30.7%ReducedHistory
XENEXenon Pharmaceuticals Inc.COM862,362$33.6M0.7%+312,362+56.8%AddedHistory
DXCMDexcom IncCOM289,900$32.9M0.7%+149,600+106.6%AddedHistory
0000000000Stock12,048,773$32.1M0.7%00.0%Unchanged–
RYTMRhythm Pharmaceuticals, Inc.COM704,842$28.9M0.6%00.0%UnchangedHistory
Avidity Biosciences, Inc.05370A108COM706,475$28.9M0.6%−287,625−28.9%Reduced–
EXASExact Sciences CorpCOM672,416$28.4M0.6%+532,016+378.9%AddedHistory
NPCENeuroPace IncCOM3,406,335$25.8M0.5%−597,632−14.9%ReducedHistory
DYNDyne Therapeutics, Inc.COM708,400$25.0M0.5%00.0%UnchangedHistory
VERAVera Therapeutics, Inc.CL A675,872$24.5M0.5%00.0%UnchangedHistory
SCPHscPharmaceuticals Inc.COM5,559,528$24.2M0.5%00.0%UnchangedHistory
REGNRegeneron Pharmaceuticals, Inc.COM22,800$24.0M0.5%00.0%UnchangedHistory
MLYSMineralys Therapeutics, Inc.COM2,021,424$23.7M0.5%00.0%UnchangedHistory
IMTXImmatics N.V.SHS2,006,381$23.3M0.5%+236,673+13.4%AddedHistory
HRTXHeron Therapeutics, Inc.COM6,512,866$22.8M0.5%−3,598,684−35.6%ReducedHistory
CMPXCompass Therapeutics, Inc.COM22,362,850$22.4M0.5%00.0%UnchangedHistory
MORFMorphic Holding, Inc.COM612,500$20.9M0.4%+54,000+9.7%AddedHistory
VIRVir Biotechnology, Inc.COM2,320,102$20.6M0.4%+1,680,102+262.5%AddedHistory
CGEMCullinan Therapeutics, Inc.COM1,147,655$20.0M0.4%+630,049+121.7%AddedHistory
SLRNACELYRIN, Inc.COM4,001,711$17.6M0.4%00.0%UnchangedHistory
APGEApogee Therapeutics, Inc.COM379,130$14.9M0.3%−339,771−47.3%ReducedHistory
NMRANeumora Therapeutics, Inc.COM1,500,000$14.7M0.3%00.0%UnchangedHistory
ACETAdicet Bio, Inc.COM11,447,140$13.9M0.3%00.0%UnchangedHistory
ADCTADC Therapeutics SASHS4,316,824$13.6M0.3%+4,316,824NewHistory
CRVSCorvus Pharmaceuticals, Inc.COM6,943,654$12.6M0.3%00.0%UnchangedHistory
ABCLAbCellera Biologics Inc.COM4,180,768$12.4M0.3%00.0%UnchangedHistory
TYRATyra Biosciences, Inc.COM768,638$12.3M0.3%00.0%UnchangedHistory
TELATELA Bio, Inc.COM2,457,542$11.6M0.2%−378,000−13.3%ReducedHistory
ALXOAlx Oncology Holdings IncCOM1,894,462$11.4M0.2%−823,508−30.3%ReducedHistory
RPTXRepare Therapeutics Inc.COM3,322,488$11.0M0.2%00.0%UnchangedHistory
PMVPPMV Pharmaceuticals, Inc.COM6,475,291$10.5M0.2%00.0%UnchangedHistory
LXRXLexicon Pharmaceuticals, Inc.COM NEW5,846,100$9.82M0.2%+2,304,100+65.1%AddedHistory
LYELLyell Immunopharma, Inc.COM6,405,098$9.29M0.2%+6,205,598+3,110.6%AddedHistory
MRUSMerus N.V.COM156,100$9.24M0.2%+156,100NewHistory
SRRKScholar Rock Holding CorpCOM1,074,382$8.95M0.2%−2,500,250−69.9%ReducedHistory
TSBXTurnstone Biologics Corp.COM3,099,265$8.12M0.2%00.0%UnchangedHistory
PASGPassage BIO, Inc.COM10,124,576$8.04M0.2%00.0%UnchangedHistory
PGNYProgyny, Inc.COM259,900$7.44M0.2%+146,600+129.4%AddedHistory
CCCCC4 Therapeutics, Inc.COM STK1,513,058$6.99M0.1%+1,513,058NewHistory
IMAImageneBio, Inc.COM3,539,358$5.84M0.1%00.0%UnchangedHistory
FOLDAmicus Therapeutics, Inc.COM570,300$5.66M0.1%00.0%UnchangedHistory
KRYSKrystal Biotech, Inc.COM29,966$5.50M0.1%−7,200−19.4%ReducedHistory
NSPRInspireMD, Inc.COM2,133,405$5.32M0.1%00.0%UnchangedHistory
CATXPerspective Therapeutics, Inc.COM NEW492,670$4.91M0.1%+492,670NewHistory
GPCRStructure Therapeutics Inc.SPONSORED ADS125,000$4.91M0.1%+125,000NewHistory
NKTXNkarta, Inc.COM800,000$4.73M0.1%00.0%UnchangedHistory
HLSQTessera Defense & Homeland Security Inc.COM13,773,653$4.63M0.1%+9,256,064+204.9%AddedHistory
VSTMVerastem, Inc.COM NEW1,529,115$4.56M0.1%00.0%UnchangedHistory
FATEFate Therapeutics IncCOM1,355,352$4.45M0.1%00.0%UnchangedHistory
XFORX4 Pharmaceuticals, IncCOM7,133,515$4.14M0.1%00.0%UnchangedHistory
IVVDInvivyd, Inc.COM2,425,800$2.67M0.1%−264,500−9.8%ReducedHistory
MISTMilestone Pharmaceuticals Inc.COM2,000,000$2.64M0.1%00.0%UnchangedHistory
ELEVElevation Acquisition Group Inc.COM941,275$2.54M0.1%00.0%UnchangedHistory
TGTXTG Therapeutics, Inc.COM133,200$2.37M0.1%+133,200NewHistory
BMRNBiomarin Pharmaceutical IncCOM26,100$2.15M<0.1%−1,252,400−98.0%ReducedHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS2,241,273$2.05M<0.1%−10.0%ReducedHistory
ORICOric Pharmaceuticals, Inc.COM287,100$2.03M<0.1%00.0%UnchangedHistory
NXTCNextCure, Inc.COM1,141,200$1.81M<0.1%00.0%UnchangedHistory
APLMApollomics Inc.CL A SHS8,565,456$1.81M<0.1%00.0%UnchangedHistory

Options (6)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of OrbiMed Advisors LLC in Q2 2024
SecurityClassPutsCalls
SOLVSolventum CorpStock–$10.6M
SRPTSarepta Therapeutics, Inc.COM–$7.90M
PFEPfizer IncStock–$7.00M
SIBNSI-BONE, Inc.COM–$3.23M
MRUSMerus N.V.COM–$2.96M
GERNGeron CorpCOM–$2.54M

Sold out since Q1 2024 (13)

Positions held at the end of Q1 2024 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q1 2024
SecurityClassShares in Q1 2024Value in Q1 2024% of portfolio in Q1 2024History
ALPNAlpine Immune Sciences, Inc.COM2,680,496$106.3M2.1%History
ESPREsperion Therapeutics, Inc.COM13,708,731$36.7M0.7%History
PRAXPraxis Precision Medicines, Inc.COM NEW460,512$28.1M0.6%History
KNTEKinnate Biopharma Inc.COM8,009,729$21.3M0.4%History
ARWRArrowhead Pharmaceuticals, Inc.COM739,651$21.2M0.4%History
JBIOJade Biosciences, Inc.COM565,374$16.7M0.3%History
VTYXVentyx Biosciences, Inc.COM1,870,456$10.3M0.2%History
TXG10x Genomics, Inc.CL A COM225,200$8.45M0.2%History
CATXPerspective Therapeutics, Inc.COM6,505,800$7.74M0.2%History
CTMXCytomX Therapeutics, Inc.COM3,544,578$7.73M0.2%History
BOLTBolt Biotherapeutics, Inc.COM1,541,000$2.16M<0.1%History
CALCCalciMedica, Inc.COM NEW297,380$1.24M<0.1%History
AFIBAcutus Medical, Inc.COM2,648,386$497.9K<0.1%History