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Livermore
Livermore
ZHEN

OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q4 2023

Holdings as of Dec 31, 2023, filed Feb 14, 2024. Long positions only; changes compare share counts with Q3 2023.

Institution overview
Positions
109
−11 vs. Q3 2023
Portfolio value
$4.99B
+$671.3M (+15.5%) vs. Q3 2023
Filed
Feb 14, 2024
SEC
Holdings of OrbiMed Advisors LLC in Q4 2023
SecurityClassSharesValue% of portfolioShare changeActionHistory
SVASinovac Biotech LtdSHS2,718,735$340.0M6.8%00.0%UnchangedHistory
BIIBBiogen Inc.COM827,600$214.2M4.3%+270,800+48.6%AddedHistory
LLYEli Lilly & CoStock365,400$213.0M4.3%+179,400+96.5%AddedHistory
BSXBoston Scientific CorpStock3,306,800$191.2M3.8%00.0%UnchangedHistory
ISRGIntuitive Surgical IncCOM NEW499,000$168.3M3.4%00.0%UnchangedHistory
EWTXEdgewise Therapeutics, Inc.COM14,567,176$159.4M3.2%00.0%UnchangedHistory
BMRNBiomarin Pharmaceutical IncCOM1,571,410$151.5M3.0%−43,800−2.7%ReducedHistory
RYZBRayzeBio, Inc.COM2,365,213$147.0M2.9%−257,696−9.8%ReducedHistory
ELVNEnliven Therapeutics, Inc.COM8,998,338$124.5M2.5%00.0%UnchangedHistory
SWTXSpringWorks Therapeutics, Inc.COM3,219,359$117.5M2.4%−749,229−18.9%ReducedHistory
MRKMerck & Co., Inc.Stock1,055,000$115.0M2.3%00.0%UnchangedHistory
IONSIonis Pharmaceuticals IncCOM2,064,797$104.5M2.1%−104,703−4.8%ReducedHistory
IRONDisc Medicine, Inc.COM1,702,237$98.3M2.0%−567,400−25.0%ReducedHistory
Gracell Biotechnologies Inc38406L103SPONSORED ADS9,308,726$93.5M1.9%00.0%Unchanged–
THCTenet Healthcare CorpCOM NEW1,224,400$92.5M1.9%00.0%UnchangedHistory
EVHEvolent Health, Inc.CL A2,746,532$90.7M1.8%−149,100−5.1%ReducedHistory
UTHRUnited Therapeutics CorpCOM386,100$84.9M1.7%−15,800−3.9%ReducedHistory
XTNTXtant Medical Holdings, Inc.COM NEW73,114,592$82.6M1.7%00.0%UnchangedHistory
SYKStryker CorpStock269,000$80.6M1.6%00.0%UnchangedHistory
SRRKScholar Rock Holding CorpCOM4,245,000$79.8M1.6%+2,211,211+108.7%AddedHistory
TMOThermo Fisher Scientific Inc.Stock143,800$76.3M1.5%00.0%UnchangedHistory
VRNAVerona Pharma plcSPONSORED ADS3,777,778$75.1M1.5%00.0%UnchangedHistory
PCVXVaxcyte, Inc.COM1,153,091$72.4M1.5%+145,943+14.5%AddedHistory
THRXTheseus Pharmaceuticals, Inc.COM17,713,600$71.7M1.4%00.0%UnchangedHistory
VRTXVertex Pharmaceuticals IncStock175,200$71.3M1.4%+9,800+5.9%AddedHistory
NBIXNeurocrine Biosciences IncStock519,279$68.4M1.4%+103,379+24.9%AddedHistory
SRPTSarepta Therapeutics, Inc.COM697,500$67.3M1.3%+168,300+31.8%AddedHistory
ELVElevance Health, Inc.Stock141,500$66.7M1.3%+141,500NewHistory
THRDThird Harmonic Bio, Inc.COM5,779,071$63.4M1.3%00.0%UnchangedHistory
NTRANatera, Inc.COM954,481$59.8M1.2%+33,900+3.7%AddedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM1,667,360$59.3M1.2%−1,228,714−42.4%ReducedHistory
APLSApellis Pharmaceuticals, Inc.COM922,200$55.2M1.1%−338,300−26.8%ReducedHistory
RCMR1 RCM Inc.COM4,803,200$50.8M1.0%+1,362,200+39.6%AddedHistory
SPRYARS Pharmaceuticals, Inc.COM9,240,887$50.6M1.0%00.0%UnchangedHistory
KROSKeros Therapeutics, Inc.COM1,268,734$50.4M1.0%−246,000−16.2%ReducedHistory
HUMHumana IncStock109,900$50.3M1.0%−232,600−67.9%ReducedHistory
TERNTerns Pharmaceuticals, Inc.COM7,619,135$49.4M1.0%00.0%UnchangedHistory
ALPNAlpine Immune Sciences, Inc.COM2,535,245$48.3M1.0%−1,546,347−37.9%ReducedHistory
SIBNSI-BONE, Inc.COM2,292,531$48.1M1.0%00.0%UnchangedHistory
PRLDPrelude Therapeutics IncCOM10,909,256$46.6M0.9%00.0%UnchangedHistory
ALXOAlx Oncology Holdings IncCOM3,095,000$46.1M0.9%+224,000+7.8%AddedHistory
NPCENeuroPace IncCOM4,003,967$41.3M0.8%−8,314−0.2%ReducedHistory
IOVAIovance Biotherapeutics, Inc.COM4,707,458$38.3M0.8%00.0%UnchangedHistory
SNDXSyndax Pharmaceuticals IncCOM1,749,000$37.8M0.8%+465,000+36.2%AddedHistory
ICLRIcon PLCCOM132,200$37.4M0.7%00.0%UnchangedHistory
UNHUnitedHealth Group IncStock70,000$36.9M0.7%00.0%UnchangedHistory
0000000000Stock12,048,773$36.8M0.7%00.0%Unchanged–
AMGNAmgen IncStock127,300$36.7M0.7%00.0%UnchangedHistory
APGEApogee Therapeutics, Inc.COM1,277,901$35.7M0.7%−150,000−10.5%ReducedHistory
JANXJanux Therapeutics, Inc.COM3,317,927$35.6M0.7%00.0%UnchangedHistory
CMPXCompass Therapeutics, Inc.COM22,362,850$34.9M0.7%00.0%UnchangedHistory
SCPHscPharmaceuticals Inc.COM5,559,528$34.9M0.7%00.0%UnchangedHistory
ARGXArgenx SESPONSORED ADR84,600$32.2M0.6%+52,000+159.5%AddedHistory
FUSNFusion Pharmaceuticals Inc.COM3,122,770$30.0M0.6%00.0%UnchangedHistory
SLRNACELYRIN, Inc.COM4,001,711$29.9M0.6%−1,324,591−24.9%ReducedHistory
NMRANeumora Therapeutics, Inc.COM1,500,000$25.6M0.5%00.0%UnchangedHistory
XENEXenon Pharmaceuticals Inc.COM550,000$25.3M0.5%−408,793−42.6%ReducedHistory
RYTMRhythm Pharmaceuticals, Inc.COM536,642$24.7M0.5%−47,000−8.1%ReducedHistory
RPTXRepare Therapeutics Inc.COM3,322,488$24.3M0.5%00.0%UnchangedHistory
ABCLAbCellera Biologics Inc.COM4,180,768$23.9M0.5%00.0%UnchangedHistory
VERAVera Therapeutics, Inc.CL A1,518,115$23.3M0.5%00.0%UnchangedHistory
PMVPPMV Pharmaceuticals, Inc.COM6,475,291$20.1M0.4%−87,786−1.3%ReducedHistory
KNTEKinnate Biopharma Inc.COM8,009,729$19.0M0.4%00.0%UnchangedHistory
TELATELA Bio, Inc.COM2,835,542$18.8M0.4%00.0%UnchangedHistory
JBIOJade Biosciences, Inc.COM756,930$17.1M0.3%00.0%UnchangedHistory
IVVDInvivyd, Inc.COM4,127,565$16.3M0.3%−1,142,835−21.7%ReducedHistory
IMTXImmatics N.V.SHS1,543,407$16.3M0.3%+493,207+47.0%AddedHistory
ACETAdicet Bio, Inc.COM8,322,140$15.7M0.3%00.0%UnchangedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM79,400$15.2M0.3%+79,400NewHistory
KRYSKrystal Biotech, Inc.COM103,700$12.9M0.3%+103,700NewHistory
VSTMVerastem, Inc.COM NEW1,529,115$12.4M0.2%00.0%UnchangedHistory
CRVSCorvus Pharmaceuticals, Inc.COM6,943,654$12.2M0.2%00.0%UnchangedHistory
REGNRegeneron Pharmaceuticals, Inc.COM13,500$11.9M0.2%00.0%UnchangedHistory
FOLDAmicus Therapeutics, Inc.COM806,000$11.4M0.2%+806,000NewHistory
PASGPassage BIO, Inc.COM10,124,576$10.2M0.2%00.0%UnchangedHistory
HRTXHeron Therapeutics, Inc.COM5,928,591$10.1M0.2%+5,125,891+638.6%AddedHistory
ARWRArrowhead Pharmaceuticals, Inc.COM319,651$9.78M0.2%−114,000−26.3%ReducedHistory
QUREuniQure N.V.SHS1,347,900$9.13M0.2%−716,555−34.7%ReducedHistory
DXCMDexcom IncCOM73,200$9.08M0.2%+73,200NewHistory
APLMApollomics Inc.CL A SHS8,565,456$8.27M0.2%−9,428,179−52.4%ReducedHistory
GILDGilead Sciences, Inc.Stock100,000$8.10M0.2%00.0%UnchangedHistory
MORFMorphic Holding, Inc.COM273,400$7.90M0.2%+64,900+31.1%AddedHistory
TSBXTurnstone Biologics Corp.COM3,099,265$7.89M0.2%00.0%UnchangedHistory
RAPTRAPT Therapeutics, Inc.COM281,413$6.99M0.1%−963,532−77.4%ReducedHistory
IMAImageneBio, Inc.COM3,539,358$6.97M0.1%+353,192+11.1%AddedHistory
NSPRInspireMD, Inc.COM2,133,405$5.99M0.1%+273,000+14.7%AddedHistory
XFORX4 Pharmaceuticals, IncCOM7,133,515$5.98M0.1%00.0%UnchangedHistory
CGEMCullinan Therapeutics, Inc.COM544,848$5.55M0.1%00.0%UnchangedHistory
ORICOric Pharmaceuticals, Inc.COM522,968$4.81M0.1%−370,700−41.5%ReducedHistory
ILMNIllumina, Inc.COM30,300$4.22M0.1%+30,300NewHistory
AMAMAmbrx Biopharma, Inc.COM296,000$4.22M0.1%+296,000NewHistory
NXTCNextCure, Inc.COM2,711,013$3.09M0.1%00.0%UnchangedHistory
CLDXCelldex Therapeutics, Inc.COM NEW58,800$2.33M<0.1%+58,800NewHistory
RCUSArcus Biosciences, Inc.COM117,000$2.23M<0.1%+117,000NewHistory
TXG10x Genomics, Inc.CL A COM39,800$2.23M<0.1%+39,800NewHistory
FATEFate Therapeutics IncCOM528,080$1.98M<0.1%+528,080NewHistory
KZRKezar Life Sciences, Inc.COM1,927,000$1.83M<0.1%−3,536,000−64.7%ReducedHistory
BOLTBolt Biotherapeutics, Inc.COM1,541,000$1.73M<0.1%00.0%UnchangedHistory
Ys Biopharma Co LtdG9845F109ORDINARY SHARES3,236,311$1.65M<0.1%−1,305,111−28.7%Reduced–
VIGLVigil Neuroscience, Inc.COM448,891$1.52M<0.1%00.0%UnchangedHistory

Options (1)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of OrbiMed Advisors LLC in Q4 2023
SecurityClassPutsCalls
PFEPfizer IncStock–$14.4M

Sold out since Q3 2023 (25)

Positions held at the end of Q3 2023 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q3 2023
SecurityClassShares in Q3 2023Value in Q3 2023% of portfolio in Q3 2023History
MRTXMirati Therapeutics, Inc.COM1,959,050$85.3M2.0%History
BAXBaxter International IncStock2,239,900$84.5M2.0%History
CICigna GroupStock231,500$66.2M1.5%History
ABBVAbbVie Inc.Stock330,000$49.2M1.1%History
MDGLMadrigal Pharmaceuticals, Inc.COM253,309$37.0M0.9%History
HZNPHorizon Therapeutics Public Ltd CoSHS266,400$30.8M0.7%History
AKROAkero Therapeutics, Inc.COM350,000$17.7M0.4%History
VTYXVentyx Biosciences, Inc.COM340,384$11.8M0.3%History
ARQTArcutis Biotherapeutics, Inc.COM1,914,479$10.2M0.2%History
SGENSeagen Inc.COM42,600$9.04M0.2%History
GDRXGoodRx Holdings, Inc.COM CL A1,595,000$8.98M0.2%History
MLTXMoonLake ImmunotherapeuticsCLASS A ORD117,000$6.67M0.2%History
KVUEKenvue Inc.Stock312,404$6.27M0.1%History
RLAYRelay Therapeutics, Inc.COM501,966$4.22M0.1%History
CUTRCutera IncCOM603,100$3.63M0.1%History
EPIXESSA Pharma Inc.COM NEW842,366$2.60M0.1%History
KRTXKaruna Therapeutics, Inc.COM14,000$2.37M0.1%History
TDOCTeladoc Health, Inc.COM110,000$2.04M<0.1%History
BCABBioAtla, Inc.COM1,009,279$1.72M<0.1%History
TARAProtara Therapeutics, Inc.COM STK772,584$1.29M<0.1%History
SYBXSynlogic, Inc.COM NEW401,998$1.13M<0.1%History
DMRADamora Therapeutics, Inc.COM924,788$665.4K<0.1%History
XNCRXencor IncCOM19,142$385.7K<0.1%History
ALTAltimmune, Inc.COM NEW100,000$260.0K<0.1%History
HARPHarpoon Therapeutics, Inc.COM NEW62,121$250.3K<0.1%History