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Livermore
Livermore
ZHEN

OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q4 2023

Holdings as of Dec 31, 2023, filed Feb 14, 2024. Long positions only; changes compare share counts with Q3 2023.

Institution overview
Positions
109
−11 vs. Q3 2023
Portfolio value
$4.99B
+$671.3M (+15.5%) vs. Q3 2023
Filed
Feb 14, 2024
SEC
Holdings of OrbiMed Advisors LLC in Q4 2023
SecurityClassSharesValue% of portfolioShare changeActionHistory
OMICSingular Genomics Systems, Inc.COM540,697$248.8K<0.1%00.0%UnchangedHistory
AFIBAcutus Medical, Inc.COM2,648,386$534.7K<0.1%00.0%UnchangedHistory
ELEVElevation Acquisition Group Inc.COM1,500,000$805.5K<0.1%00.0%UnchangedHistory
CALCCalciMedica, Inc.COM NEW297,380$850.5K<0.1%00.0%UnchangedHistory
AGIOAgios Pharmaceuticals, Inc.COM45,000$1.00M<0.1%+45,000NewHistory
VIRVir Biotechnology, Inc.COM101,000$1.02M<0.1%+101,000NewHistory
GERNGeron CorpCOM485,000$1.02M<0.1%+485,000NewHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS2,241,274$1.14M<0.1%00.0%UnchangedHistory
HLSQTessera Defense & Homeland Security Inc.COM4,517,589$1.26M<0.1%−35,900−0.8%ReducedHistory
VIGLVigil Neuroscience, Inc.COM448,891$1.52M<0.1%00.0%UnchangedHistory
Ys Biopharma Co LtdG9845F109ORDINARY SHARES3,236,311$1.65M<0.1%−1,305,111−28.7%Reduced–
BOLTBolt Biotherapeutics, Inc.COM1,541,000$1.73M<0.1%00.0%UnchangedHistory
KZRKezar Life Sciences, Inc.COM1,927,000$1.83M<0.1%−3,536,000−64.7%ReducedHistory
FATEFate Therapeutics IncCOM528,080$1.98M<0.1%+528,080NewHistory
TXG10x Genomics, Inc.CL A COM39,800$2.23M<0.1%+39,800NewHistory
RCUSArcus Biosciences, Inc.COM117,000$2.23M<0.1%+117,000NewHistory
CLDXCelldex Therapeutics, Inc.COM NEW58,800$2.33M<0.1%+58,800NewHistory
NXTCNextCure, Inc.COM2,711,013$3.09M0.1%00.0%UnchangedHistory
AMAMAmbrx Biopharma, Inc.COM296,000$4.22M0.1%+296,000NewHistory
ILMNIllumina, Inc.COM30,300$4.22M0.1%+30,300NewHistory
ORICOric Pharmaceuticals, Inc.COM522,968$4.81M0.1%−370,700−41.5%ReducedHistory
CGEMCullinan Therapeutics, Inc.COM544,848$5.55M0.1%00.0%UnchangedHistory
XFORX4 Pharmaceuticals, IncCOM7,133,515$5.98M0.1%00.0%UnchangedHistory
NSPRInspireMD, Inc.COM2,133,405$5.99M0.1%+273,000+14.7%AddedHistory
IMAImageneBio, Inc.COM3,539,358$6.97M0.1%+353,192+11.1%AddedHistory
RAPTRAPT Therapeutics, Inc.COM281,413$6.99M0.1%−963,532−77.4%ReducedHistory
TSBXTurnstone Biologics Corp.COM3,099,265$7.89M0.2%00.0%UnchangedHistory
MORFMorphic Holding, Inc.COM273,400$7.90M0.2%+64,900+31.1%AddedHistory
GILDGilead Sciences, Inc.Stock100,000$8.10M0.2%00.0%UnchangedHistory
APLMApollomics Inc.CL A SHS8,565,456$8.27M0.2%−9,428,179−52.4%ReducedHistory
DXCMDexcom IncCOM73,200$9.08M0.2%+73,200NewHistory
QUREuniQure N.V.SHS1,347,900$9.13M0.2%−716,555−34.7%ReducedHistory
ARWRArrowhead Pharmaceuticals, Inc.COM319,651$9.78M0.2%−114,000−26.3%ReducedHistory
HRTXHeron Therapeutics, Inc.COM5,928,591$10.1M0.2%+5,125,891+638.6%AddedHistory
PASGPassage BIO, Inc.COM10,124,576$10.2M0.2%00.0%UnchangedHistory
FOLDAmicus Therapeutics, Inc.COM806,000$11.4M0.2%+806,000NewHistory
REGNRegeneron Pharmaceuticals, Inc.COM13,500$11.9M0.2%00.0%UnchangedHistory
CRVSCorvus Pharmaceuticals, Inc.COM6,943,654$12.2M0.2%00.0%UnchangedHistory
VSTMVerastem, Inc.COM NEW1,529,115$12.4M0.2%00.0%UnchangedHistory
KRYSKrystal Biotech, Inc.COM103,700$12.9M0.3%+103,700NewHistory
ALNYAlnylam Pharmaceuticals, Inc.COM79,400$15.2M0.3%+79,400NewHistory
ACETAdicet Bio, Inc.COM8,322,140$15.7M0.3%00.0%UnchangedHistory
IMTXImmatics N.V.SHS1,543,407$16.3M0.3%+493,207+47.0%AddedHistory
IVVDInvivyd, Inc.COM4,127,565$16.3M0.3%−1,142,835−21.7%ReducedHistory
JBIOJade Biosciences, Inc.COM756,930$17.1M0.3%00.0%UnchangedHistory
TELATELA Bio, Inc.COM2,835,542$18.8M0.4%00.0%UnchangedHistory
KNTEKinnate Biopharma Inc.COM8,009,729$19.0M0.4%00.0%UnchangedHistory
PMVPPMV Pharmaceuticals, Inc.COM6,475,291$20.1M0.4%−87,786−1.3%ReducedHistory
VERAVera Therapeutics, Inc.CL A1,518,115$23.3M0.5%00.0%UnchangedHistory
ABCLAbCellera Biologics Inc.COM4,180,768$23.9M0.5%00.0%UnchangedHistory
RPTXRepare Therapeutics Inc.COM3,322,488$24.3M0.5%00.0%UnchangedHistory
RYTMRhythm Pharmaceuticals, Inc.COM536,642$24.7M0.5%−47,000−8.1%ReducedHistory
XENEXenon Pharmaceuticals Inc.COM550,000$25.3M0.5%−408,793−42.6%ReducedHistory
NMRANeumora Therapeutics, Inc.COM1,500,000$25.6M0.5%00.0%UnchangedHistory
SLRNACELYRIN, Inc.COM4,001,711$29.9M0.6%−1,324,591−24.9%ReducedHistory
FUSNFusion Pharmaceuticals Inc.COM3,122,770$30.0M0.6%00.0%UnchangedHistory
ARGXArgenx SESPONSORED ADR84,600$32.2M0.6%+52,000+159.5%AddedHistory
SCPHscPharmaceuticals Inc.COM5,559,528$34.9M0.7%00.0%UnchangedHistory
CMPXCompass Therapeutics, Inc.COM22,362,850$34.9M0.7%00.0%UnchangedHistory
JANXJanux Therapeutics, Inc.COM3,317,927$35.6M0.7%00.0%UnchangedHistory
APGEApogee Therapeutics, Inc.COM1,277,901$35.7M0.7%−150,000−10.5%ReducedHistory
AMGNAmgen IncStock127,300$36.7M0.7%00.0%UnchangedHistory
0000000000Stock12,048,773$36.8M0.7%00.0%Unchanged–
UNHUnitedHealth Group IncStock70,000$36.9M0.7%00.0%UnchangedHistory
ICLRIcon PLCCOM132,200$37.4M0.7%00.0%UnchangedHistory
SNDXSyndax Pharmaceuticals IncCOM1,749,000$37.8M0.8%+465,000+36.2%AddedHistory
IOVAIovance Biotherapeutics, Inc.COM4,707,458$38.3M0.8%00.0%UnchangedHistory
NPCENeuroPace IncCOM4,003,967$41.3M0.8%−8,314−0.2%ReducedHistory
ALXOAlx Oncology Holdings IncCOM3,095,000$46.1M0.9%+224,000+7.8%AddedHistory
PRLDPrelude Therapeutics IncCOM10,909,256$46.6M0.9%00.0%UnchangedHistory
SIBNSI-BONE, Inc.COM2,292,531$48.1M1.0%00.0%UnchangedHistory
ALPNAlpine Immune Sciences, Inc.COM2,535,245$48.3M1.0%−1,546,347−37.9%ReducedHistory
TERNTerns Pharmaceuticals, Inc.COM7,619,135$49.4M1.0%00.0%UnchangedHistory
HUMHumana IncStock109,900$50.3M1.0%−232,600−67.9%ReducedHistory
KROSKeros Therapeutics, Inc.COM1,268,734$50.4M1.0%−246,000−16.2%ReducedHistory
SPRYARS Pharmaceuticals, Inc.COM9,240,887$50.6M1.0%00.0%UnchangedHistory
RCMR1 RCM Inc.COM4,803,200$50.8M1.0%+1,362,200+39.6%AddedHistory
APLSApellis Pharmaceuticals, Inc.COM922,200$55.2M1.1%−338,300−26.8%ReducedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM1,667,360$59.3M1.2%−1,228,714−42.4%ReducedHistory
NTRANatera, Inc.COM954,481$59.8M1.2%+33,900+3.7%AddedHistory
THRDThird Harmonic Bio, Inc.COM5,779,071$63.4M1.3%00.0%UnchangedHistory
ELVElevance Health, Inc.Stock141,500$66.7M1.3%+141,500NewHistory
SRPTSarepta Therapeutics, Inc.COM697,500$67.3M1.3%+168,300+31.8%AddedHistory
NBIXNeurocrine Biosciences IncStock519,279$68.4M1.4%+103,379+24.9%AddedHistory
VRTXVertex Pharmaceuticals IncStock175,200$71.3M1.4%+9,800+5.9%AddedHistory
THRXTheseus Pharmaceuticals, Inc.COM17,713,600$71.7M1.4%00.0%UnchangedHistory
PCVXVaxcyte, Inc.COM1,153,091$72.4M1.5%+145,943+14.5%AddedHistory
VRNAVerona Pharma plcSPONSORED ADS3,777,778$75.1M1.5%00.0%UnchangedHistory
TMOThermo Fisher Scientific Inc.Stock143,800$76.3M1.5%00.0%UnchangedHistory
SRRKScholar Rock Holding CorpCOM4,245,000$79.8M1.6%+2,211,211+108.7%AddedHistory
SYKStryker CorpStock269,000$80.6M1.6%00.0%UnchangedHistory
XTNTXtant Medical Holdings, Inc.COM NEW73,114,592$82.6M1.7%00.0%UnchangedHistory
UTHRUnited Therapeutics CorpCOM386,100$84.9M1.7%−15,800−3.9%ReducedHistory
EVHEvolent Health, Inc.CL A2,746,532$90.7M1.8%−149,100−5.1%ReducedHistory
THCTenet Healthcare CorpCOM NEW1,224,400$92.5M1.9%00.0%UnchangedHistory
Gracell Biotechnologies Inc38406L103SPONSORED ADS9,308,726$93.5M1.9%00.0%Unchanged–
IRONDisc Medicine, Inc.COM1,702,237$98.3M2.0%−567,400−25.0%ReducedHistory
IONSIonis Pharmaceuticals IncCOM2,064,797$104.5M2.1%−104,703−4.8%ReducedHistory
MRKMerck & Co., Inc.Stock1,055,000$115.0M2.3%00.0%UnchangedHistory
SWTXSpringWorks Therapeutics, Inc.COM3,219,359$117.5M2.4%−749,229−18.9%ReducedHistory

Options (1)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of OrbiMed Advisors LLC in Q4 2023
SecurityClassPutsCalls
PFEPfizer IncStock–$14.4M

Sold out since Q3 2023 (25)

Positions held at the end of Q3 2023 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q3 2023
SecurityClassShares in Q3 2023Value in Q3 2023% of portfolio in Q3 2023History
MRTXMirati Therapeutics, Inc.COM1,959,050$85.3M2.0%History
BAXBaxter International IncStock2,239,900$84.5M2.0%History
CICigna GroupStock231,500$66.2M1.5%History
ABBVAbbVie Inc.Stock330,000$49.2M1.1%History
MDGLMadrigal Pharmaceuticals, Inc.COM253,309$37.0M0.9%History
HZNPHorizon Therapeutics Public Ltd CoSHS266,400$30.8M0.7%History
AKROAkero Therapeutics, Inc.COM350,000$17.7M0.4%History
VTYXVentyx Biosciences, Inc.COM340,384$11.8M0.3%History
ARQTArcutis Biotherapeutics, Inc.COM1,914,479$10.2M0.2%History
SGENSeagen Inc.COM42,600$9.04M0.2%History
GDRXGoodRx Holdings, Inc.COM CL A1,595,000$8.98M0.2%History
MLTXMoonLake ImmunotherapeuticsCLASS A ORD117,000$6.67M0.2%History
KVUEKenvue Inc.Stock312,404$6.27M0.1%History
RLAYRelay Therapeutics, Inc.COM501,966$4.22M0.1%History
CUTRCutera IncCOM603,100$3.63M0.1%History
EPIXESSA Pharma Inc.COM NEW842,366$2.60M0.1%History
KRTXKaruna Therapeutics, Inc.COM14,000$2.37M0.1%History
TDOCTeladoc Health, Inc.COM110,000$2.04M<0.1%History
BCABBioAtla, Inc.COM1,009,279$1.72M<0.1%History
TARAProtara Therapeutics, Inc.COM STK772,584$1.29M<0.1%History
SYBXSynlogic, Inc.COM NEW401,998$1.13M<0.1%History
DMRADamora Therapeutics, Inc.COM924,788$665.4K<0.1%History
XNCRXencor IncCOM19,142$385.7K<0.1%History
ALTAltimmune, Inc.COM NEW100,000$260.0K<0.1%History
HARPHarpoon Therapeutics, Inc.COM NEW62,121$250.3K<0.1%History