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Livermore
ZHEN

OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q4 2021

Holdings as of Dec 31, 2021, filed Feb 14, 2022. Long positions only; changes compare share counts with Q3 2021.

Institution overview
Positions
158
−9 vs. Q3 2021
Portfolio value
$7.71B
−$1.31B (−14.5%) vs. Q3 2021
Filed
Feb 14, 2022
SEC
Holdings of OrbiMed Advisors LLC in Q4 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
SWTXSpringWorks Therapeutics, Inc.COM6,028,307$373.6M4.8%00.0%UnchangedHistory
BMYBristol Myers Squibb CoStock4,339,800$270.6M3.5%−175,600−3.9%ReducedHistory
HZNPHorizon Therapeutics Public Ltd CoSHS2,500,055$269.4M3.5%−110,300−4.2%ReducedHistory
BSXBoston Scientific CorpStock5,552,300$235.9M3.1%−281,300−4.8%ReducedHistory
THRXTheseus Pharmaceuticals, Inc.COM16,838,668$213.5M2.8%+16,838,668NewHistory
EWTXEdgewise Therapeutics, Inc.COM13,944,680$213.1M2.8%00.0%UnchangedHistory
MRTXMirati Therapeutics, Inc.COM1,426,400$209.2M2.7%+53,200+3.9%AddedHistory
PMVPPMV Pharmaceuticals, Inc.COM7,330,423$169.3M2.2%00.0%UnchangedHistory
PFEPfizer IncStock2,615,400$154.4M2.0%+2,615,400NewHistory
0000000000Stock11,895,652$148.7M1.9%00.0%Unchanged–
HUMHumana IncStock318,300$147.6M1.9%−16,700−5.0%ReducedHistory
ABBVAbbVie Inc.Stock1,068,800$144.7M1.9%−351,800−24.8%ReducedHistory
VRTXVertex Pharmaceuticals IncStock658,100$144.5M1.9%−219,300−25.0%ReducedHistory
EWEdwards Lifesciences CorpStock1,076,200$139.4M1.8%−50,200−4.5%ReducedHistory
MRKMerck & Co., Inc.Stock1,779,300$136.4M1.8%−1,953,100−52.3%ReducedHistory
UNHUnitedHealth Group IncStock271,000$136.1M1.8%−118,700−30.5%ReducedHistory
ISRGIntuitive Surgical IncCOM NEW373,800$134.3M1.7%−45,000−10.7%ReducedConverted for a 3-for-1 splitHistory
NTRANatera, Inc.COM1,413,985$132.1M1.7%−158,815−10.1%ReducedHistory
ACETAdicet Bio, Inc.COM7,447,141$130.3M1.7%+214,285+3.0%AddedHistory
ARQTArcutis Biotherapeutics, Inc.COM6,073,850$126.0M1.6%00.0%UnchangedHistory
PRLDPrelude Therapeutics IncCOM10,039,691$125.0M1.6%00.0%UnchangedHistory
SYKStryker CorpStock465,300$124.4M1.6%+127,900+37.9%AddedHistory
GHGuardant Health, Inc.COM1,227,400$122.8M1.6%00.0%UnchangedHistory
IOVAIovance Biotherapeutics, Inc.COM6,337,700$121.0M1.6%−307,400−4.6%ReducedHistory
State Street SPDR S&P Biotech ETF78464A870ETF1,009,700$113.0M1.5%−56,000−5.3%Reduced–
SGENSeagen Inc.COM655,600$101.4M1.3%+387,600+144.6%AddedHistory
TPTXTurning Point Therapeutics, Inc.COM2,106,450$100.5M1.3%−254,877−10.8%ReducedHistory
HCAHCA Healthcare, Inc.COM389,500$100.1M1.3%+195,700+101.0%AddedHistory
TCDATricida, Inc.COM10,280,947$98.3M1.3%+666,667+6.9%AddedHistory
KROSKeros Therapeutics, Inc.COM1,679,417$98.3M1.3%00.0%UnchangedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM3,196,876$90.8M1.2%+200,000+6.7%AddedHistory
MGTXMeiraGTx Holdings plcCOM3,727,466$88.5M1.1%−375,459−9.2%ReducedHistory
DXCMDexcom IncCOM152,900$82.1M1.1%−75,100−32.9%ReducedHistory
NBIXNeurocrine Biosciences IncStock931,915$79.4M1.0%−260,100−21.8%ReducedHistory
BMRNBiomarin Pharmaceutical IncCOM860,880$76.1M1.0%+749,980+676.3%AddedHistory
ZBHZimmer Biomet Holdings, Inc.Stock564,300$71.7M0.9%−96,500−14.6%ReducedHistory
RPTXRepare Therapeutics Inc.COM3,322,488$70.1M0.9%00.0%UnchangedHistory
CMPXCompass Therapeutics, Inc.COM21,642,975$68.6M0.9%+21,642,975NewHistory
KNTEKinnate Biopharma Inc.COM3,847,929$68.2M0.9%00.0%UnchangedHistory
TBPHTheravance Biopharma, Inc.COM5,974,535$66.0M0.9%+79,376+1.3%AddedHistory
TMOThermo Fisher Scientific Inc.Stock94,700$63.2M0.8%−15,600−14.1%ReducedHistory
ABCLAbCellera Biologics Inc.COM4,180,768$59.8M0.8%00.0%UnchangedHistory
SPRYARS Pharmaceuticals, Inc.COM8,740,887$58.2M0.8%00.0%UnchangedHistory
ALPNAlpine Immune Sciences, Inc.COM4,081,592$56.5M0.7%00.0%UnchangedHistory
JANXJanux Therapeutics, Inc.COM2,836,386$56.0M0.7%−630,000−18.2%ReducedHistory
BIIBBiogen Inc.COM230,200$55.2M0.7%−4,000−1.7%ReducedHistory
SIBNSI-BONE, Inc.COM2,305,300$51.2M0.7%+57,300+2.5%AddedHistory
ETNB89bio, Inc.COM3,729,442$48.7M0.6%00.0%UnchangedHistory
Gracell Biotechnologies Inc38406L103SPONSORED ADS7,884,870$47.6M0.6%00.0%Unchanged–
PASGPassage BIO, Inc.COM6,962,899$44.2M0.6%00.0%UnchangedHistory
SNDXSyndax Pharmaceuticals IncCOM1,981,300$43.4M0.6%+1,790,700+939.5%AddedHistory
OSHOak Street Health, Inc.COM1,290,300$42.8M0.6%−38,000−2.9%ReducedHistory
XTNTXtant Medical Holdings, Inc.COM NEW72,873,494$40.8M0.5%00.0%UnchangedHistory
NPCENeuroPace IncCOM4,012,281$40.4M0.5%00.0%UnchangedHistory
LKFTLakefront Biotherapeutics NVSPON ADR717,257$39.5M0.5%−6,200−0.9%ReducedHistory
TELATELA Bio, Inc.COM3,027,542$38.8M0.5%00.0%UnchangedHistory
VRNAVerona Pharma plcSPONSORED ADS5,694,841$38.3M0.5%00.0%UnchangedHistory
IMAImageneBio, Inc.COM2,933,941$36.8M0.5%00.0%UnchangedHistory
SEMSelect Medical Holdings CorpCOM1,233,600$36.3M0.5%−37,500−3.0%ReducedHistory
IVVDInvivyd, Inc.COM4,983,500$36.2M0.5%−400,000−7.4%ReducedHistory
ORICOric Pharmaceuticals, Inc.COM2,337,574$34.4M0.4%00.0%UnchangedHistory
NSTGNS Wind Down Co., Inc.COM807,100$34.1M0.4%+251,100+45.2%AddedHistory
GHRSGH Research PLCORDINARY SHARES1,428,732$33.3M0.4%+660.0%AddedHistory
SRRASierra Oncology, Inc.COM NEW1,477,320$32.1M0.4%00.0%UnchangedHistory
CTKBCytek Biosciences, Inc.COM1,923,139$31.4M0.4%00.0%UnchangedHistory
IMGNImmunoGen, Inc.COM3,868,786$28.7M0.4%−11,029,128−74.0%ReducedHistory
MREOMereo BioPharma Group plcSPON ADS–$27.6M0.4%––History
TERNTerns Pharmaceuticals, Inc.COM3,791,204$26.8M0.3%00.0%UnchangedHistory
PCVXVaxcyte, Inc.COM1,096,700$26.1M0.3%+62,035+6.0%AddedHistory
ERASErasca, Inc.COM1,667,693$26.0M0.3%−499,648−23.1%ReducedHistory
EVHEvolent Health, Inc.CL A938,000$26.0M0.3%+593,000+171.9%AddedHistory
Vectivbio Hldg AGH9060V101ORD SHS5,223,804$25.6M0.3%+100,500+2.0%Added–
VTYXVentyx Biosciences, Inc.COM1,289,280$25.6M0.3%+1,289,280NewHistory
VTGNVistagen Therapeutics, Inc.COM NEW12,909,283$25.2M0.3%00.0%UnchangedHistory
THCTenet Healthcare CorpCOM NEW299,000$24.4M0.3%−12,700−4.1%ReducedHistory
OMICSingular Genomics Systems, Inc.COM2,104,359$24.3M0.3%+105,838+5.3%AddedHistory
SCPHscPharmaceuticals Inc.COM4,797,148$24.1M0.3%00.0%UnchangedHistory
JNCEJounce Therapeutics, Inc.COM2,859,900$23.9M0.3%+204,300+7.7%AddedHistory
KDNYChinook Therapeutics, Inc.COM1,418,300$23.1M0.3%−2,337−0.2%ReducedHistory
DBTXDecibel Therapeutics, Inc.COM4,945,192$23.0M0.3%00.0%UnchangedHistory
HARPHarpoon Therapeutics, Inc.COM2,903,508$21.9M0.3%+292,200+11.2%AddedHistory
GILDGilead Sciences, Inc.Stock287,600$20.9M0.3%00.0%UnchangedHistory
APLTApplied Therapeutics, Inc.COM2,313,681$20.7M0.3%+56,294+2.5%AddedHistory
XENEXenon Pharmaceuticals Inc.COM631,000$19.7M0.3%+154,000+32.3%AddedHistory
LogicBio Therapeutics, Inc.54142F102COM8,466,783$19.6M0.3%00.0%Unchanged–
LENZLENZ Therapeutics, Inc.COM1,565,812$19.5M0.3%+115,908+8.0%AddedHistory
MRSNMersana Therapeutics, Inc.COM2,888,847$18.0M0.2%00.0%UnchangedHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS2,578,174$17.8M0.2%00.0%UnchangedHistory
Danaher Corp2358514095% CONV PFD B–$17.4M0.2%–New–
CRISCuris IncCOM NEW3,634,800$17.3M0.2%+113,400+3.2%AddedHistory
ILMNIllumina, Inc.COM45,100$17.2M0.2%+45,100NewHistory
IRONDisc Medicine, Inc.COM5,826,224$17.0M0.2%00.0%UnchangedHistory
MISTMilestone Pharmaceuticals Inc.COM2,583,821$16.9M0.2%00.0%UnchangedHistory
CRVSCorvus Pharmaceuticals, Inc.COM6,943,654$16.7M0.2%00.0%UnchangedHistory
NXTCNextCure, Inc.COM2,711,013$16.3M0.2%00.0%UnchangedHistory
CLDXCelldex Therapeutics, Inc.COM NEW406,100$15.7M0.2%−8,200−2.0%ReducedHistory
RXSTRxSight, Inc.COM1,383,500$15.6M0.2%+133,500+10.7%AddedHistory
LABStandard Biotools Inc.COM3,819,348$15.0M0.2%−780,223−17.0%ReducedHistory
SYBXSynlogic, Inc.COM6,029,995$14.6M0.2%00.0%UnchangedHistory
ACRSAclaris Therapeutics, Inc.COM985,900$14.3M0.2%+334,117+51.3%AddedHistory

Sold out since Q3 2021 (23)

Positions held at the end of Q3 2021 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q3 2021
SecurityClassShares in Q3 2021Value in Q3 2021% of portfolio in Q3 2021History
ELVElevance Health, Inc.Stock207,100$77.2M0.9%History
DCPHDeciphera Pharmaceuticals, Inc.COM2,183,143$74.2M0.8%History
PGNYProgyny, Inc.COM1,270,045$71.1M0.8%History
CRSPCRISPR Therapeutics AGNAMEN AKT612,700$68.6M0.8%History
OLMAOlema Pharmaceuticals, Inc.COM807,792$22.3M0.2%History
CTICCti Biopharma CorpCOM7,520,600$22.2M0.2%History
VRCAVerrica Pharmaceuticals Inc.COM1,479,733$18.5M0.2%History
HUMAHumacyte, Inc.COM1,500,000$17.4M0.2%History
FLXNFlexion Therapeutics IncCOM2,769,383$16.9M0.2%History
DICEDICE Therapeutics, Inc.COM440,000$14.4M0.2%History
MAPSWM Technology, Inc.COM700,400$10.2M0.1%History
KZRKezar Life Sciences, Inc.COM1,150,000$9.94M0.1%History
NVAXNovavax IncCOM NEW45,580$9.45M0.1%History
KALAKALA BIO, Inc.COM3,438,998$9.01M0.1%History
CNVYConvey Health Solutions Holdings, Inc.COM1,000,000$8.40M0.1%History
REGNRegeneron Pharmaceuticals, Inc.COM13,560$8.21M0.1%History
OWLTOwlet, Inc.COMMON STOCK1,200,000$6.71M0.1%History
NBTXNanobiotix S.A.SPONSORED ADS500,000$5.68M0.1%History
APTOAptose Biosciences Inc.COM NEW2,594,348$5.66M0.1%History
PRCTPROCEPT BioRobotics CorpCOM135,000$5.15M0.1%History
RGENRepligen CorpCOM14,724$4.25M<0.1%History
SBBPStrongbridge Biopharma plcSHS USD794,675$1.62M<0.1%History
PHASPhaseBio Pharmaceuticals IncCOM177,113$551.0K<0.1%History