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Livermore
ZHEN

OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q3 2021

Holdings as of Sep 30, 2021, filed Nov 15, 2021. Long positions only; changes compare share counts with Q2 2021.

Institution overview
Positions
167
+12 vs. Q2 2021
Portfolio value
$9.01B
−$774.8M (−7.9%) vs. Q2 2021
Filed
Nov 15, 2021
SEC
Holdings of OrbiMed Advisors LLC in Q3 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
SWTXSpringWorks Therapeutics, Inc.COM6,028,307$382.4M4.2%−15,959−0.3%ReducedHistory
PRLDPrelude Therapeutics IncCOM10,039,691$313.7M3.5%00.0%UnchangedHistory
HZNPHorizon Therapeutics Public Ltd CoSHS2,610,355$285.9M3.2%−311,800−10.7%ReducedHistory
MRKMerck & Co., Inc.Stock3,732,400$280.3M3.1%00.0%UnchangedHistory
BMYBristol Myers Squibb CoStock4,515,400$267.2M3.0%00.0%UnchangedHistory
0000000000Stock11,895,652$255.9M2.8%00.0%Unchanged–
BSXBoston Scientific CorpStock5,833,600$253.1M2.8%−1,087,000−15.7%ReducedHistory
MRTXMirati Therapeutics, Inc.COM1,373,200$242.9M2.7%+109,000+8.6%AddedHistory
EWTXEdgewise Therapeutics, Inc.COM13,944,680$231.5M2.6%00.0%UnchangedHistory
IVVDInvivyd, Inc.COM5,383,500$227.4M2.5%+5,383,500NewHistory
PMVPPMV Pharmaceuticals, Inc.COM7,330,423$218.4M2.4%00.0%UnchangedHistory
NTRANatera, Inc.COM1,572,800$175.3M1.9%−485,000−23.6%ReducedHistory
IOVAIovance Biotherapeutics, Inc.COM6,645,100$163.9M1.8%00.0%UnchangedHistory
VRTXVertex Pharmaceuticals IncStock877,400$159.2M1.8%−188,000−17.6%ReducedHistory
TPTXTurning Point Therapeutics, Inc.COM2,361,327$156.9M1.7%00.0%UnchangedHistory
GHGuardant Health, Inc.COM1,227,400$153.4M1.7%00.0%UnchangedHistory
ABBVAbbVie Inc.Stock1,420,600$153.2M1.7%+253,100+21.7%AddedHistory
UNHUnitedHealth Group IncStock389,700$152.3M1.7%00.0%UnchangedHistory
ARQTArcutis Biotherapeutics, Inc.COM6,073,850$145.1M1.6%00.0%UnchangedHistory
ISRGIntuitive Surgical IncCOM NEW139,600$138.8M1.5%00.0%UnchangedHistory
State Street SPDR S&P Biotech ETF78464A870ETF1,065,700$134.0M1.5%+130,000+13.9%Added–
HUMHumana IncStock335,000$130.4M1.4%00.0%UnchangedHistory
EWEdwards Lifesciences CorpStock1,126,400$127.5M1.4%00.0%UnchangedHistory
DXCMDexcom IncCOM228,000$124.7M1.4%−69,400−23.3%ReducedHistory
NBIXNeurocrine Biosciences IncStock1,192,015$114.3M1.3%−39,100−3.2%ReducedHistory
Gracell Biotechnologies Inc38406L103SPONSORED ADS7,884,870$109.4M1.2%00.0%Unchanged–
ZBHZimmer Biomet Holdings, Inc.Stock660,800$96.7M1.1%+660,800NewHistory
SYKStryker CorpStock337,400$89.0M1.0%00.0%UnchangedHistory
KNTEKinnate Biopharma Inc.COM3,847,929$88.6M1.0%00.0%UnchangedHistory
SPRYARS Pharmaceuticals, Inc.COM8,740,887$87.2M1.0%00.0%UnchangedHistory
RPTXRepare Therapeutics Inc.COM3,322,488$87.2M1.0%−103,837−3.0%ReducedHistory
IMGNImmunoGen, Inc.COM14,897,914$84.5M0.9%+1,961,292+15.2%AddedHistory
ABCLAbCellera Biologics Inc.COM4,180,768$83.8M0.9%−2,042,251−32.8%ReducedHistory
XTNTXtant Medical Holdings, Inc.COM NEW72,873,494$80.9M0.9%00.0%UnchangedHistory
ELVElevance Health, Inc.Stock207,100$77.2M0.9%−128,600−38.3%ReducedHistory
JANXJanux Therapeutics, Inc.COM3,466,386$75.0M0.8%00.0%UnchangedHistory
DCPHDeciphera Pharmaceuticals, Inc.COM2,183,143$74.2M0.8%−1,114,158−33.8%ReducedHistory
ETNB89bio, Inc.COM3,729,442$73.1M0.8%00.0%UnchangedHistory
PGNYProgyny, Inc.COM1,270,045$71.1M0.8%−95,400−7.0%ReducedHistory
PASGPassage BIO, Inc.COM6,962,899$69.3M0.8%00.0%UnchangedHistory
CRSPCRISPR Therapeutics AGNAMEN AKT612,700$68.6M0.8%+93,700+18.1%AddedHistory
KROSKeros Therapeutics, Inc.COM1,679,417$66.4M0.7%00.0%UnchangedHistory
BIIBBiogen Inc.COM234,200$66.3M0.7%+166,800+247.5%AddedHistory
NPCENeuroPace IncCOM4,012,281$63.6M0.7%00.0%UnchangedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM2,996,876$63.1M0.7%00.0%UnchangedHistory
TMOThermo Fisher Scientific Inc.Stock110,300$63.0M0.7%00.0%UnchangedHistory
ACETAdicet Bio, Inc.COM7,232,856$56.7M0.6%00.0%UnchangedHistory
OSHOak Street Health, Inc.COM1,328,300$56.5M0.6%00.0%UnchangedHistory
MGTXMeiraGTx Holdings plcCOM4,102,925$54.1M0.6%00.0%UnchangedHistory
ORICOric Pharmaceuticals, Inc.COM2,337,574$48.9M0.5%00.0%UnchangedHistory
SIBNSI-BONE, Inc.COM2,248,000$48.2M0.5%+942,700+72.2%AddedHistory
HCAHCA Healthcare, Inc.COM193,800$47.0M0.5%+193,800NewHistory
ERASErasca, Inc.COM2,167,341$46.0M0.5%+2,167,341NewHistory
SEMSelect Medical Holdings CorpCOM1,271,100$46.0M0.5%00.0%UnchangedHistory
SGENSeagen Inc.COM268,000$45.5M0.5%+268,000NewHistory
TCDATricida, Inc.COM9,614,280$44.6M0.5%00.0%UnchangedHistory
TBPHTheravance Biopharma, Inc.COM5,895,159$43.6M0.5%+1,331,114+29.2%AddedHistory
ALPNAlpine Immune Sciences, Inc.COM4,081,592$43.6M0.5%+1,010,637+32.9%AddedHistory
MREOMereo BioPharma Group plcSPON ADS17,264,764$41.8M0.5%––History
TELATELA Bio, Inc.COM3,027,542$41.4M0.5%00.0%UnchangedHistory
CTKBCytek Biosciences, Inc.COM1,923,139$41.2M0.5%+1,923,139NewHistory
Vectivbio Hldg AGH9060V101ORD SHS5,123,304$39.6M0.4%00.0%Unchanged–
TERNTerns Pharmaceuticals, Inc.COM3,791,204$39.5M0.4%00.0%UnchangedHistory
LogicBio Therapeutics, Inc.54142F102COM8,466,783$38.8M0.4%00.0%Unchanged–
DBTXDecibel Therapeutics, Inc.COM4,945,192$38.1M0.4%00.0%UnchangedHistory
LKFTLakefront Biotherapeutics NVSPON ADR723,457$38.1M0.4%+492,552+213.3%AddedHistory
APLTApplied Therapeutics, Inc.COM2,257,387$37.5M0.4%00.0%UnchangedHistory
IMAImageneBio, Inc.COM2,933,941$37.0M0.4%00.0%UnchangedHistory
VTGNVistagen Therapeutics, Inc.COM NEW12,909,283$35.4M0.4%−1,558,589−10.8%ReducedHistory
CRVSCorvus Pharmaceuticals, Inc.COM6,943,654$33.6M0.4%−1,109,644−13.8%ReducedHistory
BNRBurning Rock Biotech LtdSPONSORED ADS1,856,201$33.2M0.4%00.0%UnchangedHistory
SRRASierra Oncology, Inc.COM NEW1,477,320$32.4M0.4%00.0%UnchangedHistory
SYRESpyre Therapeutics, Inc.COM4,015,524$31.9M0.4%00.0%UnchangedHistory
SCPHscPharmaceuticals Inc.COM4,797,148$31.9M0.4%00.0%UnchangedHistory
GHRSGH Research PLCORDINARY SHARES1,428,666$31.5M0.3%00.0%UnchangedHistory
VRNAVerona Pharma plcSPONSORED ADS5,694,841$31.2M0.3%00.0%UnchangedHistory
LABStandard Biotools Inc.COM4,599,571$30.3M0.3%−62,300−1.3%ReducedHistory
Cybin Ord23256X100COM13,447,121$29.5M0.3%+13,447,121New–
CMMBChemomab Therapeutics Ltd.SPONSORED ADS2,578,174$28.6M0.3%00.0%UnchangedHistory
CRISCuris IncCOM NEW3,521,400$27.6M0.3%00.0%UnchangedHistory
MRSNMersana Therapeutics, Inc.COM2,888,847$27.2M0.3%+88,600+3.2%AddedHistory
NSTGNS Wind Down Co., Inc.COM556,000$26.7M0.3%00.0%UnchangedHistory
PCVXVaxcyte, Inc.COM1,034,665$26.2M0.3%+89,265+9.4%AddedHistory
CGEMCullinan Therapeutics, Inc.COM1,146,145$25.9M0.3%00.0%UnchangedHistory
FUSNFusion Pharmaceuticals Inc.COM3,224,770$25.5M0.3%00.0%UnchangedHistory
LENZLENZ Therapeutics, Inc.COM1,449,904$23.8M0.3%+343,597+31.1%AddedHistory
IRONDisc Medicine, Inc.COM5,826,224$23.5M0.3%00.0%UnchangedHistory
AFIBAcutus Medical, Inc.COM2,648,386$23.4M0.3%−2,829,572−51.7%ReducedHistory
CLDXCelldex Therapeutics, Inc.COM NEW414,300$22.4M0.2%+414,300NewHistory
OMICSingular Genomics Systems, Inc.COM1,998,521$22.4M0.2%00.0%UnchangedHistory
OLMAOlema Pharmaceuticals, Inc.COM807,792$22.3M0.2%00.0%UnchangedHistory
CTICCti Biopharma CorpCOM7,520,600$22.2M0.2%00.0%UnchangedHistory
THCTenet Healthcare CorpCOM NEW311,700$20.7M0.2%+311,700NewHistory
HARPHarpoon Therapeutics, Inc.COM2,611,308$20.6M0.2%00.0%UnchangedHistory
GILDGilead Sciences, Inc.Stock287,600$20.1M0.2%00.0%UnchangedHistory
JNCEJounce Therapeutics, Inc.COM2,655,600$19.7M0.2%+508,200+23.7%AddedHistory
QUREuniQure N.V.SHS585,574$18.7M0.2%+114,400+24.3%AddedHistory
VRCAVerrica Pharmaceuticals Inc.COM1,479,733$18.5M0.2%00.0%UnchangedHistory
SYBXSynlogic, Inc.COM6,029,995$18.4M0.2%+2,333,333+63.1%AddedHistory
NXTCNextCure, Inc.COM2,711,013$18.3M0.2%00.0%UnchangedHistory

Options (5)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of OrbiMed Advisors LLC in Q3 2021
SecurityClassPutsCalls
EVHEvolent Health, Inc.CL A–$7.75M
KZRKezar Life Sciences, Inc.COM–$980.0K
WM Technology, Inc.92971A117*W EXP 06/16/202–$649.0K
AZNAstraZeneca PLCSPONSORED ADR–$312.0K
Owlet, Inc.69120X115EQUITY WRT–$207.0K

Sold out since Q2 2021 (14)

Positions held at the end of Q2 2021 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q2 2021
SecurityClassShares in Q2 2021Value in Q2 2021% of portfolio in Q2 2021History
AUPHAurinia Pharmaceuticals Inc.COM6,069,032$78.7M0.8%History
ASNDAscendis Pharma A/SSPONSORED ADR447,859$58.9M0.6%History
Trillium Therapeutics Inc.89620X506COM NEW3,322,300$32.2M0.3%–
ARCTArcturus Therapeutics Holdings Inc.COM848,503$28.7M0.3%History
ALXNAlexion Pharmaceuticals, Inc.COM150,900$27.7M0.3%History
RLAYRelay Therapeutics, Inc.COM350,000$12.8M0.1%History
ALECAlector, Inc.COM611,478$12.7M0.1%History
STROSutro Biopharma, Inc.COM433,700$8.06M0.1%History
GLUEMonte Rosa Therapeutics, Inc.COM350,000$7.95M0.1%History
DYNDyne Therapeutics, Inc.COM350,000$7.36M0.1%History
OTICOtonomy, Inc.COM3,250,000$7.25M0.1%History
VERVVerve Therapeutics, Inc.COM100,000$6.03M0.1%History
OGNOrganon & Co.Stock166,939$5.05M0.1%History
PPBTPurple Biotech Ltd.SPONSORED ADS17,712$86.0K<0.1%History