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Livermore
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OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q3 2021

Holdings as of Sep 30, 2021, filed Nov 15, 2021. Long positions only; changes compare share counts with Q2 2021.

Institution overview
Positions
167
+12 vs. Q2 2021
Portfolio value
$9.01B
−$774.8M (−7.9%) vs. Q2 2021
Filed
Nov 15, 2021
SEC
Holdings of OrbiMed Advisors LLC in Q3 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
APTXAptinyx Inc.COM153,285$359.0K<0.1%+153,285NewHistory
PHASPhaseBio Pharmaceuticals IncCOM177,113$551.0K<0.1%+177,113NewHistory
LBPHLongboard Pharmaceuticals, Inc.COM113,500$1.00M<0.1%00.0%UnchangedHistory
SBBPStrongbridge Biopharma plcSHS USD794,675$1.62M<0.1%−949,994−54.5%ReducedHistory
IFRXInflaRx N.V.COM1,064,118$2.76M<0.1%00.0%UnchangedHistory
TARAProtara Therapeutics, Inc.COM STK450,000$3.11M<0.1%00.0%UnchangedHistory
TRMLTourmaline Bio, Inc.COM247,240$3.35M<0.1%00.0%UnchangedHistory
INZYInozyme Pharma, Inc.COM294,000$3.41M<0.1%+105,296+55.8%AddedHistory
Aslan Pharmaceuticals Ltd04522R101ADS1,970,000$3.51M<0.1%−550,000−21.8%Reduced–
SNDXSyndax Pharmaceuticals IncCOM190,600$3.64M<0.1%+190,600NewHistory
CABACabaletta Bio, Inc.COM302,509$3.68M<0.1%+302,509NewHistory
ADAGAdagene Inc.ADS275,000$3.95M<0.1%00.0%UnchangedHistory
LABPLandos Biopharma, Inc.COM283,217$4.13M<0.1%−397,783−58.4%ReducedHistory
RGENRepligen CorpCOM14,724$4.25M<0.1%+14,724NewHistory
SGHTSight Sciences, Inc.COM200,000$4.54M0.1%+200,000NewHistory
OBIOOrchestra BioMed Holdings, Inc.ORD SHS500,000$4.95M0.1%00.0%UnchangedHistory
PRCTPROCEPT BioRobotics CorpCOM135,000$5.15M0.1%+135,000NewHistory
APTOAptose Biosciences Inc.COM NEW2,594,348$5.66M0.1%−5,435,652−67.7%ReducedHistory
NBTXNanobiotix S.A.SPONSORED ADS500,000$5.68M0.1%00.0%UnchangedHistory
RXDXPrometheus Biosciences, Inc.COM250,000$5.93M0.1%00.0%UnchangedHistory
SRPTSarepta Therapeutics, Inc.COM64,700$5.98M0.1%00.0%UnchangedHistory
OWLTOwlet, Inc.COMMON STOCK1,200,000$6.71M0.1%+1,200,000NewHistory
SURFSurface Oncology, Inc.COM909,666$6.89M0.1%+909,666NewHistory
Field Trip Health Ord31656R102COM1,538,470$7.00M0.1%+1,538,470New–
NTLAIntellia Therapeutics, Inc.COM53,200$7.14M0.1%+53,200NewHistory
XFORX4 Pharmaceuticals, IncCOM1,373,849$7.27M0.1%00.0%UnchangedHistory
XENEXenon Pharmaceuticals Inc.COM477,000$7.29M0.1%−857,217−64.2%ReducedHistory
Nanostring Technologies Inc63009RAD1NOTE 2.625% 5/0–$7.86M0.1%–––
NBPNovaBridge BiosciencesSPONSORED ADS111,120$8.05M0.1%00.0%UnchangedHistory
REGNRegeneron Pharmaceuticals, Inc.COM13,560$8.21M0.1%+13,560NewHistory
SYRSSyros Pharmaceuticals, Inc.COM1,837,500$8.21M0.1%00.0%UnchangedHistory
CNVYConvey Health Solutions Holdings, Inc.COM1,000,000$8.40M0.1%00.0%UnchangedHistory
BMRNBiomarin Pharmaceutical IncCOM110,900$8.57M0.1%+110,900NewHistory
HLSQTessera Defense & Homeland Security Inc.COM2,813,489$8.61M0.1%+500,000+21.6%AddedHistory
NAUTNautilus Biotechnology, Inc.COM1,452,774$8.92M0.1%−93,926−6.1%ReducedHistory
KALAKALA BIO, Inc.COM3,438,998$9.01M0.1%−2,026,032−37.1%ReducedHistory
CTMXCytomX Therapeutics, Inc.COM1,821,868$9.27M0.1%+308,700+20.4%AddedHistory
NVAXNovavax IncCOM NEW45,580$9.45M0.1%−154,715−77.2%ReducedHistory
KZRKezar Life Sciences, Inc.COM1,150,000$9.94M0.1%+592,809+106.4%AddedHistory
MAPSWM Technology, Inc.COM700,400$10.2M0.1%00.0%UnchangedHistory
IMDXInsight Molecular Diagnostics Inc.COM2,856,000$10.2M0.1%+756,000+36.0%AddedHistory
WHWKWhitehawk Therapeutics, Inc.COM346,262$10.2M0.1%00.0%UnchangedConverted for a 1-for-15 splitHistory
IPSCCentury Therapeutics, Inc.COM407,047$10.2M0.1%00.0%UnchangedHistory
EVHEvolent Health, Inc.CL A345,000$10.7M0.1%+345,000NewHistory
ALXOAlx Oncology Holdings IncCOM150,000$11.1M0.1%00.0%UnchangedHistory
NMTR9 Meters Biopharma, Inc.COM8,565,974$11.1M0.1%00.0%UnchangedHistory
GYREGyre Therapeutics, Inc.COM NEW2,711,600$11.1M0.1%+593,000+28.0%AddedHistory
JBIOJade Biosciences, Inc.COM535,714$11.2M0.1%00.0%UnchangedHistory
ACRSAclaris Therapeutics, Inc.COM651,783$11.7M0.1%+289,783+80.1%AddedHistory
AMGNAmgen IncStock57,100$12.1M0.1%00.0%UnchangedHistory
Achilles Therapeutics PLC00449L102SPONSORED ADS1,584,845$12.3M0.1%00.0%Unchanged–
VORVor Biopharma Inc.COM833,333$13.1M0.1%00.0%UnchangedHistory
CVRXCVRx, Inc.COM799,861$13.2M0.1%+399,861+100.0%AddedHistory
DNTHDianthus Therapeutics, Inc.COM1,892,953$13.8M0.2%−140,806−6.9%ReducedHistory
CALCCalciMedica, Inc.COM SHS4,163,347$13.8M0.2%00.0%UnchangedHistory
DICEDICE Therapeutics, Inc.COM440,000$14.4M0.2%+440,000NewHistory
DMRADamora Therapeutics, Inc.COM4,090,937$14.7M0.2%00.0%UnchangedHistory
MISTMilestone Pharmaceuticals Inc.COM2,583,821$14.8M0.2%00.0%UnchangedHistory
Bellus Health Inc New07987C204COM NEW2,454,800$15.0M0.2%−1,500,000−37.9%Reduced–
LUNGPulmonx CorpCOM435,000$15.7M0.2%+310,000+248.0%AddedHistory
RXSTRxSight, Inc.COM1,250,000$15.8M0.2%+1,250,000NewHistory
FLXNFlexion Therapeutics IncCOM2,769,383$16.9M0.2%00.0%UnchangedHistory
NRIXNurix Therapeutics, Inc.COM578,583$17.3M0.2%+278,583+92.9%AddedHistory
HUMAHumacyte, Inc.COM1,500,000$17.4M0.2%+1,500,000NewHistory
ELVNEnliven Therapeutics, Inc.COM4,386,568$17.9M0.2%+1,666,666+61.3%AddedHistory
KDNYChinook Therapeutics, Inc.COM1,420,637$18.1M0.2%+86,836+6.5%AddedHistory
NXTCNextCure, Inc.COM2,711,013$18.3M0.2%00.0%UnchangedHistory
SYBXSynlogic, Inc.COM6,029,995$18.4M0.2%+2,333,333+63.1%AddedHistory
VRCAVerrica Pharmaceuticals Inc.COM1,479,733$18.5M0.2%00.0%UnchangedHistory
QUREuniQure N.V.SHS585,574$18.7M0.2%+114,400+24.3%AddedHistory
JNCEJounce Therapeutics, Inc.COM2,655,600$19.7M0.2%+508,200+23.7%AddedHistory
GILDGilead Sciences, Inc.Stock287,600$20.1M0.2%00.0%UnchangedHistory
HARPHarpoon Therapeutics, Inc.COM2,611,308$20.6M0.2%00.0%UnchangedHistory
THCTenet Healthcare CorpCOM NEW311,700$20.7M0.2%+311,700NewHistory
CTICCti Biopharma CorpCOM7,520,600$22.2M0.2%00.0%UnchangedHistory
OLMAOlema Pharmaceuticals, Inc.COM807,792$22.3M0.2%00.0%UnchangedHistory
OMICSingular Genomics Systems, Inc.COM1,998,521$22.4M0.2%00.0%UnchangedHistory
CLDXCelldex Therapeutics, Inc.COM NEW414,300$22.4M0.2%+414,300NewHistory
AFIBAcutus Medical, Inc.COM2,648,386$23.4M0.3%−2,829,572−51.7%ReducedHistory
IRONDisc Medicine, Inc.COM5,826,224$23.5M0.3%00.0%UnchangedHistory
LENZLENZ Therapeutics, Inc.COM1,449,904$23.8M0.3%+343,597+31.1%AddedHistory
FUSNFusion Pharmaceuticals Inc.COM3,224,770$25.5M0.3%00.0%UnchangedHistory
CGEMCullinan Therapeutics, Inc.COM1,146,145$25.9M0.3%00.0%UnchangedHistory
PCVXVaxcyte, Inc.COM1,034,665$26.2M0.3%+89,265+9.4%AddedHistory
NSTGNS Wind Down Co., Inc.COM556,000$26.7M0.3%00.0%UnchangedHistory
MRSNMersana Therapeutics, Inc.COM2,888,847$27.2M0.3%+88,600+3.2%AddedHistory
CRISCuris IncCOM NEW3,521,400$27.6M0.3%00.0%UnchangedHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS2,578,174$28.6M0.3%00.0%UnchangedHistory
Cybin Ord23256X100COM13,447,121$29.5M0.3%+13,447,121New–
LABStandard Biotools Inc.COM4,599,571$30.3M0.3%−62,300−1.3%ReducedHistory
VRNAVerona Pharma plcSPONSORED ADS5,694,841$31.2M0.3%00.0%UnchangedHistory
GHRSGH Research PLCORDINARY SHARES1,428,666$31.5M0.3%00.0%UnchangedHistory
SCPHscPharmaceuticals Inc.COM4,797,148$31.9M0.4%00.0%UnchangedHistory
SYRESpyre Therapeutics, Inc.COM4,015,524$31.9M0.4%00.0%UnchangedHistory
SRRASierra Oncology, Inc.COM NEW1,477,320$32.4M0.4%00.0%UnchangedHistory
BNRBurning Rock Biotech LtdSPONSORED ADS1,856,201$33.2M0.4%00.0%UnchangedHistory
CRVSCorvus Pharmaceuticals, Inc.COM6,943,654$33.6M0.4%−1,109,644−13.8%ReducedHistory
VTGNVistagen Therapeutics, Inc.COM NEW12,909,283$35.4M0.4%−1,558,589−10.8%ReducedHistory
IMAImageneBio, Inc.COM2,933,941$37.0M0.4%00.0%UnchangedHistory
APLTApplied Therapeutics, Inc.COM2,257,387$37.5M0.4%00.0%UnchangedHistory

Options (5)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of OrbiMed Advisors LLC in Q3 2021
SecurityClassPutsCalls
EVHEvolent Health, Inc.CL A–$7.75M
KZRKezar Life Sciences, Inc.COM–$980.0K
WM Technology, Inc.92971A117*W EXP 06/16/202–$649.0K
AZNAstraZeneca PLCSPONSORED ADR–$312.0K
Owlet, Inc.69120X115EQUITY WRT–$207.0K

Sold out since Q2 2021 (14)

Positions held at the end of Q2 2021 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q2 2021
SecurityClassShares in Q2 2021Value in Q2 2021% of portfolio in Q2 2021History
AUPHAurinia Pharmaceuticals Inc.COM6,069,032$78.7M0.8%History
ASNDAscendis Pharma A/SSPONSORED ADR447,859$58.9M0.6%History
Trillium Therapeutics Inc.89620X506COM NEW3,322,300$32.2M0.3%–
ARCTArcturus Therapeutics Holdings Inc.COM848,503$28.7M0.3%History
ALXNAlexion Pharmaceuticals, Inc.COM150,900$27.7M0.3%History
RLAYRelay Therapeutics, Inc.COM350,000$12.8M0.1%History
ALECAlector, Inc.COM611,478$12.7M0.1%History
STROSutro Biopharma, Inc.COM433,700$8.06M0.1%History
GLUEMonte Rosa Therapeutics, Inc.COM350,000$7.95M0.1%History
DYNDyne Therapeutics, Inc.COM350,000$7.36M0.1%History
OTICOtonomy, Inc.COM3,250,000$7.25M0.1%History
VERVVerve Therapeutics, Inc.COM100,000$6.03M0.1%History
OGNOrganon & Co.Stock166,939$5.05M0.1%History
PPBTPurple Biotech Ltd.SPONSORED ADS17,712$86.0K<0.1%History