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Livermore
ZHEN

OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q4 2021

Holdings as of Dec 31, 2021, filed Feb 14, 2022. Long positions only; changes compare share counts with Q3 2021.

Institution overview
Positions
158
−9 vs. Q3 2021
Portfolio value
$7.71B
−$1.31B (−14.5%) vs. Q3 2021
Filed
Feb 14, 2022
SEC
Holdings of OrbiMed Advisors LLC in Q4 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
Owlet, Inc.69120X115EQUITY WRT220,704$86.0K<0.1%+220,704New–
AUGXAugmedix, Inc.COM88,363$278.0K<0.1%+88,363NewHistory
LBPHLongboard Pharmaceuticals, Inc.COM113,500$554.0K<0.1%00.0%UnchangedHistory
CABACabaletta Bio, Inc.COM302,509$1.15M<0.1%00.0%UnchangedHistory
LABPLandos Biopharma, Inc.COM283,217$1.36M<0.1%00.0%UnchangedHistory
PYXSPyxis Oncology, Inc.COMMON STOCK143,640$1.58M<0.1%+143,640NewHistory
GYREGyre Therapeutics, Inc.COM NEW1,729,402$1.58M<0.1%−982,198−36.2%ReducedHistory
APTXAptinyx Inc.COM749,500$2.00M<0.1%+596,215+389.0%AddedHistory
ADAGAdagene Inc.ADS263,176$2.12M<0.1%−11,824−4.3%ReducedHistory
DRUGBright Minds Biosciences Inc.COM660,600$2.13M<0.1%+660,600NewHistory
Aslan Pharmaceuticals Ltd04522R101ADS1,970,000$2.21M<0.1%00.0%Unchanged–
SURFSurface Oncology, Inc.COM467,945$2.24M<0.1%−441,721−48.6%ReducedHistory
Exscientia PLC30223G102ADS125,000$2.47M<0.1%+125,000New–
WHWKWhitehawk Therapeutics, Inc.COM127,600$3.08M<0.1%−218,662−63.1%ReducedHistory
XFORX4 Pharmaceuticals, IncCOM1,373,849$3.15M<0.1%00.0%UnchangedHistory
SGHTSight Sciences, Inc.COM200,000$3.51M<0.1%00.0%UnchangedHistory
INZYInozyme Pharma, Inc.COM526,600$3.59M<0.1%+232,600+79.1%AddedHistory
Field Trip Health Ord31656R102COM1,538,470$3.72M<0.1%00.0%Unchanged–
TRMLTourmaline Bio, Inc.COM247,240$3.78M<0.1%00.0%UnchangedHistory
IFRXInflaRx N.V.COM875,297$4.17M0.1%−188,821−17.7%ReducedHistory
ALXOAlx Oncology Holdings IncCOM207,600$4.46M0.1%+57,600+38.4%AddedHistory
HLSQTessera Defense & Homeland Security Inc.COM2,813,489$4.50M0.1%00.0%UnchangedHistory
IPSCCentury Therapeutics, Inc.COM307,047$4.87M0.1%−100,000−24.6%ReducedHistory
OBIOOrchestra BioMed Holdings, Inc.ORD SHS500,000$5.04M0.1%00.0%UnchangedHistory
NBPNovaBridge BiosciencesSPONSORED ADS111,120$5.27M0.1%00.0%UnchangedHistory
SRPTSarepta Therapeutics, Inc.COM58,700$5.29M0.1%−6,000−9.3%ReducedHistory
NRIXNurix Therapeutics, Inc.COM184,468$5.34M0.1%−394,115−68.1%ReducedHistory
TARAProtara Therapeutics, Inc.COM STK830,641$5.61M0.1%+380,641+84.6%AddedHistory
SYRSSyros Pharmaceuticals, Inc.COM1,837,500$5.99M0.1%00.0%UnchangedHistory
NTLAIntellia Therapeutics, Inc.COM53,200$6.29M0.1%00.0%UnchangedHistory
JBIOJade Biosciences, Inc.COM535,714$6.32M0.1%00.0%UnchangedHistory
Nanostring Technologies Inc63009RAD1NOTE 2.625% 5/0–$7.17M0.1%–––
NAUTNautilus Biotechnology, Inc.COM1,452,774$7.53M0.1%00.0%UnchangedHistory
IMDXInsight Molecular Diagnostics Inc.COM3,493,800$7.58M0.1%+637,800+22.3%AddedHistory
CALCCalciMedica, Inc.COM SHS4,163,347$7.62M0.1%00.0%UnchangedHistory
GOSSGossamer Bio, Inc.COM683,000$7.72M0.1%+683,000NewHistory
Achilles Therapeutics PLC00449L102SPONSORED ADS1,584,845$7.94M0.1%00.0%Unchanged–
RAPTRAPT Therapeutics, Inc.COM217,000$7.97M0.1%+217,000NewHistory
CVRXCVRx, Inc.COM723,055$8.84M0.1%−76,806−9.6%ReducedHistory
AFIBAcutus Medical, Inc.COM2,648,386$9.03M0.1%00.0%UnchangedHistory
VORVor Biopharma Inc.COM833,333$9.68M0.1%00.0%UnchangedHistory
ELVNEnliven Therapeutics, Inc.COM4,386,568$9.87M0.1%00.0%UnchangedHistory
RXDXPrometheus Biosciences, Inc.COM250,000$9.88M0.1%00.0%UnchangedHistory
DNTHDianthus Therapeutics, Inc.COM2,250,953$9.97M0.1%+358,000+18.9%AddedHistory
NMTR9 Meters Biopharma, Inc.COM10,275,887$10.1M0.1%+1,709,913+20.0%AddedHistory
SONXSonendo, Inc.COM1,968,180$11.3M0.1%+1,968,180NewHistory
Bellus Health Inc New07987C204COM NEW1,454,800$11.7M0.2%−1,000,000−40.7%Reduced–
QUREuniQure N.V.SHS585,574$12.1M0.2%00.0%UnchangedHistory
DMRADamora Therapeutics, Inc.COM4,090,937$12.4M0.2%00.0%UnchangedHistory
CGEMCullinan Therapeutics, Inc.COM805,041$12.4M0.2%−341,104−29.8%ReducedHistory
Cybin Ord23256X100COM10,524,300$12.5M0.2%−2,922,821−21.7%Reduced–
AMGNAmgen IncStock57,100$12.8M0.2%00.0%UnchangedHistory
FUSNFusion Pharmaceuticals Inc.COM3,224,770$13.4M0.2%00.0%UnchangedHistory
BNRBurning Rock Biotech LtdSPONSORED ADS1,452,402$13.8M0.2%−403,799−21.8%ReducedHistory
CTMXCytomX Therapeutics, Inc.COM3,214,509$13.9M0.2%+1,392,641+76.4%AddedHistory
LUNGPulmonx CorpCOM435,000$13.9M0.2%00.0%UnchangedHistory
SYRESpyre Therapeutics, Inc.COM2,956,124$14.0M0.2%−1,059,400−26.4%ReducedHistory
ACRSAclaris Therapeutics, Inc.COM985,900$14.3M0.2%+334,117+51.3%AddedHistory
SYBXSynlogic, Inc.COM6,029,995$14.6M0.2%00.0%UnchangedHistory
LABStandard Biotools Inc.COM3,819,348$15.0M0.2%−780,223−17.0%ReducedHistory
RXSTRxSight, Inc.COM1,383,500$15.6M0.2%+133,500+10.7%AddedHistory
CLDXCelldex Therapeutics, Inc.COM NEW406,100$15.7M0.2%−8,200−2.0%ReducedHistory
NXTCNextCure, Inc.COM2,711,013$16.3M0.2%00.0%UnchangedHistory
CRVSCorvus Pharmaceuticals, Inc.COM6,943,654$16.7M0.2%00.0%UnchangedHistory
MISTMilestone Pharmaceuticals Inc.COM2,583,821$16.9M0.2%00.0%UnchangedHistory
IRONDisc Medicine, Inc.COM5,826,224$17.0M0.2%00.0%UnchangedHistory
ILMNIllumina, Inc.COM45,100$17.2M0.2%+45,100NewHistory
CRISCuris IncCOM NEW3,634,800$17.3M0.2%+113,400+3.2%AddedHistory
Danaher Corp2358514095% CONV PFD B–$17.4M0.2%–New–
CMMBChemomab Therapeutics Ltd.SPONSORED ADS2,578,174$17.8M0.2%00.0%UnchangedHistory
MRSNMersana Therapeutics, Inc.COM2,888,847$18.0M0.2%00.0%UnchangedHistory
LENZLENZ Therapeutics, Inc.COM1,565,812$19.5M0.3%+115,908+8.0%AddedHistory
LogicBio Therapeutics, Inc.54142F102COM8,466,783$19.6M0.3%00.0%Unchanged–
XENEXenon Pharmaceuticals Inc.COM631,000$19.7M0.3%+154,000+32.3%AddedHistory
APLTApplied Therapeutics, Inc.COM2,313,681$20.7M0.3%+56,294+2.5%AddedHistory
GILDGilead Sciences, Inc.Stock287,600$20.9M0.3%00.0%UnchangedHistory
HARPHarpoon Therapeutics, Inc.COM2,903,508$21.9M0.3%+292,200+11.2%AddedHistory
DBTXDecibel Therapeutics, Inc.COM4,945,192$23.0M0.3%00.0%UnchangedHistory
KDNYChinook Therapeutics, Inc.COM1,418,300$23.1M0.3%−2,337−0.2%ReducedHistory
JNCEJounce Therapeutics, Inc.COM2,859,900$23.9M0.3%+204,300+7.7%AddedHistory
SCPHscPharmaceuticals Inc.COM4,797,148$24.1M0.3%00.0%UnchangedHistory
OMICSingular Genomics Systems, Inc.COM2,104,359$24.3M0.3%+105,838+5.3%AddedHistory
THCTenet Healthcare CorpCOM NEW299,000$24.4M0.3%−12,700−4.1%ReducedHistory
VTGNVistagen Therapeutics, Inc.COM NEW12,909,283$25.2M0.3%00.0%UnchangedHistory
VTYXVentyx Biosciences, Inc.COM1,289,280$25.6M0.3%+1,289,280NewHistory
Vectivbio Hldg AGH9060V101ORD SHS5,223,804$25.6M0.3%+100,500+2.0%Added–
EVHEvolent Health, Inc.CL A938,000$26.0M0.3%+593,000+171.9%AddedHistory
ERASErasca, Inc.COM1,667,693$26.0M0.3%−499,648−23.1%ReducedHistory
PCVXVaxcyte, Inc.COM1,096,700$26.1M0.3%+62,035+6.0%AddedHistory
TERNTerns Pharmaceuticals, Inc.COM3,791,204$26.8M0.3%00.0%UnchangedHistory
MREOMereo BioPharma Group plcSPON ADS–$27.6M0.4%––History
IMGNImmunoGen, Inc.COM3,868,786$28.7M0.4%−11,029,128−74.0%ReducedHistory
CTKBCytek Biosciences, Inc.COM1,923,139$31.4M0.4%00.0%UnchangedHistory
SRRASierra Oncology, Inc.COM NEW1,477,320$32.1M0.4%00.0%UnchangedHistory
GHRSGH Research PLCORDINARY SHARES1,428,732$33.3M0.4%+660.0%AddedHistory
NSTGNS Wind Down Co., Inc.COM807,100$34.1M0.4%+251,100+45.2%AddedHistory
ORICOric Pharmaceuticals, Inc.COM2,337,574$34.4M0.4%00.0%UnchangedHistory
IVVDInvivyd, Inc.COM4,983,500$36.2M0.5%−400,000−7.4%ReducedHistory
SEMSelect Medical Holdings CorpCOM1,233,600$36.3M0.5%−37,500−3.0%ReducedHistory
IMAImageneBio, Inc.COM2,933,941$36.8M0.5%00.0%UnchangedHistory

Sold out since Q3 2021 (23)

Positions held at the end of Q3 2021 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q3 2021
SecurityClassShares in Q3 2021Value in Q3 2021% of portfolio in Q3 2021History
ELVElevance Health, Inc.Stock207,100$77.2M0.9%History
DCPHDeciphera Pharmaceuticals, Inc.COM2,183,143$74.2M0.8%History
PGNYProgyny, Inc.COM1,270,045$71.1M0.8%History
CRSPCRISPR Therapeutics AGNAMEN AKT612,700$68.6M0.8%History
OLMAOlema Pharmaceuticals, Inc.COM807,792$22.3M0.2%History
CTICCti Biopharma CorpCOM7,520,600$22.2M0.2%History
VRCAVerrica Pharmaceuticals Inc.COM1,479,733$18.5M0.2%History
HUMAHumacyte, Inc.COM1,500,000$17.4M0.2%History
FLXNFlexion Therapeutics IncCOM2,769,383$16.9M0.2%History
DICEDICE Therapeutics, Inc.COM440,000$14.4M0.2%History
MAPSWM Technology, Inc.COM700,400$10.2M0.1%History
KZRKezar Life Sciences, Inc.COM1,150,000$9.94M0.1%History
NVAXNovavax IncCOM NEW45,580$9.45M0.1%History
KALAKALA BIO, Inc.COM3,438,998$9.01M0.1%History
CNVYConvey Health Solutions Holdings, Inc.COM1,000,000$8.40M0.1%History
REGNRegeneron Pharmaceuticals, Inc.COM13,560$8.21M0.1%History
OWLTOwlet, Inc.COMMON STOCK1,200,000$6.71M0.1%History
NBTXNanobiotix S.A.SPONSORED ADS500,000$5.68M0.1%History
APTOAptose Biosciences Inc.COM NEW2,594,348$5.66M0.1%History
PRCTPROCEPT BioRobotics CorpCOM135,000$5.15M0.1%History
RGENRepligen CorpCOM14,724$4.25M<0.1%History
SBBPStrongbridge Biopharma plcSHS USD794,675$1.62M<0.1%History
PHASPhaseBio Pharmaceuticals IncCOM177,113$551.0K<0.1%History