OrbiMed Advisors LLC

SEC CIK: 0001055951
Latest filing: Aug 14, 2026

SEC filings (opens in a new tab)

Holdings in Q3 2021

Holdings as of Sep 30, 2021, filed Nov 15, 2021. Long positions only; changes compare share counts with Q2 2021.

Positions: 167; +12 vs. Q2 2021
Portfolio value: $9.01B; −$774.8M (−7.9%) vs. Q2 2021
Filed: Nov 15, 2021; SEC

Holdings of OrbiMed Advisors LLC in Q3 2021
Security	Class	Shares	Value	% of portfolio	Share change	Action	History
LKFTLakefront Biotherapeutics NV	SPON ADR	723,457	$38.1M	0.4%	+492,552+213.3%	Added	History
DBTXDecibel Therapeutics, Inc.	COM	4,945,192	$38.1M	0.4%	00.0%	Unchanged	History
LogicBio Therapeutics, Inc.54142F102	COM	8,466,783	$38.8M	0.4%	00.0%	Unchanged	–
TERNTerns Pharmaceuticals, Inc.	COM	3,791,204	$39.5M	0.4%	00.0%	Unchanged	History
Vectivbio Hldg AGH9060V101	ORD SHS	5,123,304	$39.6M	0.4%	00.0%	Unchanged	–
CTKBCytek Biosciences, Inc.	COM	1,923,139	$41.2M	0.5%	+1,923,139	New	History
TELATELA Bio, Inc.	COM	3,027,542	$41.4M	0.5%	00.0%	Unchanged	History
MREOMereo BioPharma Group plc	SPON ADS	17,264,764	$41.8M	0.5%	–	–	History
ALPNAlpine Immune Sciences, Inc.	COM	4,081,592	$43.6M	0.5%	+1,010,637+32.9%	Added	History
TBPHTheravance Biopharma, Inc.	COM	5,895,159	$43.6M	0.5%	+1,331,114+29.2%	Added	History
TCDATricida, Inc.	COM	9,614,280	$44.6M	0.5%	00.0%	Unchanged	History
SGENSeagen Inc.	COM	268,000	$45.5M	0.5%	+268,000	New	History
SEMSelect Medical Holdings Corp	COM	1,271,100	$46.0M	0.5%	00.0%	Unchanged	History
ERASErasca, Inc.	COM	2,167,341	$46.0M	0.5%	+2,167,341	New	History
HCAHCA Healthcare, Inc.	COM	193,800	$47.0M	0.5%	+193,800	New	History
SIBNSI-BONE, Inc.	COM	2,248,000	$48.2M	0.5%	+942,700+72.2%	Added	History
ORICOric Pharmaceuticals, Inc.	COM	2,337,574	$48.9M	0.5%	00.0%	Unchanged	History
MGTXMeiraGTx Holdings plc	COM	4,102,925	$54.1M	0.6%	00.0%	Unchanged	History
OSHOak Street Health, Inc.	COM	1,328,300	$56.5M	0.6%	00.0%	Unchanged	History
ACETAdicet Bio, Inc.	COM	7,232,856	$56.7M	0.6%	00.0%	Unchanged	History
TMOThermo Fisher Scientific Inc.	Stock	110,300	$63.0M	0.7%	00.0%	Unchanged	History
CRNXCrinetics Pharmaceuticals, Inc.	COM	2,996,876	$63.1M	0.7%	00.0%	Unchanged	History
NPCENeuroPace Inc	COM	4,012,281	$63.6M	0.7%	00.0%	Unchanged	History
BIIBBiogen Inc.	COM	234,200	$66.3M	0.7%	+166,800+247.5%	Added	History
KROSKeros Therapeutics, Inc.	COM	1,679,417	$66.4M	0.7%	00.0%	Unchanged	History
CRSPCRISPR Therapeutics AG	NAMEN AKT	612,700	$68.6M	0.8%	+93,700+18.1%	Added	History
PASGPassage BIO, Inc.	COM	6,962,899	$69.3M	0.8%	00.0%	Unchanged	History
PGNYProgyny, Inc.	COM	1,270,045	$71.1M	0.8%	−95,400−7.0%	Reduced	History
ETNB89bio, Inc.	COM	3,729,442	$73.1M	0.8%	00.0%	Unchanged	History
DCPHDeciphera Pharmaceuticals, Inc.	COM	2,183,143	$74.2M	0.8%	−1,114,158−33.8%	Reduced	History
JANXJanux Therapeutics, Inc.	COM	3,466,386	$75.0M	0.8%	00.0%	Unchanged	History
ELVElevance Health, Inc.	Stock	207,100	$77.2M	0.9%	−128,600−38.3%	Reduced	History
XTNTXtant Medical Holdings, Inc.	COM NEW	72,873,494	$80.9M	0.9%	00.0%	Unchanged	History
ABCLAbCellera Biologics Inc.	COM	4,180,768	$83.8M	0.9%	−2,042,251−32.8%	Reduced	History
IMGNImmunoGen, Inc.	COM	14,897,914	$84.5M	0.9%	+1,961,292+15.2%	Added	History
RPTXRepare Therapeutics Inc.	COM	3,322,488	$87.2M	1.0%	−103,837−3.0%	Reduced	History
SPRYARS Pharmaceuticals, Inc.	COM	8,740,887	$87.2M	1.0%	00.0%	Unchanged	History
KNTEKinnate Biopharma Inc.	COM	3,847,929	$88.6M	1.0%	00.0%	Unchanged	History
SYKStryker Corp	Stock	337,400	$89.0M	1.0%	00.0%	Unchanged	History
ZBHZimmer Biomet Holdings, Inc.	Stock	660,800	$96.7M	1.1%	+660,800	New	History
Gracell Biotechnologies Inc38406L103	SPONSORED ADS	7,884,870	$109.4M	1.2%	00.0%	Unchanged	–
NBIXNeurocrine Biosciences Inc	Stock	1,192,015	$114.3M	1.3%	−39,100−3.2%	Reduced	History
DXCMDexcom Inc	COM	228,000	$124.7M	1.4%	−69,400−23.3%	Reduced	History
EWEdwards Lifesciences Corp	Stock	1,126,400	$127.5M	1.4%	00.0%	Unchanged	History
HUMHumana Inc	Stock	335,000	$130.4M	1.4%	00.0%	Unchanged	History
State Street SPDR S&P Biotech ETF78464A870	ETF	1,065,700	$134.0M	1.5%	+130,000+13.9%	Added	–
ISRGIntuitive Surgical Inc	COM NEW	139,600	$138.8M	1.5%	00.0%	Unchanged	History
ARQTArcutis Biotherapeutics, Inc.	COM	6,073,850	$145.1M	1.6%	00.0%	Unchanged	History
UNHUnitedHealth Group Inc	Stock	389,700	$152.3M	1.7%	00.0%	Unchanged	History
ABBVAbbVie Inc.	Stock	1,420,600	$153.2M	1.7%	+253,100+21.7%	Added	History
GHGuardant Health, Inc.	COM	1,227,400	$153.4M	1.7%	00.0%	Unchanged	History
TPTXTurning Point Therapeutics, Inc.	COM	2,361,327	$156.9M	1.7%	00.0%	Unchanged	History
VRTXVertex Pharmaceuticals Inc	Stock	877,400	$159.2M	1.8%	−188,000−17.6%	Reduced	History
IOVAIovance Biotherapeutics, Inc.	COM	6,645,100	$163.9M	1.8%	00.0%	Unchanged	History
NTRANatera, Inc.	COM	1,572,800	$175.3M	1.9%	−485,000−23.6%	Reduced	History
PMVPPMV Pharmaceuticals, Inc.	COM	7,330,423	$218.4M	2.4%	00.0%	Unchanged	History
IVVDInvivyd, Inc.	COM	5,383,500	$227.4M	2.5%	+5,383,500	New	History
EWTXEdgewise Therapeutics, Inc.	COM	13,944,680	$231.5M	2.6%	00.0%	Unchanged	History
MRTXMirati Therapeutics, Inc.	COM	1,373,200	$242.9M	2.7%	+109,000+8.6%	Added	History
BSXBoston Scientific Corp	Stock	5,833,600	$253.1M	2.8%	−1,087,000−15.7%	Reduced	History
0000000000	Stock	11,895,652	$255.9M	2.8%	00.0%	Unchanged	–
BMYBristol Myers Squibb Co	Stock	4,515,400	$267.2M	3.0%	00.0%	Unchanged	History
MRKMerck & Co., Inc.	Stock	3,732,400	$280.3M	3.1%	00.0%	Unchanged	History
HZNPHorizon Therapeutics Public Ltd Co	SHS	2,610,355	$285.9M	3.2%	−311,800−10.7%	Reduced	History
PRLDPrelude Therapeutics Inc	COM	10,039,691	$313.7M	3.5%	00.0%	Unchanged	History
SWTXSpringWorks Therapeutics, Inc.	COM	6,028,307	$382.4M	4.2%	−15,959−0.3%	Reduced	History
SVASinovac Biotech Ltd	SHS	2,839,500	–	–	00.0%	Unchanged	History

Options (5)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of OrbiMed Advisors LLC in Q3 2021
Security	Class	Puts	Calls
EVHEvolent Health, Inc.	CL A	–	$7.75M
KZRKezar Life Sciences, Inc.	COM	–	$980.0K
WM Technology, Inc.92971A117	*W EXP 06/16/202	–	$649.0K
AZNAstraZeneca PLC	SPONSORED ADR	–	$312.0K
Owlet, Inc.69120X115	EQUITY WRT	–	$207.0K

Sold out since Q2 2021 (14)

Positions held at the end of Q2 2021 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q2 2021
Security	Class	Shares in Q2 2021	Value in Q2 2021	% of portfolio in Q2 2021	History
AUPHAurinia Pharmaceuticals Inc.	COM	6,069,032	$78.7M	0.8%	History
ASNDAscendis Pharma A/S	SPONSORED ADR	447,859	$58.9M	0.6%	History
Trillium Therapeutics Inc.89620X506	COM NEW	3,322,300	$32.2M	0.3%	–
ARCTArcturus Therapeutics Holdings Inc.	COM	848,503	$28.7M	0.3%	History
ALXNAlexion Pharmaceuticals, Inc.	COM	150,900	$27.7M	0.3%	History
RLAYRelay Therapeutics, Inc.	COM	350,000	$12.8M	0.1%	History
ALECAlector, Inc.	COM	611,478	$12.7M	0.1%	History
STROSutro Biopharma, Inc.	COM	433,700	$8.06M	0.1%	History
GLUEMonte Rosa Therapeutics, Inc.	COM	350,000	$7.95M	0.1%	History
DYNDyne Therapeutics, Inc.	COM	350,000	$7.36M	0.1%	History
OTICOtonomy, Inc.	COM	3,250,000	$7.25M	0.1%	History
VERVVerve Therapeutics, Inc.	COM	100,000	$6.03M	0.1%	History
OGNOrganon & Co.	Stock	166,939	$5.05M	0.1%	History
PPBTPurple Biotech Ltd.	SPONSORED ADS	17,712	$86.0K	<0.1%	History