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Artal Group S.A.

SEC CIK
0001053906
Latest filing
Aug 13, 2026

Holdings in Q3 2022

Holdings as of Sep 30, 2022, filed Nov 14, 2022. Long positions only; changes compare share counts with Q2 2022.

Institution overview
Positions
130
−2 vs. Q2 2022
Portfolio value
$1.92B
+$117.7M (+6.5%) vs. Q2 2022
Filed
Nov 14, 2022
SEC
Holdings of Artal Group S.A. in Q3 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
LXRXLexicon Pharmaceuticals, Inc.COM NEW89,778,234$215.5M11.2%+18,599,870+26.1%AddedHistory
MRTXMirati Therapeutics, Inc.COM1,325,000$92.5M4.8%+225,000+20.5%AddedHistory
ONCBeOne Medicines Ltd.ADR650,000$87.6M4.6%00.0%UnchangedHistory
APLSApellis Pharmaceuticals, Inc.COM1,000,000$68.3M3.6%+1,000,000NewHistory
Bellus Health Inc New07987C204COM NEW6,000,000$63.4M3.3%−1,000,000−14.3%Reduced–
MORFMorphic Holding, Inc.COM2,150,000$60.8M3.2%+500,000+30.3%AddedHistory
SRRKScholar Rock Holding CorpCOM8,750,034$60.6M3.2%00.0%UnchangedHistory
SWTXSpringWorks Therapeutics, Inc.COM2,053,403$58.6M3.1%+1,153,403+128.2%AddedHistory
FATEFate Therapeutics IncCOM2,600,000$58.3M3.0%00.0%UnchangedHistory
WWWW International, Inc.COM14,818,300$58.2M3.0%00.0%UnchangedHistory
CERECerevel Therapeutics Holdings, Inc.COM2,000,000$56.5M2.9%+500,000+33.3%AddedHistory
IGMSIGM Biosciences, Inc.COM2,450,000$55.7M2.9%+450,000+22.5%AddedHistory
ARGXArgenx SESPONSORED ADR150,000$53.0M2.8%−250,000−62.5%ReducedHistory
CYTKCytokinetics IncCOM NEW1,000,000$48.5M2.5%−275,000−21.6%ReducedHistory
SGENSeagen Inc.COM350,000$47.9M2.5%−175,000−33.3%ReducedHistory
KLRSKalaris Therapeutics, Inc.COM5,577,167$44.0M2.3%+3,253,796+140.0%AddedHistory
FOLDAmicus Therapeutics, Inc.COM4,000,000$41.8M2.2%00.0%UnchangedHistory
GOSSGossamer Bio, Inc.COM3,246,624$38.9M2.0%+887,656+37.6%AddedHistory
SEERSeer, Inc.COM CL A4,750,000$36.8M1.9%00.0%UnchangedHistory
KRYSKrystal Biotech, Inc.COM500,000$34.9M1.8%00.0%UnchangedHistory
KYMRKymera Therapeutics, Inc.COM1,500,000$32.7M1.7%+500,000+50.0%AddedHistory
RLAYRelay Therapeutics, Inc.COM1,454,716$32.5M1.7%+754,716+107.8%AddedHistory
SAGESage Therapeutics, Inc.COM750,000$29.4M1.5%+300,000+66.7%AddedHistory
KRTXKaruna Therapeutics, Inc.COM125,000$28.1M1.5%+125,000NewHistory
ERASErasca, Inc.COM3,172,221$24.7M1.3%00.0%UnchangedHistory
VIGLVigil Neuroscience, Inc.COM2,285,574$20.8M1.1%+1,164,383+103.9%AddedHistory
EQRXEQRx, Inc.COM4,000,000$19.8M1.0%00.0%UnchangedHistory
DNLIDenali Therapeutics Inc.COM600,000$18.4M1.0%00.0%UnchangedHistory
SDGRSchrodinger, Inc.COM700,000$17.5M0.9%00.0%UnchangedHistory
REPLReplimune Group, Inc.COM900,000$15.5M0.8%00.0%UnchangedHistory
NTLAIntellia Therapeutics, Inc.COM275,000$15.4M0.8%00.0%UnchangedHistory
KURAKura Oncology, Inc.COM1,100,000$15.0M0.8%+50,000+4.8%AddedHistory
GBIOGeneration Bio Co.COM2,814,191$14.9M0.8%00.0%UnchangedHistory
MRSNMersana Therapeutics, Inc.COM2,200,000$14.9M0.8%00.0%UnchangedHistory
FHTXFoghorn Therapeutics Inc.COM1,720,720$14.8M0.8%00.0%UnchangedHistory
VERVVerve Therapeutics, Inc.COM400,000$13.7M0.7%00.0%UnchangedHistory
ISEEIVERIC bio, Inc.COM750,000$13.5M0.7%+750,000NewHistory
OMGAOmega Therapeutics, Inc.COMMON STOCK2,273,530$12.3M0.6%00.0%UnchangedHistory
WVEWave Life Sciences, Inc.SHS3,000,000$10.8M0.6%00.0%UnchangedHistory
EVOEvotec SESPONSORED ADS1,149,425$10.1M0.5%00.0%UnchangedHistory
SESea LtdSPONSORD ADS172,500$9.67M0.5%+115,000+200.0%AddedHistory
SYRSSyros Pharmaceuticals, Inc.COM NEW1,463,829$9.43M0.5%+1,063,829+266.0%AddedConverted for a 1-for-10 splitHistory
ALPNAlpine Immune Sciences, Inc.COM1,193,030$8.59M0.4%+600,000+101.2%AddedHistory
RPTXRepare Therapeutics Inc.COM700,000$8.49M0.4%00.0%UnchangedHistory
AGENAgenus IncCOM NEW4,000,000$8.20M0.4%+1,000,000+33.3%AddedHistory
RNACCartesian Therapeutics, Inc.COM4,883,200$8.01M0.4%00.0%UnchangedHistory
ITOSiTeos Therapeutics, Inc.COM400,000$7.62M0.4%00.0%UnchangedHistory
AUPHAurinia Pharmaceuticals Inc.COM1,000,000$7.52M0.4%00.0%UnchangedHistory
Omega Alpha SpacG6749V107CL A750,000$7.45M0.4%00.0%Unchanged–
DYNDyne Therapeutics, Inc.COM525,000$6.67M0.3%00.0%UnchangedHistory
YMABY-mAbs Therapeutics, Inc.COM400,000$5.77M0.3%00.0%UnchangedHistory
IMAImageneBio, Inc.COM1,549,513$5.50M0.3%00.0%UnchangedHistory
TRMLTourmaline Bio, Inc.COM2,064,262$5.43M0.3%00.0%UnchangedHistory
KRONKronos Bio, Inc.COM1,542,954$5.17M0.3%00.0%UnchangedHistory
LYELLyell Immunopharma, Inc.COM700,000$5.13M0.3%00.0%UnchangedHistory
Achilles Therapeutics PLC00449L102SPONSORED ADS2,255,375$5.10M0.3%00.0%Unchanged–
RXRXRecursion Pharmaceuticals, Inc.CL A450,000$4.79M0.2%00.0%UnchangedHistory
ALXOAlx Oncology Holdings IncCOM500,000$4.79M0.2%00.0%UnchangedHistory
OVIDOvid Therapeutics Inc.COM2,500,000$4.60M0.2%00.0%UnchangedHistory
Exscientia PLC30223G102ADS550,000$4.52M0.2%00.0%Unchanged–
NTRANatera, Inc.COM100,000$4.38M0.2%+100,000NewHistory
Avidity Biosciences, Inc.05370A108COM250,000$4.08M0.2%00.0%Unchanged–
OTLYOatly Group ABSPONSORED ADS1,500,000$3.94M0.2%00.0%UnchangedHistory
CNCEConcert Pharmaceuticals, Inc.COM573,062$3.84M0.2%+573,062NewHistory
THRDThird Harmonic Bio, Inc.COM200,000$3.79M0.2%+200,000NewHistory
MIRMirion Technologies, Inc.COM CL A500,000$3.73M0.2%00.0%UnchangedHistory
PFTAPerception Capital Corp. IIICLASS A ORD SHS380,000$3.71M0.2%00.0%UnchangedHistory
SQZSQZ Biotechnologies CoCOM1,606,309$3.66M0.2%00.0%UnchangedHistory
NBTXNanobiotix S.A.SPONSORED ADS1,000,000$3.54M0.2%00.0%UnchangedHistory
CYPHCypherpunk Technologies Inc.COM4,000,000$3.52M0.2%00.0%UnchangedHistory
NBPNovaBridge BiosciencesSPONSORED ADS850,000$3.41M0.2%00.0%UnchangedHistory
STOKStoke Therapeutics, Inc.COM250,000$3.21M0.2%00.0%UnchangedHistory
CGEMCullinan Therapeutics, Inc.COM250,000$3.21M0.2%00.0%UnchangedHistory
ACIUAC Immune SASHS1,000,000$3.16M0.2%00.0%UnchangedHistory
BDTXBlack Diamond Therapeutics, Inc.COM1,646,517$2.78M0.1%00.0%UnchangedHistory
ZYMEZymeworks Inc.COM450,000$2.77M0.1%00.0%UnchangedHistory
PRAXPraxis Precision Medicines, Inc.COM1,200,000$2.72M0.1%00.0%UnchangedHistory
BBIOBridgeBio Pharma, Inc.COM250,000$2.48M0.1%00.0%UnchangedHistory
HOOKHOOKIPA Pharma Inc.COM1,849,616$2.48M0.1%00.0%UnchangedHistory
SANASana Biotechnology, Inc.COM400,000$2.40M0.1%00.0%UnchangedHistory
KRSAKorsana Biosciences, Inc.COM2,779,122$2.39M0.1%00.0%UnchangedHistory
AMAMAmbrx Biopharma Cayman, Inc.SPONSORED ADS2,152,291$2.32M0.1%00.0%UnchangedHistory
NERVMinerva Neurosciences, Inc.COM NEW250,000$2.31M0.1%+250,000NewHistory
SNTISenti Biosciences Holdings, Inc.COM1,055,555$2.29M0.1%00.0%UnchangedHistory
FUSNFusion Pharmaceuticals Inc.COM750,000$2.26M0.1%00.0%UnchangedHistory
APTXAptinyx Inc.COM6,116,493$2.25M0.1%00.0%UnchangedHistory
LENZLENZ Therapeutics, Inc.COM700,000$2.22M0.1%00.0%UnchangedHistory
IMUXImmunic, Inc.COM700,000$2.21M0.1%00.0%UnchangedHistory
VORVor Biopharma Inc.COM550,000$2.19M0.1%00.0%UnchangedHistory
TILInstil Bio, Inc.COM450,000$2.18M0.1%00.0%UnchangedHistory
TSHATaysha Gene Therapies, Inc.COM SHS1,040,882$2.01M0.1%00.0%UnchangedHistory
GRTSGritstone bio, Inc.COM750,000$1.93M0.1%00.0%UnchangedHistory
MEHCQChrome Holding Co.CLASS A COM661,009$1.89M0.1%00.0%UnchangedHistory
YI111, Inc.ADS686,431$1.84M0.1%−279,918−29.0%ReducedHistory
IMMPIMMUTEP LtdSPONSORED ADS1,000,000$1.56M0.1%00.0%UnchangedHistory
KNTEKinnate Biopharma Inc.COM125,000$1.49M0.1%00.0%UnchangedHistory
SLDBSolid Biosciences Inc.COM3,000,000$1.40M0.1%00.0%UnchangedHistory
TCRRTCR2 Therapeutics Inc.COM750,000$1.35M0.1%00.0%UnchangedHistory
XLOXilio Therapeutics, Inc.COM450,000$1.31M0.1%00.0%UnchangedHistory
MREOMereo BioPharma Group plcSPON ADS1,500,000$1.29M0.1%00.0%UnchangedHistory

Options (5)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Artal Group S.A. in Q3 2022
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF–$396.6M
SGENSeagen Inc.COM–$13.7M
ISEEIVERIC bio, Inc.COM–$8.97M
ONCBeOne Medicines Ltd.ADR–$6.74M
IGMSIGM Biosciences, Inc.COM–$1.14M

Sold out since Q2 2022 (12)

Positions held at the end of Q2 2022 that are gone from this filing.

Positions of Artal Group S.A. sold out since Q2 2022
SecurityClassShares in Q2 2022Value in Q2 2022% of portfolio in Q2 2022History
ALNYAlnylam Pharmaceuticals, Inc.COM600,000$87.5M4.9%History
ATRAAtara Biotherapeutics, Inc.COM1,000,000$7.79M0.4%History
DSGNDesign Therapeutics, Inc.COM400,000$5.60M0.3%History
ADVMAdverum Biotechnologies, Inc.COM3,000,000$3.60M0.2%History
IVVDInvivyd, Inc.COM1,000,000$3.28M0.2%History
CINCCinCor Pharma, Inc.COM137,010$2.58M0.1%History
AMLXAmylyx Pharmaceuticals, Inc.COM75,000$1.45M0.1%History
HIPOHippo Holdings Inc.COMMON STOCK600,000$527.0K<0.1%History
CLFCleveland-Cliffs Inc.COM25,000$384.0K<0.1%History
UNGUnited States Natural Gas Fund, LPUNIT PAR20,000$380.0K<0.1%History
BBWIBath & Body Works, Inc.COM12,500$337.0K<0.1%History
KLDOKaleido Biosciences, Inc.COM500,500$31.0K<0.1%History