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Artal Group S.A.

SEC CIK
0001053906
Latest filing
Aug 13, 2026

Holdings in Q4 2022

Holdings as of Dec 31, 2022, filed Feb 13, 2023. Long positions only; changes compare share counts with Q3 2022.

Institution overview
Positions
125
−5 vs. Q3 2022
Portfolio value
$1.73B
−$181.1M (−9.5%) vs. Q3 2022
Filed
Feb 13, 2023
SEC
Holdings of Artal Group S.A. in Q4 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
LXRXLexicon Pharmaceuticals, Inc.COM NEW89,778,234$171.5M9.9%00.0%UnchangedHistory
ONCBeOne Medicines Ltd.ADR600,000$132.0M7.6%−50,000−7.7%ReducedHistory
MRTXMirati Therapeutics, Inc.COM1,832,758$83.0M4.8%+507,758+38.3%AddedHistory
SRRKScholar Rock Holding CorpCOM8,980,270$81.3M4.7%+230,236+2.6%AddedHistory
CERECerevel Therapeutics Holdings, Inc.COM1,900,000$59.9M3.5%−100,000−5.0%ReducedHistory
MORFMorphic Holding, Inc.COM2,150,000$57.5M3.3%00.0%UnchangedHistory
WWWW International, Inc.COM14,818,300$57.2M3.3%00.0%UnchangedHistory
SWTXSpringWorks Therapeutics, Inc.COM2,000,000$52.0M3.0%−53,403−2.6%ReducedHistory
KYMRKymera Therapeutics, Inc.COM2,000,000$49.9M2.9%+500,000+33.3%AddedHistory
FOLDAmicus Therapeutics, Inc.COM4,000,000$48.8M2.8%00.0%UnchangedHistory
APLSApellis Pharmaceuticals, Inc.COM900,000$46.5M2.7%−100,000−10.0%ReducedHistory
CYTKCytokinetics IncCOM NEW1,000,000$45.8M2.6%00.0%UnchangedHistory
IGMSIGM Biosciences, Inc.COM2,450,000$41.7M2.4%00.0%UnchangedHistory
AGENAgenus IncCOM NEW14,500,000$34.8M2.0%+10,500,000+262.5%AddedHistory
KRYSKrystal Biotech, Inc.COM400,000$31.7M1.8%−100,000−20.0%ReducedHistory
Bellus Health Inc New07987C204COM NEW3,700,000$30.4M1.8%−2,300,000−38.3%Reduced–
KRTXKaruna Therapeutics, Inc.COM150,000$29.5M1.7%+25,000+20.0%AddedHistory
KLRSKalaris Therapeutics, Inc.COM5,577,167$28.6M1.6%00.0%UnchangedHistory
SAGESage Therapeutics, Inc.COM750,000$28.6M1.6%00.0%UnchangedHistory
VIGLVigil Neuroscience, Inc.COM2,243,352$28.0M1.6%−42,222−1.8%ReducedHistory
SEERSeer, Inc.COM CL A4,750,000$27.6M1.6%00.0%UnchangedHistory
FATEFate Therapeutics IncCOM2,600,000$26.2M1.5%00.0%UnchangedHistory
RVMDRevolution Medicines, Inc.COM1,000,000$23.8M1.4%+1,000,000NewHistory
DNLIDenali Therapeutics Inc.COM800,000$22.2M1.3%+200,000+33.3%AddedHistory
RLAYRelay Therapeutics, Inc.COM1,454,716$21.7M1.3%00.0%UnchangedHistory
ISEEIVERIC bio, Inc.COM1,000,000$21.4M1.2%+250,000+33.3%AddedHistory
KURAKura Oncology, Inc.COM1,700,000$21.1M1.2%+600,000+54.5%AddedHistory
WVEWave Life Sciences, Inc.SHS3,000,000$21.0M1.2%00.0%UnchangedHistory
ERASErasca, Inc.COM4,710,682$20.3M1.2%+1,538,461+48.5%AddedHistory
VORVor Biopharma Inc.COM2,875,581$19.1M1.1%+2,325,581+422.8%AddedHistory
REPLReplimune Group, Inc.COM700,000$19.0M1.1%−200,000−22.2%ReducedHistory
SDGRSchrodinger, Inc.COM700,000$13.1M0.8%00.0%UnchangedHistory
OMGAOmega Therapeutics, Inc.COMMON STOCK2,273,530$13.0M0.7%00.0%UnchangedHistory
MRSNMersana Therapeutics, Inc.COM2,200,000$12.9M0.7%00.0%UnchangedHistory
Avidity Biosciences, Inc.05370A108COM500,000$11.1M0.6%+250,000+100.0%Added–
GBIOGeneration Bio Co.COM2,814,191$11.1M0.6%00.0%UnchangedHistory
FHTXFoghorn Therapeutics Inc.COM1,720,720$11.0M0.6%00.0%UnchangedHistory
TVTXTravere Therapeutics, Inc.COM500,000$10.5M0.6%+500,000NewHistory
RPTXRepare Therapeutics Inc.COM700,000$10.3M0.6%00.0%UnchangedHistory
INSMINSMED IncCOM PAR $.01500,000$9.99M0.6%+500,000NewHistory
NTLAIntellia Therapeutics, Inc.COM275,000$9.60M0.6%00.0%UnchangedHistory
EVOEvotec SESPONSORED ADS1,149,425$9.30M0.5%00.0%UnchangedHistory
SESea LtdSPONSORD ADS172,500$8.97M0.5%00.0%UnchangedHistory
ALPNAlpine Immune Sciences, Inc.COM1,193,030$8.77M0.5%00.0%UnchangedHistory
NTRANatera, Inc.COM200,000$8.03M0.5%+100,000+100.0%AddedHistory
ITOSiTeos Therapeutics, Inc.COM400,000$7.81M0.5%00.0%UnchangedHistory
RXRXRecursion Pharmaceuticals, Inc.CL A960,204$7.40M0.4%+510,204+113.4%AddedHistory
GOSSGossamer Bio, Inc.COM3,246,624$7.04M0.4%00.0%UnchangedHistory
BEKEKE Holdings Inc.SPONSORED ADS500,000$6.98M0.4%+500,000NewHistory
BHVNBiohaven Ltd.COM500,000$6.94M0.4%+500,000NewHistory
GRTSGritstone bio, Inc.COM1,856,194$6.40M0.4%+1,106,194+147.5%AddedHistory
DYNDyne Therapeutics, Inc.COM525,000$6.08M0.4%00.0%UnchangedHistory
ARAVAravive, Inc.COM4,572,515$6.04M0.3%+3,261,224+248.7%AddedHistory
VERVVerve Therapeutics, Inc.COM300,000$5.80M0.3%−100,000−25.0%ReducedHistory
ALXOAlx Oncology Holdings IncCOM500,000$5.63M0.3%00.0%UnchangedHistory
RNACCartesian Therapeutics, Inc.COM4,883,200$5.52M0.3%00.0%UnchangedHistory
SYRSSyros Pharmaceuticals, Inc.COM NEW1,463,829$5.25M0.3%00.0%UnchangedHistory
ETNB89bio, Inc.COM400,000$5.09M0.3%+400,000NewHistory
EQRXEQRx, Inc.COM2,000,000$4.92M0.3%−2,000,000−50.0%ReducedHistory
SLDBSolid Biosciences Inc.COM NEW909,219$4.89M0.3%+709,219+354.6%AddedConverted for a 1-for-15 splitHistory
AMAMAmbrx Biopharma Cayman, Inc.SPONSORED ADS2,152,291$4.89M0.3%00.0%UnchangedHistory
OVIDOvid Therapeutics Inc.COM2,500,000$4.65M0.3%00.0%UnchangedHistory
AUPHAurinia Pharmaceuticals Inc.COM1,000,000$4.32M0.2%00.0%UnchangedHistory
AURAAura Biosciences, Inc.COM410,000$4.30M0.2%+410,000NewHistory
IMAImageneBio, Inc.COM1,549,513$4.12M0.2%00.0%UnchangedHistory
PFTAPerception Capital Corp. IIICLASS A ORD SHS380,000$3.82M0.2%00.0%UnchangedHistory
NBTXNanobiotix S.A.SPONSORED ADS1,000,000$3.67M0.2%00.0%UnchangedHistory
NBPNovaBridge BiosciencesSPONSORED ADS850,000$3.55M0.2%00.0%UnchangedHistory
ZYMEZymeworks Inc.COM450,000$3.54M0.2%00.0%UnchangedHistory
MIRMirion Technologies, Inc.COM CL A500,000$3.31M0.2%00.0%UnchangedHistory
TSHATaysha Gene Therapies, Inc.COM SHS1,440,882$3.26M0.2%+400,000+38.4%AddedHistory
BDTXBlack Diamond Therapeutics, Inc.COM1,646,517$2.96M0.2%00.0%UnchangedHistory
Exscientia PLC30223G102ADS550,000$2.93M0.2%00.0%Unchanged–
PRAXPraxis Precision Medicines, Inc.COM1,200,000$2.86M0.2%00.0%UnchangedHistory
CGEMCullinan Therapeutics, Inc.COM250,000$2.64M0.2%00.0%UnchangedHistory
OTLYOatly Group ABSPONSORED ADS1,500,000$2.61M0.2%00.0%UnchangedHistory
KRONKronos Bio, Inc.COM1,542,954$2.50M0.1%00.0%UnchangedHistory
LYELLyell Immunopharma, Inc.COM700,000$2.43M0.1%00.0%UnchangedHistory
FUSNFusion Pharmaceuticals Inc.COM750,000$2.36M0.1%00.0%UnchangedHistory
ORICOric Pharmaceuticals, Inc.COM400,000$2.36M0.1%00.0%UnchangedHistory
LENZLENZ Therapeutics, Inc.COM700,000$2.32M0.1%00.0%UnchangedHistory
STOKStoke Therapeutics, Inc.COM250,000$2.31M0.1%00.0%UnchangedHistory
TRMLTourmaline Bio, Inc.COM2,064,262$2.11M0.1%00.0%UnchangedHistory
ACIUAC Immune SASHS1,000,000$2.04M0.1%00.0%UnchangedHistory
Achilles Therapeutics PLC00449L102SPONSORED ADS2,255,375$2.03M0.1%00.0%Unchanged–
YMABY-mAbs Therapeutics, Inc.COM400,000$1.95M0.1%00.0%UnchangedHistory
BBIOBridgeBio Pharma, Inc.COM250,000$1.91M0.1%00.0%UnchangedHistory
KRSAKorsana Biosciences, Inc.COM2,779,122$1.82M0.1%00.0%UnchangedHistory
CYPHCypherpunk Technologies Inc.COM4,000,000$1.80M0.1%00.0%UnchangedHistory
IMUXImmunic, Inc.COM1,274,713$1.78M0.1%+574,713+82.1%AddedHistory
IMMPIMMUTEP LtdSPONSORED ADS1,000,000$1.75M0.1%00.0%UnchangedHistory
APTXAptinyx Inc.COM6,116,493$1.75M0.1%00.0%UnchangedHistory
SANASana Biotechnology, Inc.COM400,000$1.58M0.1%00.0%UnchangedHistory
HOOKHOOKIPA Pharma Inc.COM1,849,616$1.50M0.1%00.0%UnchangedHistory
MEHCQChrome Holding Co.CLASS A COM661,009$1.43M0.1%00.0%UnchangedHistory
IRWDIronwood Pharmaceuticals IncCOM CL A110,532$1.37M0.1%00.0%UnchangedHistory
ADAGAdagene Inc.ADS1,000,000$1.32M0.1%00.0%UnchangedHistory
XLOXilio Therapeutics, Inc.COM450,000$1.21M0.1%00.0%UnchangedHistory
SQZSQZ Biotechnologies CoCOM1,606,309$1.19M0.1%00.0%UnchangedHistory
MREOMereo BioPharma Group plcSPON ADS1,500,000$1.13M0.1%00.0%UnchangedHistory

Options (4)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Artal Group S.A. in Q4 2022
SecurityClassPutsCalls
MRTXMirati Therapeutics, Inc.COM–$22.7M
ONCBeOne Medicines Ltd.ADR–$22.0M
BEKEKE Holdings Inc.SPONSORED ADS–$11.2M
IGMSIGM Biosciences, Inc.COM–$851.0K

Sold out since Q3 2022 (14)

Positions held at the end of Q3 2022 that are gone from this filing.

Positions of Artal Group S.A. sold out since Q3 2022
SecurityClassShares in Q3 2022Value in Q3 2022% of portfolio in Q3 2022History
ARGXArgenx SESPONSORED ADR150,000$53.0M2.8%History
SGENSeagen Inc.COM350,000$47.9M2.5%History
Omega Alpha SpacG6749V107CL A750,000$7.45M0.4%–
CNCEConcert Pharmaceuticals, Inc.COM573,062$3.84M0.2%History
THRDThird Harmonic Bio, Inc.COM200,000$3.79M0.2%History
NERVMinerva Neurosciences, Inc.COM NEW250,000$2.31M0.1%History
YI111, Inc.ADS686,431$1.84M0.1%History
AXLAAxcella Health Inc.COM712,500$1.22M0.1%History
MRNSMarinus Pharmaceuticals, Inc.COM NEW157,000$1.04M0.1%History
SPROSpero Therapeutics, Inc.COM500,000$1.00M0.1%History
AVTRAvantor, Inc.COM45,000$882.0K<0.1%History
ADBEAdobe Inc.Stock1,300$358.0K<0.1%History
ATXSAstria Therapeutics, Inc.COM33,333$301.0K<0.1%History
SGTXSigilon Therapeutics, Inc.COM276,000$139.0K<0.1%History