| Wellington Management Group LLP | 4,355,767 | $4.34 億 | 0.08% | – | – |
| CPMG Inc | 2,896,901 | $2.89 億 | 55.24% | – | – |
| Vanguard Group Inc | 2,434,499 | $2.43 億 | 0.01% | – | – |
| Invesco Ltd. | 2,056,360 | $2.05 億 | 0.05% | – | – |
| BlackRock Inc. | 1,483,998 | $1.48 億 | 0.00% | – | – |
| Franklin Resources Inc | 1,459,789 | $1.46 億 | 0.06% | – | – |
| Price T Rowe Associates Inc | 1,053,732 | $1.05 億 | 0.01% | – | – |
| Duquesne Family Office LLC大師杜肯家族辦公室 | 749,897 | $7,477 萬 | 1.65% | – | – |
| Deutsche Bank AG | 607,503 | $6,057 萬 | 0.03% | – | – |
| Deerfield Management Company, L.P. (Series C) | 420,000 | $4,187 萬 | 0.88% | – | – |
| Camber Capital Management LP | 400,000 | $3,988 萬 | 1.58% | – | – |
| Cormorant Asset Management, LP | 400,000 | $3,988 萬 | 1.15% | – | – |
| State Street Corp | 380,389 | $3,793 萬 | 0.00% | – | – |
| Pictet Asset Management Ltd | 351,555 | $3,505 萬 | 0.04% | – | – |
| Blackstone Group Inc. | 340,793 | $3,398 萬 | 0.08% | – | – |
| Geode Capital Management, LLC | 336,041 | $3,350 萬 | 0.01% | – | – |
| Emerald Advisers, LLC | 261,467 | $2,607 萬 | 0.94% | – | – |
| Emerald Mutual Fund Advisers Trust | 251,497 | $2,507 萬 | 0.83% | – | – |
| Sofinnova Investments, Inc. | 238,520 | $2,378 萬 | 1.50% | – | – |
| Goldman Sachs Group Inc | 231,751 | $2,311 萬 | 0.01% | – | – |
| Baker Bros. Advisors LP | 223,976 | $2,233 萬 | 0.10% | – | – |
| Norges Bank | 193,738 | $1,932 萬 | 0.00% | – | – |
| Candriam Luxembourg S.C.A. | 151,707 | $1,801 萬 | 0.15% | – | – |
| Rice Hall James & Associates, LLC | 134,723 | $1,343 萬 | 0.44% | – | – |
| Northern Trust Corp | 131,819 | $1,314 萬 | 0.00% | – | – |
| Nuveen Asset Management, LLC | 128,506 | $1,281 萬 | 0.00% | – | – |
| Charles Schwab Investment Management Inc | 126,450 | $1,261 萬 | 0.00% | – | – |
| King Luther Capital Management Corp | 111,661 | $1,113 萬 | 0.06% | – | – |
| Artisan Partners Limited Partnership | 109,653 | $1,093 萬 | 0.01% | – | – |
| Balyasny Asset Management LLC | 108,809 | $1,085 萬 | 0.07% | – | – |
| Tolleson Wealth Management, Inc. | 108,000 | $1,077 萬 | 3.25% | – | – |
| Keel Point, LLC | 107,459 | $1,071 萬 | 1.15% | – | – |
| Ameriprise Financial Inc | 102,734 | $1,024 萬 | 0.00% | – | – |
| Biondo Investment Advisors, LLC | 101,204 | $1,009 萬 | 2.01% | – | – |
| Paragon Associates & Paragon Associates II Joint Venture | 100,000 | $997.0 萬 | 15.20% | – | – |
| Bank of New York Mellon Corp | 95,090 | $948.1 萬 | 0.00% | – | – |
| California Public Employees Retirement System | 90,923 | $906.5 萬 | 0.01% | – | – |
| Bank of America Corp | 82,229 | $819.7 萬 | 0.00% | – | – |
| Susquehanna International Group, LLP | 79,698 | $794.6 萬 | 0.01% | – | – |
| Kennedy Capital Management, Inc. | 74,629 | $744.1 萬 | 0.15% | – | – |
| Janus Henderson Group PLC | 71,876 | $716.8 萬 | 0.00% | – | – |
| Hood River Capital Management LLC | 66,820 | $666.2 萬 | 0.21% | – | – |
| Morgan Stanley | 62,387 | $622.0 萬 | 0.00% | – | – |
| FMR LLC | 60,932 | $607.5 萬 | 0.00% | – | – |
| HighTower Advisors, LLC | 58,958 | $587.8 萬 | 0.02% | – | – |
| Point72 Asset Management, L.P. | 58,800 | $586.2 萬 | 0.03% | – | – |
| Swiss National Bank | 56,000 | $558.3 萬 | 0.00% | – | – |
| Millennium Management LLC | 55,723 | $555.6 萬 | 0.01% | – | – |
| Parametric Portfolio Associates LLC | 53,136 | $529.8 萬 | 0.00% | – | – |
| Thrivent Financial for Lutherans | 51,421 | $512.7 萬 | 0.01% | – | – |
| California State Teachers Retirement System | 46,697 | $465.6 萬 | 0.01% | – | – |
| Integral Health Asset Management, LLC | 44,000 | $438.7 萬 | 1.25% | – | – |
| Teachers Retirement System of the State of Kentucky | 43,320 | $431.9 萬 | 0.04% | – | – |
| Stifel Financial Corp | 42,075 | $419.5 萬 | 0.01% | – | – |
| WCM Investment Management, LLC | 40,959 | $408.4 萬 | 0.01% | – | – |
| Tekla Capital Management LLC | 38,219 | $381.0 萬 | 0.13% | – | – |
| Man Group plc | 38,140 | $380.3 萬 | 0.02% | – | – |
| UBS Asset Management Americas Inc | 38,028 | $379.1 萬 | 0.00% | – | – |
| JPMorgan Chase & Co | 37,080 | $369.7 萬 | 0.00% | – | – |
| Hennion & Walsh Asset Management, Inc. | 35,710 | $356.0 萬 | 0.21% | – | – |
| Cubist Systematic Strategies, LLC | 35,317 | $352.1 萬 | 0.05% | – | – |
| Madden Securities Corp | 34,787 | $346.8 萬 | 2.03% | – | – |
| American Century Companies Inc | 33,653 | $335.5 萬 | 0.00% | – | – |
| State Board of Administration of Florida Retirement System | 32,452 | $323.5 萬 | 0.01% | – | – |
| GAM Holding AG | 31,100 | $310.1 萬 | 0.15% | – | – |
| New York State Common Retirement Fund | 30,426 | $303.3 萬 | 0.00% | – | – |
| LBJ Family Wealth Advisors, Ltd. | 30,368 | $302.7 萬 | 1.91% | – | – |
| Fayez Sarofim & Co | 30,129 | $300.4 萬 | 0.01% | – | – |
| TD Asset Management Inc | 29,588 | $295.0 萬 | 0.00% | – | – |
| CIBC Private Wealth Group, LLC | 29,496 | $294.1 萬 | 0.01% | – | – |
| Eagle Global Advisors LLC | 25,805 | $257.3 萬 | 0.19% | – | – |
| Rhumbline Advisers | 25,390 | $253.1 萬 | 0.00% | – | – |
| Serengeti Asset Management LP | 25,000 | $249.3 萬 | 3.36% | – | – |
| Credit Suisse AG | 24,994 | $249.1 萬 | 0.00% | – | – |
| ExodusPoint Capital Management, LP | 22,123 | $220.6 萬 | 0.04% | – | – |
| Tudor Investment Corp Et Al | 22,085 | $220.2 萬 | 0.05% | – | – |
| Hourglass Capital, LLC | 21,842 | $217.8 萬 | 0.55% | – | – |
| Citadel Advisors LLC | 21,229 | $211.6 萬 | 0.00% | – | – |
| Woodstock Corp | 21,217 | $211.5 萬 | 0.27% | – | – |
| TCTC Holdings, LLC | 20,982 | $209.2 萬 | 0.10% | – | – |
| Gyon Technologies Capital Management, LP | 20,288 | $202.3 萬 | 0.88% | – | – |
| Bokf, NA | 20,220 | $201.6 萬 | 0.04% | – | – |
| AWM Investment Company, Inc. | 20,000 | $199.4 萬 | 0.22% | – | – |
| State of New Jersey Common Pension Fund D | 19,890 | $198.3 萬 | 0.01% | – | – |
| Citigroup Inc | 19,080 | $190.2 萬 | 0.00% | – | – |
| Jane Street Group, LLC | 18,474 | $184.2 萬 | 0.01% | – | – |
| Erste Asset Management GmbH | 17,700 | $171.9 萬 | 0.04% | – | – |
| Capital Counsel LLC | 17,000 | $169.5 萬 | 0.09% | – | – |
| Voloridge Investment Management, LLC | 16,689 | $166.4 萬 | 0.01% | – | – |
| Legal & General Group Plc | 16,665 | $166.2 萬 | 0.00% | – | – |
| Eaton Vance Management | 15,926 | $158.8 萬 | 0.00% | – | – |
| Royal Bank of Canada | 14,667 | $146.2 萬 | 0.00% | – | – |
| DekaBank Deutsche Girozentrale | 14,740 | $140.3 萬 | 0.00% | – | – |
| Acuta Capital Partners, LLC | 14,000 | $139.6 萬 | 0.50% | – | – |
| Public Employees Retirement System of Ohio | 13,888 | $138.5 萬 | 0.01% | – | – |
| Knights of Columbus Asset Advisors LLC | 13,433 | $133.9 萬 | 0.13% | – | – |
| Victory Capital Management Inc | 13,314 | $132.7 萬 | 0.00% | – | – |
| Am Investment Strategies LLC | 12,465 | $124.3 萬 | 0.35% | – | – |
| Allianz Asset Management GmbH | 11,330 | $112.9 萬 | 0.00% | – | – |
| The PNC Financial Services Group, Inc. | 10,194 | $101.5 萬 | 0.00% | – | – |
