Upstream Bio, Inc.
UPB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
In the last 90 days, Upstream Bio, Inc. insiders filed 0 open-market purchases and 5 sales; 148 institutions reported holding it in 13F filings for Q2 2026, worth $350.1M in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Upstream Bio, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 79
- +10 vs. Q4 2024
- Shares held
- 46.3M
- +4.23M (+10.1%) vs. Q4 2024
- Total value
- $266.9M
- −$422.8M (−61.3%) vs. Q4 2024
- New holders
- 24
- 11 more added
- Sold out
- 14
- 26 more reduced
1 institution that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting UPB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 148 | $350.1M |
| Q1 2026 | 140 | $404.5M |
| Q4 2025 | 133 | $1.39B |
| Q3 2025 | 95 | $836.3M |
| Q2 2025 | 83 | $530.9M |
| Q1 2025 | 79 | $266.9M |
| Q4 2024 | 70 | $690.1M |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Upstream Bio, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| True Wealth Design, LLC | 16 | $98 | 0.00% | +16 | New |
| Principal Securities, Inc. | 12 | $197 | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 69 | $423 | 0.00% | +69 | New |
| Signaturefd, LLC | 90 | $551 | 0.00% | +90 | New |
| EverSource Wealth Advisors, LLC | 135 | $826 | 0.00% | +135 | New |
| Nisa Investment Advisors, LLC | 136 | $832 | 0.00% | +136 | New |
| Sterling Capital Management LLC | 137 | $838 | 0.00% | −112−45.0% | Reduced |
| Allworth Financial LP | 185 | $1.66K | 0.00% | +185 | New |
| US Bancorp | 562 | $3.44K | 0.00% | −1,098−66.1% | Reduced |
| GAMMA Investing LLC | 593 | $3.63K | 0.00% | +593 | New |
| Versant Capital Management, Inc | 615 | $3.76K | 0.00% | +615 | New |
| Amalgamated Bank | 594 | $4.00K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 832 | $5.00K | 0.00% | −450−35.1% | Reduced |
| BNP Paribas Arbitrage, SA | 939 | $5.75K | 0.00% | −572−37.9% | Reduced |
| California State Teachers Retirement System | 1,290 | $7.89K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 1,582 | $9.68K | 0.00% | −1,264−44.4% | Reduced |
| CWM, LLC | 1,596 | $10.0K | 0.00% | +1,596 | New |
| Legal & General Group Plc | 1,734 | $10.6K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 1,822 | $11.2K | 0.00% | 00.0% | Unchanged |
| STRS Ohio | 3,200 | $19.6K | 0.00% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 3,350 | $20.5K | 0.00% | +3,350 | New |
| New York State Common Retirement Fund | 4,700 | $28.8K | 0.00% | +4,700 | New |
| Corebridge Financial, Inc. | 8,533 | $52.2K | 0.00% | −127−1.5% | Reduced |
| Wells Fargo & Company | 9,250 | $56.6K | 0.00% | +203+2.2% | Added |
| Walleye Capital LLC | 10,000 | $61.2K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global ETFs Holdings Ltd. | 10,296 | $63.0K | 0.00% | +468+4.8% | Added |
| Bank of America Corp | 10,531 | $64.5K | 0.00% | −3,432−24.6% | Reduced |
| MetLife Investment Management | 11,034 | $67.5K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 12,731 | $77.9K | 0.00% | +12,731 | New |
| Rhumbline Advisers | 13,327 | $81.6K | 0.00% | −3,394−20.3% | Reduced |
| ADAR1 Capital Management, LLC | 15,000 | $91.8K | 0.02% | +15,000 | New |
| Deutsche Bank AG | 15,192 | $93.0K | 0.00% | +341+2.3% | Added |
| JPMorgan Chase & Co | 15,194 | $93.0K | 0.00% | −32,598−68.2% | Reduced |
| Quantinno Capital Management LP | 15,225 | $93.2K | 0.00% | +15,225 | New |
| Intech Investment Management LLC | 15,285 | $93.5K | 0.00% | +15,285 | New |
| Invesco Ltd. | 15,315 | $93.7K | 0.00% | −287−1.8% | Reduced |
| Citigroup Inc | 18,178 | $111.2K | 0.00% | −8,326−31.4% | Reduced |
| AQR Capital Management LLC | 18,822 | $115.2K | 0.00% | +18,822 | New |
| Susquehanna International Group, LLP | 21,264 | $130.1K | 0.00% | +21,264 | New |
| Two Sigma Investments, LP | 21,789 | $133.3K | 0.00% | +21,789 | New |
| Nuveen, LLC | 22,586 | $138.2K | 0.00% | +22,586 | New |
| Barclays PLC | 24,993 | $153.0K | 0.00% | −2,024−7.5% | Reduced |
| Goldman Sachs Group Inc | 32,955 | $201.7K | 0.00% | −11,535−25.9% | Reduced |
| Bank of New York Mellon Corp | 36,912 | $225.9K | 0.00% | −10.0% | Reduced |
| Alps Advisors Inc | 39,079 | $239.2K | 0.00% | −4,261−9.8% | Reduced |
| Morgan Stanley | 51,391 | $314.5K | 0.00% | +8,228+19.1% | Added |
| EcoR1 Capital, LLC | 60,000 | $367.2K | 0.02% | 00.0% | Unchanged |
| Millennium Management LLC | 61,796 | $378.2K | 0.00% | +61,796 | New |
| Alyeska Investment Group, L.P. | 85,000 | $520.2K | 0.00% | 00.0% | Unchanged |
| Velan Capital Investment Management LP | 107,000 | $654.8K | 0.67% | +107,000 | New |
| UBS Group AG | 131,551 | $805.1K | 0.00% | −29,961−18.6% | Reduced |
| Charles Schwab Investment Management Inc | 132,173 | $808.9K | 0.00% | −3,150−2.3% | Reduced |
| Northern Trust Corp | 137,771 | $843.2K | 0.00% | −5,950−4.1% | Reduced |
| Schonfeld Strategic Advisors LLC | 177,984 | $1.09M | 0.01% | +177,984 | New |
| Lynx1 Capital Management LP | 219,247 | $1.34M | 0.48% | −20,795−8.7% | Reduced |
| Parkman Healthcare Partners LLC | 233,563 | $1.43M | 0.17% | +233,563 | New |
| State Street Corp | 295,587 | $1.81M | 0.00% | +48,400+19.6% | Added |
| Great Point Partners LLC | 300,000 | $1.84M | 1.00% | 00.0% | Unchanged |
| Marshall Wace, LLP | 304,963 | $1.87M | 0.00% | +14,229+4.9% | Added |
| Geode Capital Management, LLC | 410,677 | $2.51M | 0.00% | +47,408+13.1% | Added |
| Woodline Partners LP | 557,063 | $3.41M | 0.02% | +30,552+5.8% | Added |
| Altshuler Shaham Ltd | 3,235,293 | $3.52M | 0.09% | +3,235,293 | New |
| Nantahala Capital Management, LLC | 594,971 | $3.64M | 0.30% | −5,029−0.8% | Reduced |
| Siren, L.L.C. | 788,450 | $4.83M | 0.27% | −11,550−1.4% | Reduced |
| Vanguard Group Inc | 907,026 | $5.55M | 0.00% | −7,995−0.9% | Reduced |
| Norges Bank | 969,916 | $5.94M | 0.00% | −30,084−3.0% | Reduced |
| Alliancebernstein L.P. | 1,091,186 | $6.68M | 0.00% | −20,151−1.8% | Reduced |
| BlackRock, Inc. | 1,185,768 | $7.26M | 0.00% | +67,968+6.1% | Added |
| Wellington Management Group LLP | 1,313,457 | $8.03M | 0.00% | −269,697−17.0% | Reduced |
| Omega Fund Management, LLC | 2,036,293 | $12.5M | 7.35% | 00.0% | Unchanged |
| Samsara BioCapital, LLC | 2,067,146 | $12.7M | 2.26% | −150,000−6.8% | Reduced |
| VR Adviser, LLC | 2,295,319 | $14.0M | 1.20% | 00.0% | Unchanged |
| Bain Capital Life Sciences Investors, LLC | 2,295,322 | $14.0M | 2.08% | 00.0% | Unchanged |
| Deep Track Capital, LP | 2,299,567 | $14.1M | 0.46% | +1,299,567+130.0% | Added |
| Enavate Sciences GP, LLC | 2,459,703 | $15.1M | 11.34% | 00.0% | Unchanged |
| TCG Crossover Management, LLC | 2,801,763 | $17.1M | 2.34% | 00.0% | Unchanged |
| Decheng Capital LLC | 3,285,293 | $20.1M | 5.64% | 00.0% | Unchanged |
| OrbiMed Advisors LLC | 5,693,589 | $34.8M | 0.84% | 00.0% | Unchanged |
| FMR LLC | 7,255,859 | $44.4M | 0.00% | +79,672+1.1% | Added |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −301,152−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −180,000−100.0% | Sold out |
| Moody Aldrich Partners LLC | 0 | $0 | 0.00% | −74,773−100.0% | Sold out |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 0 | $0 | 0.00% | −46,350−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −45,549−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −37,379−100.0% | Sold out |
| Davidson Kempner Capital Management LP | 0 | $0 | 0.00% | −12,500−100.0% | Sold out |
| Sandia Investment Management LP | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −7,590−100.0% | Sold out |
| R Squared Ltd | 0 | $0 | 0.00% | −160−100.0% | Sold out |
| Aster Capital Management (DIFC) Ltd | 0 | $0 | 0.00% | −134−100.0% | Sold out |
| Caitong International Asset Management Co., Ltd | 0 | $0 | 0.00% | −44−100.0% | Sold out |
| Advisor Group Holdings, Inc. | 0 | $0 | 0.00% | −17−100.0% | Sold out |
| National Bank of Canada | 0 | $0 | 0.00% | −7−100.0% | Sold out |
| Nuveen Asset Management, LLC | – | – | – | – | Not filed |