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Q32 Bio Inc.

QTTB
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001661998

In the last 90 days, Q32 Bio Inc. insiders filed 0 open-market purchases and 3 sales; 72 institutions reported holding it in 13F filings for Q2 2026, worth $282.6M in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Q32 Bio Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
52
−1 vs. Q3 2025
Shares held
8.04M
−384.9K (−4.6%) vs. Q3 2025
Total value
$26.7M
+$10.0M (+60.3%) vs. Q3 2025
New holders
7
9 more added
Sold out
8
20 more reduced

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting QTTB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 52 institutions
Q1 2021: 109 institutionsQ2 2021: 118 institutionsQ3 2021: 119 institutionsQ4 2021: 121 institutionsQ1 2022: 107 institutionsQ2 2022: 87 institutionsQ3 2022: 83 institutionsQ4 2022: 79 institutionsQ1 2023: 62 institutionsQ2 2023: 59 institutionsQ3 2023: 58 institutionsQ4 2023: 58 institutionsQ1 2024: 39 institutionsQ2 2024: 54 institutionsQ3 2024: 73 institutionsQ4 2024: 92 institutionsQ1 2025: 73 institutionsQ2 2025: 61 institutionsQ3 2025: 53 institutionsQ4 2025: 52 institutionsQ1 2026: 54 institutionsQ2 2026: 72 institutions
Value heldQ4 2025: $26.7M
Q1 2021: $272.7MQ2 2021: $239.9MQ3 2021: $252.1MQ4 2021: $123.0MQ1 2022: $89.7MQ2 2022: $49.9MQ3 2022: $38.7MQ4 2022: $27.3MQ1 2023: $20.0MQ2 2023: $15.9MQ3 2023: $20.8MQ4 2023: $11.4MQ1 2024: $125.9MQ2 2024: $144.2MQ3 2024: $405.8MQ4 2024: $37.8MQ1 2025: $15.5MQ2 2025: $13.4MQ3 2025: $16.6MQ4 2025: $26.7MQ1 2026: $60.6MQ2 2026: $282.6M
Institutions holding QTTB and their total value by quarter
QuarterHoldersValue
Q2 202672$282.6M
Q1 202654$60.6M
Q4 202552$26.7M
Q3 202553$16.6M
Q2 202561$13.4M
Q1 202573$15.5M
Q4 202492$37.8M
Q3 202473$405.8M
Q2 202454$144.2M
Q1 202439$125.9M
Q4 202358$11.4M
Q3 202358$20.8M
Q2 202359$15.9M
Q1 202362$20.0M
Q4 202279$27.3M
Q3 202283$38.7M
Q2 202287$49.9M
Q1 2022107$89.7M
Q4 2021121$123.0M
Q3 2021119$252.1M
Q2 2021118$239.9M
Q1 2021109$272.7M

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Q32 Bio Inc.; share changes are against Q3 2025.

Institutions holding QTTB in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
OrbiMed Advisors LLC2,252,987$7.48M0.15%00.0%Unchanged
Atlas Venture Life Science Advisors, LLC2,092,106$6.95M0.80%00.0%Unchanged
Carlyle Group Inc.1,102,741$3.62M0.03%00.0%Unchanged
Acorn Capital Advisors, LLC493,425$1.64M0.56%−310,000−38.6%Reduced
Vanguard Group Inc321,051$1.07M0.00%+25,642+8.7%Added
ARCH Venture Management, LLC320,482$1.06M0.16%00.0%Unchanged
Pfizer Inc277,777$922.2K0.39%00.0%Unchanged
Sanofi244,083$810.4K0.26%00.0%Unchanged
Opaleye Management Inc.213,363$708.4K0.09%+213,363New
Geode Capital Management, LLC106,113$352.4K0.00%+17,617+19.9%Added
Renaissance Technologies LLC99,600$330.7K0.00%+52,300+110.6%Added
BlackRock, Inc.59,932$199.0K0.00%−33,073−35.6%Reduced
Millennium Management LLC51,268$170.2K0.00%−53,504−51.1%Reduced
Monaco Asset Management SAM50,919$169.1K0.05%−260,218−83.6%Reduced
Acadian Asset Management LLC48,373$159.0K0.00%+18,634+62.7%Added
Two Sigma Investments, LP46,825$155.5K0.00%+15,319+48.6%Added
Citadel Advisors LLC45,728$151.8K0.00%+35,611+352.0%Added
Affinity Asset Advisors, LLC27,777$92.2K0.01%00.0%Unchanged
Jane Street Group, LLC25,374$84.2K0.00%+25,374New
Northern Trust Corp25,033$83.1K0.00%−6,920−21.7%Reduced
HRT Financial LP24,698$81.0K0.00%+9,862+66.5%Added
State Street Corp21,237$70.5K0.00%00.0%Unchanged
XTX Topco Ltd20,353$67.6K0.00%+20,353New
ADAR1 Capital Management, LLC20,000$66.4K0.00%+20,000New
Scientech Research LLC15,510$51.5K0.03%+15,510New
UBS Group AG13,606$45.2K0.00%+8,360+159.4%Added
Morgan Stanley5,478$18.2K0.00%−5,865−51.7%Reduced
EverSource Wealth Advisors, LLC4,640$15.4K0.00%−385−7.7%Reduced
FMR LLC3,364$11.2K0.00%−12,503−78.8%Reduced
Federated Hermes, Inc.2,273$7.55K0.00%−101−4.3%Reduced
Global Retirement Partners, LLC1,500$4.98K0.00%−3,500−70.0%Reduced
SRS Capital Advisors, Inc.1,111$3.69K0.00%−104−8.6%Reduced
Bank of America Corp1,035$3.44K0.00%−490−32.1%Reduced
Tower Research Capital LLC (TRC)976$3.24K0.00%−5,506−84.9%Reduced
Rockefeller Capital Management L.P.577$1.92K0.00%00.0%Unchanged
Jones Financial Companies LLLP500$1.66K0.00%+500New
Russell Investments Group, Ltd.454$1.51K0.00%00.0%Unchanged
JPMorgan Chase & Co324$1.08K0.00%+320+8,000.0%Added
BNP Paribas Arbitrage, SA308$1.02K0.00%−124−28.7%Reduced
Royal Bank of Canada235$1.00K0.00%−818−77.7%Reduced
Nisa Investment Advisors, LLC166$5510.00%00.0%Unchanged
SBI Securities Co., Ltd.157$5210.00%−7,999−98.1%Reduced
Advisor Group Holdings, Inc.132$4370.00%−55−29.4%Reduced
Allworth Financial LP98$3260.00%−512−83.9%Reduced
Federation des caisses Desjardins du Quebec70$2310.00%00.0%Unchanged
Group One Trading, L.P.34$1130.00%00.0%Unchanged
Northwestern Mutual Wealth Management Co30$1000.00%+30New
Barclays PLC19$630.00%−803−97.7%Reduced
Harbour Investments, Inc.11$370.00%00.0%Unchanged
AdvisorNet Financial, Inc2$70.00%00.0%Unchanged
Danske Bank A/S1$30.00%00.0%Unchanged
CWM, LLC54$00.00%−165−75.3%Reduced
Trustees of Columbia University in the City of New York0$00.00%−133,903−100.0%Sold out
Two Sigma Securities, LLC0$00.00%−13,749−100.0%Sold out
DLK Investment Management, LLC0$00.00%−10,333−100.0%Sold out
China Universal Asset Management Co., Ltd.0$00.00%−2,138−100.0%Sold out
Mirae Asset Global Investments Co., Ltd.0$00.00%−472−100.0%Sold out
Citigroup Inc0$00.00%−236−100.0%Sold out
GF Fund Management Co. Ltd.0$00.00%−227−100.0%Sold out
St Germain D J Co Inc0$00.00%−11−100.0%Sold out