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Orchestra BioMed Holdings, Inc.

OBIO
Exchange
Nasdaq
Industry
Surgical & Medical Instruments & Apparatus
SEC CIK
0001814114

In the last 90 days, Orchestra BioMed Holdings, Inc. insiders filed 2 open-market purchases and 3 sales; 77 institutions reported holding it in 13F filings for Q2 2026, worth $119.4M in total; no superinvestor holds it.

13F holders, Q2 2025

Institutional positions in Orchestra BioMed Holdings, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
59
+3 vs. Q1 2025
Shares held
18.1M
−857.2K (−4.5%) vs. Q1 2025
Total value
$47.6M
−$33.7M (−41.5%) vs. Q1 2025
New holders
22
14 more added
Sold out
19
16 more reduced

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting OBIO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 59 institutions
Q1 2021: 46 institutionsQ2 2021: 51 institutionsQ3 2021: 48 institutionsQ4 2021: 53 institutionsQ1 2022: 59 institutionsQ2 2022: 62 institutionsQ3 2022: 23 institutionsQ4 2022: 24 institutionsQ1 2023: 22 institutionsQ2 2023: 39 institutionsQ3 2023: 42 institutionsQ4 2023: 39 institutionsQ1 2024: 43 institutionsQ2 2024: 47 institutionsQ3 2024: 48 institutionsQ4 2024: 54 institutionsQ1 2025: 56 institutionsQ2 2025: 59 institutionsQ3 2025: 52 institutionsQ4 2025: 63 institutionsQ1 2026: 65 institutionsQ2 2026: 77 institutions
Value heldQ2 2025: $47.6M
Q1 2021: $130.2MQ2 2021: $124.1MQ3 2021: $120.6MQ4 2021: $129.0MQ1 2022: $139.4MQ2 2022: $142.3MQ3 2022: $56.4MQ4 2022: $56.6MQ1 2023: $193.2MQ2 2023: $75.5MQ3 2023: $114.2MQ4 2023: $121.2MQ1 2024: $70.3MQ2 2024: $115.9MQ3 2024: $97.8MQ4 2024: $77.0MQ1 2025: $81.3MQ2 2025: $47.6MQ3 2025: $56.1MQ4 2025: $90.1MQ1 2026: $98.2MQ2 2026: $119.4M
Institutions holding OBIO and their total value by quarter
QuarterHoldersValue
Q2 202677$119.4M
Q1 202665$98.2M
Q4 202563$90.1M
Q3 202552$56.1M
Q2 202559$47.6M
Q1 202556$81.3M
Q4 202454$77.0M
Q3 202448$97.8M
Q2 202447$115.9M
Q1 202443$70.3M
Q4 202339$121.2M
Q3 202342$114.2M
Q2 202339$75.5M
Q1 202322$193.2M
Q4 202224$56.6M
Q3 202223$56.4M
Q2 202262$142.3M
Q1 202259$139.4M
Q4 202153$129.0M
Q3 202148$120.6M
Q2 202151$124.1M
Q1 202146$130.2M

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Orchestra BioMed Holdings, Inc.; share changes are against Q1 2025.

Institutions holding OBIO in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
RTW Investments, LP8,306,062$22.3M0.32%+99,900+1.2%Added
Perceptive Advisors LLC4,592,556$12.3M0.46%00.0%Unchanged
Vanguard Group Inc1,157,317$3.10M0.00%−150,449−11.5%Reduced
BlackRock, Inc.681,349$1.83M0.00%−1,264,307−65.0%Reduced
Price T Rowe Associates Inc438,369$1.18M0.00%−21,751−4.7%Reduced
Millennium Management LLC409,674$1.10M0.00%+409,674New
Geode Capital Management, LLC302,082$809.9K0.00%−293,350−49.3%Reduced
Renaissance Technologies LLC169,400$454.0K0.00%+169,400New
Charles Schwab Investment Management Inc138,591$371.4K0.00%−78,394−36.1%Reduced
State Street Corp130,133$348.8K0.00%−343,586−72.5%Reduced
Susquehanna International Group, LLP118,558$317.7K0.00%+85,570+259.4%Added
Northern Trust Corp100,435$269.2K0.00%−138,266−57.9%Reduced
Knott David M Jr100,000$268.0K0.12%+100,000New
Goldman Sachs Group Inc96,841$259.5K0.00%+48,112+98.7%Added
TD Asset Management Inc92,678$248.4K0.00%00.0%Unchanged
IFP Advisors, Inc85,358$228.8K0.01%−76,563−47.3%Reduced
HighTower Advisors, LLC66,500$178.2K0.00%+5,500+9.0%Added
Knoll Capital Management, LLC455,128$169.8K0.12%+455,128New
Lasry Marc60,869$163.1K0.91%00.0%Unchanged
Holos Integrated Wealth LLC51,595$139.8K0.08%00.0%Unchanged
Marshall Wace, LLP49,465$132.6K0.00%+49,465New
Citadel Advisors LLC49,441$132.5K0.00%+28,961+141.4%Added
Y-Intercept (Hong Kong) Ltd45,447$121.8K0.00%+45,447New
GWM Advisors LLC44,083$118.1K0.00%+44,083New
Manufacturers Life Insurance Company, The32,518$87.1K0.00%−9,466−22.5%Reduced
Squarepoint Ops LLC28,221$75.6K0.00%+28,221New
HRT Financial LP28,217$75.0K0.00%+28,217New
Tower Research Capital LLC (TRC)27,922$74.8K0.00%+25,666+1,137.7%Added
UBS Group AG26,139$70.1K0.00%+8,869+51.4%Added
Bridgeway Capital Management, LLC25,000$67.0K0.00%+25,000New
Jain Global LLC24,462$65.6K0.00%+24,462New
Dimensional Fund Advisors LP22,207$59.7K0.00%+22,207New
Bank of America Corp21,577$57.8K0.00%+5,678+35.7%Added
Point72 Asia (Singapore) Pte. Ltd.18,710$50.1K0.01%+18,710New
Jane Street Group, LLC18,513$49.6K0.00%+18,513New
Cubist Systematic Strategies, LLC17,716$47.5K0.00%+17,716New
XTX Topco Ltd16,817$45.1K0.00%+16,817New
Creative Planning15,000$40.2K0.00%+15,000New
ABLE Financial Group, LLC13,402$35.9K0.01%00.0%Unchanged
Morgan Stanley13,382$35.9K0.00%−18,752−58.4%Reduced
Catalyst Funds Management Pty Ltd11,400$30.6K0.01%+11,400New
Royal Bank of Canada7,829$21.0K0.00%+7,215+1,175.1%Added
Citigroup Inc7,661$20.5K0.00%−9,557−55.5%Reduced
Wells Fargo & Company4,474$12.0K0.00%−8,979−66.7%Reduced
BNP Paribas Arbitrage, SA2,405$6.45K0.00%+570+31.1%Added
Harbour Investments, Inc.1,988$5.33K0.00%00.0%Unchanged
Larson Financial Group LLC1,983$5.31K0.00%+152+8.3%Added
FMR LLC1,646$4.41K0.00%+550+50.2%Added
Barclays PLC874$2.34K0.00%−24,735−96.6%Reduced
SBI Securities Co., Ltd.681$1.82K0.00%+680+68,000.0%Added
JPMorgan Chase & Co470$1.26K0.00%−11,482−96.1%Reduced
CWM, LLC381$1.00K0.00%+333+693.8%Added
Point72 (DIFC) Ltd354$9490.00%+354New
Nisa Investment Advisors, LLC241$6460.00%−564−70.1%Reduced
Fortitude Family Office, LLC203$5440.00%+203New
Russell Investments Group, Ltd.193$5170.00%+193New
Sierra Ocean, LLC119$3190.00%00.0%Unchanged
Essential Partners LLC4$110.00%+4New
EverSource Wealth Advisors, LLC1$30.00%−4−80.0%Reduced
Bank of New York Mellon Corp0$00.00%−52,490−100.0%Sold out
Nuveen, LLC0$00.00%−41,729−100.0%Sold out
Rhumbline Advisers0$00.00%−31,657−100.0%Sold out
Deutsche Bank AG0$00.00%−20,219−100.0%Sold out
Intech Investment Management LLC0$00.00%−16,002−100.0%Sold out
Mirae Asset Global ETFs Holdings Ltd.0$00.00%−15,043−100.0%Sold out
Corebridge Financial, Inc.0$00.00%−12,030−100.0%Sold out
SEI Investments Co0$00.00%−10,290−100.0%Sold out
Massar Capital Management, LP0$00.00%−10,000−100.0%Sold out
Police & Firemen's Retirement System of New Jersey0$00.00%−4,671−100.0%Sold out
New York State Common Retirement Fund0$00.00%−3,623−100.0%Sold out
Legal & General Group Plc0$00.00%−2,225−100.0%Sold out
California State Teachers Retirement System0$00.00%−1,893−100.0%Sold out
Ameritas Investment Partners, Inc.0$00.00%−1,396−100.0%Sold out
Amalgamated Bank0$00.00%−847−100.0%Sold out
Northwestern Mutual Wealth Management Co0$00.00%−447−100.0%Sold out
Sterling Capital Management LLC0$00.00%−247−100.0%Sold out
GAMMA Investing LLC0$00.00%−101−100.0%Sold out
True Wealth Design, LLC0$00.00%−6−100.0%Sold out