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Orchestra BioMed Holdings, Inc.

OBIO
Exchange
Nasdaq
Industry
Surgical & Medical Instruments & Apparatus
SEC CIK
0001814114

In the last 90 days, Orchestra BioMed Holdings, Inc. insiders filed 2 open-market purchases and 3 sales; 77 institutions reported holding it in 13F filings for Q2 2026, worth $119.4M in total; no superinvestor holds it.

Holders of 5% or more of OBIO

Holders whose latest Schedule 13D or 13G filing reports 5% or more of Orchestra BioMed Holdings, Inc., largest stake first. The change is against the holder's previous filing.

Holders of 5% or more of OBIO
HolderLatest formStakeChangeFirst filedLatest filingFiling
RTW Investments, LP13D/A19.20%11.9M shares−0.50 ppfrom 19.70%Oct 12, 20228 filingsApr 29, 2026SEC
Medtronic plc13G/A17.80%10.1M shares+2.40 ppfrom 15.40%Feb 6, 20234 filingsFeb 27, 2026SEC
Perceptive Advisors LLC13G/A9.99%5.68M shares–Sep 13, 20234 filingsNov 14, 2025SEC
Tasso Partners, LLC13G5.50%3.10M sharesNewNov 19, 20251 filingNov 19, 2025SEC

Stakes are as of each holder's latest filing. Holders whose last filing was in the old format (before December 18, 2024) have no stake on record and are not listed, and after an acquisition or delisting holders usually stop filing.

13D and 13G filings

28 Schedule 13D and 13G filings on Orchestra BioMed Holdings, Inc., newest first, including old-format filings without a stake.

Schedule 13D and 13G filings on OBIO
Filed (ET)FilerFormStakeChangeEvent dateFiling
Apr 29, 20265:37 PM ETRTW Investments, LPand 3 others13D/A19.20%11.9M shares−0.50 ppfrom 19.70%Apr 27, 2026SEC
Feb 27, 20264:07 PM ETMedtronic plcand 1 other13G/A17.80%10.1M shares+2.40 ppfrom 15.40%Dec 31, 2025SEC
Feb 25, 20264:28 PM ETRTW Investments, LPand 3 others13D/A19.70%11.9M shares+4.30 ppfrom 15.40%Feb 23, 2026SEC
Nov 19, 20254:05 PM ETTasso Partners, LLCand 1 other13G5.50%3.10M sharesNewNov 15, 2025SEC
Nov 14, 20254:00 PM ETPerceptive Advisors LLCand 2 others13G/A9.99%5.68M shares–Sep 30, 2025SEC
Aug 6, 20254:29 PM ETRTW Investments, LPand 3 others13D/A15.40%8.31M shares−6.30 ppfrom 21.70%Aug 4, 2025SEC
May 1, 20255:41 PM ETRTW Investments, LPand 3 others13D/A21.70%8.31M shares–Apr 29, 2025SEC
Apr 29, 20256:53 AM ETBlackRock, Inc.13G/A3.70%1.43M shares–Below 5%Mar 31, 2025SEC
Feb 14, 20254:06 PM ETMedtronic plcand 1 other13G/A15.40%5.87M shares–Dec 31, 2024SEC
Nov 8, 2024BlackRock, Inc.13GOld format–––SEC
Oct 23, 2024BlackRock, Inc.13GOld format–New–SEC
Aug 7, 2024RTW Investments, LP13D/AOld format–––SEC
Aug 7, 2024HSAC 2 Holdings, LLC13D/AOld format–––SEC
Jul 17, 2024Perceptive Advisors LLC13G/AOld format–––SEC
Feb 14, 2024Medtronic plc13G/AOld format–––SEC
Feb 14, 2024Perceptive Advisors LLC13G/AOld format–––SEC
Feb 14, 2024Price T Rowe Associates Inc13GOld format–––SEC
Sep 13, 2023Perceptive Advisors LLC13GOld format–New–SEC
May 5, 2023RTW Investments, LP13D/AOld format–––SEC
Feb 14, 2023Ra Capital Management, L.P.13GOld format–New–SEC
Feb 14, 2023Price T Rowe Associates Inc13GOld format–New–SEC
Feb 7, 2023Smith Geoffrey Wade13DOld format–New–SEC
Feb 6, 2023Medtronic plc13GOld format–New–SEC
Jan 30, 2023HSAC 2 Holdings, LLC13D/AOld format–––SEC
Jan 27, 2023RTW Investments, LP13D/AOld format–––SEC
Oct 12, 2022RTW Investments, LP13DOld format–New–SEC
Oct 12, 2022HSAC 2 Holdings, LLC13DOld format–––SEC
Feb 16, 2021HSAC 2 Holdings, LLC13GOld format–New–SEC

Form 144: proposed insider sales

Notices from officers, directors and other affiliates planning to sell Orchestra BioMed Holdings, Inc. shares.

No Form 144 notices for Orchestra BioMed Holdings, Inc. are on file.