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Assembly Biosciences, Inc.

ASMB
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001426800

No open-market purchases or sales by Assembly Biosciences, Inc. insiders were filed in the last 90 days; 92 institutions reported holding it in 13F filings for Q2 2026, worth $514.8M in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Assembly Biosciences, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
69
+14 vs. Q3 2025
Shares held
13.7M
+1.26M (+10.1%) vs. Q3 2025
Total value
$466.7M
+$142.2M (+43.8%) vs. Q3 2025
New holders
22
23 more added
Sold out
8
13 more reduced

2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting ASMB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 69 institutions
Q1 2021: 107 institutionsQ2 2021: 91 institutionsQ3 2021: 65 institutionsQ4 2021: 62 institutionsQ1 2022: 54 institutionsQ2 2022: 54 institutionsQ3 2022: 50 institutionsQ4 2022: 40 institutionsQ1 2023: 38 institutionsQ2 2023: 32 institutionsQ3 2023: 32 institutionsQ4 2023: 45 institutionsQ1 2024: 24 institutionsQ2 2024: 27 institutionsQ3 2024: 30 institutionsQ4 2024: 35 institutionsQ1 2025: 37 institutionsQ2 2025: 33 institutionsQ3 2025: 57 institutionsQ4 2025: 69 institutionsQ1 2026: 75 institutionsQ2 2026: 92 institutions
Value heldQ4 2025: $466.7M
Q1 2021: $133.6MQ2 2021: $105.1MQ3 2021: $79.0MQ4 2021: $54.3MQ1 2022: $39.3MQ2 2022: $36.1MQ3 2022: $27.2MQ4 2022: $18.4MQ1 2023: $11.1MQ2 2023: $12.0MQ3 2023: $8.62MQ4 2023: $7.12MQ1 2024: $8.68MQ2 2024: $16.1MQ3 2024: $15.6MQ4 2024: $50.3MQ1 2025: $30.4MQ2 2025: $57.1MQ3 2025: $324.9MQ4 2025: $466.7MQ1 2026: $381.5MQ2 2026: $514.8M
Institutions holding ASMB and their total value by quarter
QuarterHoldersValue
Q2 202692$514.8M
Q1 202675$381.5M
Q4 202569$466.7M
Q3 202557$324.9M
Q2 202533$57.1M
Q1 202537$30.4M
Q4 202435$50.3M
Q3 202430$15.6M
Q2 202427$16.1M
Q1 202424$8.68M
Q4 202345$7.12M
Q3 202332$8.62M
Q2 202332$12.0M
Q1 202338$11.1M
Q4 202240$18.4M
Q3 202250$27.2M
Q2 202254$36.1M
Q1 202254$39.3M
Q4 202162$54.3M
Q3 202165$79.0M
Q2 202191$105.1M
Q1 2021107$133.6M

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Assembly Biosciences, Inc.; share changes are against Q3 2025.

Institutions holding ASMB in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Gilead Sciences, Inc.4,505,391$153.2M7.92%00.0%Unchanged
Farallon Capital Management, L.L.C.1,227,590$41.8M0.22%00.0%Unchanged
Ra Capital Management, L.P.1,020,410$34.7M0.36%00.0%Unchanged
Commodore Capital LP1,000,000$34.0M2.26%00.0%Unchanged
Janus Henderson Group PLC837,925$28.5M0.01%+85,299+11.3%Added
Paradigm Biocapital Advisors LP665,251$22.6M0.61%+665,251New
Point72 Asset Management, L.P.600,609$20.4M0.03%+304,592+102.9%Added
Vanguard Group Inc572,898$19.5M0.00%+70,786+14.1%Added
Blackstone Group Inc.318,754$10.8M0.05%−129,035−28.8%Reduced
Parkman Healthcare Partners LLC249,357$8.48M0.81%−1,624−0.6%Reduced
Franklin Resources Inc210,528$7.16M0.00%−27,641−11.6%Reduced
BlackRock, Inc.192,296$6.54M0.00%+22,097+13.0%Added
B Group, Inc.175,706$5.98M4.43%00.0%Unchanged
Adage Capital Partners GP, L.L.C.161,000$5.48M0.01%+161,000New
Eversept Partners, LP159,676$5.43M0.30%+159,676New
StemPoint Capital LP156,728$5.33M0.91%+90,598+137.0%Added
Geode Capital Management, LLC131,307$4.47M0.00%+1,212+0.9%Added
Marshall Wace, LLP129,075$4.39M0.00%+43,860+51.5%Added
Patient Square Capital LP127,000$4.32M0.92%−8,182−6.1%Reduced
Caption Management, LLC106,591$3.63M0.16%+106,591New
Millennium Management LLC98,221$3.34M0.00%+76,613+354.6%Added
Susquehanna International Group, LLP80,394$2.73M0.00%−50,632−38.6%Reduced
Seven Fleet Capital Management LP73,762$2.51M1.70%+73,762New
Superstring Capital Management LP65,273$2.22M1.19%+65,273New
Schonfeld Strategic Advisors LLC54,235$1.84M0.01%−67,653−55.5%Reduced
Jane Street Group, LLC53,702$1.83M0.00%+19,874+58.8%Added
State Street Corp52,989$1.80M0.00%+8,175+18.2%Added
JPMorgan Chase & Co48,159$1.64M0.00%+48,145+343,892.9%Added
Qube Research & Technologies Ltd42,185$1.43M0.00%+31,155+282.5%Added
Northern Trust Corp41,227$1.40M0.00%+1,272+3.2%Added
Monimus Capital Management, LP38,301$1.30M0.86%−3,766−9.0%Reduced
Arrowstreet Capital, Limited Partnership37,812$1.29M0.00%+37,812New
Palumbo Wealth Management LLC37,305$1.27M0.31%+2,507+7.2%Added
Goldman Sachs Group Inc34,794$1.18M0.00%+17,138+97.1%Added
Citadel Advisors LLC32,866$1.12M0.00%−21,012−39.0%Reduced
EAM Investors, LLC29,523$1.00M0.11%+451+1.6%Added
Trexquant Investment LP28,276$961.7K0.01%+15,750+125.7%Added
683 Capital Management, LLC27,863$947.6K0.08%+27,863New
Ellsworth Advisors, LLC29,735$889.4K0.18%−215−0.7%Reduced
Federated Hermes, Inc.25,394$863.6K0.00%00.0%Unchanged
Barclays PLC24,741$841.4K0.00%+20,780+524.6%Added
Morgan Stanley22,534$766.4K0.00%+19,007+538.9%Added
Connor, Clark & Lunn Investment Management Ltd.20,802$707.5K0.00%+9,646+86.5%Added
ADAR1 Capital Management, LLC19,747$671.6K0.05%+800+4.2%Added
SEI Investments Co17,745$603.5K0.00%+17,745New
Omers Administration Corp15,598$530.5K0.00%+15,598New
Hudson Bay Capital Management LP15,050$511.9K0.00%+15,050New
Susquehanna Portfolio Strategies, LLC13,903$472.8K0.01%+13,903New
Raymond James Financial Inc13,082$444.9K0.00%+13,082New
Gsa Capital Partners LLP12,699$432.0K0.04%+279+2.2%Added
Acadian Asset Management LLC12,446$422.0K0.00%−10,844−46.6%Reduced
Engineers Gate Manager LP10,375$352.9K0.00%+10,375New
UBS Group AG9,779$332.6K0.00%−5,984−38.0%Reduced
Renaissance Technologies LLC9,240$314.3K0.00%−144,371−94.0%Reduced
Virtus Investment Advisers, Inc.7,369$250.6K0.07%+7,369New
Charles Schwab Investment Management Inc6,704$228.0K0.00%+6,704New
Bank of America Corp5,110$173.8K0.00%+1,739+51.6%Added
Canada Pension Plan Investment Board3,500$119.0K0.00%+3,500New
Citigroup Inc2,201$74.9K0.00%+2,201New
Tower Research Capital LLC (TRC)607$20.6K0.00%+607New
Northwestern Mutual Wealth Management Co260$8.84K0.00%00.0%Unchanged
Rhumbline Advisers190$6.46K0.00%00.0%Unchanged
Farther Finance Advisors, LLC154$5.24K0.00%+154New
Advisor Group Holdings, Inc.100$3.40K0.00%00.0%Unchanged
US Bancorp59$2.01K0.00%+59New
EverSource Wealth Advisors, LLC55$1.87K0.00%00.0%Unchanged
Allworth Financial LP32$1.09K0.00%+32New
Quadrant Capital Group LLC22$7490.00%00.0%Unchanged
BNP Paribas Arbitrage, SA2$680.00%−56−96.6%Reduced
Frazier Life Sciences Management, L.P.0$00.00%−456,249−100.0%Sold out
MPM Oncology Impact Management LP0$00.00%−39,665−100.0%Sold out
Walleye Capital LLC0$00.00%−24,501−100.0%Sold out
Quadrature Capital Ltd0$00.00%−17,935−100.0%Sold out
Bridgeway Capital Management, LLC0$00.00%−15,225−100.0%Sold out
XTX Topco Ltd0$00.00%−12,806−100.0%Sold out
Wells Fargo & Company0$00.00%−145−100.0%Sold out
SBI Securities Co., Ltd.0$00.00%−68−100.0%Sold out
Cubist Systematic Strategies, LLC––––Not filed
Point72 Europe (London) LLP––––Not filed