Ikarian Capital, LLC
- SEC CIK
- 0001778253
- Latest filing
- Aug 14, 2026
Holdings in Q4 2024
Holdings as of Dec 31, 2024, filed Feb 14, 2025. Long positions only; changes compare share counts with Q3 2024.
- Positions
- 122
- +26 vs. Q3 2024
- Portfolio value
- $350.2M
- +$28.2M (+8.8%) vs. Q3 2024
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| TARSTarsus Pharmaceuticals, Inc. | COM | 607,689 | $33.6M | 9.6% | −422,588−41.0% | Reduced | History |
| CRNXCrinetics Pharmaceuticals, Inc. | COM | 516,431 | $26.4M | 7.5% | +89,518+21.0% | Added | History |
| SRRKScholar Rock Holding Corp | COM | 357,185 | $15.4M | 4.4% | +357,185 | New | History |
| BPMCBlueprint Medicines Corp | COM | 169,374 | $14.8M | 4.2% | +84,374+99.3% | Added | History |
| FBRXForte Biosciences, Inc. | COM NEW | 609,225 | $13.8M | 4.0% | +609,225 | New | History |
| VRDNViridian Therapeutics, Inc. | COM | 469,949 | $9.01M | 2.6% | −30,028−6.0% | Reduced | History |
| ELVNEnliven Therapeutics, Inc. | COM | 394,538 | $8.88M | 2.5% | −105,028−21.0% | Reduced | History |
| TGTXTG Therapeutics, Inc. | COM | 291,240 | $8.77M | 2.5% | +291,240 | New | History |
| INSMINSMED Inc | COM PAR $.01 | 119,800 | $8.27M | 2.4% | −35,035−22.6% | Reduced | History |
| GPCRStructure Therapeutics Inc. | SPONSORED ADS | 284,085 | $7.70M | 2.2% | +168,885+146.6% | Added | History |
| RAREUltragenyx Pharmaceutical Inc. | COM | 178,989 | $7.53M | 2.2% | −110.0% | Reduced | History |
| CPRXCatalyst Pharmaceuticals, Inc. | COM | 349,649 | $7.30M | 2.1% | −68,201−16.3% | Reduced | History |
| AVTXAvalo Therapeutics, Inc. | COM NEW | 970,259 | $7.21M | 2.1% | −1000.0% | Reduced | History |
| CYTKCytokinetics Inc | COM NEW | 149,982 | $7.06M | 2.0% | −20,165−11.9% | Reduced | History |
| VIRVir Biotechnology, Inc. | COM | 897,862 | $6.59M | 1.9% | +897,862 | New | History |
| TECXTectonic Therapeutic, Inc. | COM | 142,328 | $6.57M | 1.9% | −124,817−46.7% | Reduced | History |
| SYRESpyre Therapeutics, Inc. | COM NEW | 282,159 | $6.57M | 1.9% | −20,088−6.6% | Reduced | History |
| BBIOBridgeBio Pharma, Inc. | COM | 215,713 | $5.92M | 1.7% | −69,900−24.5% | Reduced | History |
| KODKodiak Sciences Inc. | COM | 576,166 | $5.73M | 1.6% | +99,580+20.9% | Added | History |
| RCUSArcus Biosciences, Inc. | COM | 378,363 | $5.63M | 1.6% | −365,637−49.1% | Reduced | History |
| DRUGBright Minds Biosciences Inc. | COM NEW | 152,211 | $5.48M | 1.6% | +152,211 | New | History |
| ELDNEledon Pharmaceuticals, Inc. | COM | 1,126,637 | $4.64M | 1.3% | +1,126,637 | New | History |
| ACOGAlpha Cognition Inc. | COM NEW | 755,867 | $4.45M | 1.3% | +755,867 | New | History |
| LENZLENZ Therapeutics, Inc. | COM | 149,502 | $4.32M | 1.2% | −55,011−26.9% | Reduced | History |
| RZLTRezolute, Inc. | COM NEW | 857,230 | $4.20M | 1.2% | −30,000−3.4% | Reduced | History |
| SRPTSarepta Therapeutics, Inc. | COM | 34,087 | $4.14M | 1.2% | −20,089−37.1% | Reduced | History |
| EOLSEvolus, Inc. | COM | 373,265 | $4.12M | 1.2% | +114,986+44.5% | Added | History |
| MLYSMineralys Therapeutics, Inc. | COM | 332,390 | $4.09M | 1.2% | +152,390+84.7% | Added | History |
| NUVLNuvalent, Inc. | COM | 52,216 | $4.09M | 1.2% | −220.0% | Reduced | History |
| JANXJanux Therapeutics, Inc. | COM | 74,691 | $4.00M | 1.1% | +74,691 | New | History |
| VRNAVerona Pharma plc | SPONSORED ADS | 80,000 | $3.72M | 1.1% | +80,000 | New | History |
| HELPHelus Pharma Inc. | COM NEW | 397,175 | $3.50M | 1.0% | +29,980+8.2% | Added | History |
| ARCTArcturus Therapeutics Holdings Inc. | COM | 200,000 | $3.39M | 1.0% | +200,000 | New | History |
| LXEOLexeo Therapeutics, Inc. | COM | 499,301 | $3.29M | 0.9% | +242,085+94.1% | Added | History |
| ABEOAbeona Therapeutics Inc. | COM NEW | 533,581 | $2.97M | 0.8% | −50,012−8.6% | Reduced | History |
| RLAYRelay Therapeutics, Inc. | COM | 693,308 | $2.86M | 0.8% | −420.0% | Reduced | History |
| RCKTRocket Pharmaceuticals, Inc. | COM | 221,911 | $2.79M | 0.8% | +24,815+12.6% | Added | History |
| PTGXProtagonist Therapeutics, Inc | COM | 70,000 | $2.70M | 0.8% | +70,000 | New | History |
| ALGSAligos Therapeutics, Inc. | COM NEW | 64,300 | $2.56M | 0.7% | +64,300 | New | History |
| ZVRAZevra Therapeutics, Inc. | COM NEW | 292,772 | $2.44M | 0.7% | +292,772 | New | History |
| XENEXenon Pharmaceuticals Inc. | COM | 62,052 | $2.43M | 0.7% | −45,135−42.1% | Reduced | History |
| VTYXVentyx Biosciences, Inc. | COM | 1,092,590 | $2.39M | 0.7% | +899,943+467.1% | Added | History |
| OKUROnKure Therapeutics, Inc. | COM CL A | 253,754 | $2.18M | 0.6% | +253,754 | New | History |
| GLUEMonte Rosa Therapeutics, Inc. | COM | 311,575 | $2.16M | 0.6% | −180.0% | Reduced | History |
| SLRNACELYRIN, Inc. | COM | 676,608 | $2.12M | 0.6% | −466−0.1% | Reduced | History |
| CRDFCardiff Oncology, Inc. | COM | 450,000 | $1.95M | 0.6% | +450,000 | New | History |
| SGMOQSangamo Therapeutics, Inc | COM | 1,860,179 | $1.90M | 0.5% | +1,860,179 | New | History |
| NKTRNektar Therapeutics | COM | 2,029,028 | $1.89M | 0.5% | +716,623+54.6% | Added | History |
| TARAProtara Therapeutics, Inc. | COM STK | 350,489 | $1.85M | 0.5% | +194,777+125.1% | Added | History |
| ALECAlector, Inc. | COM | 950,000 | $1.80M | 0.5% | +950,000 | New | History |
| TERNTerns Pharmaceuticals, Inc. | COM | 308,491 | $1.71M | 0.5% | −60.0% | Reduced | History |
| Achilles Therapeutics PLC00449L102 | SPONSORED ADS | 1,441,141 | $1.64M | 0.5% | −2,040−0.1% | Reduced | – |
| IMUXImmunic, Inc. | COM | 1,614,170 | $1.61M | 0.5% | +1,120,674+227.1% | Added | History |
| ANROAlto Neuroscience, Inc. | COM SHS | 350,000 | $1.48M | 0.4% | +350,000 | New | History |
| IBIOiBio, Inc. | COM NEW | 599,913 | $1.47M | 0.4% | −870.0% | Reduced | History |
| CDTXCidara Therapeutics, Inc. | COM NEW | 53,940 | $1.45M | 0.4% | +53,940 | New | History |
| TRMLTourmaline Bio, Inc. | COM | 67,927 | $1.38M | 0.4% | −40,556−37.4% | Reduced | History |
| SWTXSpringWorks Therapeutics, Inc. | COM | 37,519 | $1.36M | 0.4% | +37,519 | New | History |
| TRVITrevi Therapeutics, Inc. | COM | 325,000 | $1.34M | 0.4% | +325,000 | New | History |
| DCTHDelcath Systems, Inc. | COM NEW | 100,365 | $1.21M | 0.3% | −50.0% | Reduced | History |
| JSPRJasper Therapeutics, Inc. | COM NEW | 55,107 | $1.18M | 0.3% | −68−0.1% | Reduced | History |
| ALLKAllakos Inc. | COM | 971,950 | $1.18M | 0.3% | −725−0.1% | Reduced | History |
| LXRXLexicon Pharmaceuticals, Inc. | COM NEW | 1,550,000 | $1.14M | 0.3% | +1,550,000 | New | History |
| MISTMilestone Pharmaceuticals Inc. | COM | 466,030 | $1.10M | 0.3% | +110.0% | Added | History |
| THRDThird Harmonic Bio, Inc. | COM | 100,000 | $1.03M | 0.3% | +100,000 | New | History |
| VERVVerve Therapeutics, Inc. | COM | 169,991 | $958.7K | 0.3% | −90.0% | Reduced | History |
| PYXSPyxis Oncology, Inc. | COMMON STOCK | 613,253 | $956.7K | 0.3% | −344,155−35.9% | Reduced | History |
| FULCFulcrum Therapeutics, Inc. | COM | 200,096 | $940.5K | 0.3% | +125,096+166.8% | Added | History |
| RNACCartesian Therapeutics, Inc. | COM NEW | 52,166 | $934.3K | 0.3% | −27−0.1% | Reduced | History |
| TRAWTraws Pharma, Inc. | COM NEW | 98,493 | $874.6K | 0.2% | +98,493 | New | History |
| ACRSAclaris Therapeutics, Inc. | COM | 350,000 | $868.0K | 0.2% | +350,000 | New | History |
| VIGLVigil Neuroscience, Inc. | COM | 500,000 | $850.0K | 0.2% | +500,000 | New | History |
| TYRATyra Biosciences, Inc. | COM | 60,000 | $834.0K | 0.2% | +60,000 | New | History |
| LYELLyell Immunopharma, Inc. | COM | 1,276,037 | $816.7K | 0.2% | +749,971+142.6% | Added | History |
| CMPSCOMPASS Pathways plc | SPONSORED ADS | 202,894 | $766.9K | 0.2% | −140.0% | Reduced | History |
| AMLXAmylyx Pharmaceuticals, Inc. | COM | 201,187 | $760.5K | 0.2% | −73,364−26.7% | Reduced | History |
| KZRKezar Life Sciences, Inc. | COM | 106,901 | $718.4K | 0.2% | 00.0% | UnchangedConverted for a 1-for-10 split | History |
| NRIXNurix Therapeutics, Inc. | COM | 34,985 | $659.1K | 0.2% | −225,015−86.5% | Reduced | History |
| HLSQTessera Defense & Homeland Security Inc. | COM NEW | 892,976 | $652.0K | 0.2% | −240.0% | Reduced | History |
| INBXInhibrx Biosciences, Inc. | COM | 42,122 | $648.7K | 0.2% | −10.0% | Reduced | History |
| AEMDAethlon Medical Inc | COM NEW | 750,000 | $645.0K | 0.2% | +750,000 | New | History |
| VERUVeru Inc. | COM | 945,239 | $614.9K | 0.2% | −1,143−0.1% | Reduced | History |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | COM NEW | 51,431 | $606.9K | 0.2% | −233,284−81.9% | Reduced | History |
| ITOSiTeos Therapeutics, Inc. | COM | 78,585 | $603.5K | 0.2% | +110.0% | Added | History |
| SANASana Biotechnology, Inc. | COM | 365,000 | $594.9K | 0.2% | +365,000 | New | History |
| OLMAOlema Pharmaceuticals, Inc. | COM | 91,994 | $536.3K | 0.2% | −60.0% | Reduced | History |
| ABOSAcumen Pharmaceuticals, Inc. | COM | 265,769 | $457.1K | 0.1% | −666−0.2% | Reduced | History |
| DFTXDefinium Therapeutics, Inc. | Stock | 62,691 | $436.3K | 0.1% | +210+0.3% | Added | History |
| SPRBSpruce Biosciences, Inc. | COM | 1,000,000 | $420.0K | 0.1% | +1,000,000 | New | History |
| TVTXTravere Therapeutics, Inc. | COM | 22,600 | $393.7K | 0.1% | +22,600 | New | History |
| ELEVElevation Acquisition Group Inc. | COM | 690,050 | $388.2K | 0.1% | −390.0% | Reduced | History |
| CMMBChemomab Therapeutics Ltd. | SPONSORED ADS | 213,052 | $385.6K | 0.1% | −340−0.2% | Reduced | History |
| CATXPerspective Therapeutics, Inc. | COM NEW | 108,300 | $345.5K | 0.1% | +108,300 | New | History |
| FTHFaeth Therapeutics, Inc. | COM | 649,963 | $318.5K | 0.1% | −370.0% | Reduced | History |
| VYGRVoyager Therapeutics, Inc. | COM | 55,766 | $316.2K | 0.1% | −91−0.2% | Reduced | History |
| CLYMClimb Bio, Inc. | COM | 175,088 | $315.2K | 0.1% | −120.0% | Reduced | History |
| ATXIAvenue Therapeutics, Inc. | COM NEW | 140,000 | $280.0K | 0.1% | +140,000 | New | History |
| KPTIKaryopharm Therapeutics Inc. | COM | 408,899 | $276.5K | 0.1% | −456−0.1% | Reduced | History |
| ANEBAnebulo Pharmaceuticals, Inc. | COM | 157,720 | $265.0K | 0.1% | −142−0.1% | Reduced | History |
| MGNXMacrogenics Inc | COM | 80,071 | $260.2K | 0.1% | −80.0% | Reduced | History |
Options (39)
Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.
| Security | Class | Puts | Calls |
|---|---|---|---|
| State Street SPDR S&P Biotech ETF78464A870 | ETF | $67.5M | $63.0M |
| TSNTyson Foods, Inc. | Stock | $36.2M | – |
| AMGNAmgen Inc | Stock | – | $19.3M |
| BBIOBridgeBio Pharma, Inc. | COM | – | $19.2M |
| Avidity Biosciences, Inc.05370A108 | COM | $11.6M | $2.91M |
| PPCPilgrims Pride Corp | Stock | $13.6M | – |
| NMRANeumora Therapeutics, Inc. | COM | $3.71M | $9.54M |
| INSMINSMED Inc | COM PAR $.01 | – | $10.4M |
| SRPTSarepta Therapeutics, Inc. | COM | – | $9.85M |
| CAPRCapricor Therapeutics, Inc. | COM NEW | $4.14M | $4.98M |
| AXSMAxsome Therapeutics, Inc. | COM | – | $8.46M |
| CALMCal-Maine Foods Inc | COM NEW | $7.72M | – |
| DNAGinkgo Bioworks Holdings, Inc. | CL A NEW | – | $7.56M |
| IMVTImmunovant, Inc. | COM | – | $7.43M |
| ANABAnaptysbio, Inc | COM | $4.11M | $3.31M |
| CRVSCorvus Pharmaceuticals, Inc. | COM | $2.67M | $4.04M |
| DYNDyne Therapeutics, Inc. | COM | $6.62M | – |
| AKROAkero Therapeutics, Inc. | COM | $5.54M | – |
| ONCBeOne Medicines Ltd. | ADR | – | $5.50M |
| VIRVir Biotechnology, Inc. | COM | – | $5.29M |
| CLDXCelldex Therapeutics, Inc. | COM NEW | $5.19M | – |
| SRRKScholar Rock Holding Corp | COM | – | $4.41M |
| MRNAModerna, Inc. | Stock | $4.16M | – |
| SLNOSoleno Therapeutics Inc | COM | $3.37M | – |
| VRDNViridian Therapeutics, Inc. | COM | – | $3.36M |
| GALTGalectin Therapeutics Inc | COM NEW | $1.55M | $1.55M |
| NVAXNovavax Inc | COM NEW | – | $2.41M |
| ALTAltimmune, Inc. | COM NEW | $1.19M | $1.19M |
| TEVATeva Pharmaceutical Industries Ltd | SPONSORED ADS | – | $2.20M |
| RCUSArcus Biosciences, Inc. | COM | – | $2.10M |
| HROWHarrow, Inc. | COM | – | $1.96M |
| SANASana Biotechnology, Inc. | COM | $815.0K | $1.06M |
| BMEABiomea Fusion, Inc. | COM | $1.67M | – |
| SLDBSolid Biosciences Inc. | COM NEW | – | $1.20M |
| IMUXImmunic, Inc. | COM | – | $635.8K |
| ABEOAbeona Therapeutics Inc. | COM NEW | – | $362.1K |
| CATXPerspective Therapeutics, Inc. | COM NEW | $342.0K | – |
| CADLCandel Therapeutics, Inc. | COM | $31.2K | $31.2K |
| EWTXEdgewise Therapeutics, Inc. | COM | $5.34K | – |
Sold out since Q3 2024 (17)
Positions held at the end of Q3 2024 that are gone from this filing.
| Security | Class | Shares in Q3 2024 | Value in Q3 2024 | % of portfolio in Q3 2024 | History |
|---|---|---|---|---|---|
| SLNOSoleno Therapeutics Inc | COM | 221,437 | $11.2M | 3.5% | History |
| CAPRCapricor Therapeutics, Inc. | COM NEW | 300,000 | $4.56M | 1.4% | History |
| WVEWave Life Sciences, Inc. | SHS | 544,265 | $4.46M | 1.4% | History |
| AMGNAmgen Inc | Stock | 13,300 | $4.29M | 1.3% | History |
| SLNSilence Therapeutics plc | ADS | 587,343 | $3.37M | 1.0% | History |
| CRVOCervoMed Inc. | COM | 202,345 | $2.95M | 0.9% | History |
| ALNYAlnylam Pharmaceuticals, Inc. | COM | 8,741 | $2.40M | 0.7% | History |
| OKUROnKure Therapeutics, Inc. | COM | 1,025,668 | $1.74M | 0.5% | History |
| ONCBeOne Medicines Ltd. | ADR | 88,167 | $1.64M | 0.5% | History |
| MRNSMarinus Pharmaceuticals, Inc. | COM NEW | 706,154 | $1.24M | 0.4% | History |
| ROIVRoivant Sciences Ltd. | SHS | 100,609 | $1.16M | 0.4% | History |
| IFRXInflaRx N.V. | COM | 704,987 | $1.08M | 0.3% | History |
| PRQRProQR Therapeutics N.V. | SHS EURO | 483,583 | $880.1K | 0.3% | History |
| JBIOJade Biosciences, Inc. | COM | 367,965 | $769.0K | 0.2% | History |
| IMTXImmatics N.V. | SHS | 49,415 | $563.8K | 0.2% | History |
| NYXHNyxoah SA | COMMONSTOCK | 50,699 | $484.2K | 0.2% | History |
| RAPTRAPT Therapeutics, Inc. | COM | 154,625 | $310.8K | 0.1% | History |