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Livermore
Livermore
ZHEN

Ikarian Capital, LLC

SEC CIK
0001778253
Latest filing
Aug 14, 2026

Holdings in Q3 2024

Holdings as of Sep 30, 2024, filed Nov 14, 2024. Long positions only; changes compare share counts with Q2 2024.

Institution overview
Positions
96
+11 vs. Q2 2024
Portfolio value
$322.0M
+$1.54M (+0.5%) vs. Q2 2024
Filed
Nov 14, 2024
SEC
Holdings of Ikarian Capital, LLC in Q3 2024
SecurityClassSharesValue% of portfolioShare changeActionHistory
TARSTarsus Pharmaceuticals, Inc.COM1,030,277$33.9M10.5%+230,000+28.7%AddedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM426,913$21.8M6.8%−161,905−27.5%ReducedHistory
ELVNEnliven Therapeutics, Inc.COM499,566$12.8M4.0%−86,986−14.8%ReducedHistory
RCUSArcus Biosciences, Inc.COM744,000$11.4M3.5%+599,000+413.1%AddedHistory
VRDNViridian Therapeutics, Inc.COM499,977$11.4M3.5%+499,977NewHistory
INSMINSMED IncCOM PAR $.01154,835$11.3M3.5%+107,000+223.7%AddedHistory
SLNOSoleno Therapeutics IncCOM221,437$11.2M3.5%−224,014−50.3%ReducedHistory
RAREUltragenyx Pharmaceutical Inc.COM179,000$9.94M3.1%+179,000NewHistory
AVTXAvalo Therapeutics, Inc.COM NEW970,359$9.22M2.9%+915,629+1,673.0%AddedHistory
CYTKCytokinetics IncCOM NEW170,147$8.98M2.8%00.0%UnchangedHistory
SYRESpyre Therapeutics, Inc.COM NEW302,247$8.89M2.8%+302,247NewHistory
CPRXCatalyst Pharmaceuticals, Inc.COM417,850$8.31M2.6%−100,536−19.4%ReducedHistory
TECXTectonic Therapeutic, Inc.COM267,145$8.09M2.5%+204,309+325.1%AddedHistory
BPMCBlueprint Medicines CorpCOM85,000$7.86M2.4%+85,000NewHistory
BBIOBridgeBio Pharma, Inc.COM285,613$7.27M2.3%−46,400−14.0%ReducedHistory
SRPTSarepta Therapeutics, Inc.COM54,176$6.77M2.1%−149,436−73.4%ReducedHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM NEW284,715$5.87M1.8%−24,825−8.0%ReducedHistory
NRIXNurix Therapeutics, Inc.COM260,000$5.84M1.8%−180,500−41.0%ReducedHistory
NUVLNuvalent, Inc.COM52,238$5.34M1.7%−99,363−65.5%ReducedHistory
GPCRStructure Therapeutics Inc.SPONSORED ADS115,200$5.06M1.6%+115,200NewHistory
RLAYRelay Therapeutics, Inc.COM693,350$4.91M1.5%+693,350NewHistory
LENZLENZ Therapeutics, Inc.COM204,513$4.86M1.5%00.0%UnchangedHistory
CAPRCapricor Therapeutics, Inc.COM NEW300,000$4.56M1.4%+300,000NewHistory
WVEWave Life Sciences, Inc.SHS544,265$4.46M1.4%−30,823−5.4%ReducedHistory
RZLTRezolute, Inc.COM NEW887,230$4.30M1.3%−16,514−1.8%ReducedHistory
AMGNAmgen IncStock13,300$4.29M1.3%−25,000−65.3%ReducedHistory
XENEXenon Pharmaceuticals Inc.COM107,187$4.22M1.3%00.0%UnchangedHistory
EOLSEvolus, Inc.COM258,279$4.18M1.3%+258,279NewHistory
ABEOAbeona Therapeutics Inc.COM NEW583,593$3.69M1.1%−185,000−24.1%ReducedHistory
RCKTRocket Pharmaceuticals, Inc.COM197,096$3.64M1.1%00.0%UnchangedHistory
PYXSPyxis Oncology, Inc.COMMON STOCK957,408$3.51M1.1%−705,000−42.4%ReducedHistory
SLNSilence Therapeutics plcADS587,343$3.37M1.0%+80,678+15.9%AddedHistory
SLRNACELYRIN, Inc.COM677,074$3.34M1.0%−798,000−54.1%ReducedHistory
HELPHelus Pharma Inc.COM NEW367,195$3.26M1.0%+367,195NewHistory
CRVOCervoMed Inc.COM202,345$2.95M0.9%−35,000−14.7%ReducedHistory
TRMLTourmaline Bio, Inc.COM108,483$2.79M0.9%00.0%UnchangedHistory
TERNTerns Pharmaceuticals, Inc.COM308,497$2.57M0.8%−150,000−32.7%ReducedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM8,741$2.40M0.7%+8,741NewHistory
LXEOLexeo Therapeutics, Inc.COM257,216$2.33M0.7%+257,216NewHistory
MLYSMineralys Therapeutics, Inc.COM180,000$2.18M0.7%+180,000NewHistory
OKUROnKure Therapeutics, Inc.COM1,025,668$1.74M0.5%+1,025,668NewHistory
NKTRNektar TherapeuticsCOM1,312,405$1.71M0.5%00.0%UnchangedHistory
GLUEMonte Rosa Therapeutics, Inc.COM311,593$1.65M0.5%+311,593NewHistory
ONCBeOne Medicines Ltd.ADR88,167$1.64M0.5%+88,167NewHistory
Achilles Therapeutics PLC00449L102SPONSORED ADS1,443,181$1.47M0.5%00.0%Unchanged–
IBIOiBio, Inc.COM NEW600,000$1.33M0.4%00.0%UnchangedHistory
CMPSCOMPASS Pathways plcSPONSORED ADS202,908$1.28M0.4%−100,000−33.0%ReducedHistory
KODKodiak Sciences Inc.COM476,586$1.24M0.4%00.0%UnchangedHistory
MRNSMarinus Pharmaceuticals, Inc.COM NEW706,154$1.24M0.4%00.0%UnchangedHistory
ROIVRoivant Sciences Ltd.SHS100,609$1.16M0.4%00.0%UnchangedHistory
OLMAOlema Pharmaceuticals, Inc.COM92,000$1.10M0.3%+92,000NewHistory
IFRXInflaRx N.V.COM704,987$1.08M0.3%00.0%UnchangedHistory
SGMTSagimet Biosciences Inc.COM SER A387,565$1.07M0.3%−25,000−6.1%ReducedHistory
JSPRJasper Therapeutics, Inc.COM NEW55,175$1.04M0.3%−50,000−47.5%ReducedHistory
HLSQTessera Defense & Homeland Security Inc.COM NEW893,000$910.9K0.3%+893,000NewHistory
DCTHDelcath Systems, Inc.COM NEW100,370$906.3K0.3%00.0%UnchangedHistory
CLYMClimb Bio, Inc.COM175,100$891.3K0.3%+75,100+75.1%AddedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM274,551$889.5K0.3%00.0%UnchangedHistory
PRQRProQR Therapeutics N.V.SHS EURO483,583$880.1K0.3%00.0%UnchangedHistory
RNACCartesian Therapeutics, Inc.COM NEW52,193$841.4K0.3%−190,177−78.5%ReducedHistory
KZRKezar Life Sciences, Inc.COM1,068,992$826.5K0.3%+200,000+23.0%AddedHistory
VERVVerve Therapeutics, Inc.COM170,000$822.8K0.3%+170,000NewHistory
IMUXImmunic, Inc.COM493,496$814.3K0.3%00.0%UnchangedHistory
ITOSiTeos Therapeutics, Inc.COM78,574$802.2K0.2%00.0%UnchangedHistory
JBIOJade Biosciences, Inc.COM367,965$769.0K0.2%00.0%UnchangedHistory
VERUVeru Inc.COM946,382$727.8K0.2%00.0%UnchangedHistory
LYELLyell Immunopharma, Inc.COM526,066$726.0K0.2%00.0%UnchangedHistory
MISTMilestone Pharmaceuticals Inc.COM466,019$708.3K0.2%00.0%UnchangedHistory
ABOSAcumen Pharmaceuticals, Inc.COM266,435$660.8K0.2%00.0%UnchangedHistory
INBXInhibrx Biosciences, Inc.COM42,123$659.6K0.2%−187,877−81.7%ReducedHistory
ALLKAllakos Inc.COM972,675$635.4K0.2%00.0%UnchangedHistory
IMTXImmatics N.V.SHS49,415$563.8K0.2%00.0%UnchangedHistory
NYXHNyxoah SACOMMONSTOCK50,699$484.2K0.2%00.0%UnchangedHistory
VTYXVentyx Biosciences, Inc.COM192,647$420.0K0.1%−250,000−56.5%ReducedHistory
ELEVElevation Acquisition Group Inc.COM690,089$414.0K0.1%00.0%UnchangedHistory
FTHFaeth Therapeutics, Inc.COM650,000$388.7K0.1%00.0%UnchangedHistory
LRMRLarimar Therapeutics, Inc.COM58,528$383.4K0.1%−265,000−81.9%ReducedHistory
DFTXDefinium Therapeutics, Inc.Stock62,481$355.5K0.1%−100,000−61.5%ReducedHistory
KPTIKaryopharm Therapeutics Inc.COM409,355$339.8K0.1%00.0%UnchangedHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS213,392$335.0K0.1%00.0%UnchangedHistory
VYGRVoyager Therapeutics, Inc.COM55,857$326.8K0.1%00.0%UnchangedHistory
RAPTRAPT Therapeutics, Inc.COM154,625$310.8K0.1%00.0%UnchangedHistory
ANEBAnebulo Pharmaceuticals, Inc.COM157,862$304.7K0.1%00.0%UnchangedHistory
TARAProtara Therapeutics, Inc.COM STK155,712$285.0K0.1%−25,000−13.8%ReducedHistory
LYRALyra Therapeutics, Inc.COM1,056,829$271.6K0.1%00.0%UnchangedHistory
AEONAEON Biopharma, Inc.CL A257,977$270.9K0.1%00.0%UnchangedHistory
FULCFulcrum Therapeutics, Inc.COM75,000$267.8K0.1%+75,000NewHistory
MGNXMacrogenics IncCOM80,079$263.5K0.1%−120,000−60.0%ReducedHistory
HOOKHOOKIPA Pharma Inc.COM53,076$228.2K0.1%+53,076NewHistory
NUVBNuvation Bio Inc.COM CL A83,282$190.7K0.1%−275,000−76.8%ReducedHistory
TPSTTempest Therapeutics, Inc.COM105,600$147.8K<0.1%00.0%UnchangedHistory
RLMDRelmada Therapeutics, Inc.COM40,369$130.8K<0.1%00.0%UnchangedHistory
STOKStoke Therapeutics, Inc.COM6,816$83.8K<0.1%00.0%UnchangedHistory
SYBXSynlogic, Inc.COM NEW20,448$30.5K<0.1%00.0%UnchangedHistory
CTMXCytomX Therapeutics, Inc.COM8,924$10.5K<0.1%00.0%UnchangedHistory
FDMT4D Molecular Therapeutics, Inc.COM39$421<0.1%+39NewHistory

Options (35)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ikarian Capital, LLC in Q3 2024
SecurityClassPutsCalls
VRTXVertex Pharmaceuticals IncStock$46.5M$46.5M
State Street SPDR S&P Biotech ETF78464A870ETF$49.4M–
AMGNAmgen IncStock–$47.0M
ANABAnaptysbio, IncCOM$13.5M$11.7M
CLDXCelldex Therapeutics, Inc.COM NEW$10.4M$10.4M
JANXJanux Therapeutics, Inc.COM$16.6M–
BHVNBiohaven Ltd.COM$16.3M–
IMVTImmunovant, Inc.COM–$14.3M
NMRANeumora Therapeutics, Inc.COM$5.28M$5.28M
APLSApellis Pharmaceuticals, Inc.COM$5.77M$4.33M
ANROAlto Neuroscience, Inc.COM SHS$5.15M$4.93M
CAPRCapricor Therapeutics, Inc.COM NEW$4.56M$4.56M
BDTXBlack Diamond Therapeutics, Inc.COM$4.13M$3.04M
CRBPCorbus Pharmaceuticals Holdings, Inc.COM NEW$4.81M$2.22M
ONCBeOne Medicines Ltd.ADR–$6.69M
AKROAkero Therapeutics, Inc.COM$5.71M–
SLNOSoleno Therapeutics IncCOM–$5.55M
SANASana Biotechnology, Inc.COM$2.70M$2.70M
MDGLMadrigal Pharmaceuticals, Inc.COM$4.99M–
DYNDyne Therapeutics, Inc.COM$4.78M–
VRDNViridian Therapeutics, Inc.COM–$4.55M
SRRKScholar Rock Holding CorpCOM$1.62M$1.62M
CYTKCytokinetics IncCOM NEW–$2.76M
GALTGalectin Therapeutics IncCOM NEW$1.38M$1.38M
SLDBSolid Biosciences Inc.COM NEW–$2.09M
RCUSArcus Biosciences, Inc.COM–$1.74M
FULCFulcrum Therapeutics, Inc.COM$81.4K$1.51M
SWTXSpringWorks Therapeutics, Inc.COM–$1.40M
PYXSPyxis Oncology, Inc.COMMON STOCK–$1.32M
CRVSCorvus Pharmaceuticals, Inc.COM–$1.15M
CATXPerspective Therapeutics, Inc.COM NEW$1.03M–
BMEABiomea Fusion, Inc.COM$535.3K–
NAMSNewAmsterdam Pharma Co N.V.ORDINARY SHARES–$483.1K
PRTAProthena Corp Public Ltd CoSHS$197.4K$197.4K
APGEApogee Therapeutics, Inc.COM–$293.7K

Sold out since Q2 2024 (10)

Positions held at the end of Q2 2024 that are gone from this filing.

Positions of Ikarian Capital, LLC sold out since Q2 2024
SecurityClassShares in Q2 2024Value in Q2 2024% of portfolio in Q2 2024History
VKTXViking Therapeutics, Inc.COM138,262$7.33M2.3%History
IMVTImmunovant, Inc.COM276,925$7.31M2.3%History
NBIXNeurocrine Biosciences IncStock40,000$5.51M1.7%History
ARQTArcutis Biotherapeutics, Inc.COM489,642$4.55M1.4%History
Cybin Ord23256X100COM13,953,488$3.78M1.2%–
VRNAVerona Pharma plcSPONSORED ADS201,116$2.91M0.9%History
QTTBQ32 Bio Inc.COM109,094$1.96M0.6%History
ANNXAnnexon, Inc.COM380,000$1.86M0.6%History
SRRKScholar Rock Holding CorpCOM183,701$1.53M0.5%History
BCLIBrainstorm Cell Therapeutics Inc.COM NEW90,242$30.5K<0.1%History