Skip to main content
Livermore
Livermore
ZHEN

Ikarian Capital, LLC

SEC CIK
0001778253
Latest filing
Aug 14, 2026

Holdings in Q3 2023

Holdings as of Sep 30, 2023, filed Nov 14, 2023. Long positions only; changes compare share counts with Q2 2023.

Institution overview
Positions
81
0 vs. Q2 2023
Portfolio value
$269.4M
−$14.1M (−5.0%) vs. Q2 2023
Filed
Nov 14, 2023
SEC
Holdings of Ikarian Capital, LLC in Q3 2023
SecurityClassSharesValue% of portfolioShare changeActionHistory
SLRNACELYRIN, Inc.COM2,918,426$29.7M11.0%00.0%UnchangedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM792,920$23.6M8.8%+317,920+66.9%AddedHistory
SLNOSoleno Therapeutics IncCOM536,720$15.8M5.9%+536,720NewHistory
RCKTRocket Pharmaceuticals, Inc.COM654,726$13.4M5.0%+654,726NewHistory
NUVLNuvalent, Inc.COM278,034$12.8M4.7%+5,282+1.9%AddedHistory
BBIOBridgeBio Pharma, Inc.COM473,126$12.5M4.6%+43,440+10.1%AddedHistory
IMVTImmunovant, Inc.COM297,794$11.4M4.2%+297,794NewHistory
AKROAkero Therapeutics, Inc.COM200,000$10.1M3.8%+200,000NewHistory
TARSTarsus Pharmaceuticals, Inc.COM518,519$9.21M3.4%+518,519NewHistory
PCVXVaxcyte, Inc.COM142,417$7.26M2.7%+2,417+1.7%AddedHistory
GPCRStructure Therapeutics Inc.SPONSORED ADS137,824$6.95M2.6%+137,824NewHistory
IRONDisc Medicine, Inc.COM142,766$6.71M2.5%−97,265−40.5%ReducedHistory
RAREUltragenyx Pharmaceutical Inc.COM174,945$6.24M2.3%+53,287+43.8%AddedHistory
IMGNImmunoGen, Inc.COM390,162$6.19M2.3%−57,538−12.9%ReducedHistory
MRNSMarinus Pharmaceuticals, Inc.COM NEW746,069$6.01M2.2%+134,137+21.9%AddedHistory
CPRXCatalyst Pharmaceuticals, Inc.COM505,862$5.91M2.2%+505,862NewHistory
IDYAIDEAYA Biosciences, Inc.COM216,949$5.85M2.2%−273,944−55.8%ReducedHistory
LYRALyra Therapeutics, Inc.COM1,254,384$4.90M1.8%+275,758+28.2%AddedHistory
RCUSArcus Biosciences, Inc.COM254,876$4.58M1.7%−25,124−9.0%ReducedHistory
SWTXSpringWorks Therapeutics, Inc.COM178,360$4.12M1.5%+178,360NewHistory
INSMINSMED IncCOM PAR $.01154,900$3.91M1.5%−330,100−68.1%ReducedHistory
PRAXPraxis Precision Medicines, Inc.COM2,250,000$3.85M1.4%+2,250,000NewHistory
ITOSiTeos Therapeutics, Inc.COM346,471$3.79M1.4%+346,471NewHistory
CHRSCoherus Oncology, Inc.COM865,787$3.24M1.2%+865,787NewHistory
LBPHLongboard Pharmaceuticals, Inc.COM514,101$2.86M1.1%+9,848+2.0%AddedHistory
ATXSAstria Therapeutics, Inc.COM374,807$2.80M1.0%−204,583−35.3%ReducedHistory
BHVNBiohaven Ltd.COM106,138$2.76M1.0%−321,279−75.2%ReducedHistory
LRMRLarimar Therapeutics, Inc.COM682,868$2.70M1.0%+682,868NewHistory
VYGRVoyager Therapeutics, Inc.COM305,857$2.37M0.9%+5,857+2.0%AddedHistory
IFRXInflaRx N.V.COM688,604$2.05M0.8%+688,604NewHistory
MRSNMersana Therapeutics, Inc.COM1,579,770$2.01M0.7%+1,529,770+3,059.5%AddedHistory
ALLKAllakos Inc.COM787,056$1.79M0.7%+14,964+1.9%AddedHistory
ESPREsperion Therapeutics, Inc.COM1,737,636$1.70M0.6%+32,031+1.9%AddedHistory
NUVBNuvation Bio Inc.COM CL A1,222,852$1.64M0.6%+1,222,852NewHistory
BDTXBlack Diamond Therapeutics, Inc.COM555,572$1.59M0.6%+10,469+1.9%AddedHistory
BIVIBiovie Inc.CL A NEW457,345$1.56M0.6%+8,789+2.0%AddedHistory
CBAYCymaBay Therapeutics, Inc.COM104,300$1.56M0.6%+104,300NewHistory
AEONAEON Biopharma, Inc.CL A257,977$1.44M0.5%+257,977NewHistory
MISTMilestone Pharmaceuticals Inc.COM462,828$1.43M0.5%+2,412+0.5%AddedHistory
CRSPCRISPR Therapeutics AGNAMEN AKT30,546$1.39M0.5%+30,546NewHistory
KALVKalVista Pharmaceuticals, Inc.COM142,692$1.37M0.5%+2,692+1.9%AddedHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM NEW195,899$1.32M0.5%+3,639+1.9%AddedHistory
ABOSAcumen Pharmaceuticals, Inc.COM315,265$1.31M0.5%−339,680−51.9%ReducedHistory
VTGNVistagen Therapeutics, Inc.COM229,100$1.20M0.4%+229,100NewHistory
TECXTectonic Therapeutic, Inc.COM718,259$1.11M0.4%+584,113+435.4%AddedHistory
QUREuniQure N.V.SHS157,365$1.06M0.4%+157,365NewHistory
KZRKezar Life Sciences, Inc.COM853,391$1.02M0.4%+11,795+1.4%AddedHistory
TERNTerns Pharmaceuticals, Inc.COM165,480$832.4K0.3%−150,000−47.5%ReducedHistory
JSPRJasper Therapeutics, Inc.COM1,125,087$787.6K0.3%00.0%UnchangedHistory
ELEVElevation Acquisition Group Inc.COM1,171,939$776.5K0.3%+22,449+2.0%AddedHistory
TYRATyra Biosciences, Inc.COM48,170$663.3K0.2%00.0%UnchangedHistory
IMUXImmunic, Inc.COM450,000$661.5K0.2%−200,000−30.8%ReducedHistory
LLYEli Lilly & CoStock1,227$659.1K0.2%+1,227NewHistory
PRQRProQR Therapeutics N.V.SHS EURO472,625$614.4K0.2%00.0%UnchangedHistory
AUTLAutolus Therapeutics plcSPON ADS262,694$612.1K0.2%+2,607+1.0%AddedHistory
COGTCogent Biosciences, Inc.COM62,766$612.0K0.2%00.0%UnchangedHistory
IMTXImmatics N.V.SHS49,031$567.8K0.2%00.0%UnchangedHistory
KODKodiak Sciences Inc.COM312,881$563.2K0.2%+250,354+400.4%AddedHistory
KPTIKaryopharm Therapeutics Inc.COM400,000$536.0K0.2%00.0%UnchangedHistory
ANEBAnebulo Pharmaceuticals, Inc.COM157,862$503.6K0.2%+1,659+1.1%AddedHistory
TCONTracon Pharmaceuticals, Inc.COM NEW2,765,530$492.3K0.2%00.0%UnchangedHistory
HOOKHOOKIPA Pharma Inc.COM530,776$327.0K0.1%−69,224−11.5%ReducedHistory
TARAProtara Therapeutics, Inc.COM STK188,664$315.1K0.1%00.0%UnchangedHistory
TGTXTG Therapeutics, Inc.COM32,547$272.1K0.1%+32,547NewHistory
PTCTPTC Therapeutics, Inc.COM10,862$243.4K0.1%+10,862NewHistory
VRNAVerona Pharma plcSPONSORED ADS318,591$213.8K0.1%+4,914+1.6%AddedHistory
MREOMereo BioPharma Group plcSPON ADS591,676$191.3K0.1%−300,000−33.6%ReducedHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS213,392$191.0K0.1%00.0%UnchangedHistory
SCPHscPharmaceuticals Inc.COM18,647$132.8K<0.1%−131,353−87.6%ReducedHistory
RLMDRelmada Therapeutics, Inc.COM40,369$121.1K<0.1%−25,122−38.4%ReducedHistory
FHTXFoghorn Therapeutics Inc.COM15,292$76.5K<0.1%+292+1.9%AddedHistory
OCULOcular Therapeutix, IncCOM21,590$67.8K<0.1%−78,410−78.4%ReducedHistory
SNDXSyndax Pharmaceuticals IncCOM4,000$58.1K<0.1%+4,000NewHistory
SYBXSynlogic, Inc.COM NEW20,448$57.5K<0.1%00.0%UnchangedConverted for a 1-for-15 splitHistory
STOKStoke Therapeutics, Inc.COM12,116$47.7K<0.1%−58,274−82.8%ReducedHistory
FNCHFinch Therapeutics Group, Inc.COM NEW6,892$35.1K<0.1%−1,025−12.9%ReducedHistory
ROIVRoivant Sciences Ltd.SHS1,821$21.3K<0.1%−223,179−99.2%ReducedHistory
BCLIBrainstorm Cell Therapeutics Inc.COM NEW90,242$18.1K<0.1%−99,693−52.5%ReducedHistory
Aslan Pharmaceuticals Ltd04522R200SPON ADS NEW35,420$6.21K<0.1%−128,668−78.4%Reduced–
KYNBKyntra Bio, Inc.COM2,774$2.39K<0.1%−225,646−98.8%ReducedHistory
Phaxiam Therapeutics S A29604W207SPON ADR NEW301$1.56K<0.1%+301New–

Options (43)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ikarian Capital, LLC in Q3 2023
SecurityClassPutsCalls
SRPTSarepta Therapeutics, Inc.COM$44.5M$25.7M
SPYSPDR S&P 500 ETF TrustETF$64.1M–
IMVTImmunovant, Inc.COM$21.2M$27.8M
Invesco QQQ Trust Series I46090E103ETF$43.0M–
State Street SPDR S&P Biotech ETF78464A870ETF$36.5M–
CRNXCrinetics Pharmaceuticals, Inc.COM$13.5M$12.1M
AKROAkero Therapeutics, Inc.COM$15.4M$10.1M
MRNAModerna, Inc.Stock$25.2M–
ABBVAbbVie Inc.Stock–$19.8M
SNDXSyndax Pharmaceuticals IncCOM$10.9M$3.63M
NVAXNovavax IncCOM NEW$8.78M$5.16M
NUVLNuvalent, Inc.COM$2.40M$11.0M
REPLReplimune Group, Inc.COM$9.30M$3.98M
CYTKCytokinetics IncCOM NEW$6.00M$6.00M
APLSApellis Pharmaceuticals, Inc.COM$1.57M$9.00M
KRYSKrystal Biotech, Inc.COM$9.80M–
CRSPCRISPR Therapeutics AGNAMEN AKT$9.26M$177.0K
BMRNBiomarin Pharmaceutical IncCOM$9.01M–
IRONDisc Medicine, Inc.COM$7.17M$1.33M
BBIOBridgeBio Pharma, Inc.COM–$8.05M
RCUSArcus Biosciences, Inc.COM–$7.18M
ACRSAclaris Therapeutics, Inc.COM$4.08M$2.49M
VERVVerve Therapeutics, Inc.COM$3.20M$2.65M
AMAMAmbrx Biopharma Cayman, Inc.SPONSORED ADS–$5.67M
IMGNImmunoGen, Inc.COM–$5.66M
RVMDRevolution Medicines, Inc.COM$5.63M–
JAZZJazz Pharmaceuticals plcSHS USD–$5.41M
ETNB89bio, Inc.COM–$5.41M
CBAYCymaBay Therapeutics, Inc.COM$1.22M$3.32M
VTYXVentyx Biosciences, Inc.COM$4.28M–
AMLXAmylyx Pharmaceuticals, Inc.COM–$3.78M
EYPTEyePoint, Inc.COM NEW$3.59M–
ITOSiTeos Therapeutics, Inc.COM–$3.35M
RCKTRocket Pharmaceuticals, Inc.COM–$3.07M
CLDXCelldex Therapeutics, Inc.COM NEW$2.67M–
RVPHReviva Pharmaceuticals Holdings, Inc.COM–$2.49M
DYNDyne Therapeutics, Inc.COM–$2.44M
SLRNACELYRIN, Inc.COM–$1.39M
TERNTerns Pharmaceuticals, Inc.COM–$1.01M
MORFMorphic Holding, Inc.COM$295.5K$32.1K
STOKStoke Therapeutics, Inc.COM–$197.0K
XENEXenon Pharmaceuticals Inc.COM$37.6K–
INSMINSMED IncCOM PAR $.01–$5.05K

Sold out since Q2 2023 (24)

Positions held at the end of Q2 2023 that are gone from this filing.

Positions of Ikarian Capital, LLC sold out since Q2 2023
SecurityClassShares in Q2 2023Value in Q2 2023% of portfolio in Q2 2023History
APLSApellis Pharmaceuticals, Inc.COM133,800$12.2M4.3%History
MRKMerck & Co., Inc.Stock100,000$11.5M4.1%History
BMEABiomea Fusion, Inc.COM275,875$6.06M2.1%History
XENEXenon Pharmaceuticals Inc.COM135,486$5.22M1.8%History
BCYCBicycle Therapeutics PLCSPONSORED ADS203,037$5.18M1.8%History
ARWRArrowhead Pharmaceuticals, Inc.COM130,000$4.64M1.6%History
DCPHDeciphera Pharmaceuticals, Inc.COM174,510$2.46M0.9%History
ACRSAclaris Therapeutics, Inc.COM200,163$2.08M0.7%History
ICPTIntercept Pharmaceuticals, Inc.COM160,200$1.77M0.6%History
LEGNLegend Biotech CorpSPONSORED ADS25,000$1.73M0.6%History
MRUSMerus N.V.COM63,125$1.66M0.6%History
BLUEbluebird bio, Inc.COM412,628$1.36M0.5%History
OKUROnKure Therapeutics, Inc.COM155,819$1.02M0.4%History
PTGXProtagonist Therapeutics, IncCOM35,000$966.7K0.3%History
ARDXArdelyx, Inc.COM278,825$945.2K0.3%History
XFORX4 Pharmaceuticals, IncCOM349,133$677.3K0.2%History
RETAReata Pharmaceuticals IncCL A5,472$557.9K0.2%History
ELDNEledon Pharmaceuticals, Inc.COM221,830$303.9K0.1%History
PNTPOINT Biopharma Global Inc.COM28,784$260.8K0.1%History
CNTBConnect Biopharma Holdings LtdADS219,501$243.6K0.1%History
ASNDAscendis Pharma A/SSPONSORED ADR2,090$186.5K0.1%History
KDNYChinook Therapeutics, Inc.COM283,464$130.4K<0.1%History
MDGLMadrigal Pharmaceuticals, Inc.COM75$17.3K<0.1%History
Erytech Pharma29604W108SPONSORED ADR3,019$2.26K<0.1%–