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Livermore
Livermore
ZHEN

Affinity Asset Advisors, LLC

SEC CIK
0001773195
Latest filing
Aug 13, 2026

Holdings in Q1 2025

Holdings as of Mar 31, 2025, filed May 14, 2025. Long positions only; changes compare share counts with Q4 2024.

Institution overview
Positions
81
+6 vs. Q4 2024
Portfolio value
$638.8M
−$1.35M (−0.2%) vs. Q4 2024
Filed
May 14, 2025
SEC
Holdings of Affinity Asset Advisors, LLC in Q1 2025
SecurityClassSharesValue% of portfolioShare changeActionHistory
XENEXenon Pharmaceuticals Inc.COM1,328,175$44.6M7.0%+166,938+14.4%AddedHistory
APGEApogee Therapeutics, Inc.COM1,151,199$43.0M6.7%+219,471+23.6%AddedHistory
VRNAVerona Pharma plcSPONSORED ADS615,000$39.0M6.1%−45,000−6.8%ReducedHistory
ACLXArcellx, Inc.COMMON STOCK530,000$34.8M5.4%+105,000+24.7%AddedHistory
ALKSAlkermes plc.SHS1,000,000$33.0M5.2%−100,000−9.1%ReducedHistory
NUVLNuvalent, Inc.COM460,000$32.6M5.1%+175,000+61.4%AddedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM80,000$26.5M4.1%−2,500−3.0%ReducedHistory
CNTACentessa Pharmaceuticals plcSPONSORED ADS1,546,662$22.2M3.5%+450,738+41.1%AddedHistory
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS1,400,000$21.5M3.4%00.0%UnchangedHistory
PTGXProtagonist Therapeutics, IncCOM400,000$19.3M3.0%+270,000+207.7%AddedHistory
TVTXTravere Therapeutics, Inc.COM1,070,000$19.2M3.0%+870,000+435.0%AddedHistory
MLYSMineralys Therapeutics, Inc.COM1,100,000$17.5M2.7%+750,000+214.3%AddedHistory
SPYSPDR S&P 500 ETF TrustETF30,000$16.8M2.6%+30,000NewHistory
WVEWave Life Sciences, Inc.SHS1,825,000$14.7M2.3%+325,000+21.7%AddedHistory
Omeros Corp682143AG7NOTE 5.250% 2/1–$14.3M2.2%–––
MRUSMerus N.V.COM321,962$13.6M2.1%−67,279−17.3%ReducedHistory
AXSMAxsome Therapeutics, Inc.COM100,000$11.7M1.8%+25,000+33.3%AddedHistory
Karyopharm Therapeutics Inc.48576UAA4NOTE 3.000%10/1–$11.6M1.8%–––
ESTAEstablishment Labs Holdings Inc.COM280,000$11.4M1.8%+555+0.2%AddedHistory
INSMINSMED IncCOM PAR $.01140,000$10.7M1.7%+90,000+180.0%AddedHistory
BBIOBridgeBio Pharma, Inc.COM300,000$10.4M1.6%+100,000+50.0%AddedHistory
NRIXNurix Therapeutics, Inc.COM810,669$9.63M1.5%−129,414−13.8%ReducedHistory
VERAVera Therapeutics, Inc.CL A355,143$8.53M1.3%−69,857−16.4%ReducedHistory
TRVITrevi Therapeutics, Inc.COM1,250,000$7.86M1.2%+1,250,000NewHistory
SYRESpyre Therapeutics, Inc.COM NEW481,678$7.77M1.2%−342,650−41.6%ReducedHistory
IMVTImmunovant, Inc.COM430,000$7.35M1.2%+330,000+330.0%AddedHistory
Travere Therapeutics, Inc.89422GAA5NOTE 2.250% 3/0–$6.99M1.1%–––
NAMSNewAmsterdam Pharma Co N.V.ORDINARY SHARES325,000$6.65M1.0%−100,000−23.5%ReducedHistory
ORKAOruka Therapeutics, Inc.COM545,362$5.60M0.9%+176,664+47.9%AddedHistory
NBIXNeurocrine Biosciences IncStock50,000$5.53M0.9%+50,000NewHistory
AVTXAvalo Therapeutics, Inc.COM NEW657,154$5.26M0.8%+106,389+19.3%AddedHistory
VRDNViridian Therapeutics, Inc.COM390,000$5.26M0.8%+230,386+144.3%AddedHistory
LXEOLexeo Therapeutics, Inc.COM1,480,881$5.14M0.8%+1,480,881NewHistory
CRNXCrinetics Pharmaceuticals, Inc.COM152,252$5.11M0.8%−307,748−66.9%ReducedHistory
RZLTRezolute, Inc.COM NEW1,700,000$4.93M0.8%+125,000+7.9%AddedHistory
CATXPerspective Therapeutics, Inc.COM NEW2,224,196$4.74M0.7%+924,196+71.1%AddedHistory
AUTLAutolus Therapeutics plcSPON ADS3,045,000$4.72M0.7%−1,455,000−32.3%ReducedHistory
ERASErasca, Inc.COM3,341,519$4.58M0.7%+842,088+33.7%AddedHistory
PRQRProQR Therapeutics N.V.SHS EURO3,284,512$4.37M0.7%+459,512+16.3%AddedHistory
QUREuniQure N.V.SHS400,000$4.24M0.7%+400,000NewHistory
FRNMFreenome, Inc.CL A ORD SHS350,000$3.62M0.6%00.0%UnchangedHistory
SLNOSoleno Therapeutics IncCOM50,000$3.57M0.6%−80,000−61.5%ReducedHistory
INZYInozyme Pharma, Inc.COM3,867,710$3.52M0.6%−104,608−2.6%ReducedHistory
AKBAAkebia Therapeutics, Inc.COM1,500,000$2.88M0.5%+1,500,000NewHistory
MAZEMaze Therapeutics, Inc.COM250,000$2.75M0.4%+250,000NewHistory
NAMSWNewAmsterdam Pharma Co N.V.*W EXP 11/22/202241,957$2.75M0.4%+4,022+1.7%AddedHistory
KYMRKymera Therapeutics, Inc.COM100,000$2.74M0.4%+60,000+150.0%AddedHistory
OACCUOaktree Acquisition Corp. III Life SciencesUNIT 10/04/2029250,000$2.60M0.4%00.0%UnchangedHistory
GERNGeron CorpCOM1,500,000$2.38M0.4%−750,000−33.3%ReducedHistory
MNPRMonopar TherapeuticsCOM NEW62,000$2.26M0.4%+62,000NewHistory
MIRMMirum Pharmaceuticals, Inc.COM49,692$2.24M0.4%−21,050−29.8%ReducedHistory
JBIOJade Biosciences, Inc.COM800,000$2.01M0.3%00.0%UnchangedHistory
CGEMCullinan Therapeutics, Inc.COM263,817$2.00M0.3%00.0%UnchangedHistory
CLYMClimb Bio, Inc.COM1,500,000$1.83M0.3%+1,000,000+200.0%AddedHistory
OKUROnKure Therapeutics, Inc.COM CL A394,159$1.69M0.3%+250,000+173.4%AddedHistory
ROIVRoivant Sciences Ltd.SHS150,000$1.51M0.2%+150,000NewHistory
NKTXNkarta, Inc.COM800,000$1.47M0.2%00.0%UnchangedHistory
AVRAnteris Technologies Global Corp.COM390,000$1.42M0.2%+90,000+30.0%AddedHistory
MBXMBX Biosciences, Inc.COM175,000$1.29M0.2%+175,000NewHistory
THRDThird Harmonic Bio, Inc.COM370,000$1.28M0.2%+370,000NewHistory
ETNB89bio, Inc.COM175,000$1.27M0.2%+175,000NewHistory
ABVXAbivax S.A.SPONSORED ADS200,000$1.25M0.2%+200,000NewHistory
OLMAOlema Pharmaceuticals, Inc.COM325,000$1.22M0.2%+325,000NewHistory
NXTCNextCure, Inc.COM2,302,598$1.11M0.2%00.0%UnchangedHistory
MGTXMeiraGTx Holdings plcCOM150,000$1.02M0.2%+150,000NewHistory
PCVXVaxcyte, Inc.COM25,000$944.0K0.1%00.0%UnchangedHistory
VKTXViking Therapeutics, Inc.COM25,000$603.8K0.1%+25,000NewHistory
STROSutro Biopharma, Inc.COM752,722$489.7K0.1%+752,722NewHistory
CNTXContext Therapeutics Inc.COM660,589$404.3K0.1%−354,751−34.9%ReducedHistory
BDTXBlack Diamond Therapeutics, Inc.COM250,000$387.5K0.1%−309,163−55.3%ReducedHistory
RADXRadiopharm Theranostics LtdSPONSORED ADS64,600$310.7K<0.1%−91,571−58.6%ReducedHistory
ZURAZura Bio LtdCLASS A ORD SHS223,335$288.1K<0.1%00.0%UnchangedHistory
CMPXCompass Therapeutics, Inc.COM130,807$248.5K<0.1%+130,807NewHistory
OVIDOvid Therapeutics Inc.COM667,516$208.2K<0.1%+667,516NewHistory
RPTXRepare Therapeutics Inc.COM200,000$197.2K<0.1%+100,000+100.0%AddedHistory
ADGMAdagio Medical Holdings, Inc.COM213,235$169.5K<0.1%00.0%UnchangedHistory
OMEROmeros CorpCOM9,958$81.9K<0.1%00.0%UnchangedHistory
ALLKAllakos Inc.COM250,000$56.9K<0.1%+250,000NewHistory
QTTBQ32 Bio Inc.COM27,777$45.8K<0.1%00.0%UnchangedHistory
Rocket Pharmaceuticals, Inc.77313F114*W EXP 09/02/20275,000$3.52K<0.1%00.0%Unchanged–
Immatics N.V.N44445117*W EXP 07/01/202187,204$2.96K<0.1%00.0%Unchanged–

Options (16)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Affinity Asset Advisors, LLC in Q1 2025
SecurityClassPutsCalls
SPYSPDR S&P 500 ETF TrustETF$223.8M–
iShares Russell 2000 ETF464287655ETF$59.8M–
State Street SPDR S&P Biotech ETF78464A870ETF$40.5M–
AMGNAmgen IncStock–$21.8M
ALNYAlnylam Pharmaceuticals, Inc.COM–$14.9M
PTGXProtagonist Therapeutics, IncCOM–$8.34M
CORTCorcept Therapeutics IncCOM–$8.00M
VERAVera Therapeutics, Inc.CL A–$6.37M
EXELExelixis, Inc.COM–$4.98M
EWTXEdgewise Therapeutics, Inc.COM$4.40M–
NAMSNewAmsterdam Pharma Co N.V.ORDINARY SHARES$1.54M$2.04M
MLYSMineralys Therapeutics, Inc.COM$3.18M–
IBRXImmunityBio, Inc.COM$3.09M–
CMPXCompass Therapeutics, Inc.COM$2.53M–
GALTGalectin Therapeutics IncCOM NEW$2.24M–
TRMLTourmaline Bio, Inc.COM–$1.52M

Sold out since Q4 2024 (14)

Positions held at the end of Q4 2024 that are gone from this filing.

Positions of Affinity Asset Advisors, LLC sold out since Q4 2024
SecurityClassShares in Q4 2024Value in Q4 2024% of portfolio in Q4 2024History
Coherus Biosciences Inc19249HAB9NOTE 1.500% 4/1–$16.2M2.5%–
ARVNArvinas, Inc.COM630,000$12.1M1.9%History
ARWRArrowhead Pharmaceuticals, Inc.COM300,000$5.64M0.9%History
CMPSCOMPASS Pathways plcSPONSORED ADS850,512$3.21M0.5%History
CGONCG Oncology, Inc.COM100,000$2.87M0.4%History
TECXTectonic Therapeutic, Inc.COM58,331$2.69M0.4%History
BBOTBridgeBio Oncology Therapeutics, Inc.CL A ORD SHS250,000$2.63M0.4%History
APLSApellis Pharmaceuticals, Inc.COM50,000$1.60M0.2%History
RAPTRAPT Therapeutics, Inc.COM1,000,000$1.58M0.2%History
NARIInari Medical, Inc.Stock25,000$1.28M0.2%History
SVRASavara IncCOM410,586$1.26M0.2%History
KZRKezar Life Sciences, Inc.COM142,316$956.4K0.1%History
CLDXCelldex Therapeutics, Inc.COM NEW9,992$252.5K<0.1%History
SYRSSyros Pharmaceuticals, Inc.COM NEW150,000$34.5K<0.1%History