Sphera Funds Management Ltd.
- SEC CIK
- 0001496201
- Latest filing
- Aug 14, 2026
Holdings in Q1 2026
Holdings as of Mar 31, 2026, filed May 15, 2026. Long positions only; changes compare share counts with Q4 2025.
- Positions
- 92
- −2 vs. Q4 2025
- Portfolio value
- $581.5M
- +$103.0M (+21.5%) vs. Q4 2025
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| MLYSMineralys Therapeutics, Inc. | COM | 1,339,971 | $36.3M | 6.2% | +890,968+198.4% | Added | History |
| TEVATeva Pharmaceutical Industries Ltd | SPONSORED ADS | 1,136,975 | $34.2M | 5.9% | +13,450+1.2% | Added | History |
| TSEMTower Semiconductor Ltd | SHS NEW | 145,735 | $25.6M | 4.4% | +23,222+19.0% | Added | History |
| NVMINova Ltd. | COM | 53,366 | $23.2M | 4.0% | +5,520+11.5% | Added | History |
| BBIOBridgeBio Pharma, Inc. | COM | 245,246 | $18.2M | 3.1% | +137,500+127.6% | Added | History |
| BIIBBiogen Inc. | COM | 92,526 | $17.0M | 2.9% | −2,212−2.3% | Reduced | History |
| RAREUltragenyx Pharmaceutical Inc. | COM | 809,333 | $17.0M | 2.9% | +508,710+169.2% | Added | History |
| SNDXSyndax Pharmaceuticals Inc | COM | 724,563 | $16.9M | 2.9% | −38,000−5.0% | Reduced | History |
| COGTCogent Biosciences, Inc. | COM | 416,340 | $16.0M | 2.8% | +37,840+10.0% | Added | History |
| SNYSanofi | SPONSORED ADR | 269,515 | $13.0M | 2.2% | +30,000+12.5% | Added | History |
| AZNAstraZeneca PLC | ADR | 62,530 | $12.3M | 2.1% | −5,000−7.4% | ReducedConverted for a 1-for-2 split | History |
| FOLDAmicus Therapeutics, Inc. | COM | 603,377 | $8.72M | 1.5% | −55,000−8.4% | Reduced | History |
| CLBTCellebrite DI Ltd. | ORDINARY SHARES | 631,521 | $8.70M | 1.5% | +631,521 | New | History |
| APLSApellis Pharmaceuticals, Inc. | COM | 214,914 | $8.65M | 1.5% | −36,047−14.4% | Reduced | History |
| PANWPalo Alto Networks Inc | Stock | 52,800 | $8.46M | 1.5% | +52,800 | New | History |
| LLYEli Lilly & Co | Stock | 9,040 | $8.31M | 1.4% | 00.0% | Unchanged | History |
| BCRXBiocryst Pharmaceuticals Inc | COM | 866,464 | $8.25M | 1.4% | +28,575+3.4% | Added | History |
| CAMTCamtek Ltd | ORD | 53,020 | $8.04M | 1.4% | +13,522+34.2% | Added | History |
| BMRNBiomarin Pharmaceutical Inc | COM | 139,900 | $7.90M | 1.4% | −7,100−4.8% | Reduced | History |
| CLDXCelldex Therapeutics, Inc. | COM NEW | 243,575 | $7.73M | 1.3% | +3,811+1.6% | Added | History |
| ORAOrmat Technologies, Inc. | COM | 68,250 | $7.64M | 1.3% | +68,250 | New | History |
| XENEXenon Pharmaceuticals Inc. | COM | 127,000 | $7.39M | 1.3% | +127,000 | New | History |
| SLNOSoleno Therapeutics Inc | COM | 216,281 | $7.24M | 1.2% | +79,967+58.7% | Added | History |
| TNGXTango Therapeutics, Inc. | COM | 343,563 | $7.19M | 1.2% | −201,000−36.9% | Reduced | History |
| JNJJohnson & Johnson | Stock | 28,831 | $7.05M | 1.2% | −7,000−19.5% | Reduced | History |
| Solaredge Technologies, Inc.83417MAE4 | NOTE 2.250% 7/0 | 4,000,000 | $6.91M | 1.2% | 00.0% | Unchanged | – |
| IMTXImmatics N.V. | SHS | 696,105 | $6.85M | 1.2% | −165,000−19.2% | Reduced | History |
| TRVITrevi Therapeutics, Inc. | COM | 574,029 | $6.85M | 1.2% | −24,505−4.1% | Reduced | History |
| ORICOric Pharmaceuticals, Inc. | COM | 537,628 | $6.81M | 1.2% | −466,750−46.5% | Reduced | History |
| MAZEMaze Therapeutics, Inc. | COM | 227,343 | $6.79M | 1.2% | +155,500+216.4% | Added | History |
| GSKGSK plc | ADR | 122,000 | $6.73M | 1.2% | 00.0% | Unchanged | History |
| AMZNAmazon Com Inc | Stock | 31,940 | $6.65M | 1.1% | +31,940 | New | History |
| ABBVAbbVie Inc. | Stock | 30,256 | $6.58M | 1.1% | +5,000+19.8% | Added | History |
| AAOIApplied Optoelectronics, Inc. | COM | 73,400 | $6.21M | 1.1% | +73,400 | New | History |
| ELVNEnliven Therapeutics, Inc. | COM | 153,265 | $6.01M | 1.0% | −73,500−32.4% | Reduced | History |
| MRKMerck & Co., Inc. | Stock | 48,600 | $5.85M | 1.0% | 00.0% | Unchanged | History |
| VORVor Biopharma Inc. | COM NEW | 321,917 | $5.74M | 1.0% | −88,500−21.6% | Reduced | History |
| ACADAcadia Pharmaceuticals Inc | COM | 256,202 | $5.70M | 1.0% | +44,000+20.7% | Added | History |
| NVSNovartis AG | ADR | 37,000 | $5.65M | 1.0% | 00.0% | Unchanged | History |
| ELDNEledon Pharmaceuticals, Inc. | COM | 1,772,131 | $5.46M | 0.9% | −360,000−16.9% | Reduced | History |
| ENPHEnphase Energy, Inc. | Stock | 142,419 | $5.38M | 0.9% | −44,081−23.6% | Reduced | History |
| RVMDRevolution Medicines, Inc. | COM | 55,110 | $5.36M | 0.9% | +2,610+5.0% | Added | History |
| PFEPfizer Inc | Stock | 186,000 | $5.22M | 0.9% | +100,000+116.3% | Added | History |
| BHVNBiohaven Ltd. | COM | 594,000 | $5.03M | 0.9% | +594,000 | New | History |
| FBRXForte Biosciences, Inc. | COM NEW | 184,984 | $4.79M | 0.8% | −885−0.5% | Reduced | History |
| HELPHelus Pharma Inc. | COM NEW | 987,090 | $4.74M | 0.8% | +161,514+19.6% | Added | History |
| MDGLMadrigal Pharmaceuticals, Inc. | COM | 9,040 | $4.73M | 0.8% | +5,740+173.9% | Added | History |
| SRRKScholar Rock Holding Corp | COM | 94,265 | $4.63M | 0.8% | −64,000−40.4% | Reduced | History |
| NVONovo Nordisk A S | ADR | 120,677 | $4.43M | 0.8% | +5,000+4.3% | Added | History |
| MDWDMediWound Ltd. | SHS NEW | 273,192 | $4.40M | 0.8% | +42,845+18.6% | Added | History |
| KODKodiak Sciences Inc. | COM | 114,796 | $4.38M | 0.8% | −60,704−34.6% | Reduced | History |
| ZBIOZenas BioPharma, Inc. | COM | 214,334 | $4.19M | 0.7% | +214,334 | New | History |
| PMNProMIS Neurosciences Inc. | COM SHS | 325,591 | $4.14M | 0.7% | +313,784+2,657.6% | Added | History |
| RLAYRelay Therapeutics, Inc. | COM | 408,436 | $4.06M | 0.7% | +408,436 | New | History |
| SVRASavara Inc | COM | 739,164 | $4.04M | 0.7% | −439,000−37.3% | Reduced | History |
| WVEWave Life Sciences, Inc. | SHS | 548,272 | $3.97M | 0.7% | +140,106+34.3% | Added | History |
| CRVSCorvus Pharmaceuticals, Inc. | COM | 247,961 | $3.63M | 0.6% | −159,748−39.2% | Reduced | History |
| OVIDOvid Therapeutics Inc. | COM | 1,622,828 | $3.60M | 0.6% | +1,622,828 | New | History |
| IRONDisc Medicine, Inc. | COM | 53,538 | $3.42M | 0.6% | +53,538 | New | History |
| UPBUpstream Bio, Inc. | COM | 358,000 | $3.22M | 0.6% | +358,000 | New | History |
| ACOGAlpha Cognition Inc. | COM NEW | 567,616 | $3.12M | 0.5% | 00.0% | Unchanged | History |
| PALIPalisade Bio, Inc. | COM | 1,733,471 | $3.03M | 0.5% | +1,549,371+841.6% | Added | History |
| DYNDyne Therapeutics, Inc. | COM | 160,594 | $2.91M | 0.5% | −232,300−59.1% | Reduced | History |
| CLYMClimb Bio, Inc. | COM | 419,247 | $2.87M | 0.5% | −513,000−55.0% | Reduced | History |
| ZIMZIM Integrated Shipping Services Ltd. | SHS | 105,950 | $2.79M | 0.5% | −30,055−22.1% | Reduced | History |
| MSLESatellos Bioscience Inc. | COM | 489,207 | $2.75M | 0.5% | +489,207 | New | History |
| SEDGSolaredge Technologies, Inc. | COM | 52,836 | $2.70M | 0.5% | −143,700−73.1% | Reduced | History |
| AMGNAmgen Inc | Stock | 7,500 | $2.64M | 0.5% | 00.0% | Unchanged | History |
| CYTKCytokinetics Inc | COM NEW | 39,817 | $2.62M | 0.5% | −51,900−56.6% | Reduced | History |
| GPCRStructure Therapeutics Inc. | SPONSORED ADS | 50,800 | $2.45M | 0.4% | +9,800+23.9% | Added | History |
| KURAKura Oncology, Inc. | COM | 295,522 | $2.40M | 0.4% | 00.0% | Unchanged | History |
| GENBGenerate Biomedicines, Inc. | COM SHS | 185,000 | $2.31M | 0.4% | +185,000 | New | History |
| IBITiShares Bitcoin Trust ETF | ETF | 59,505 | $2.29M | 0.4% | +29,450+98.0% | Added | History |
| CTNMContineum Therapeutics, Inc. | CL A | 173,475 | $2.27M | 0.4% | 00.0% | Unchanged | History |
| TENXTenax Therapeutics, Inc. | COM NEW | 136,015 | $2.17M | 0.4% | −54,096−28.5% | Reduced | History |
| PRLDPrelude Therapeutics Inc | COM | 558,339 | $1.91M | 0.3% | +435,587+354.9% | Added | History |
| ASNDAscendis Pharma A/S | SPONSORED ADR | 8,000 | $1.83M | 0.3% | −3,000−27.3% | Reduced | History |
| VSTMVerastem, Inc. | COM NEW | 343,678 | $1.82M | 0.3% | 00.0% | Unchanged | History |
| VYGRVoyager Therapeutics, Inc. | COM | 469,761 | $1.81M | 0.3% | +130,000+38.3% | Added | History |
| STTKShattuck Labs, Inc. | COM | 280,786 | $1.81M | 0.3% | +85,574+43.8% | Added | History |
| EVMNEvommune, Inc. | COM SHS | 78,234 | $1.80M | 0.3% | −87,913−52.9% | Reduced | History |
| BIOABioAge Labs, Inc. | COM | 86,518 | $1.51M | 0.3% | −156,517−64.4% | Reduced | History |
| ORGOOrganogenesis Holdings Inc. | COM | 550,000 | $1.30M | 0.2% | +550,000 | New | History |
| CRISCuris Inc | COM | 1,994,937 | $1.09M | 0.2% | +1,994,937 | New | History |
| BMYBristol Myers Squibb Co | Stock | 17,500 | $1.06M | 0.2% | 00.0% | Unchanged | History |
| CTMXCytomX Therapeutics, Inc. | COM | 220,000 | $1.03M | 0.2% | +220,000 | New | History |
| NICENICE Ltd. | SPONSORED ADR | 5,611 | $618.7K | 0.1% | +5,611 | New | History |
| HOWLWerewolf Therapeutics, Inc. | COM | 626,810 | $521.9K | 0.1% | 00.0% | Unchanged | History |
| SKYESkye Bioscience, Inc. | COM NEW | 678,928 | $417.3K | 0.1% | +200,000+41.8% | Added | History |
| DTILPrecision Biosciences Inc | COM NEW | 40,000 | $220.0K | <0.1% | −356,116−89.9% | Reduced | History |
| APREAprea Therapeutics, Inc. | COM NEW | 270,000 | $206.0K | <0.1% | 00.0% | Unchanged | History |
| FHTXFoghorn Therapeutics Inc. | COM | 12,224 | $58.4K | <0.1% | +12,224 | New | History |
Options (4)
Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.
Sold out since Q4 2025 (21)
Positions held at the end of Q4 2025 that are gone from this filing.
| Security | Class | Shares in Q4 2025 | Value in Q4 2025 | % of portfolio in Q4 2025 | History |
|---|---|---|---|---|---|
| ANNXAnnexon, Inc. | COM | 1,316,212 | $6.61M | 1.4% | History |
| ATXSAstria Therapeutics, Inc. | COM | 355,725 | $4.66M | 1.0% | History |
| AMDAdvanced Micro Devices Inc | Stock | 18,040 | $3.86M | 0.8% | History |
| TARAProtara Therapeutics, Inc. | COM STK | 650,000 | $3.46M | 0.7% | History |
| AVGOBroadcom Inc. | Stock | 9,755 | $3.38M | 0.7% | History |
| ESLTElbit Systems Ltd | Stock | 5,340 | $3.08M | 0.6% | History |
| NRIXNurix Therapeutics, Inc. | COM | 124,000 | $2.35M | 0.5% | History |
| JANXJanux Therapeutics, Inc. | COM | 157,840 | $2.18M | 0.5% | History |
| TSHATaysha Gene Therapies, Inc. | COM SHS | 368,146 | $2.02M | 0.4% | History |
| PHVSPharvaris N.V. | COM | 63,953 | $1.77M | 0.4% | History |
| VRNSVaronis Systems Inc | COM | 52,500 | $1.72M | 0.4% | History |
| VTYXVentyx Biosciences, Inc. | COM | 180,114 | $1.63M | 0.3% | History |
| DAWNDay One Biopharmaceuticals, Inc. | Stock | 145,371 | $1.35M | 0.3% | History |
| TRDAEntrada Therapeutics, Inc. | COM | 110,942 | $1.14M | 0.2% | History |
| TNYATenaya Therapeutics, Inc. | COM | 1,500,000 | $1.07M | 0.2% | History |
| CATXPerspective Therapeutics, Inc. | COM NEW | 349,973 | $962.4K | 0.2% | History |
| JSPRJasper Therapeutics, Inc. | COM NEW | 485,401 | $888.3K | 0.2% | History |
| PEPGPepGen Inc. | COM | 121,467 | $790.8K | 0.2% | History |
| OKUROnKure Therapeutics, Inc. | COM CL A | 60,454 | $175.3K | <0.1% | History |
| MREOMereo BioPharma Group plc | SPON ADS | 255,400 | $106.4K | <0.1% | History |
| APLTApplied Therapeutics, Inc. | COM | 50,000 | $5.00K | <0.1% | History |