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Livermore
ZHEN

Two Sigma Advisers, LP

SEC CIK
0001478735
Latest filing
Aug 14, 2026

Holdings in Q4 2021

Holdings as of Dec 31, 2021, filed Feb 14, 2022. Long positions only; changes compare share counts with Q3 2021.

Institution overview
Positions
2,591
+173 vs. Q3 2021
Portfolio value
$39.9B
+$1.35B (+3.5%) vs. Q3 2021
Filed
Feb 14, 2022
SEC
Holdings of Two Sigma Advisers, LP in Q4 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
MSFTMicrosoft CorpStock2,763,900$929.6M2.3%−581,600−17.4%ReducedHistory
JNJJohnson & JohnsonStock3,186,900$545.2M1.4%−82,100−2.5%ReducedHistory
VVisa Inc.Stock2,471,400$535.6M1.3%+232,015+10.4%AddedHistory
AAPLApple Inc.Stock2,933,300$520.9M1.3%−191,600−6.1%ReducedHistory
LLYEli Lilly & CoStock1,776,000$490.6M1.2%−249,500−12.3%ReducedHistory
METAMeta Platforms, Inc.Stock1,455,400$489.5M1.2%+265,704+22.3%AddedHistory
KOCoca Cola CoStock8,038,301$475.9M1.2%+1,550,000+23.9%AddedHistory
MDTMedtronic plcStock4,171,620$431.6M1.1%+1,192,100+40.0%AddedHistory
CHTRCharter Communications, Inc.CL A651,825$425.0M1.1%+98,900+17.9%AddedHistory
BMYBristol Myers Squibb CoStock6,616,599$412.5M1.0%+13,300+0.2%AddedHistory
SPGIS&P Global Inc.Stock870,800$411.0M1.0%+233,100+36.6%AddedHistory
AMGNAmgen IncStock1,808,400$406.8M1.0%−44,000−2.4%ReducedHistory
TSLATesla, Inc.Stock383,784$405.6M1.0%+376,857+5,440.4%AddedHistory
ZSZscaler, Inc.Stock1,211,500$389.3M1.0%+142,500+13.3%AddedHistory
PFEPfizer IncStock6,483,701$382.9M1.0%+5,476,701+543.9%AddedHistory
ATVIActivision Blizzard, Inc.COM5,610,800$373.3M0.9%+5,015,200+842.0%AddedHistory
NVDANVIDIA CorpStock1,256,400$369.5M0.9%+1,256,400NewHistory
MRKMerck & Co., Inc.Stock4,700,599$360.3M0.9%−1,579,700−25.2%ReducedHistory
CATCaterpillar IncStock1,737,800$359.3M0.9%−262,800−13.1%ReducedHistory
TEAMAtlassian CorpCL A939,500$358.2M0.9%+487,300+107.8%AddedHistory
BSXBoston Scientific CorpStock8,381,260$356.0M0.9%+299,700+3.7%AddedHistory
CERNCERNER CorpCOM3,758,433$349.0M0.9%+1,245,700+49.6%AddedHistory
DDOGDatadog, Inc.CL A COM1,932,800$344.3M0.9%+922,300+91.3%AddedHistory
PYPLPayPal Holdings, Inc.Stock1,716,100$323.6M0.8%+1,516,200+758.5%AddedHistory
ETSYEtsy IncCOM1,453,100$318.1M0.8%+370,800+34.3%AddedHistory
INTCIntel CorpStock6,114,675$314.9M0.8%−2,220,100−26.6%ReducedHistory
MAMastercard IncStock875,200$314.5M0.8%+185,800+27.0%AddedHistory
FTNTFortinet, Inc.Stock872,444$313.6M0.8%+54,200+6.6%AddedHistory
CSXCSX CorpStock8,230,600$309.5M0.8%−818,224−9.0%ReducedHistory
AMDAdvanced Micro Devices IncStock2,075,657$298.7M0.7%+2,075,657NewHistory
TMOThermo Fisher Scientific Inc.Stock435,500$290.6M0.7%+429,600+7,281.4%AddedHistory
ABBVAbbVie Inc.Stock2,106,166$285.2M0.7%+1,704,209+424.0%AddedHistory
ORCLOracle CorpStock3,196,100$278.7M0.7%−666,100−17.2%ReducedHistory
PANWPalo Alto Networks IncStock497,302$276.9M0.7%−286,300−36.5%ReducedHistory
HONHoneywell International IncCOM1,307,400$272.6M0.7%+608,992+87.2%AddedHistory
FCXFreeport-McMoran IncStock6,451,800$269.2M0.7%−2,674,200−29.3%ReducedHistory
ILMNIllumina, Inc.COM702,400$267.2M0.7%+59,000+9.2%AddedHistory
CRWDCrowdStrike Holdings, Inc.Stock1,288,000$263.7M0.7%−333,900−20.6%ReducedHistory
BAXBaxter International IncStock2,961,550$254.2M0.6%−855,464−22.4%ReducedHistory
NVSNovartis AGADR2,869,700$251.0M0.6%+772,900+36.9%AddedHistory
CCitigroup IncStock4,152,500$250.8M0.6%+502,600+13.8%AddedHistory
EMREmerson Electric CoStock2,692,100$250.3M0.6%+1,646,100+157.4%AddedHistory
GILDGilead Sciences, Inc.Stock3,443,100$250.0M0.6%−1,284,000−27.2%ReducedHistory
GOOGLAlphabet Inc.Stock84,900$246.0M0.6%−140,886−62.4%ReducedHistory
REGNRegeneron Pharmaceuticals, Inc.COM388,500$245.3M0.6%+388,500NewHistory
EWEdwards Lifesciences CorpStock1,878,003$243.3M0.6%+65,700+3.6%AddedHistory
MDLZMondelez International, Inc.Stock3,599,899$238.7M0.6%−3,026,200−45.7%ReducedHistory
DXCMDexcom IncCOM441,369$237.0M0.6%+435,700+7,685.7%AddedHistory
CMCSAComcast CorpStock4,384,600$220.7M0.6%+3,979,700+982.9%AddedHistory
MCHPMicrochip Technology IncStock2,431,000$211.6M0.5%−378,600−13.5%ReducedConverted for a 2-for-1 splitHistory
AAgilent Technologies, Inc.COM1,266,800$202.2M0.5%−183,400−12.6%ReducedHistory
State Street Health Care Select Sector SPDR ETF81369Y209ETF1,414,500$199.3M0.5%−2,900−0.2%Reduced–
ABNBAirbnb, Inc.Stock1,178,400$196.2M0.5%+848,200+256.9%AddedHistory
AMZNAmazon Com IncStock58,811$196.1M0.5%−6,400−9.8%ReducedHistory
Invesco QQQ Trust Series I46090E103ETF486,580$193.6M0.5%−20,700−4.1%Reduced–
NSCNorfolk Southern CorpStock638,300$190.0M0.5%+288,000+82.2%AddedHistory
TWTRTwitter, Inc.COM4,363,300$188.6M0.5%+1,969,600+82.3%AddedHistory
ADPAutomatic Data Processing IncStock760,800$187.6M0.5%+142,800+23.1%AddedHistory
AZOAutoZone IncCOM85,274$178.8M0.4%+79,600+1,402.9%AddedHistory
STXSeagate Technology Holdings plcORD SHS1,571,400$177.5M0.4%+839,100+114.6%AddedHistory
SPYSPDR S&P 500 ETF TrustETF373,303$177.3M0.4%−39,712−9.6%ReducedHistory
DKNGDraftKings Inc.COM CL A6,343,100$174.2M0.4%+2,535,300+66.6%AddedHistory
CPCanadian Pacific Kansas City LtdCOM2,407,336$173.2M0.4%−344,399−12.5%ReducedHistory
ELVElevance Health, Inc.Stock368,662$170.9M0.4%−239,900−39.4%ReducedHistory
VMWVmware LLCCL A COM1,455,042$168.6M0.4%+134,442+10.2%AddedHistory
PEverpure, Inc.CL A4,988,400$162.4M0.4%+389,500+8.5%AddedHistory
ECLEcolab Inc.Stock663,246$155.6M0.4%+133,800+25.3%AddedHistory
UNPUnion Pacific CorpStock615,101$155.0M0.4%+177,500+40.6%AddedHistory
iShares MSCI USA Min Vol Factor ETF46429B697ETF1,879,800$152.1M0.4%+589,500+45.7%Added–
CARAvis Budget Group, Inc.COM718,500$149.0M0.4%−110,700−13.4%ReducedHistory
State Street Consumer Staples Select Sector SPDR ETF81369Y308ETF1,932,100$149.0M0.4%−670,300−25.8%Reduced–
MROMarathon Oil CorpCOM9,010,000$147.9M0.4%+4,742,600+111.1%AddedHistory
INFOIHS Markit Ltd.SHS1,109,085$147.4M0.4%+319,600+40.5%AddedHistory
DTDynatrace, Inc.Stock2,423,500$146.3M0.4%+1,218,400+101.1%AddedHistory
ANETArista Networks, Inc.COM937,000$134.7M0.3%+610,200+186.7%AddedConverted for a 4-for-1 splitHistory
State Street Industrial Select Sector SPDR ETF81369Y704ETF1,256,500$132.9M0.3%+667,400+113.3%Added–
DBXDropbox, Inc.CL A5,304,700$130.2M0.3%+798,700+17.7%AddedHistory
State Street Technology Select Sector SPDR ETF81369Y803ETF741,400$128.9M0.3%−469,300−38.8%Reduced–
INTUIntuit Inc.Stock197,200$126.8M0.3%+92,100+87.6%AddedHistory
XOMExxonMobil Holdings CorpCOM2,052,900$125.6M0.3%+1,076,600+110.3%AddedHistory
BKNGBooking Holdings Inc.Stock51,700$124.0M0.3%+50,400+3,876.9%AddedHistory
DHRDanaher CorpStock373,000$122.7M0.3%−733,800−66.3%ReducedHistory
CHKPCheck Point Software Technologies LtdORD1,032,200$120.3M0.3%−55,700−5.1%ReducedHistory
DUKDuke Energy CORPStock1,135,500$119.1M0.3%+632,700+125.8%AddedHistory
ZENZendesk, Inc.COM1,119,500$116.8M0.3%+720,200+180.4%AddedHistory
SNPSSynopsys IncCOM311,400$114.8M0.3%+118,900+61.8%AddedHistory
Vanguard Dividend Appreciation ETF921908844ETF641,800$110.2M0.3%+127,700+24.8%Added–
BIIBBiogen Inc.COM455,200$109.2M0.3%+404,500+797.8%AddedHistory
RSGRepublic Services, Inc.COM764,900$106.7M0.3%+122,527+19.1%AddedHistory
VEEVVeeva Systems IncStock413,700$105.7M0.3%+167,400+68.0%AddedHistory
ISRGIntuitive Surgical IncCOM NEW293,609$105.5M0.3%−635,200−68.4%ReducedConverted for a 3-for-1 splitHistory
NETCloudflare, Inc.CL A COM800,000$105.2M0.3%+800,000NewHistory
ORLYO Reilly Automotive IncStock148,400$104.8M0.3%+25,400+20.7%AddedHistory
CNICanadian National Railway CoStock824,372$101.3M0.3%+54,972+7.1%AddedHistory
IQVIQVIA Holdings Inc.Stock354,600$100.0M0.3%−148,200−29.5%ReducedHistory
iShares Core S&P 500 ETF464287200ETF206,500$98.5M0.2%−95,900−31.7%Reduced–
STLAStellantis N.V.SHS5,205,205$97.7M0.2%−300,900−5.5%ReducedHistory
MIMEMimecast LtdORD SHS1,204,700$95.9M0.2%+431,200+55.7%AddedHistory
INMDInMode Ltd.SHS1,340,500$94.6M0.2%−21,100−1.5%ReducedConverted for a 2-for-1 splitHistory
ICLRIcon PLCCOM300,802$93.2M0.2%−354,961−54.1%ReducedHistory

Sold out since Q3 2021 (320)

Positions held at the end of Q3 2021 that are gone from this filing.

The largest 100 of 320 by value last quarter.

Positions of Two Sigma Advisers, LP sold out since Q3 2021
SecurityClassShares in Q3 2021Value in Q3 2021% of portfolio in Q3 2021History
SNAPSnap IncStock5,130,877$379.0M1.0%History
ADIAnalog Devices IncStock1,687,414$282.6M0.7%History
BEKEKE Holdings Inc.SPONSORED ADS6,320,100$115.4M0.3%History
ACNAccenture plcStock345,501$110.5M0.3%History
PPDPPD, Inc.COM1,264,700$59.2M0.2%History
HRCHill-Rom Holdings, Inc.COM380,000$57.0M0.1%History
BCEBce IncCOM NEW904,927$45.3M0.1%History
CMECME Group Inc.COM223,901$43.3M0.1%History
FLFoot Locker, Inc.COM837,000$38.2M0.1%History
ARCCAres Capital CorpCEF1,661,013$33.8M0.1%History
CRSPCRISPR Therapeutics AGNAMEN AKT220,600$24.7M0.1%History
EPAMEPAM Systems, Inc.COM42,080$24.0M0.1%History
CFGCitizens Financial Group IncCOM510,400$24.0M0.1%History
VALEVale S.A.SPONSORED ADS1,661,700$23.2M0.1%History
SIGSignet Jewelers LtdSHS259,560$20.5M0.1%History
BBYBest Buy Co IncStock177,699$18.8M<0.1%History
XUnited States Steel CorpCOM850,500$18.7M<0.1%History
CADECadence BancorporationCL A743,499$16.3M<0.1%History
CALYCallaway Golf CoCOM581,900$16.1M<0.1%History
DRNADicerna Pharmaceuticals IncCOM765,550$15.4M<0.1%History
XECCimarex Energy CoCOM171,724$15.0M<0.1%History
KLACKLA CorpCOM NEW43,425$14.5M<0.1%History
ARRArmour Residential REIT, Inc.COM NEW1,341,765$14.5M<0.1%History
CSODCornerstone OnDemand IncCOM238,909$13.7M<0.1%History
HALOHalozyme Therapeutics, Inc.COM318,120$12.9M<0.1%History
VERVEREIT, Inc.COM283,086$12.8M<0.1%History
FAFFirst American Financial CorpStock167,361$11.2M<0.1%History
TDToronto Dominion BankStock160,555$10.6M<0.1%History
LMTLockheed Martin CorpStock29,111$10.0M<0.1%History
VFCV F CorpStock147,201$9.86M<0.1%History
RIORio Tinto PLCADR140,200$9.37M<0.1%History
XENTIntersect ENT, Inc.COM336,800$9.16M<0.1%History
BFHBread Financial Holdings, Inc.COM85,777$8.65M<0.1%History
MGMMGM Resorts InternationalStock200,300$8.64M<0.1%History
SGISomnigroup International Inc.COM182,044$8.45M<0.1%History
STMPStamps.com IncCOM NEW25,300$8.34M<0.1%History
BAMBrookfield Asset Management Ltd.CL A LTD VT SH146,432$7.84M<0.1%History
TFIITFI International Inc.COM72,900$7.45M<0.1%History
GPIGroup 1 Automotive IncCOM38,430$7.22M<0.1%History
iShares Semiconductor ETF464287523ETF16,000$7.13M<0.1%–
MPCMarathon Petroleum CorpStock109,100$6.74M<0.1%History
IAAIAA, Inc.COM118,800$6.48M<0.1%History
ENBEnbridge IncStock159,698$6.36M<0.1%History
CCKCrown Holdings, Inc.COM62,600$6.31M<0.1%History
RAREUltragenyx Pharmaceutical Inc.COM69,400$6.26M<0.1%History
ATECAlphatec Holdings, Inc.COM NEW469,700$5.73M<0.1%History
ESTCElastic N.V.ORD SHS38,300$5.71M<0.1%History
FIZZNational Beverage CorpCOM108,500$5.70M<0.1%History
MEOHMethanex CorpCOM120,073$5.53M<0.1%History
FIVNFive9, Inc.COM34,200$5.46M<0.1%History
CMOCapstead Mortgage CorpCOM NO PAR812,643$5.44M<0.1%History
MLKNMillerknoll, Inc.COM138,448$5.21M<0.1%History
VanEck ETF Trust92189H607OIL SERVICES ETF26,400$5.20M<0.1%–
CoreSite Realty Corp21870Q105COM35,800$4.96M<0.1%–
Echo Global Logistics, Inc.27875T101COM103,100$4.92M<0.1%–
HPEHewlett Packard Enterprise CoCOM341,900$4.87M<0.1%History
NINisource Inc.COM199,600$4.84M<0.1%History
COINCoinbase Global, Inc.COM CL A21,200$4.82M<0.1%History
PIIPolaris Inc.Stock40,300$4.82M<0.1%History
BDXBecton Dickinson & CoStock19,300$4.74M<0.1%History
Bancorpsouth BK Tupelo Miss05971J102COM155,500$4.63M<0.1%–
Qad Inc74727D306CL A52,100$4.55M<0.1%–
FRHCFreedom Holding Corp.COM72,400$4.55M<0.1%History
CTSHCognizant Technology Solutions CorpCL A56,800$4.21M<0.1%History
IPGInterpublic Group of Companies, Inc.COM113,200$4.15M<0.1%History
VTLEVital Energy, Inc.COM49,763$4.03M<0.1%History
UFSDomtar CORPCOM NEW70,328$3.84M<0.1%History
USNAUsana Health Sciences IncCOM41,122$3.79M<0.1%History
WYWeyerhaeuser CoCOM NEW106,180$3.78M<0.1%History
CTVACorteva, Inc.Stock86,598$3.64M<0.1%History
DXCDXC Technology CoStock107,220$3.60M<0.1%History
UMCUnited Microelectronics CorpSPON ADR NEW310,935$3.55M<0.1%History
MKSIMKS IncCOM23,500$3.55M<0.1%History
GAPGap IncCOM150,961$3.43M<0.1%History
TRPTC Energy CorpCOM70,600$3.40M<0.1%History
FSKFS KKR Capital CorpCOM149,967$3.31M<0.1%History
DFSDiscover Financial ServicesCOM26,500$3.26M<0.1%History
GNTXGentex CorpCOM96,600$3.19M<0.1%History
RPAIRetail Properties of America, Inc.CL A245,200$3.16M<0.1%History
KSUKansas City SouthernCOM NEW11,400$3.08M<0.1%History
ALTAAltabancorpCOM69,700$3.08M<0.1%History
MGAMagna International IncCOM39,484$2.97M<0.1%History
SMTCSemtech CorpStock37,600$2.93M<0.1%History
Zix Corp98974P100COM414,300$2.93M<0.1%–
AMKRAmkor Technology, Inc.COM113,185$2.82M<0.1%History
INOVInovalon Holdings, Inc.COM CL A70,100$2.82M<0.1%History
SICSelect Interior Concepts, Inc.CL A193,700$2.79M<0.1%History
FLXNFlexion Therapeutics IncCOM457,744$2.79M<0.1%History
KDMNKadmon Holdings, Inc.COM310,204$2.70M<0.1%History
LOVELovesac CoCOM38,600$2.55M<0.1%History
EVRGEvergy, Inc.Stock40,400$2.51M<0.1%History
DSPGDSP Group IncCOM111,894$2.45M<0.1%History
BOHBank of Hawaii CorpCOM29,700$2.44M<0.1%History
LYVLive Nation Entertainment, Inc.COM26,600$2.42M<0.1%History
CPBCAMPBELL'S CoCOM57,600$2.41M<0.1%History
BALYBally's CorpCOM45,600$2.29M<0.1%History
CVACovanta Holding CorpCOM112,500$2.26M<0.1%History
RGNXREGENXBIO Inc.COM53,000$2.22M<0.1%History
CAI International, Inc.12477X106COM38,933$2.18M<0.1%–
NRGNRG Energy, Inc.Stock53,100$2.17M<0.1%History