Baker Bros. Advisors LP
- SEC CIK
- 0001263508
- Latest filing
- Aug 14, 2026
Holdings in Q2 2021
Holdings as of Jun 30, 2021, filed Aug 16, 2021. Long positions only; changes compare share counts with Q1 2021.
- Positions
- 120
- −6 vs. Q1 2021
- Portfolio value
- $22.8B
- −$295.4M (−1.3%) vs. Q1 2021
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| SGENSeagen Inc. | COM | 47,288,259 | $7.47B | 32.8% | +17,5000.0% | Added | History |
| ONCBeOne Medicines Ltd. | ADR | 11,668,897 | $4.00B | 17.6% | 00.0% | Unchanged | History |
| INCYIncyte Corp | COM | 32,021,732 | $2.69B | 11.8% | +20,345+0.1% | Added | History |
| KODKodiak Sciences Inc. | COM | 14,137,881 | $1.31B | 5.8% | +257,929+1.9% | Added | History |
| ACADAcadia Pharmaceuticals Inc | COM | 41,910,704 | $1.02B | 4.5% | 00.0% | Unchanged | History |
| BMRNBiomarin Pharmaceutical Inc | COM | 7,589,294 | $633.3M | 2.8% | 00.0% | Unchanged | History |
| ASNDAscendis Pharma A/S | SPONSORED ADR | 3,540,270 | $465.7M | 2.0% | 00.0% | Unchanged | History |
| NVTAInvitae Corp | COM | 10,248,575 | $345.7M | 1.5% | −5,500,607−34.9% | Reduced | History |
| ARGXArgenx SE | SPONSORED ADR | 1,119,557 | $337.1M | 1.5% | 00.0% | Unchanged | History |
| PRLDPrelude Therapeutics Inc | COM | 10,123,824 | $289.8M | 1.3% | 00.0% | Unchanged | History |
| IGMSIGM Biosciences, Inc. | COM | 3,156,102 | $262.6M | 1.2% | 00.0% | Unchanged | History |
| ABCLAbCellera Biologics Inc. | COM | 10,450,180 | $229.9M | 1.0% | 00.0% | Unchanged | History |
| MRTXMirati Therapeutics, Inc. | COM | 1,409,784 | $227.7M | 1.0% | 00.0% | Unchanged | History |
| BCRXBiocryst Pharmaceuticals Inc | COM | 12,710,818 | $201.0M | 0.9% | 00.0% | Unchanged | History |
| MDGLMadrigal Pharmaceuticals, Inc. | COM | 1,499,213 | $146.0M | 0.6% | 00.0% | Unchanged | History |
| APLSApellis Pharmaceuticals, Inc. | COM | 2,271,917 | $143.6M | 0.6% | +597,913+35.7% | Added | History |
| HRTXHeron Therapeutics, Inc. | COM | 8,131,678 | $126.2M | 0.6% | +2,136,974+35.6% | Added | History |
| AMRNAmarin Corp PLC | SPONS ADR NEW | 26,453,422 | $115.9M | 0.5% | 00.0% | Unchanged | History |
| GBTGlobal Blood Therapeutics, Inc. | COM | 3,217,441 | $112.7M | 0.5% | 00.0% | Unchanged | History |
| PACBPacific Biosciences of California, Inc. | COM | 3,201,972 | $112.0M | 0.5% | 00.0% | Unchanged | History |
| IMCRImmunocore Holdings plc | ADS | 2,520,730 | $98.4M | 0.4% | 00.0% | Unchanged | History |
| KYMRKymera Therapeutics, Inc. | COM | 1,959,211 | $95.0M | 0.4% | 00.0% | Unchanged | History |
| VSTMVerastem, Inc. | COM | 21,491,630 | $87.5M | 0.4% | +4,472,336+26.3% | Added | History |
| VERVVerve Therapeutics, Inc. | COM | 1,416,530 | $85.3M | 0.4% | +1,416,530 | New | History |
| TLISTalis Biomedical Corp | COM | 7,574,835 | $83.5M | 0.4% | 00.0% | Unchanged | History |
| CERSCerus Corp | COM | 13,713,195 | $81.0M | 0.4% | 00.0% | Unchanged | History |
| DBVTDBV Technologies S.A. | SPONSORED ADR | 14,614,264 | $79.8M | 0.4% | 00.0% | Unchanged | History |
| RYTMRhythm Pharmaceuticals, Inc. | COM | 3,863,239 | $75.6M | 0.3% | +383,366+11.0% | Added | History |
| TILInstil Bio, Inc. | COM | 3,893,700 | $75.2M | 0.3% | 00.0% | Unchanged | History |
| LEGNLegend Biotech Corp | SPONSORED ADS | 1,664,534 | $68.3M | 0.3% | +1,548,908+1,339.6% | Added | History |
| NBIXNeurocrine Biosciences Inc | Stock | 676,975 | $65.9M | 0.3% | 00.0% | Unchanged | History |
| NRIXNurix Therapeutics, Inc. | COM | 2,454,082 | $65.1M | 0.3% | 00.0% | Unchanged | History |
| INSMINSMED Inc | COM PAR $.01 | 2,156,001 | $61.4M | 0.3% | 00.0% | Unchanged | History |
| ALLKAllakos Inc. | COM | 703,050 | $60.0M | 0.3% | 00.0% | Unchanged | History |
| ZYMEZymeworks Inc. | COM | 1,708,472 | $59.3M | 0.3% | 00.0% | Unchanged | History |
| HZNPHorizon Therapeutics Public Ltd Co | SHS | 599,110 | $56.1M | 0.2% | 00.0% | Unchanged | History |
| FMTXForma Therapeutics Holdings, Inc. | SHS | 2,024,876 | $50.4M | 0.2% | 00.0% | Unchanged | History |
| IMTXImmatics N.V. | SHS | 4,282,938 | $49.7M | 0.2% | +290,182+7.3% | Added | History |
| INSMED Inc457669AB5 | NOTE 0.750% 6/0 | – | $44.1M | 0.2% | – | New | – |
| MRUSMerus N.V. | COM | 2,037,469 | $42.9M | 0.2% | 00.0% | Unchanged | History |
| RAREUltragenyx Pharmaceutical Inc. | COM | 444,444 | $42.4M | 0.2% | 00.0% | Unchanged | History |
| ADAPYAdaptimmune Therapeutics PLC | SPONDS ADR | 9,830,877 | $41.9M | 0.2% | 00.0% | Unchanged | History |
| KRYSKrystal Biotech, Inc. | COM | 607,735 | $41.3M | 0.2% | −152,677−20.1% | Reduced | History |
| KNSAKiniksa Pharmaceuticals International, plc | COM CL A | 2,799,577 | $39.0M | 0.2% | 00.0% | Unchanged | History |
| Sarepta Therapeutics, Inc.803607AB6 | DBCV 1.500%11/1 | – | $38.5M | 0.2% | – | – | – |
| FLGTFulgent Genetics, Inc. | COM | 401,016 | $37.0M | 0.2% | 00.0% | Unchanged | History |
| AXSMAxsome Therapeutics, Inc. | COM | 539,057 | $36.4M | 0.2% | −89,357−14.2% | Reduced | History |
| NGNENeurogene Inc. | COM | 3,821,740 | $35.3M | 0.2% | 00.0% | Unchanged | History |
| BCABBioAtla, Inc. | COM | 825,000 | $35.0M | 0.2% | 00.0% | Unchanged | History |
| ADCTADC Therapeutics SA | SHS | 1,418,107 | $34.5M | 0.2% | 00.0% | Unchanged | History |
| ALGSAligos Therapeutics, Inc. | COM | 1,610,000 | $32.8M | 0.1% | 00.0% | Unchanged | History |
| JBIOJade Biosciences, Inc. | COM | 1,428,571 | $32.6M | 0.1% | +1,428,571 | New | History |
| RETAReata Pharmaceuticals Inc | CL A | 223,976 | $31.7M | 0.1% | 00.0% | Unchanged | History |
| NVAXNovavax Inc | COM NEW | 143,756 | $30.5M | 0.1% | 00.0% | Unchanged | History |
| ALKSAlkermes plc. | SHS | 1,228,170 | $30.1M | 0.1% | 00.0% | Unchanged | History |
| BCELAtreca, Inc. | CL A COM | 3,532,760 | $30.1M | 0.1% | 00.0% | Unchanged | History |
| DSGNDesign Therapeutics, Inc. | COM | 1,436,636 | $28.6M | 0.1% | 00.0% | Unchanged | History |
| Apellis Pharmaceuticals, Inc.03753UAB2 | NOTE 3.500% 9/1 | – | $27.8M | 0.1% | – | New | – |
| Tricida, Inc.89610FAB7 | NOTE 3.500% 5/1 | – | $27.3M | 0.1% | – | New | – |
| CYVNYOpthea Ltd | SPONSORED ADS | 3,412,062 | $27.1M | 0.1% | +103,357+3.1% | Added | History |
| Achilles Therapeutics PLC00449L102 | SPONSORED ADS | 2,591,366 | $25.4M | 0.1% | 00.0% | Unchanged | – |
| SYRESpyre Therapeutics, Inc. | COM | 3,410,106 | $23.7M | 0.1% | 00.0% | Unchanged | History |
| PTGXProtagonist Therapeutics, Inc | COM | 455,276 | $20.4M | 0.1% | −980,916−68.3% | Reduced | History |
| CYTCyteir Therapeutics, Inc. | COM | 812,640 | $17.4M | 0.1% | +812,640 | New | History |
| CRNXCrinetics Pharmaceuticals, Inc. | COM | 920,656 | $17.4M | 0.1% | +304,136+49.3% | Added | History |
| OTICOtonomy, Inc. | COM | 7,222,474 | $16.1M | 0.1% | +2,4000.0% | Added | History |
| Biomarin Pharmaceutical Inc09061GAH4 | NOTE 0.599% 8/0 | – | $15.6M | 0.1% | – | – | – |
| KDNYChinook Therapeutics, Inc. | COM | 1,080,393 | $15.3M | 0.1% | +331,700+44.3% | Added | History |
| AUPHAurinia Pharmaceuticals Inc. | COM | 1,119,962 | $14.5M | 0.1% | −290,102−20.6% | Reduced | History |
| ALBOAlbireo Pharma, Inc. | COM | 412,466 | $14.5M | 0.1% | 00.0% | Unchanged | History |
| XENEXenon Pharmaceuticals Inc. | COM | 751,639 | $14.0M | 0.1% | 00.0% | Unchanged | History |
| Invitae Corp46185LAB9 | NOTE 2.000% 9/0 | – | $13.9M | 0.1% | – | – | – |
| MIRMMirum Pharmaceuticals, Inc. | COM | 647,313 | $11.2M | <0.1% | 00.0% | Unchanged | History |
| ANABAnaptysbio, Inc | COM | 427,179 | $11.1M | <0.1% | 00.0% | Unchanged | History |
| EWTXEdgewise Therapeutics, Inc. | COM | 500,000 | $10.7M | <0.1% | 00.0% | Unchanged | History |
| ALTAltimmune, Inc. | COM NEW | 1,072,038 | $10.6M | <0.1% | −1,686,480−61.1% | Reduced | History |
| CBAYCymaBay Therapeutics, Inc. | COM | 2,170,464 | $9.46M | <0.1% | 00.0% | Unchanged | History |
| Genetron Hldgs Ltd37186H100 | ADS | 455,306 | $9.17M | <0.1% | 00.0% | Unchanged | – |
| CNTACentessa Pharmaceuticals plc | SPONSORED ADS | 400,000 | $8.88M | <0.1% | +400,000 | New | History |
| ISEEIVERIC bio, Inc. | COM | 1,406,037 | $8.87M | <0.1% | 00.0% | Unchanged | History |
| LONALeonaBio, Inc. | COM | 806,367 | $8.26M | <0.1% | 00.0% | Unchanged | History |
| ASMBAssembly Biosciences, Inc. | COM | 2,108,621 | $8.18M | <0.1% | +567,203+36.8% | Added | History |
| KRTXKaruna Therapeutics, Inc. | COM | 69,966 | $7.97M | <0.1% | 00.0% | Unchanged | History |
| MREOMereo BioPharma Group plc | SPON ADS | 2,459,399 | $7.80M | <0.1% | −4,260,549−63.4% | Reduced | History |
| SPRYARS Pharmaceuticals, Inc. | COM | 238,095 | $7.36M | <0.1% | 00.0% | Unchanged | History |
| BLUEbluebird bio, Inc. | COM | 226,988 | $7.26M | <0.1% | 00.0% | Unchanged | History |
| RVMDRevolution Medicines, Inc. | COM | 222,222 | $7.05M | <0.1% | 00.0% | Unchanged | History |
| DNLIDenali Therapeutics Inc. | COM | 88,738 | $6.96M | <0.1% | 00.0% | Unchanged | History |
| Chiasma, Inc16706W102 | COM | 1,420,740 | $6.72M | <0.1% | +678,607+91.4% | Added | – |
| HOOKHOOKIPA Pharma Inc. | COM | 700,481 | $6.42M | <0.1% | 00.0% | Unchanged | History |
| BNRBurning Rock Biotech Ltd | SPONSORED ADS | 209,131 | $6.16M | <0.1% | 00.0% | Unchanged | History |
| REPLReplimune Group, Inc. | COM | 153,512 | $5.90M | <0.1% | 00.0% | Unchanged | History |
| NGMNGM Biopharmaceuticals Inc | COM | 291,801 | $5.75M | <0.1% | 00.0% | Unchanged | History |
| CABACabaletta Bio, Inc. | COM | 636,363 | $5.47M | <0.1% | 00.0% | Unchanged | History |
| MGNXMacrogenics Inc | COM | 200,679 | $5.39M | <0.1% | 00.0% | Unchanged | History |
| ORTXOrchard Therapeutics plc | ADS | 1,192,003 | $5.23M | <0.1% | +457,572+62.3% | Added | History |
| ALECAlector, Inc. | COM | 239,228 | $4.98M | <0.1% | 00.0% | Unchanged | History |
| NEXINexImmune, Inc. | COM | 294,117 | $4.80M | <0.1% | 00.0% | Unchanged | History |
| BMEABiomea Fusion, Inc. | COM | 294,117 | $4.59M | <0.1% | +294,117 | New | History |
| GMDAGamida Cell Ltd. | SHS | 610,626 | $3.91M | <0.1% | −426,600−41.1% | Reduced | History |
Sold out since Q1 2021 (15)
Positions held at the end of Q1 2021 that are gone from this filing.
| Security | Class | Shares in Q1 2021 | Value in Q1 2021 | % of portfolio in Q1 2021 | History |
|---|---|---|---|---|---|
| ALXNAlexion Pharmaceuticals, Inc. | COM | 3,993,312 | $610.6M | 2.6% | History |
| ChemoCentryx, Inc.16383L106 | COM | 656,710 | $33.6M | 0.1% | – |
| XNCRXencor Inc | COM | 369,370 | $15.9M | 0.1% | History |
| SGMOQSangamo Therapeutics, Inc | COM | 429,063 | $5.38M | <0.1% | History |
| SRPTSarepta Therapeutics, Inc. | COM | 58,700 | $4.38M | <0.1% | History |
| CNSTConstellation Pharmaceuticals Inc | COM | 114,735 | $2.68M | <0.1% | History |
| ACGNAceragen, Inc. | COM PAR | 2,047,180 | $2.66M | <0.1% | History |
| AUTLAutolus Therapeutics plc | SPON ADS | 461,726 | $2.65M | <0.1% | History |
| VKTXViking Therapeutics, Inc. | COM | 363,980 | $2.30M | <0.1% | History |
| MTEMMolecular Templates, Inc. | COM | 133,833 | $1.69M | <0.1% | History |
| LKFTLakefront Biotherapeutics NV | SPON ADR | 11,180 | $862.0K | <0.1% | History |
| ADMSAdamas Pharmaceuticals Inc | COM | 147,996 | $710.0K | <0.1% | History |
| EOCNGalmed Pharmaceuticals Ltd. | SHS | 184,927 | $634.0K | <0.1% | History |
| IFRXInflaRx N.V. | COM | 138,040 | $538.0K | <0.1% | History |
| Genfit S A372279109 | ADS | 14,720 | $68.0K | <0.1% | – |