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Livermore
Livermore
ZHEN

OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q1 2025

Holdings as of Mar 31, 2025, filed May 15, 2025. Long positions only; changes compare share counts with Q4 2024.

Institution overview
Positions
106
−5 vs. Q4 2024
Portfolio value
$4.16B
−$652.4M (−13.5%) vs. Q4 2024
Filed
May 15, 2025
SEC
Holdings of OrbiMed Advisors LLC in Q1 2025
SecurityClassSharesValue% of portfolioShare changeActionHistory
Lakeshore Biopharma Co LtdG9845F208ORD SHS NEW140,428$344.0K<0.1%00.0%Unchanged–
XERSXeris Biopharma Holdings, Inc.COM80,420$441.5K<0.1%00.0%UnchangedHistory
DHAIDih Holding US, Inc.CL A1,915,000$442.9K<0.1%+1,915,000NewHistory
ANROAlto Neuroscience, Inc.COM SHS250,000$540.0K<0.1%00.0%UnchangedHistory
NXTCNextCure, Inc.COM1,141,200$548.1K<0.1%00.0%UnchangedHistory
KRROKorro Bio, Inc.COM32,400$564.1K<0.1%00.0%UnchangedHistory
IVVDInvivyd, Inc.COM933,500$565.0K<0.1%−215,800−18.8%ReducedHistory
TNGXTango Therapeutics, Inc.COM550,000$753.5K<0.1%00.0%UnchangedHistory
KZRKezar Life Sciences, Inc.COM192,700$940.4K<0.1%00.0%UnchangedHistory
HLSQTessera Defense & Homeland Security Inc.COM NEW1,787,767$993.5K<0.1%00.0%UnchangedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM348,000$1.23M<0.1%00.0%UnchangedHistory
TSBXTurnstone Biologics Corp.COM3,099,265$1.27M<0.1%00.0%UnchangedHistory
FATEFate Therapeutics IncCOM1,680,580$1.33M<0.1%00.0%UnchangedHistory
TRAWTraws Pharma, Inc.COM NEW605,531$1.39M<0.1%00.0%UnchangedHistory
NKTXNkarta, Inc.COM821,400$1.51M<0.1%00.0%UnchangedHistory
XFORX4 Pharmaceuticals, IncCOM6,776,515$1.60M<0.1%−357,000−5.0%ReducedHistory
CRDFCardiff Oncology, Inc.COM573,884$1.80M<0.1%−964,578−62.7%ReducedHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS1,741,273$1.90M<0.1%00.0%UnchangedHistory
TILInstil Bio, Inc.COM NEW116,785$2.03M<0.1%00.0%UnchangedHistory
CBLLCeribell, Inc.COM112,500$2.16M0.1%00.0%UnchangedHistory
INSMINSMED IncCOM PAR $.0128,659$2.19M0.1%−65,900−69.7%ReducedHistory
PASGPassage BIO, Inc.COM7,034,626$2.48M0.1%−370,243−5.0%ReducedHistory
RPTXRepare Therapeutics Inc.COM3,322,488$3.28M0.1%00.0%UnchangedHistory
BIOABioAge Labs, Inc.COM921,959$3.47M0.1%00.0%UnchangedHistory
QTTBQ32 Bio Inc.COM2,252,987$3.72M0.1%00.0%UnchangedHistory
BCAXBicara Therapeutics Inc.COM298,301$3.89M0.1%00.0%UnchangedHistory
ORICOric Pharmaceuticals, Inc.COM700,000$3.91M0.1%+700,000NewHistory
ENGNenGene Therapeutics Inc.COM891,616$3.99M0.1%−28,723−3.1%ReducedHistory
KRYSKrystal Biotech, Inc.COM23,500$4.24M0.1%00.0%UnchangedHistory
IMAImageneBio, Inc.COM3,539,358$4.53M0.1%00.0%UnchangedHistory
FBRXForte Biosciences, Inc.COM NEW593,088$4.60M0.1%−6,912−1.2%ReducedHistory
SRRKScholar Rock Holding CorpCOM151,800$4.88M0.1%00.0%UnchangedHistory
NSPRInspireMD, Inc.COM2,133,405$5.74M0.1%00.0%UnchangedHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM NEW1,172,287$6.22M0.1%00.0%UnchangedHistory
KMTSKestra Medical Technologies, Ltd.SHS250,000$6.23M0.1%+250,000NewHistory
TRVITrevi Therapeutics, Inc.COM1,120,000$7.04M0.2%+1,120,000NewHistory
PMVPPMV Pharmaceuticals, Inc.COM6,475,291$7.06M0.2%00.0%UnchangedHistory
AKROAkero Therapeutics, Inc.COM179,900$7.28M0.2%+113,900+172.6%AddedHistory
WHWKWhitehawk Therapeutics, Inc.COM4,166,000$7.42M0.2%+4,166,000NewHistory
AVTXAvalo Therapeutics, Inc.COM NEW967,000$7.75M0.2%00.0%UnchangedHistory
PRLDPrelude Therapeutics IncCOM10,909,256$8.38M0.2%00.0%UnchangedHistory
ADCTADC Therapeutics SASHS5,968,451$8.42M0.2%00.0%UnchangedHistory
ACETAdicet Bio, Inc.COM11,447,140$8.64M0.2%00.0%UnchangedHistory
ABCLAbCellera Biologics Inc.COM4,180,768$9.32M0.2%00.0%UnchangedHistory
AGIOAgios Pharmaceuticals, Inc.COM325,500$9.54M0.2%+298,800+1,119.1%AddedHistory
SLRNACELYRIN, Inc.COM4,001,711$9.88M0.2%00.0%UnchangedHistory
KROSKeros Therapeutics, Inc.COM1,018,734$10.4M0.2%00.0%UnchangedHistory
DYNDyne Therapeutics, Inc.COM1,014,611$10.6M0.3%−212,469−17.3%ReducedHistory
CCCCC4 Therapeutics, Inc.COM STK6,830,300$10.9M0.3%+2,452,400+56.0%AddedHistory
GPCRStructure Therapeutics Inc.SPONSORED ADS652,028$11.3M0.3%00.0%UnchangedHistory
VERAVera Therapeutics, Inc.CL A481,065$11.6M0.3%−261,507−35.2%ReducedHistory
0000000000Stock12,048,773$12.5M0.3%00.0%Unchanged–
AMGNAmgen IncStock44,200$13.8M0.3%+44,200NewHistory
IMTXImmatics N.V.SHS3,087,462$13.9M0.3%00.0%UnchangedHistory
CGEMCullinan Therapeutics, Inc.COM1,923,855$14.6M0.3%−18,700−1.0%ReducedHistory
VIRVir Biotechnology, Inc.COM2,248,249$14.6M0.3%−970,368−30.1%ReducedHistory
SCPHscPharmaceuticals Inc.COM6,059,528$15.9M0.4%00.0%UnchangedHistory
RAPTRAPT Therapeutics, Inc.COM13,135,260$16.0M0.4%00.0%UnchangedHistory
TYRATyra Biosciences, Inc.COM1,752,831$16.3M0.4%+282,745+19.2%AddedHistory
VSTMVerastem, Inc.COM NEW2,862,448$17.3M0.4%00.0%UnchangedHistory
FOLDAmicus Therapeutics, Inc.COM2,285,400$18.6M0.4%00.0%UnchangedHistory
THRDThird Harmonic Bio, Inc.COM5,779,071$20.1M0.5%00.0%UnchangedHistory
RYTMRhythm Pharmaceuticals, Inc.COM380,000$20.1M0.5%−20,000−5.0%ReducedHistory
JANXJanux Therapeutics, Inc.COM758,566$20.5M0.5%00.0%UnchangedHistory
TERNTerns Pharmaceuticals, Inc.COM7,562,971$20.9M0.5%00.0%UnchangedHistory
CRVSCorvus Pharmaceuticals, Inc.COM6,943,654$22.1M0.5%00.0%UnchangedHistory
GILDGilead Sciences, Inc.Stock197,500$22.1M0.5%−48,100−19.6%ReducedHistory
EXASExact Sciences CorpCOM679,816$29.4M0.7%00.0%UnchangedHistory
MBXMBX Biosciences, Inc.COM4,002,887$29.5M0.7%+190,672+5.0%AddedHistory
APLSApellis Pharmaceuticals, Inc.COM1,432,300$31.3M0.8%+1,432,300NewHistory
XENEXenon Pharmaceuticals Inc.COM947,877$31.8M0.8%00.0%UnchangedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM999,000$33.5M0.8%00.0%UnchangedHistory
TARSTarsus Pharmaceuticals, Inc.COM653,743$33.6M0.8%+653,743NewHistory
XTNTXtant Medical Holdings, Inc.COM NEW73,114,592$34.4M0.8%00.0%UnchangedHistory
UPBUpstream Bio, Inc.COM5,693,589$34.8M0.8%00.0%UnchangedHistory
SIONSionna Therapeutics, Inc.COM3,704,959$38.8M0.9%+3,704,959NewHistory
NPCENeuroPace IncCOM3,406,335$41.9M1.0%00.0%UnchangedHistory
SWTXSpringWorks Therapeutics, Inc.COM950,200$41.9M1.0%−304,831−24.3%ReducedHistory
CMPXCompass Therapeutics, Inc.COM22,362,850$42.5M1.0%00.0%UnchangedHistory
AXSMAxsome Therapeutics, Inc.COM386,700$45.1M1.1%+386,700NewHistory
SIBNSI-BONE, Inc.COM3,442,853$48.3M1.2%00.0%UnchangedHistory
Avidity Biosciences, Inc.05370A108COM1,812,886$53.5M1.3%+700,000+62.9%Added–
AVBPArriVent BioPharma, Inc.COM3,027,328$56.0M1.3%00.0%UnchangedHistory
CGONCG Oncology, Inc.COM2,471,994$60.5M1.5%+1,040,880+72.7%AddedHistory
CYTKCytokinetics IncCOM NEW1,509,205$60.7M1.5%−74,800−4.7%ReducedHistory
THCTenet Healthcare CorpCOM NEW465,000$62.5M1.5%−327,000−41.3%ReducedHistory
TMOThermo Fisher Scientific Inc.Stock129,000$64.2M1.5%+44,600+52.8%AddedHistory
IRONDisc Medicine, Inc.COM1,415,020$70.2M1.7%−370,551−20.8%ReducedHistory
IONSIonis Pharmaceuticals IncCOM2,540,136$76.6M1.8%−277,211−9.8%ReducedHistory
NTRANatera, Inc.COM547,000$77.4M1.9%+134,000+32.4%AddedHistory
VRTXVertex Pharmaceuticals IncStock159,900$77.5M1.9%+8,900+5.9%AddedHistory
ITGRInteger Holdings CorpCOM662,500$78.2M1.9%+87,500+15.2%AddedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM346,100$93.5M2.2%−69,500−16.7%ReducedHistory
PFEPfizer IncStock3,850,200$97.6M2.3%+3,850,200NewHistory
NBIXNeurocrine Biosciences IncStock934,640$103.4M2.5%−3,480−0.4%ReducedHistory
SPRYARS Pharmaceuticals, Inc.COM8,288,510$104.3M2.5%00.0%UnchangedHistory
UNHUnitedHealth Group IncStock201,200$105.4M2.5%+70,300+53.7%AddedHistory
EWEdwards Lifesciences CorpStock1,532,000$111.0M2.7%+386,698+33.8%AddedHistory
ARGXArgenx SESPONSORED ADR206,700$122.3M2.9%+17,000+9.0%AddedHistory
SYKStryker CorpStock359,200$133.7M3.2%+14,800+4.3%AddedHistory

Options (4)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of OrbiMed Advisors LLC in Q1 2025
SecurityClassPutsCalls
PFEPfizer IncStock–$12.7M
State Street SPDR S&P Biotech ETF78464A870ETF–$8.11M
SWTXSpringWorks Therapeutics, Inc.COM–$7.62M
GPCRStructure Therapeutics Inc.SPONSORED ADS–$2.60M

Sold out since Q4 2024 (16)

Positions held at the end of Q4 2024 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q4 2024
SecurityClassShares in Q4 2024Value in Q4 2024% of portfolio in Q4 2024History
SRPTSarepta Therapeutics, Inc.COM963,400$117.1M2.4%History
MRKMerck & Co., Inc.Stock829,900$82.6M1.7%History
BIIBBiogen Inc.COM509,100$77.9M1.6%History
UHSUniversal Health Services IncCL B269,300$48.3M1.0%History
State Street SPDR S&P Biotech ETF78464A870ETF372,000$33.5M0.7%–
MLYSMineralys Therapeutics, Inc.COM1,611,637$19.8M0.4%History
MEDPMedpace Holdings, Inc.COM44,900$14.9M0.3%History
ITCIIntra-Cellular Therapies, Inc.COM163,000$13.6M0.3%History
NMRANeumora Therapeutics, Inc.COM804,996$8.53M0.2%History
GERNGeron CorpCOM2,168,000$7.67M0.2%History
MISTMilestone Pharmaceuticals Inc.COM2,000,000$4.72M0.1%History
ARDTArdent Health, Inc.COM206,000$3.52M0.1%History
PEPGPepGen Inc.COM653,016$2.47M0.1%History
LYELLyell Immunopharma, Inc.COM3,103,623$1.99M<0.1%History
IMVTImmunovant, Inc.COM78,500$1.94M<0.1%History
ELEVElevation Acquisition Group Inc.COM941,275$529.6K<0.1%History