| BlackRock Inc. | 3,101,973 | $7,060 萬 | 0.00% | – | – |
| Franklin Resources Inc | 2,646,804 | $6,024 萬 | 0.02% | – | – |
| State Street Corp | 2,514,164 | $5,722 萬 | 0.00% | – | – |
| Eventide Asset Management, LLC | 2,370,975 | $5,396 萬 | 0.80% | – | – |
| Ra Capital Management, L.P. | 2,118,212 | $4,821 萬 | 0.73% | – | – |
| First Light Asset Management, LLC | 2,058,447 | $4,685 萬 | 3.11% | – | – |
| Vanguard Group Inc | 2,039,989 | $4,643 萬 | 0.00% | – | – |
| SV Health Investors, LLC | 1,824,542 | $4,153 萬 | 15.56% | – | – |
| Baillie Gifford & Co | 1,695,654 | $3,859 萬 | 0.02% | – | – |
| Samsara BioCapital, LLC | 1,675,579 | $3,814 萬 | 7.68% | – | – |
| Holocene Advisors, LP | 1,423,205 | $3,239 萬 | 0.21% | – | – |
| Loomis Sayles & Co L P | 1,354,993 | $3,084 萬 | 0.04% | – | – |
| Suvretta Capital Management, LLC | 1,284,976 | $2,925 萬 | 0.43% | – | – |
| Frazier Management LLC | 1,001,421 | $2,279 萬 | 1.83% | – | – |
| Citadel Advisors LLC | 976,620 | $2,223 萬 | 0.02% | – | – |
| Point72 Asset Management, L.P. | 958,200 | $2,181 萬 | 0.11% | – | – |
| BVF Inc | 826,825 | $1,882 萬 | 0.71% | – | – |
| Morgan Stanley | 773,106 | $1,760 萬 | 0.00% | – | – |
| FIL Ltd | 771,790 | $1,757 萬 | 0.02% | – | – |
| FMR LLC | 737,300 | $1,678 萬 | 0.00% | – | – |
| Tekla Capital Management LLC | 573,823 | $1,306 萬 | 0.45% | – | – |
| Geode Capital Management, LLC | 566,649 | $1,290 萬 | 0.00% | – | – |
| Millennium Management LLC | 556,799 | $1,267 萬 | 0.02% | – | – |
| Verition Fund Management LLC | 471,332 | $1,073 萬 | 0.20% | – | – |
| Adage Capital Partners GP, L.L.C. | 450,300 | $1,025 萬 | 0.02% | – | – |
| Nuveen Asset Management, LLC | 385,228 | $876.8 萬 | 0.00% | – | – |
| Dimensional Fund Advisors LP | 362,177 | $822.9 萬 | 0.00% | – | – |
| OrbiMed Advisors LLC | 350,000 | $796.6 萬 | 0.08% | – | – |
| Northern Trust Corp | 344,321 | $783.7 萬 | 0.00% | – | – |
| Opaleye Management Inc. | 341,950 | $778.3 萬 | 1.14% | – | – |
| Candriam Luxembourg S.C.A. | 368,110 | $767.7 萬 | 0.06% | – | – |
| Federated Hermes, Inc. | 328,774 | $748.3 萬 | 0.01% | – | – |
| Marshall Wace, LLP | 320,444 | $729.4 萬 | 0.04% | – | – |
| Sphera Funds Management Ltd. | 294,825 | $671.0 萬 | 0.62% | – | – |
| Invesco Ltd. | 293,033 | $667.0 萬 | 0.00% | – | – |
| Lombard Odier Asset Management (Switzerland) SA | 290,418 | $661.0 萬 | 0.44% | – | – |
| Compagnie Lombard Odier SCmA | 290,418 | $661.0 萬 | 0.15% | – | – |
| Barclays PLC | 260,123 | $591.9 萬 | 0.01% | – | – |
| Acadian Asset Management LLC | 237,393 | $540.4 萬 | 0.02% | – | – |
| Altium Capital Management LP | 226,719 | $516.0 萬 | 1.43% | – | – |
| Driehaus Capital Management LLC | 218,800 | $498.0 萬 | 0.07% | – | – |
| Woodline Partners LP | 215,974 | $491.6 萬 | 0.11% | – | – |
| Neuberger Berman Group LLC | 212,209 | $483.0 萬 | 0.00% | – | – |
| Parkman Healthcare Partners LLC | 202,696 | $461.3 萬 | 1.11% | – | – |
| Pentwater Capital Management LP | 184,501 | $419.9 萬 | 0.05% | – | – |
| Marshall Wace North America L.P. | 177,343 | $403.8 萬 | 0.02% | – | – |
| AJU IB Investment Co., Ltd. | 175,000 | $398.3 萬 | 1.50% | – | – |
| Citigroup Inc | 169,594 | $386.0 萬 | 0.00% | – | – |
| Janus Henderson Group PLC | 162,472 | $370.4 萬 | 0.00% | – | – |
| Victory Capital Management Inc | 146,274 | $333.0 萬 | 0.00% | – | – |
| Wells Fargo & Company | 143,735 | $327.1 萬 | 0.00% | – | – |
| Kennedy Capital Management, Inc. | 141,290 | $321.6 萬 | 0.06% | – | – |
| International Biotechnology Trust PLC | 139,331 | $317.1 萬 | 0.84% | – | – |
| Rafferty Asset Management, LLC | 137,303 | $312.5 萬 | 0.02% | – | – |
| Ikarian Capital, LLC | 135,360 | $308.1 萬 | 0.46% | – | – |
| Two Sigma Investments, LP | 118,510 | $269.7 萬 | 0.01% | – | – |
| Deutsche Bank AG | 116,807 | $265.8 萬 | 0.00% | – | – |
| Jacobs Levy Equity Management, Inc | 106,581 | $242.6 萬 | 0.02% | – | – |
| Bank of New York Mellon Corp | 101,398 | $230.8 萬 | 0.00% | – | – |
| Alliancebernstein L.P. | 88,824 | $202.2 萬 | 0.00% | – | – |
| DAFNA Capital Management LLC | 85,000 | $193.5 萬 | 0.46% | – | – |
| Charles Schwab Investment Management Inc | 81,398 | $185.3 萬 | 0.00% | – | – |
| Affinity Asset Advisors, LLC | 80,000 | $182.1 萬 | 0.89% | – | – |
| EAM Global Investors LLC | 74,142 | $168.7 萬 | 0.47% | – | – |
| Goldman Sachs Group Inc | 73,393 | $167.0 萬 | 0.00% | – | – |
| Schonfeld Strategic Advisors LLC | 71,614 | $163.1 萬 | 0.02% | – | – |
| Panagora Asset Management Inc | 67,265 | $153.1 萬 | 0.01% | – | – |
| Susquehanna International Group, LLP | 66,575 | $151.5 萬 | 0.00% | – | – |
| Two Sigma Advisers, LP | 59,800 | $136.1 萬 | 0.00% | – | – |
| JPMorgan Chase & Co | 59,087 | $134.5 萬 | 0.00% | – | – |
| Russell Investments Group, Ltd. | 55,534 | $126.3 萬 | 0.00% | – | – |
| California Public Employees Retirement System | 52,700 | $119.9 萬 | 0.00% | – | – |
| EAM Investors, LLC | 52,643 | $119.8 萬 | 0.18% | – | – |
| Susquehanna Fundamental Investments, LLC | 50,949 | $116.0 萬 | 0.02% | – | – |
| California State Teachers Retirement System | 49,024 | $111.6 萬 | 0.00% | – | – |
| J. Goldman & Co LP | 48,916 | $111.3 萬 | 0.07% | – | – |
| ExodusPoint Capital Management, LP | 46,473 | $105.8 萬 | 0.02% | – | – |
| Algert Global LLC | 45,790 | $104.2 萬 | 0.33% | – | – |
| AQR Capital Management LLC | 42,670 | $97.1 萬 | 0.00% | – | – |
| D. E. Shaw & Co., Inc. | 42,606 | $97.0 萬 | 0.00% | – | – |
| Cubist Systematic Strategies, LLC | 39,160 | $89.1 萬 | 0.01% | – | – |
| HighVista Strategies LLC | 38,982 | $88.7 萬 | 0.66% | – | – |
| State of Wisconsin Investment Board | 36,430 | $82.9 萬 | 0.00% | – | – |
| Rhumbline Advisers | 29,251 | $66.6 萬 | 0.00% | – | – |
| BNP Paribas Arbitrage, SA | 28,054 | $63.9 萬 | 0.00% | – | – |
| Arrowstreet Capital, Limited Partnership | 27,300 | $62.1 萬 | 0.00% | – | – |
| Bank of America Corp | 23,936 | $54.5 萬 | 0.00% | – | – |
| New York State Common Retirement Fund | 23,500 | $53.5 萬 | 0.00% | – | – |
| Jane Street Group, LLC | 22,404 | $51.0 萬 | 0.00% | – | – |
| AMP Capital Investors Ltd | 21,788 | $49.6 萬 | 0.00% | – | – |
| Boothbay Fund Management, LLC | 21,692 | $49.4 萬 | 0.03% | – | – |
| Price T Rowe Associates Inc | 21,399 | $48.7 萬 | 0.00% | – | – |
| American International Group, Inc. | 18,943 | $43.1 萬 | 0.00% | – | – |
| Manufacturers Life Insurance Company, The | 18,833 | $42.9 萬 | 0.00% | – | – |
| Parametric Portfolio Associates LLC | 16,340 | $37.2 萬 | 0.00% | – | – |
| ProShare Advisors LLC | 14,911 | $33.9 萬 | 0.00% | – | – |
| Connor, Clark & Lunn Investment Management Ltd. | 14,462 | $32.9 萬 | 0.00% | – | – |
| Virtus ETF Advisers LLC | 13,812 | $31.4 萬 | 0.13% | – | – |
| Voya Investment Management LLC | 13,615 | $31.0 萬 | 0.00% | – | – |
| MetLife Investment Management | 13,083 | $29.8 萬 | 0.00% | – | – |
