| FMR LLC | 5,392,412 | $3.41 億 | 0.03% | – | – |
| EcoR1 Capital, LLC | 2,999,315 | $1.90 億 | 8.50% | – | – |
| Novo Holdings A/S | 2,645,446 | $1.67 億 | 6.91% | – | – |
| Omega Fund Management, LLC | 2,272,478 | $1.44 億 | 13.60% | – | – |
| Artal Group S.A. | 1,819,186 | $1.15 億 | 2.44% | – | – |
| BlackRock Inc. | 1,155,420 | $7,312 萬 | 0.00% | – | – |
| Vanguard Group Inc | 950,298 | $6,014 萬 | 0.00% | – | – |
| Perceptive Advisors LLC | 938,140 | $5,937 萬 | 0.79% | – | – |
| Marshall Wace North America L.P. | 583,642 | $3,693 萬 | 0.15% | – | – |
| Jefferies Group LLC | 490,432 | $3,103 萬 | 0.73% | – | – |
| Point72 Asset Management, L.P. | 413,200 | $2,615 萬 | 0.13% | – | – |
| Ensign Peak Advisors, Inc | 395,039 | $2,500 萬 | 0.05% | – | – |
| Alkeon Capital Management LLC | 392,000 | $2,481 萬 | 0.09% | – | – |
| Price T Rowe Associates Inc | 370,507 | $2,345 萬 | 0.00% | – | – |
| Marshall Wace, LLP | 355,678 | $2,251 萬 | 0.12% | – | – |
| Cormorant Asset Management, LP | 350,000 | $2,215 萬 | 0.64% | – | – |
| Federated Hermes, Inc. | 300,043 | $1,899 萬 | 0.04% | – | – |
| Geode Capital Management, LLC | 247,258 | $1,565 萬 | 0.00% | – | – |
| State Street Corp | 241,527 | $1,528 萬 | 0.00% | – | – |
| Fiduciary Trust Co | 214,367 | $1,357 萬 | 0.28% | – | – |
| Driehaus Capital Management LLC | 205,237 | $1,299 萬 | 0.19% | – | – |
| Affinity Asset Advisors, LLC | 195,000 | $1,234 萬 | 6.05% | – | – |
| DAFNA Capital Management LLC | 181,467 | $1,148 萬 | 2.72% | – | – |
| Northern Trust Corp | 177,871 | $1,126 萬 | 0.00% | – | – |
| Polar Capital Holdings Plc | 150,000 | $949.2 萬 | 0.06% | – | – |
| D. E. Shaw & Co., Inc. | 128,815 | $815.1 萬 | 0.01% | – | – |
| Morgan Stanley | 119,040 | $753.2 萬 | 0.00% | – | – |
| Charles Schwab Investment Management Inc | 98,966 | $626.3 萬 | 0.00% | – | – |
| Tekla Capital Management LLC | 89,559 | $566.7 萬 | 0.19% | – | – |
| Rubric Capital Management LP | 89,047 | $563.5 萬 | 0.33% | – | – |
| Norges Bank | 81,900 | $518.3 萬 | 0.00% | – | – |
| Altrinsic Global Advisors LLC | 68,485 | $433.4 萬 | 0.14% | – | – |
| Silverarc Capital Management, LLC | 60,000 | $379.7 萬 | 2.13% | – | – |
| Two Sigma Investments, LP | 59,355 | $375.6 萬 | 0.01% | – | – |
| Bank of New York Mellon Corp | 52,294 | $330.9 萬 | 0.00% | – | – |
| Ikarian Capital, LLC | 49,925 | $316.0 萬 | 0.47% | – | – |
| Pinz Capital Management, LP | 48,496 | $306.9 萬 | 0.81% | – | – |
| Wells Fargo & Company | 48,307 | $305.7 萬 | 0.00% | – | – |
| Altium Capital Management LP | 46,541 | $294.5 萬 | 0.82% | – | – |
| Swiss National Bank | 45,300 | $286.7 萬 | 0.00% | – | – |
| Deutsche Bank AG | 41,618 | $263.4 萬 | 0.00% | – | – |
| SG Americas Securities, LLC | 40,199 | $254.4 萬 | 0.02% | – | – |
| Nuveen Asset Management, LLC | 68,448 | $247.5 萬 | 0.00% | – | – |
| Jacobs Levy Equity Management, Inc | 35,514 | $224.7 萬 | 0.02% | – | – |
| Goldman Sachs Group Inc | 32,726 | $207.1 萬 | 0.00% | – | – |
| EAM Global Investors LLC | 32,285 | $204.3 萬 | 0.57% | – | – |
| California Public Employees Retirement System | 27,900 | $176.6 萬 | 0.00% | – | – |
| Citadel Advisors LLC | 26,791 | $169.6 萬 | 0.00% | – | – |
| Woodline Partners LP | 24,909 | $157.6 萬 | 0.03% | – | – |
| State of Wisconsin Investment Board | 23,300 | $147.4 萬 | 0.00% | – | – |
| EAM Investors, LLC | 22,933 | $145.1 萬 | 0.22% | – | – |
| Two Sigma Advisers, LP | 21,900 | $138.6 萬 | 0.00% | – | – |
| Soleus Capital Management, L.P. | 21,500 | $136.1 萬 | 0.25% | – | – |
| California State Teachers Retirement System | 20,948 | $132.6 萬 | 0.00% | – | – |
| Millennium Management LLC | 18,518 | $117.2 萬 | 0.00% | – | – |
| Bank of America Corp | 16,159 | $102.3 萬 | 0.00% | – | – |
| Alliancebernstein L.P. | 13,600 | $86.1 萬 | 0.00% | – | – |
| STRS Ohio | 13,500 | $85.4 萬 | 0.00% | – | – |
| Acadian Asset Management LLC | 13,288 | $84.1 萬 | 0.00% | – | – |
| Rhumbline Advisers | 13,208 | $83.6 萬 | 0.00% | – | – |
| New York State Common Retirement Fund | 12,902 | $81.6 萬 | 0.00% | – | – |
| Barclays PLC | 11,644 | $73.7 萬 | 0.00% | – | – |
| AQR Capital Management LLC | 10,998 | $69.6 萬 | 0.00% | – | – |
| Jane Street Group, LLC | 10,999 | $69.6 萬 | 0.00% | – | – |
| Russell Investments Group, Ltd. | 10,838 | $68.4 萬 | 0.00% | – | – |
| UBS Asset Management Americas Inc | 10,485 | $66.3 萬 | 0.00% | – | – |
| Credit Suisse AG | 10,445 | $66.2 萬 | 0.00% | – | – |
| TD Asset Management Inc | 10,304 | $65.2 萬 | 0.00% | – | – |
| Virtus ETF Advisers LLC | 8,928 | $56.5 萬 | 0.24% | – | – |
| JPMorgan Chase & Co | 8,631 | $54.6 萬 | 0.00% | – | – |
| Manufacturers Life Insurance Company, The | 8,435 | $53.4 萬 | 0.00% | – | – |
| Cubist Systematic Strategies, LLC | 8,187 | $51.8 萬 | 0.01% | – | – |
| American International Group, Inc. | 8,119 | $51.4 萬 | 0.00% | – | – |
| HRT Financial LP | 7,606 | $48.1 萬 | 0.00% | – | – |
| MetLife Investment Management | 6,630 | $42.0 萬 | 0.00% | – | – |
| Martingale Asset Management L P | 6,206 | $39.4 萬 | 0.00% | – | – |
| Voya Investment Management LLC | 6,031 | $38.2 萬 | 0.00% | – | – |
| Raymond James & Associates | 6,004 | $38.0 萬 | 0.00% | – | – |
| Arizona State Retirement System | 5,724 | $36.2 萬 | 0.00% | – | – |
| Caxton Associates LP | 5,642 | $35.7 萬 | 0.03% | – | – |
| Susquehanna Fundamental Investments, LLC | 5,540 | $35.1 萬 | 0.01% | – | – |
| AlphaCentric Advisors LLC | 5,500 | $34.8 萬 | 0.12% | – | – |
| Parametric Portfolio Associates LLC | 5,477 | $34.7 萬 | 0.00% | – | – |
| Boothbay Fund Management, LLC | 5,298 | $33.5 萬 | 0.02% | – | – |
| Prosight Management, LP | 5,202 | $32.9 萬 | 0.27% | – | – |
| Invesco Ltd. | 5,066 | $32.1 萬 | 0.00% | – | – |
| Regency Capital Management Inc. | 4,700 | $29.7 萬 | 0.31% | – | – |
| Los Angeles Capital Management LLC | 4,595 | $29.1 萬 | 0.00% | – | – |
| State Board of Administration of Florida Retirement System | 4,566 | $28.9 萬 | 0.00% | – | – |
| Metropolitan Life Insurance Co | 4,326 | $27.4 萬 | 0.00% | – | – |
| Walleye Capital LLC | 4,320 | $27.3 萬 | 0.02% | – | – |
| Cetera Advisors LLC | 3,775 | $23.9 萬 | 0.01% | – | – |
| ProShare Advisors LLC | 3,721 | $23.5 萬 | 0.00% | – | – |
| Jump Financial, LLC | 3,247 | $20.5 萬 | 0.02% | – | – |
| Legal & General Group Plc | 2,667 | $16.9 萬 | 0.00% | – | – |
| Tower Research Capital LLC (TRC) | 2,047 | $13.0 萬 | 0.00% | – | – |
| BNP Paribas Arbitrage, SA | 1,818 | $11.5 萬 | 0.00% | – | – |
| O'Shaughnessy Asset Management, LLC | 1,349 | $8.50 萬 | 0.00% | – | – |
| Ameritas Investment Partners, Inc. | 1,210 | $7.70 萬 | 0.00% | – | – |
| FORA Capital, LLC | 1,189 | $7.50 萬 | 0.02% | – | – |
