| NEA Management Company, LLC | 8,533,072 | $2,927 萬 | 0.66% | – | – |
| BlackRock Inc. | 7,462,245 | $2,560 萬 | 0.00% | – | – |
| Wasatch Advisors Inc | 6,662,404 | $2,285 萬 | 0.10% | – | – |
| First Light Asset Management, LLC | 6,378,935 | $2,188 萬 | 1.45% | – | – |
| Vanguard Group Inc | 5,362,989 | $1,840 萬 | 0.00% | – | – |
| BVF Inc | 3,588,155 | $1,231 萬 | 0.46% | – | – |
| Boxer Capital, LLC | 2,913,091 | $999.2 萬 | 0.34% | – | – |
| Citadel Advisors LLC | 2,342,248 | $803.4 萬 | 0.01% | – | – |
| Burrage Capital Management LLC | 2,331,313 | $799.6 萬 | 6.48% | – | – |
| Sectoral Asset Management Inc | 1,961,667 | $672.9 萬 | 0.51% | – | – |
| Renaissance Technologies LLC | 1,789,486 | $613.8 萬 | 0.01% | – | – |
| State Street Corp | 1,770,116 | $607.1 萬 | 0.00% | – | – |
| Geode Capital Management, LLC | 1,647,355 | $565.0 萬 | 0.00% | – | – |
| Opaleye Management Inc. | 1,556,000 | $533.7 萬 | 0.78% | – | – |
| Point72 Asset Management, L.P. | 1,150,200 | $394.5 萬 | 0.02% | – | – |
| Northern Trust Corp | 1,089,166 | $373.6 萬 | 0.00% | – | – |
| Two Sigma Advisers, LP | 829,604 | $284.6 萬 | 0.01% | – | – |
| Goldman Sachs Group Inc | 822,225 | $282.1 萬 | 0.00% | – | – |
| Charles Schwab Investment Management Inc | 785,265 | $269.4 萬 | 0.00% | – | – |
| Acadian Asset Management LLC | 775,388 | $265.9 萬 | 0.01% | – | – |
| Artal Group S.A. | 760,000 | $260.7 萬 | 0.06% | – | – |
| Wells Fargo & Company | 742,736 | $254.8 萬 | 0.00% | – | – |
| Two Sigma Investments, LP | 673,688 | $231.1 萬 | 0.01% | – | – |
| DAFNA Capital Management LLC | 646,000 | $221.6 萬 | 0.53% | – | – |
| Altium Capital Management LP | 638,083 | $218.9 萬 | 0.61% | – | – |
| Woodline Partners LP | 637,341 | $218.6 萬 | 0.05% | – | – |
| Macquarie Group Ltd | 600,000 | $205.8 萬 | 0.00% | – | – |
| Assenagon Asset Management S.A. | 530,744 | $182.0 萬 | 0.01% | – | – |
| Sio Capital Management, LLC | 426,047 | $146.1 萬 | 0.31% | – | – |
| Millennium Management LLC | 402,690 | $138.1 萬 | 0.00% | – | – |
| Nuveen Asset Management, LLC | 397,754 | $136.5 萬 | 0.00% | – | – |
| Connor, Clark & Lunn Investment Management Ltd. | 372,224 | $127.7 萬 | 0.01% | – | – |
| Bank of New York Mellon Corp | 355,893 | $122.1 萬 | 0.00% | – | – |
| Bank of Montreal | 234,731 | $77.9 萬 | 0.00% | – | – |
| Arrowstreet Capital, Limited Partnership | 226,695 | $77.8 萬 | 0.00% | – | – |
| California Public Employees Retirement System | 210,200 | $72.1 萬 | 0.00% | – | – |
| Alps Advisors Inc | 203,576 | $69.8 萬 | 0.01% | – | – |
| Panagora Asset Management Inc | 197,484 | $67.7 萬 | 0.00% | – | – |
| California State Teachers Retirement System | 165,876 | $56.9 萬 | 0.00% | – | – |
| Strategic Wealth Advisors Group, LLC | 154,300 | $52.9 萬 | 0.03% | – | – |
| State of Wisconsin Investment Board | 152,400 | $52.3 萬 | 0.00% | – | – |
| ClariVest Asset Management LLC | 144,600 | $49.6 萬 | 0.02% | – | – |
| Barclays PLC | 121,889 | $41.8 萬 | 0.00% | – | – |
| Rhumbline Advisers | 116,197 | $39.9 萬 | 0.00% | – | – |
| Bank of America Corp | 114,972 | $39.5 萬 | 0.00% | – | – |
| Dimensional Fund Advisors LP | 108,896 | $37.4 萬 | 0.00% | – | – |
| Virtus ETF Advisers LLC | 103,723 | $35.6 萬 | 0.15% | – | – |
| New York State Common Retirement Fund | 91,608 | $31.4 萬 | 0.00% | – | – |
| EMC Capital Management | 91,008 | $31.2 萬 | 0.22% | – | – |
| Sigma Planning Corp | 79,450 | $27.3 萬 | 0.01% | – | – |
| Deutsche Bank AG | 74,143 | $25.4 萬 | 0.00% | – | – |
| Alliancebernstein L.P. | 68,400 | $23.5 萬 | 0.00% | – | – |
| Manufacturers Life Insurance Company, The | 68,005 | $23.3 萬 | 0.00% | – | – |
| American International Group, Inc. | 63,921 | $21.9 萬 | 0.00% | – | – |
| Truist Financial Corp | 59,257 | $20.3 萬 | 0.00% | – | – |
| Voya Investment Management LLC | 52,123 | $17.9 萬 | 0.00% | – | – |
| AQR Capital Management LLC | 49,618 | $17.0 萬 | 0.00% | – | – |
| MetLife Investment Management | 47,925 | $16.4 萬 | 0.00% | – | – |
| State Board of Administration of Florida Retirement System | 47,514 | $16.3 萬 | 0.00% | – | – |
| Boothbay Fund Management, LLC | 45,965 | $15.8 萬 | 0.01% | – | – |
| JPMorgan Chase & Co | 45,171 | $15.5 萬 | 0.00% | – | – |
| Invesco Ltd. | 41,863 | $14.3 萬 | 0.00% | – | – |
| Commonwealth Equity Services, LLC | 40,000 | $13.7 萬 | 0.00% | – | – |
| Los Angeles Capital Management LLC | 39,195 | $13.4 萬 | 0.00% | – | – |
| AlphaCentric Advisors LLC | 35,000 | $12.0 萬 | 0.04% | – | – |
| Jaffetilchin Investment Partners, LLC | 33,000 | $11.3 萬 | 0.01% | – | – |
| Hancock Whitney Corp | 31,218 | $10.7 萬 | 0.00% | – | – |
| Transform Wealth, LLC | 30,355 | $10.4 萬 | 0.02% | – | – |
| Raymond James & Associates | 29,913 | $10.3 萬 | 0.00% | – | – |
| ProShare Advisors LLC | 29,306 | $10.1 萬 | 0.00% | – | – |
| Winton Group Ltd | 26,125 | $9.00 萬 | 0.01% | – | – |
| Prelude Capital Management, LLC | 23,000 | $7.90 萬 | 0.01% | – | – |
| Principal Financial Group Inc | 22,291 | $7.60 萬 | 0.00% | – | – |
| UBS Group AG | 21,823 | $7.50 萬 | 0.00% | – | – |
| HighVista Strategies LLC | 20,077 | $6.90 萬 | 0.05% | – | – |
| Parametric Portfolio Associates LLC | 19,903 | $6.80 萬 | 0.00% | – | – |
| SG Americas Securities, LLC | 19,748 | $6.80 萬 | 0.00% | – | – |
| American Century Companies Inc | 16,885 | $5.80 萬 | 0.00% | – | – |
| BNP Paribas Arbitrage, SA | 16,466 | $5.65 萬 | 0.00% | – | – |
| Morgan Stanley | 16,398 | $5.60 萬 | 0.00% | – | – |
| Metropolitan Life Insurance Co | 16,080 | $5.52 萬 | 0.00% | – | – |
| Victory Capital Management Inc | 15,905 | $5.50 萬 | 0.00% | – | – |
| Amalgamated Bank | 15,763 | $5.40 萬 | 0.00% | – | – |
| Engineers Gate Manager LP | 15,208 | $5.20 萬 | 0.00% | – | – |
| Brown Advisory Securities, LLC | 15,000 | $5.10 萬 | 0.01% | – | – |
| Legal & General Group Plc | 13,895 | $4.80 萬 | 0.00% | – | – |
| Prudential Financial Inc | 13,419 | $4.60 萬 | 0.00% | – | – |
| Credit Suisse AG | 12,766 | $4.40 萬 | 0.00% | – | – |
| Private Advisor Group, LLC | 10,441 | $3.60 萬 | 0.00% | – | – |
| Jane Street Group, LLC | 10,089 | $3.50 萬 | 0.00% | – | – |
| Tower Research Capital LLC (TRC) | 10,052 | $3.40 萬 | 0.00% | – | – |
| Ameritas Investment Partners, Inc. | 7,667 | $2.60 萬 | 0.00% | – | – |
| Steward Partners Investment Advisory, LLC | 7,500 | $2.57 萬 | 0.00% | – | – |
| Citigroup Inc | 7,258 | $2.50 萬 | 0.00% | – | – |
| Royal Bank of Canada | 6,973 | $2.40 萬 | 0.00% | – | – |
| HighMark Wealth Management LLC | 4,384 | $1.50 萬 | 0.01% | – | – |
| Newbridge Financial Services Group, Inc. | 4,000 | $1.40 萬 | 0.01% | – | – |
| Mesirow Financial Investment Management, Inc. | 3,912 | $1.30 萬 | 0.04% | – | – |
| Sowell Financial Services LLC | 1,999 | $7,000 | 0.00% | – | – |
| Lindbrook Capital, LLC | 2,011 | $7,000 | 0.00% | – | – |
